1U1H,1XR2


Conserved Protein Domain Family
met_syn_B12ind

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TIGR01371: met_syn_B12ind 
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5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase
This model describes the cobalamin-independent methionine synthase. A family of uncharacterized archaeal proteins is homologous to the C-terminal region of this family. That family is excluded from this model but, along with this family, belongs to pfam01717. [Amino acid biosynthesis, Aspartate family]
Statistics
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PSSM-Id: 273583
Aligned: 14 rows
Threshold Bit Score: 1170.59
Created: 8-Oct-2014
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1U1H_A         6 VGYPRXGPKRELKFALESFWDGKSTAEDLQKVSADLRSSIWKQXSAAgTKFIPSNTFAHYDQVLDTTAXLGAVPPRYGYT 85  thale cress
O50008         6 VGYPRMGPKRELKFALESFWDGKSTAEDLQKVSADLRSSIWKQMSAAgTKFIPSNTFAHYDQVLDTTAMLGAVPPRYGYT 85  thale cress
CAC25212      10 AGLPRIGAKRELKFALEGYWNGSIEGRELAQTARQLVNTASDSLSg--LDSVPFAGRSYYDAMLDTAAILGVLPERFDDI 87  Corynebacterium...
O06584        15 TGSPRIGPRRELKRATEGYWAGRTSRSELEAVAATLRRDTWSALAAAgLDSVPVNTFSYYDQMLDTAVLLGALPPRVSPV 94  Mycobacterium t...
WP_010918370   8 LGFPRIGPKRELKFALEAYWAGKTDADALLDTARDLRAKTWTRQAALgVAHVPSNDFSLYDHVLDTAVMVGAIPAAYGWS 87  Caulobacter vib...
WP_009873990   8 LGFPRIGLNRELKKAQEQYWSGELMIKDLLLVGSELRKKNWQKQKESgIDYIPVGDFAWYDHVLTTSMMLGNIPERHNNT 87  Buchnera aphidi...
WP_010896616   6 LGYPRIGENREWKKALESFWANDTTEEQLLATMKELRLNHLRVQQEQeVDLIPVGDFTLYDHVLDMAVMFGIIPKRFLQQ 85  Bacillus halodu...
WP_000213942   7 LGYPRIGEKRELKFALEKYWRGEIDQAALKQVGSQIRQKNWALQKEAgLDFVTAGDFAWYDHVLTTTLLLGHVPKRHSH- 85  Vibrio cholerae
WP_002864555   6 ISYPRIGANRELKFAIEKYFKNQSSKEELLKSAKDLRIRHWQEIQKAgIDFIPSNDFSLYDNVLDAAVLFNIVHTKYKNL 85  Campylobacter j...
WP_000207614   9 LGFPRLGRKREWKKAIESYWAKKISKEELDQTLTDLHKENLLLQKYYhLDSIPVGDFSLYDHILDTSLLFNIIPERFQGR 88  Staphylococcus ...
1U1H_A        86 gGEIgl------dVYFSXARGn-------------------ASvpAXEXTKWFDTNYHYIVPELGpEVNFSYASHKAVNE 140 thale cress
O50008        86 -GGEig-----ldVYFSMARGnas-------------------vpAMEMTKWFDTNYHYIVPELGpEVNFSYASHKAVNE 140 thale cress
CAC25212      88 aDHEndglplwidRYFGAARGtet-------------------lpAQAMTKWFDTNYHYLVPELSaDTRFVLDASALIED 148 Corynebacterium...
O06584        95 sDGl--------dRYFAAARGtdq-------------------iaPLEMTKWFDTNYHYLVPEIGpSTTFTLHPGKVLAE 147 Mycobacterium t...
WP_010918370  88 gGTVdl------aTYFAMARGdqgrpaaeacgpgcghapgaDGvpALEMTKWFDTNYHYLAPELSpGQAFALTSSKPVDE 161 Caulobacter vib...
