4KAM,4OC9


Conserved Protein Domain Family
OAH_OAS_sulfhy

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TIGR01326: OAH_OAS_sulfhy 
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OAH/OAS sulfhydrylase
This model describes a distinct clade of the Cys/Met metabolism pyridoxal phosphate-dependent enzyme superfamily. Members include examples of OAH/OAS sulfhydrylase, an enzyme with activity both as O-acetylhomoserine (OAH) sulfhydrylase (EC 2.5.1.49) and O-acetylserine (OAS) sulphydrylase (EC 2.5.1.47). An alternate name for OAH sulfhydrylase is homocysteine synthase. This model is designated subfamily because it may or may not have both activities. [Amino acid biosynthesis, Aspartate family, Amino acid biosynthesis, Serine family]
Statistics
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PSSM-Id: 273555
Aligned: 14 rows
Threshold Bit Score: 672.917
Created: 8-Oct-2014
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
4KAM_A        21 SFETKQIHAGQQPDSATNARALPIYQTTSYTFENTAHAAALFGLEVPGNIYTRLGNPTTDVVEQRIAALEGGVAALFLSS 100 Mycobacterium m...
WP_010932291   8 RFETLQVHAGQEPDPVTGSRAVPIYQTTSYVFENAEHGADLFALRKAGNIYTRLMNPTTDVLEKRMAALEGGKAALGVAS 87  Chlorobaculum t...
WP_015084623   9 KFETIQVHGGHTPDGDTHSRAVPIYQTTSYTFDSPEHAAALFGLQETGNIYTRIMNPTTAVLEERLTLLEGGIGAVATAS 88  Listeria monocy...
WP_010953458   2 KLETLAIHAGFSPDPTTKAVAVPIYQTTSFAFDDTQHGADLFDLKVAGNIYSRIMNPTNDVLEQRMAALEGGVGALAVAS 81  Pseudomonas putida
WP_003910746  17 SFETKQIHAGQHPDPTTNARALPIYATTSYTFDDTAHAAALFGLEIPGNIYTRIGNPTTDVVEQRIAALEGGVAALFLSS 96  Mycobacterium a...
WP_007327082  10 RLATRALHAGQVADPTTKSRAVPIYATTSYQFDSTEHAAALFGLAEFGNIYSRLMNPTVDVLEKRIAALDGGVTGLCFAS 89  Rhodopirellula ...
WP_010906827   2 EFATKCLHAGYTPKNGE-PRVQPIVQSTTFTYDSAEEIGKLFDLQAAGYFYTRLSNPTTNAAEEKITALEGGVATMCTAS 80  Pasteurella mul...
WP_010887518 140 HFETLQVHAGQRPDPVTGAQQTPIYATNSYVFESPEHAADLFGLRQFGNIYSRIMNPTNDVFEQRVAALEGGVGALSVSS 219 Deinococcus rad...
WP_006769642  14 GFETRSIHAGQPVDSDTGSRNLPIHLTTAFVFDSAEHAKQRFALEDLGPVYTRLTNPTVEAVENRINNLEGGAHTVFFAS 93  Corynebacterium...
CAA71732      14 KPETIALHGGQEPDPTTTSRAVPLYQTTSYVFKDTDHAARLFGLQEFGNIYTRLMNPTTDVLEKRVAALEGGVAALATAS 93  Leptospira meyeri
4KAM_A       101 GQAAETFAILNLAGAGDHIVSSPRLYGGTYNLFHYSLAKLGIEVSFVDdPDN-L-DSWQAAVRPNTKAFFGETISNPQID 178 Mycobacterium m...
WP_010932291  88 GHSAQFIAIATICQAGDNIVSSSYLYGGTYNQFKVAFKRLGIEVRFVD-GND-Q-EAFRKAIDENTKALYMESIGNPAFH 164 Chlorobaculum t...
WP_015084623  89 GMAAITYSILNIAGSGDHIVAAATLYGGTHTLFSHTFKTFGIDVTFVD-PNE-P-ENFEKAIKDNTKAVFIETIGNPDIN 165 Listeria monocy...
WP_010953458  82 GMAAITYAIQTVAEAGDNIVSVAKLYGGTYNLLAHTLPRMGIHTRFAA-HDD-I-AALEALIDARTKAVFCESIGNPAGN 158 Pseudomonas putida
WP_003910746  97 GQAAETFAILNLAGAGDHIVSSPRLYGGTYNLFHYSLAKLGIEVSFVDdPDD-L-DTWQAAVRPNTKAFFAETISNPQID 174 Mycobacterium a...
WP_007327082  90 GQAAITAAVLAIAHSGQNIVSSTSLYGGTWTLFTQTLKNLGIEVRFFD-PDH-P-EQIHGLVDENTRLVYMESIGNPRND 166 Rhodopirellula ...
