Conserved Protein Domain Family
agmatinase

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TIGR01230: agmatinase 
agmatinase
Members of this family include known and predicted examples of agmatinase (agmatine ureohydrolase). The seed includes members of archaea, for which no definitive agmatinase sequence has yet been made available. However, archaeal sequences are phylogenetically close to the experimentally verified B. subtilis sequence. One species of Halobacterium has been demonstrated in vitro to produce agmatine from arginine, but no putrescine from ornithine, suggesting that arginine decarboxylase and agmatinase, rather than arginase and ornithine decarboxylase, lead from Arg to polyamine biosynthesis. Note: a history of early misannotation of members of this family is detailed in PUBMED:10931887.
Statistics
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PSSM-Id: 273514
View PSSM: TIGR01230
Aligned: 5 rows
Threshold Bit Score: 360.997
Threshold Setting Gi: 499180609
Created: 8-Oct-2014
Updated: 25-Oct-2021
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q57757         9 SKFMMANCP--YEEAEGVIFSIPYDETTSFKPGAREGGNAIRTASWGLETYSPILD----RDLAE---LKYCDLKDLDL- 78  Methanocaldococ...
P16936        21 RLPMNFQPY--DSDADWVITGVPFDMATSGRAGGRHGPAAIRQVSTNLAWEHNRFP----WNFDMrerLNVVDCGDLVYa 94  Escherichia coli
WP_003227545  10 KVFIASRPE--WEEADAILYGMPMDWTVSYRPGSRFGPSRIREVSIGLEEYSPYLD----RDLAD---LNFFDAGDIPLp 80  Bacillales
WP_010871340  12 KQFLESEAItsYADAAVVVVPIPYEATTSYRKGCEHGPEAVLEASDQLEAYDEELGtspcHDLGIytcAPLADSNKHPAl 91  Synechocystis s...
WP_010878149   5 SYFSLSNCD--AEEAEYLIYGIPYDATQSFKPGSRFAPNAIREASWNLESYSNLFD----VELSL---VKVGDAGNINCd 75  Archaeoglobus f...
Q57757        79 YGSqeEIFGTIHSVSREILKENK-KIIVFGGEHSITYPIIKAVKD-IYDDFIVIQFDAHCDLR---DEYLGNKLSHACVM 153 Methanocaldococ...
P16936        95 FGDarEMSEKLQAHAEKLLAAGK-RMLSFGGDHFVTLPLLRAHAK-HFGKMALVHFDAHTDTYangCEFDHGTMFYTAPK 172 Escherichia coli
WP_003227545  81 FGNpqRSLDMIEEYVDSILEKGK-FPMGMGGEHLVSWPVIKAMYK-KYPDLAIIHFDAHTDLR---VDYEGEPLSHSTPI 155 Bacillales
WP_010871340  92 AGDa--MVTEVCDGIAPFVEDGK-FVVAIGGEHAITTGVVRAMQRgTSEPFTVVQIDAHGDMR---DKFEGSCHNHACVM 165 Synechocystis s...
WP_010878149  76 GG-----FEQIVERTKEFLGEVEgFPVAIGGEHSISF----AATS-KFRKACFVVFDAHFDLR---DEFDGDRFNHACTT 142 Archaeoglobus f...
Q57757       154 RRVYELTk--NIFQFGIRSGDKEEWDLARKNNL-YLK-MDLMNK---DDLEYIKSLDKPIYVTIDIDVLDPAYAPGTGTP 226 Methanocaldococ...
P16936       173 EGLIDPN---HSVQIGIRTEFDKDNGFTVLDACqVND-RSVDDV---IAQVKQIVGDMPVYLTFDIDCLDPAFAPGTGTP 245 Escherichia coli
WP_003227545 156 RKAAELIgphNVYSFGIRSGMKEEFEWAKENGMhISK-FEVLEP---LKEVLPKLAGRPVYVTIDIDVLDPAHAPGTGTV 231 Bacillales
WP_010871340 166 RRVLELGl--PTLPIAIRAICQEEADLIREKNIpVFWaREMADNpnwINEAIASITTQKVFLTIDMDGFDPGFMPGVGTP 243 Synechocystis s...
WP_010878149 143 RRIFESGm--RVAIFGVRSGIKEEKRFAEENGIkYLHaWDFEVE---KAVKMVEDFDK-IYVSLDVDAFDPAFAPGVSTP 216 Archaeoglobus f...
Q57757       227 EPCGFSTRELFNslYLLEEVKDKIIGFDIVEVSPiYDIANITAITAAKIARELMLM 282 Methanocaldococcus jannaschii DSM 2661
P16936       246 VIGGLTSDRAIK--LVRGLKDLNIVGMDVVEVAPaYDQSEITALAAATLALEMLYI 299 Escherichia coli
WP_003227545 232 DAGGITSKELLAsvHEIARSEVNVKGADLVEVAPvYDHSEQTANTASKIIREMLLG 287 Bacillales
WP_010871340 244 EPGGLGWYEGLNf-FRRLFQTKQVIGCDLMELAPv-RGSVVSEFSTAKLAYKLMGY 297 Synechocystis sp. PCC 6803
WP_010878149 217 EPFGLKPIDFIRf-F--AGIADRVVGFDVVEVVP--DSNKVTQTLAAKIILEAIAA 267 Archaeoglobus fulgidus
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