WP_009873990  88 vDSIdl------dCLFRIARGc------------------pPDisASEMTKWFNTNYHYIVPEFYkNKVLKYSWKQILDE 143 Buchnera aphidi...
WP_010896616  86 gDTPtl------sTYFAMARGs-------------------KNaqACEMTKWYNTNYHYIVPELHdAAP-RLTKNAPLEA 139 Bacillus halodu...
WP_000213942  86 -GFPdl------dTLFRVGRGqsqna-----------cgcgTGsaASDMTKWFNTNYHYIVPEFSsNDTFNVSWPQLFEE 147 Vibrio cholerae
WP_002864555  86 nLDAl-------dEYFAQSRGyqg---------------enGDvtALAMKKWFNTNYHYLVPECDnADIIALTGDKIFKE 143 Campylobacter j...
WP_000207614  89 tIDd--------dLLFDIARGn-------------------KDhvASALIKWFNTNYHYIVPEWDnVEP-KVSRNVLLDR 140 Staphylococcus ...
1U1H_A       141 YKEAK-ALGVDTVPVLVGPVSYLLLSKAakgVd---kSFELLSLLPKILPIYKEVITELKAAGATWIQLDEPVLVXDLEG 216 thale cress
O50008       141 YKEAK-ALGVDTVPVLVGPVSYLLLSKA---AkgvdkSFELLSLLPKILPIYKEVITELKAAGATWIQLDEPVLVMDLEG 216 thale cress
CAC25212     149 LRCQQ-VRGVNARPVLVGPLTFLSLART---Tdg----sNPLDHLPALFEVYERLIKSFDT---EWVQIDEPALVTDVAP 217 Corynebacterium...
O06584       148 LKEAL-GQGIPARPVIIGPITFLLLSKA---Vdg---agAPIERLEELVPVYSELLSLLADGGAQWVQFDEPALVTDLSP 220 Mycobacterium t...
WP_010918370 162 FLEAK-ALGVHTRPVLLGPVTFLKLAKT---Ka---eGFSPLSLLSALLPVYGQVLRGLAAAGADWVQIDEPCLALDLTD 234 Caulobacter vib...
WP_009873990 144 VDEAL-LLGHKVKPILLGPITYLWLGKV---Kg---eYFDRLDILKDIILIYKHVLKELSNRSIDFVQIDEPVLVLELPK 216 Buchnera aphidi...
WP_010896616 140 YLEAKnELGIDGKPVILGPYSFVKLAKG---Ye---eD-KLQETIQSLLPLYIQVIQELVDAGARSIQVDEPSLVTSISA 212 Bacillus halodu...
WP_000213942 148 VNEAL-QAGHDVKPVLLGPISYLYLGKE---Ve---eGFDRLTLLPRLLTAYQAILSKLAKQGVQWVQIDEPILALELEP 220 Vibrio cholerae
WP_002864555 144 YLEAK-ELGIESKPVLIGIFTLFKLI-A---Fk---dEKTQKLAKEKLLNAYIELFDKLNELKVTWLELDEPYLVYDLSK 215 Campylobacter j...
WP_000207614 141 FKYAQ-SLNVNAHPVIVGPITFVKLSKG---Gh---qTFE--EKVKTLLPLYKEVFESLIDAGAEYIQVDEPILVTDDSE 211 Staphylococcus ...
1U1H_A       217 qKLQAFTGAYAELESTlsglNVLVETYFADIpAeAYKTLT-SLKgVTAFGFDLVRGTkT--LDLVK-AGFPEGKYLFAGV 292 thale cress
O50008       217 qKLQAFTGAYAELESTlsglNVLVETYFADIpA-EAYKTLtSLKgVTAFGFDLVRGTkT--LDLVK-AGFPEGKYLFAGV 292 thale cress
CAC25212     218 eVLEQVRAGYTTLAkr---dGVFVNTYFGSGdQ-ALNTLA-GIG-LGAIGVDLVTHGvT---ELAA-WKGEE--LLVAGI 285 Corynebacterium...