WP_010906827  81 GQAAVFYAMLNILQAGDHFISSSYVYGGSYNLFAHTFKKMGIEVTFVD-QDL-PlEELKKAIRPNTKAIFAETIANPALR 158 Pasteurella mul...
WP_010887518 220 GHAGQLVTLLTLAQAGDNIVSSPNLYGGTVNQFRVTLKRLGIEVRFTS-KDErP-EEFAALIDERTRAVYLETIGNPALN 297 Deinococcus rad...
WP_006769642  94 GQAATTAAILNLGGAGSHVVTSPRLYGGTETLFLVTLKRLGIEFTFVEnPDD-P-ESWQAAVRDNTIAFFGETFANPQAD 171 Corynebacterium...
CAA71732      94 GQSAEMLALLNIVEAGQEIVASSSLYGGTYNLLHYTFPKLGIKVHFVD-QSD-P-ENFRKASNDKTRAFYAETLGNPKLD 170 Leptospira meyeri
4KAM_A       179 LLDTPGVAEVAHRN---GIPLIVDNTIAT-P-YLIRPFTQGADIVVHSATKYLGGHGAAIAGVIVDGGTFDWT--Q--GR 249 Mycobacterium m...
WP_010932291 165 VPDFDAIAKIAREN---GIPLIVDNTFGCaG-YLCRPIDHGASIVVESATKWIGGHGTSMGGIIVDAGTFDWG--N--GK 236 Chlorobaculum t...
WP_015084623 166 IVDIEKVAEIAHAS---DIPLIVDNTFAT-A-YLNRPFDFGADIVVYSATKFIGGHGVAIGGAVIDSGKFNWA--N--GK 236 Listeria monocy...
WP_010953458 159 IVDIAALAEAAHRH---GVPLIVDNTVAT-P-VLCRPFEHGADIVVHSLTKYIGGHGTSIGGIVIDSGKFPWAenK--ER 231 Pseudomonas putida
WP_003910746 175 LLDTPAVSEVAHRN---GVPLIVDNTIAT-P-YLIQPLAQGADIVVHSATKYLGGHGAAIAGVIVDGGNFDWT--Q--GR 245 Mycobacterium a...
WP_007327082 167 VPDFKAIADAAHSAphgAIPVLCDNTVMT-P-YLLRPIDHGIDIVIYSTTKFLGGHGTHIGGCIVDSGNFKWA--DqpEK 242 Rhodopirellula ...
WP_010906827 159 VLDIEKFVALAKAA---QAPLLVDNTFAT-P-YFCRPIEFGANVVIHSTSKYLDGHAIALGGSITDGGNFDWN--N--GK 229 Pasteurella mul...
WP_010887518 298 IPDFEGVAKVAHEH---GVAVVVDNTFGA-GgYYCQPLRHGANIVLHSASKWIGGHGNGIGGVIVDGGNFDWG--S--GR 369 Deinococcus rad...
WP_006769642 172 VLDIPAVSEVAHRN---QVPLIVDNTIAT-A-ALVRPIELGADIVVASLTKFYTGNGSALGGALVDGGKFDWT--V--ER 242 Corynebacterium...
CAA71732     171 TLDIAAVSKVAKEV---GVPLVIDNTMPS-P-YLVNPLKHGADIVVHSLTKFLGGHGTSIGGIIIDGGSFNWG--N--GK 241 Leptospira meyeri
4KAM_A       250 -----FPEFTTPDPSYHGVVFAE-L---G--------APAYALKARVQLLRDLGSAASPFNAFLVAQGLETLSLRIERHV 312 Mycobacterium m...
WP_010932291 237 -----FPLFTEPSEGYHGLKFYEaV---G--------ELAFIIRARVEGLRDFGPAISPFNSFMLLQGLETLSLRVQRHL 300 Chlorobaculum t...
WP_015084623 237 -----FPKLVVPDDSYNGLSYTNdV---G--------AAAYITKLRVSLLRDTGAALSPFNAFLLILGLETLSLRLEQHV 300 Listeria monocy...
WP_010953458 232 -----FALLNTPDPSYHGVTYTEaF---G--------PAAFIGRCRVVPLRNTGAALSPFNAFLILQGLETLALRMERHT 295 Pseudomonas putida
WP_003910746 246 -----FPGFTTPDPSYHGVVFAE-L---G--------PPAFALKARVQLLRDYGSAASPFNAFLVAQGLETLSLRIERHV 308 Mycobacterium a...
WP_007327082 243 -----WPEFCGPSPSYHGAVFEEhLrgmG--------NIAYNVHIRTHWLRDTGAAMSPFAAFLFLQGIETLHLRMPRHC 309 Rhodopirellula ...
WP_010906827 230 -----FPQLSTPDQTYHGLVYTEtF---V--------PAAYIVKARVQLMRDLGATPAPQNSFLLNVGMETLALRMQRHY 293 Pasteurella mul...
