2VUG,3QWU


Conserved Protein Domain Family
TIGR01209
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TIGR01209: TIGR01209 
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RNA ligase, Pab1020 family
Members of this family are found, so far, in a single copy per genome and largely in thermophiles, of which only Aquifex aeolicus is bacterial rather than archaeal. PSI-BLAST converges after a single iteration to the whole of this family and reveals no convincing similarity to any other protein. The member protein Pab1020 has been characterized as an RNA ligase with circularization activity. [Transcription, RNA processing]
Links
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Statistics
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PSSM-Id: 273501
Aligned: 8 rows
Threshold Bit Score: 473.05
Created: 8-Oct-2014
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
2VUG_A        19 ILVKLGLTEDRIETLEMKGGIIEDEFDGIRYVRFKDSAGKLRRGTVVId---eEYVIPGFPHIKRIINLRSGIRRIFKRG 95  Pyrococcus abys...
CAB50450      12 ILVKLGLTEDRIETLEMKGGIIEDEFDGIRYVRFKDSAGKLRRGTVVId---eEYVIPGFPHIKRIINLRSGIRRIFKRG 88  Pyrococcus abys...
Q57857        16 IAEKLNLSIKDLNKAFSRKILREDEYKEIKTLLFKKEFKGIEKGTVIFln-dnLDVVRGYPKTYRAITLYPTIKKHFIDK 94  Methanocaldococ...
WP_010884602   9 ILYRLGIPEGKVEDLEARGGLVEDKFDDIKYLRIRNSVGKLRRGTVVLn---dKFIILGFPHIKRIVNLKNGIKRTFKRG 85  Pyrococcus hori...
WP_010876845  13 IQERTGVPSSRLKVAFARGSLRLLESAGMQALLFKKPLGDLEAGTVIYlg-deTEVIRGFPKIRRTLLLSPTIQEHFRDR 91  Methanothermoba...
WP_010878352  13 SAAGRLEERNILRKAFVRHPFFADIEEAF---RFEKKFGQYEEGTIVIkakdsLKVFRGFPKIRRALLLDPTIKKHFGDR 89  Archaeoglobus f...
WP_010866453  13 RAVGVDPGSVDLEALSTRRSVRVSRFEDVVYVGFRRQFRGVPEGTLVAfrrgeQIVVWGYPSIKRMLLPRVAVPRWFPGP 92  Aeropyrum pernix
3QWU_A         8 ELVKEALKKKKVRSEEAFG---------LEYLRFNDDYKDIPRGTAIFk----dFIIWGYPHIGRIFLLETGLREQFEAP 74  Aquifex aeolicus

2VUG_A        96 eFYVEEKVDGYNVRVVMYK-GKMLGITRGGFICPFTTERIPDFVP---Q-EFFKDN--PNLILVGEMAGPESPYLVEGPP 168 Pyrococcus abys...
CAB50450      89 eFYVEEKVDGYNVRVVMYK-GKMLGITRGGFICPFTTERIPDFVP---Q-EFFKDN--PNLILVGEMAGPESPYLVEGPP 161 Pyrococcus abys...
Q57857        95 -VVIEEKLNGYNIRIVKID-GEVYALTRSGYICPFTTKKVKKFLN---L-EILDDY--SEYMLCGEMIGINNPYTPYYYK 166 Methanocaldococ...
WP_010884602  86 eFYVEEKVDGYNVRVVKFR-GKILGITRGGFICPFTTERISDFIP---E-EFFKDH--PNLILVGEMAGPESPYLVEGPP 158 Pyrococcus hori...
WP_010876845  92 -VAVEEKMNGYNVRIACLSsGETVALTRGGHVCPFTTRKAQELLD---LsEFFREH--PDLVICGEMIGRDNPYVSQDYP 165 Methanothermoba...
WP_010878352  90 eVVLEEKMNGYNVRIVKVG-DNLYAITRRGLICPYTTEKARTLID---D-EFFRDY--PDYMLCCEAVGRASPYVPTDVY 162 Archaeoglobus f...
WP_010866453  93 tVLVEEKMNGYNVRVFTLG-GMVYAATRGGLICPYTTRRLRRLYGgalQ-KILEDLgaEGSFIAGEVVGLENPYTRYYYE 170 Aeropyrum pernix
3QWU_A        75 -FWVEEKVDGYNTRIFKYG-DNYYALSRGGFICPFTTDRLPDLID---L-RILDEN--PDLVICAEVAGPENPYIEESPP 146 Aquifex aeolicus