O06584       221 dAPALAEAVYTALCSVsnrpAIYVATYFGDPgA-ALPALA-RTP-VEAIGVDLVAGAdT---SVAG-VPELAGKTLVAGV 293 Mycobacterium t...
WP_010918370 235 fERAELRRAYGALTHAapgvRLMLTSYFGGYgE-NLATAV-NLP-VEGLHLDLVRAPdE--LEAAL-AASRESLVLSLGV 308 Caulobacter vib...
WP_009873990 217 kWKDAYHYAYKELSGIt---KLLLTTYFDSIeH-NIEFIR-DLP-VQGIHIDLVHGKyN--LKNFS-SKIPSEWMLSLGV 287 Buchnera aphidi...
WP_010896616 213 rEMALVTRIYEQINEAiadaPLFLQTYFDAV-T-FYEEVV-SLP-VKGIGLDFVHGGaKnlEALRT-FGFPEDKVLAAGI 287 Bacillus halodu...
WP_000213942 221 rWQEAFKLAYQVIRGd---vKLLLTTYFDSVlD-TLDKIV-ELP-VDGLHVDISAAPaQ--LETIV-NRLPSDWVLSAGV 291 Vibrio cholerae
WP_002864555 216 eDIALFEEFYQELLNHkkdlKILLQSYFGDLrD-IYPKLL-ESK-FDALGLDFIEGKqS--LALVQqYGFAKDKILFGGL 290 Campylobacter j...
WP_000207614 212 sYENITREAYDYFEKAgvakKLVIQTYFEr--A-HLKFLS-SLP-VGGIGLDFVHDNgYnlKQIEA-GDFDKSKTLYAGI 285 Staphylococcus ...
1U1H_A       293 VDGRNIWANDFAASLSTLQALEgIVgkdklVVSTSCSLLHTAVDLINETKLDDEIKSWXAFAAQKVVEVNALAKALAGqK 372 thale cress
O50008       293 VDGRNIWANDFAASLSTLQALEgIVgkdklVVSTSCSLLHTAVDLINETKLDDEIKSWLAFAAQKVVEVNALAKALAG-- 370 thale cress
CAC25212     286 VDGRNIWRTDLCAALASLKRLAaRGp---iAVSTSCSLLHVPYTLEAEN-IEPEVRDWLAFGSEKITEVKLLADALAGnI 361 Corynebacterium...
O06584       294 VDGRNVWRTDLEAALGTLATLLgSAat--vAVSTSCSTLHVPYSLEPETDLDDALRSWLAFGAEKVREVVVLARALRDgH 371 Mycobacterium t...
WP_010918370 309 IDGRNVWRADLPALLDRLEPVVaRRgsdrvVLAPSCSLLHTPIDLDLETALDPEIRQWLAFAVQKVEALAVLAQALNGgR 388 Caulobacter vib...
WP_009873990 288 INGRNIWRSDLLKWFKSIKSISnHHrk--iLIGSSCSLLHTPIDLVAEKHLDKEVKRWFSFAVQKCEELRLLSSALN--- 362 Buchnera aphidi...
WP_010896616 288 IDGRNIWISNLRERHELVHQLEqHVakdrlVLQPSCSLLHVPVTTKREEKLDPTLLGVLAFANEKLTELHTLKQLAAGnE 367 Bacillus halodu...
WP_000213942 292 INGRNVWRADLSAILARLQPVKtLLge-rlWVASSCSLLHSPVDLDLEGDLSAETRSWFAFAKQKVTEVALLGRALEG-D 369 Vibrio cholerae
WP_002864555 291 INGKNIYANDYAKSLKLIKELQkYTqn--iILNTSCSLLHVPYSTEFESKLDSSYLKLFAFAKEKLQELKDLKEILNSsE 368 Campylobacter j...