WP_010887518 370 -----YPLMTEPSPSYHGLKFWEtF---GegnglglpNIAFITRARTEGLRDLGTTLAPQQAWQFLQGLETLSLRAERHA 441 Deinococcus rad...
WP_006769642 243 dgkpvFPDFVTPDPAYHGLKYAD-L---G--------APAFGLKARVGLLRDTGAAPSPFNAWVTNQGLDTLSLRLERHN 310 Corynebacterium...
CAA71732     242 -----FKNFTEPDPSYHGLKFWEvF---GkfepfggvNIAFILKARVQGLRDLGPAISPFNAWQILQGVETLPLRMERHS 313 Leptospira meyeri
4KAM_A       313 SNAQRVAEFLADREDVVTVNYAGLPGSPWHERAKKLSPKG-TGAVLSFELAGGVEAGKAFVNALKLHSHVANIGDVRSLV 391 Mycobacterium m...
WP_010932291 301 DNTLELARWLERHDAVAWVNYPGLESHPTHALAKKYLTHG-FGCVLTFGVKGGYENAVKFIDSVKLASHLANVGDAKTLV 379 Chlorobaculum t...
WP_015084623 301 KNAKQVANFLNDHPKVAWVNYPGLSDNKYHELAQKYLPKG-PGSIFTFGVKGGYEAGKKVIESVELFSHLANVGDAKSLI 379 Listeria monocy...
WP_010953458 296 ENALKVAHYLQAHEQVAWVKFAGLPDHPEHALAQRYTGGK-PASILSFGIKGGQAAGARFIDALQLVVRLVNIGDAKSLA 374 Pseudomonas putida
WP_003910746 309 ANAQRVAEFLAARDDVLSVNYAGLPSSPWHERAKRLAPKG-TGAVLSFELAGGIEAGKAFVNALKLHSHVANIGDVRSLV 387 Mycobacterium a...
WP_007327082 310 ENAMKVAEFLEAHDAVEWVNYPGLKTHSHNKLAEQYLTNG-KGAILGFGIKGGMEAGKKFINACQLCSHLANIGDAKTLV 388 Rhodopirellula ...
WP_010906827 294 ENAQAVAEFLENHPQVAKVSYPGLASSPDHALKQKYLPNG-LCGVISFEIRGGRETAAKWLNALQLASREVHVADIRTCA 372 Pasteurella mul...
WP_010887518 442 ENTLALAHWLISHPDVKQVTYPGLSNHPHYDRAQTYLPRG-AGAVLTFELRGGRAAGEAFIRSVKLAQHVANVGDTRTLV 520 Deinococcus rad...
WP_006769642 311 ENAIKVAEFLNNHEKVTKVHFAGLPDSPWYATKEKLGLKY-TGSVLTFELAGGKDEAWAFIDALKLHSNLANIGDVRSLV 389 Corynebacterium...
CAA71732     314 GNALKVAEFLQKHPKIEWVNYPGLSTDKNYATAKKYHERGlFGAIVGFEIKGGVEKAKKFIDGLELFSLLANIGDAKSLA 393 Leptospira meyeri
4KAM_A       392 IHPASTTHAQLSPAEQLSTGVSPGLVRLAVGIEGIEDILADLELGFA 438 Mycobacterium marinum M
WP_010932291 380 IHPASTTHQQLSAEEQVSAGVTADMVRVSVGIEHIDDIKADFSQAFE 426 Chlorobaculum tepidum
WP_015084623 380 IHPASTTHQQLSEEQQLTAGVKPESIRLSIGIENADDIIQDLTKALE 426 Listeria monocytogenes
WP_010953458 375 CHPASTTHRQLNDDELEKAGVPRDMVRLSIGIEHSDDIIADLAQALE 421 Pseudomonas putida
WP_003910746 388 IHPASTTHAQLSPAEQLATGVSPGLVRLAVGIEGIDDILADLELGFA 434 Mycobacterium africanum
WP_007327082 389 IHPASTTHQQLAEDEQRRAGVSPEYIRVSVGIEDIDDILDDLKQALA 435 Rhodopirellula baltica
WP_010906827 373 LHPATSTHRQLSEAELEKVGISAGLIRLSCGIESIQDILADLEQAFH 419 Pasteurella multocida
WP_010887518 521 IHPASTTHSQLDEVTQTNAGVTPGLIRVSVGIEHVDDIREDFAQALA 567 Deinococcus radiodurans
WP_006769642 390 VHPATTTHSQSDEAGLARAGITQGTVRLSVGIENVEDIIADLERGFA 436 Corynebacterium efficiens
CAA71732     394 IHPASTTHQQLTGPEQISAGVTPGFVRLSVGLENIDDILVDLEEALK 440 Leptospira meyeri
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