Conserved Protein Domain Family
strep_his_triad

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TIGR01363: strep_his_triad 
streptococcal histidine triad protein
This model represents the N-terminal half of a family of Streptococcal proteins that contain a signal peptide and then up to five repeats of a region that includes a His-X-X-His-X-His (histidine triad) motif. Three repeats are found in the seed alignment. Additional copies in more poorly conserved regions may be detected. Members of this family from Streptococcus pneumoniae are suggested to cleave human C3, and the member PhpA has been shown in vaccine studies to be a protective antigen in mice. [Cellular processes, Pathogenesis]
Statistics
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PSSM-Id: 273578
Aligned: 3 rows
Threshold Bit Score: 563.427
Created: 8-Oct-2014
Updated: 25-Oct-2021
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
AAK19155       1 MKINKKYLVGSAAALILS-VCSYELGLYQAR-TVKENNRVSYIDGKQ--ATQKTENLTPDEVSKREGINAEQIVIKITDQ 76  Streptococcus p...
WP_010922709   1 MKKTYGYIGSVAAILLAThIGSYQLGKHHMG-SATKDNQIAYIDDSKgkAKAPKTNKTMDQISAEEGISAEQIVVKITDQ 79  Streptococcus p...
WP_000700393   1 MKINKKYLAGSVAVLALS-VCSYELGRYQAGqDKKESNRVAYIDGDQ--AGQKAENLTPDEVSKREGINAEQIVIKITDQ 77  Streptococcus p...
AAK19155      77 GYVTSHGDHYHYYNGKVPYDAIISEELLMKDPNYKLKDEDIVNEVKGGYVIKVDGKYYVYLKDAAHADNVRTKEEINRQK 156 Streptococcus p...
WP_010922709  80 GYVTSHGDHYHFYNGKVPYDAIISEELLMTDPNYRFKQSDVINEILDGYVIKVNGNYYVYLKPGSKRKNIRTKQQIAEQV 159 Streptococcus p...
WP_000700393  78 GYVTSHGDHYHYYNGKVPYDAIISEELLMKDPNYQLKDSDIVNEIKGGYVIKVNGKYYVYLKDAAHADNIRTKEEIKRQK 157 Streptococcus p...
AAK19155     157 QEHSQHREGG--------TPRNDGAVALARSQGRYTTDDGYIFNASDIIEDTGDAYIVPHGDHYHYIPKNELSASELAAA 228 Streptococcus p...
WP_010922709 160 AKGTKEAKEKglaqvahlSKEEVAAVNEAKRQGRYTTDDGYIFSPTDIIDDLGDAYLVPHGNHYHYIPKKDLSPSELAAA 239 Streptococcus p...
WP_000700393 158 QERSHNHN-----------SRADNAVAAARAQGRYTTDDGYIFNASDIIEDTGDAYIVPHGDHYHYIPKNELSASELAAA 226 Streptococcus p...
AAK19155     229 EAFLSGRGNLSNSRTYRR------QNSDNTSRTNWVPSVSN----------PGTTNTNTSNNSNTNSQASQSNDIDSLLK 292 Streptococcus p...
WP_010922709 240 QAYWSQKQGRGARPSDYRptpapaPGRRKAPIPDVTPNPGQghqpdnggyhPAPPRPNDASQNKHQRDEFKGKTFKELLD 319 Streptococcus p...
WP_000700393 227 EAYWNGK-----------------QGSRPSSSSSYNANPAQ----------PRLSENHNLTVTPTYHQN-QGENISSLLR 278 Streptococcus p...
AAK19155     293 QLYKLPLSQRHVESDGLVFDPAQITSRTARGVAVPHGDHYHFIPYSQMSELEERIA 348 Streptococcus pneumoniae
WP_010922709 320 QLHRLDLKYRHVEEDGLIFEPTQVIKSNAFGYVVPHGDHYHIIPRSQLSPLEMELA 375 Streptococcus pyogenes
WP_000700393 279 ELYAKPLSERHVESDGLIFDPAQITSRTARGVAVPHGNHYHFIPYSQMSELEKRIA 334 Streptococcus pneumoniae
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