WP_000207614 286 IDGRNVWASDIEAKKVLIDKLLaHTne--lVIQPSSSLLHVPVSLDDET-LDTSVGEGLSFATEKLDELDALRRLFNQnD 362 Staphylococcus ...
1U1H_A       373 DEALFS--ANaaalasrrsspRVTNEGVQKAAAALKGSDHRRATNVSARLDAQQKKLNLPILPTTTIGSFPQTVELRRVR 450 thale cress
O50008       371 QKDEALfsANaaalasrrsspRVTNEGVQKAAAALKGSDHRRATNVSARLDAQQKKLNLPILPTTTIGSFPQTVELRRVR 450 thale cress
CAC25212     362 DAAAFDaaSaaias--rrtspR------TAPITQELP--GRSRGSFDTRVTLQEKSLELPALPTTTIGSFPQTPSIRSAR 431 Corynebacterium...
O06584       372 DAVADEiaSSraaiasrkrdpRLHNGQIRARIEAIVAS-GAHRGNAAQRRASQDARLHLPPLPTTTIGSYPQTSAIRVAR 450 Mycobacterium t...
WP_010918370 389 ASVAAAleASaqaararatspRIHDPKVAERLAAVTPDMTRRRSPYDQRREAQRARLNLPPLPTTTIGSFPQTTEVRQAR 468 Caulobacter vib...
WP_009873990 363 DNDIDSikEWslpiyersvskRVNKIEVENRLSNVLIDKHQRLSPYKTRSIEQNKKFNFPILPTTTIGSFPQTISIRKLR 442 Buchnera aphidi...
WP_010896616 368 AEVKEAleANddalaaleksgWRSGAATSHNLENKK-----RPQSFNERRPLQEEKWQLPLLPTTTIGSFPQTKDVRRTR 442 Bacillus halodu...
WP_000213942 370 AAAILAcdTYsqpivarksshIVNKASVQTRINNITAALAERSAPYIERAHHQAEVLGLPFLPTTTIGSFPQTGEIRTER 449 Vibrio cholerae
WP_002864555 369 ENPLFRanQElfk-----nipERLDEKVKARLKALKKEDFTRTPSFKERALIQKEFLKLPLLPTTTIGSFPQSADVRSNR 443 Campylobacter j...
WP_000207614 363 SVKYDKlkARyerf---qnqsFKNLDYDFESVRTS------RQSPFAQRIEQQQKRLNLPDLPTTTIGSFPQSREVRKYR 433 Staphylococcus ...
1U1H_A       451 REYKAKKVSEEDYVKAIKEEIKKVVDLQEELDIDVLVHGEPERNDXVEYFGEQLSGFAFTANGWVQSYGSRCVKPPVIYG 530 thale cress
O50008       451 REYKAKKVSEEDYVKAIKEEIKKVVDLQEELDIDVLVHGEPERNDMVEYFGEQLSGFAFTANGWVQSYGSRCVKPPVIYG 530 thale cress
CAC25212     432 ARLRKESITLEQYEEAMREEIDLVIAKQEELGLDVLVHGEPERNDMVQYFSELLDGFLSTANGWVQSYGSRCVRPPVLFG 511 Corynebacterium...
O06584       451 AALRAGEIDEAEYVRRMRQEITEVIALQERLGLDVLVHGEPERNDMVQYFAEQLAGFFATQNGWVQSYGSRCVRPPILYG 530 Mycobacterium t...
WP_010918370 469 AAFAKGQISDATYEAFLRQETARAVAWQETVGLDVLVHGEFERNDMVQYFGEQLAGFAFTQSGWVQSYGSRCVRPPILFG 548 Caulobacter vib...
WP_009873990 443 RDFKLGLVTEEEYTKIIKKNIKKVIKIQEELDIDVLVHGEAERNDMVEYFGEHLDGFAFTDNGWVQSYGSRCVKPPIIIG 522 Buchnera aphidi...
WP_010896616 443 SLWRKGELSTVEYERTMKSYIEKWINIQEELGLDVLVHGEFERNDMVEFFGEKLDGFAFTANGWVQSYGSRCVKPPIIYG 522 Bacillus halodu...
WP_000213942 450 SAYRQGKLSEQEYVQALKGHIADAVKRQEALGLDVLVHGEAERNDMVEYFAENLAGFQTTQFGWVQSYGSRCVKPAIVVA 529 Vibrio cholerae
WP_002864555 444 LAFKQEKISAQNYTEFNQQKIKECIQIQEEIGLDVLVHGEFERNDMVEYFGENLKGFLFTQNGWVQSYGTRCVKPPVIWG 523 Campylobacter j...
WP_000207614 434 ADWKNKRITDEAYETFLKNEIARWIKIQEDIGLDVLVHGEFERNDMVEFFGEKLQGFLVTKFGWVQSYGSRAVKPPIIYG 513 Staphylococcus ...
1U1H_A       531 DVSRPKAXTVFWSAXAQSXTSRPXKGXLTGPVTILNWSFVRNDQPRHETCYQIALAIKDEVEDLEKGGIGVIQIDEAALR 610 thale cress
O50008       531 DVSRPKAMTVFWSAMAQSMTSRPMKGMLTGPVTILNWSFVRNDQPRHETCYQIALAIKDEVEDLEKGGIGVIQIDEAALR 610 thale cress
CAC25212     512 NVSRPAPMTVKWFQYAQSLTQKHVKGMLTGPVTILAWSFVRDDQPLATTADQVALALRDEINDLIEAGAKIIQVDEPAIR 591 Corynebacterium...
O06584       531 DVSRPRAMTVEWITYAQSLTDKPVKGMLTGPVTILAWSFVRDDQPLADTANQVALAIRDETVDLQSAGIAVIQVDEPALR 610 Mycobacterium t...
WP_010918370 549 DVSRPAPMTVDWWRYAQGLTRRPMKGMLTGPVTILNWSFVRDDLPRETACRQIALAIRDEVVDLEATGAAIIQIDEAALR 628 Caulobacter vib...
WP_009873990 523 DISRPKPMTIEWSKYAQSLTKKPVKGMLTGPVTILLWSFPREDVSLKKIATQIALALYDEVLDLEKEKIEIIQIDEPALR 602 Buchnera aphidi...
WP_010896616 523 NVSFTEPMTVAETVYAQSLTDKPVKGMLTGPVTILNWSFVRDDLPLTVIAHQIAEALTHEVTALEEAGIEMIQIDEPAIR 602 Bacillus halodu...
WP_000213942 530 DIEREKPITVEWSTYAQSLTSKQMKGMLTGPVTILCWTFPREDISRQEIAQQLALALRDEVADLQDAGINIIQIDEPAIR 609 Vibrio cholerae
WP_002864555 524 DVSRTKPITLAWSKFAQSLSQKIVKGMLTGPVTILNWSFPREDISLKESTEQIALAIRDEVLDLENAGIKIIQIDEAALR 603 Campylobacter j...
WP_000207614 514 DVKWTAPLTVDETVYAQSLTDKPVKGMLTGPVTILNWSFERVDLPRKVVQDQIALAINEEVLALEAAGIKVIQVDEPALR 593 Staphylococcus ...
1U1H_A       611 EGLPLRKSEHA-FYLDWAVHSFRITNCgVQDSTQIHTHXCYSHFNDIIHSIIDXDADVITIENSRSDEKLLSVFREgVkY 689 thale cress
O50008       611 EGLPLRKSEHA-FYLDWAVHSFRITNCgVQDSTQIHTHMCYSHFNDIIHSIIDMDADVITIENSRSDEKLLSVFREgVkY 689 thale cress
CAC25212     592 ELLPLRDVDKP-AYLQWSVDSFRLATAgAPDDVQIHTHMCYSEFNEVISSVIALDADVTTIEAARSDMQVLAALKS-SgF 669 Corynebacterium...
O06584       611 ELLPLRRADQA-EYLRWAVGAFRLATSgVSDATQIHTHLCYSEFGEVIGAIADLDADVTSIEAARSHMEVLDDLNA-IgF 688 Mycobacterium t...
WP_010918370 629 EGLPLRRGDWD-AYLDWAVESFRLAASgVADATQIHTHMCYSEFNDIIAAIGAMDADVISIETARSKMELLDAFVg-YaY 706 Caulobacter vib...
WP_009873990 603 EGLPLRKSSWH-EYLSWAVDVFRLSASgVKNTTQIHTHMCYCEFNDIMDSIALLDADVITIEAARSDMELLESFKK-FkY 680 Buchnera aphidi...
WP_010896616 603 EGLPLKAEDQQ-EYLDWAVSAFRASCAhVKATTQIHTHMCYSEFHEMIEAIDDLDADVISIETSRSHGEMISAFEKtT-Y 680 Bacillus halodu...
WP_000213942 610 EGLPLKKRDHQ-TYLDWAVQAFKISAGsARPETQIHTHMCYSEFNEIIESVAALDADVITIETSRSNMELLKAFEE-FnY 687 Vibrio cholerae
WP_002864555 604 EKLPLRKSDWHsEYLDWAIPAFNLVHSgVKAKTQIHTHMCYSEFSDILKEIDAMDADVISFEASRSNLSLLDTLKAiR-F 682 Campylobacter j...
WP_000207614 594 EGLPLRSEYHE-QYLKDAVLSFKLATSsVRDETQIHTHMCYSQFGQIIHAIHDLDADVISIETSRSHGDLIKDFEDi-nY 671 Staphylococcus ...
1U1H_A       690 GAGIGPGVYDIHSPRIPSSEEIADRVNKXLAVLEQNILWVNPDCGLKTRKYTEVKPALKNXVDAAKLIRSQ 760 thale cress
O50008       690 GAGIGPGVYDIHSPRIPSSEEIADRVNKMLAVLEQNILWVNPDCGLKTRKYTEVKPALKNMVDAAKLIRSQ 760 thale cress
CAC25212     670 ELGVGPGVWDIHSPRVPSAQKVDGLLEAALQSVDPRQLWVNPDCGLKTRGWPEVEASLKVLVESAKQAREK 740 Corynebacterium glutamicum
O06584       689 ANGVGPGVYDIHSPRVPSAEEMADSLRAALRAVPAERLWVNPDCGLKTRNVDEVTASLHNMVAAAREVRAG 759 Mycobacterium tuberculosis
WP_010918370 707 PAQIGPGVYDIHSPRVPAVEEMTTLLAAARQRLAGEQLWVNPDCGLKTRKWPETQAAIVNMVEAARRARAS 777 Caulobacter vibrioides
WP_009873990 681 PNEVGPGAYDIHSSNIPSVQSIISLLNKAMKYIPLKRIWVNPDCGLKTRNWNETILSLKNMVEATKILREK 751 Buchnera aphidicola
WP_010896616 681 EKGIGLGVYDIHSPRVPSEEEMLNVIRRALTVLPASLFWVNPDCGLKTRAEKETVAALKNMVaaaraaree 751 Bacillus halodurans
WP_000213942 688 PNEIGPGVYDIHSPNIPAQAWIEDLLRKAAEKIPAQRLWVNPDCGLKTRNWPEVEAALTNMVNAAKALRAE 758 Vibrio cholerae
WP_002864555 683 KTEVGPGVYDIHSPRVPSVEELSLTIEKILNKLPKEQIWINPDCGLKTRAYEEVITSLKNLVTATQKIREQ 753 Campylobacter jejuni
WP_000207614 672 DLGIGLGVYDIHSPRIPTKEEITTAINRSLQQIDRSLFWVNPDCGLKTRKEEEVKDALTVLVNAVKAKRQE 742 Staphylococcus aureus
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