2VUG_A       169 YVKe---DIQFFLFDVQEIKTGRSLPVEERLKIAEEYGINHVEVFGKYTK-DD--VDELYQLIERLSKEGREGIIMK-SP 241 Pyrococcus abys...
CAB50450     162 YVKe---DIQFFLFDVQEIKTGRSLPVEERLKIAEEYGINHVEVFGKYTK-DD--VDELYQLIERLSKEGREGIIMK-SP 234 Pyrococcus abys...
Q57857       167 EVDrgfeNLGFYIFDIKERETNKSLPIKERINLCEKYNLPYVKPLAVVDK-DEa-HIHVREIIEKLNKEGREGVVLKdPD 244 Methanocaldococ...
WP_010884602 159 YVKe---DIQFFLFDIQELGTGRSLPVEERLKIAEEYGISHVEVFGKFTY-KD--LEEIYEIVERLSREGREGIVMKsPD 232 Pyrococcus hori...
WP_010876845 166 EVG----PLGFRVFDLREKNTNRPLPVEERRALLDSYGLPNVRLFGVYPI-EEa-ASEVADIIRALGMAGREGVVMKdPS 239 Methanothermoba...
WP_010878352 163 GIe----TLEFFLFDVREGKTNQPVTIDEKKEIAEKYGFRLAEILETVSS-DDv-A-RIKEVVEKLNKNRREGVVFKdRE 235 Archaeoglobus f...
WP_010866453 171 EAP----GFGYFIFDIFKG--GRQLPPRVKFSLAPEYGLKTVNLLAEIPA-TAsgVERLYTIVEDLEKRGREGVIVKdPE 243 Aeropyrum pernix
3QWU_A       147 YVKe---DVQLFVFDFMKKNEQGFLSQEEKMELIEKYNLPHVEILGRFTAsEEg-IKKIKEILKRFNEEGREGVVFKeDS 222 Aquifex aeolicus

2VUG_A       242 DMKKIVKYVTPYANINDIKIGARVFYELPPGYFTSRISRLAFYLAEKRIKGEEFERVAKELGSALLQPFVESIFDVEQEE 321 Pyrococcus abys...
CAB50450     235 DMKKIVKYVTPYANINDIKIGARVFYELPPGYFTSRISRLAFYLAEKRIKGEEFERVAKELGSALLQPFVESIFDVEQEE 314 Pyrococcus abys...
Q57857       245 MAVSPIKYTTHYTQCEDLKSAFTFFFDLGMDFLFSRVVREGFMSYEFKETLEERKNRAKDLGEAILLPMVETINKVASGE 324 Methanocaldococ...
WP_010884602 233 MR-KMVKYVTPYANINDIKIGARVFYELPPGYFTSRISRLAFYIAEKRLRGENFEELAKELGKALLQPLVESIHDVEQED 311 Pyrococcus hori...
WP_010876845 240 MEVPPLKYTSSQAHARELAYAFSYPFDFGRPFFFSRVIREGFQAYELDESDDETRERARRLGEAIIYPMLERIKSISAGE 319 Methanothermoba...
WP_010878352 236 MVLNPLKYTTSYANQSDLRYAFRFFGEYGRDFMLSRVIREAFQSFEFEEGEEDFNQRCLRLGRAILEPMIESIRECKRGE 315 Archaeoglobus f...
WP_010866453 244 GRVEPLKYTTSRTNIGDIRLGMRYPFEEGRSFLFPRILREIFREWETG------RRRYGELGEAILAPAIEAVEAVSRGG 317 Aeropyrum pernix
3QWU_A       223 ERNKRAKYITSYANLMDIKTNAKNMLQLPPEYYTNRILRLVLFMYEEGLKTTE--HLYEELGRAFIDGLFQAIEQFEKEH 300 Aquifex aeolicus

2VUG_A       322 DIHELFKVRVKRIETAYKMVTHFEKLGLKIEIVDIe--EIKDGw--RITFKRLYPDATNEIRELIGGKAFV 388 Pyrococcus abyssi GE5
CAB50450     315 DIHELFKVRVKRIETAYKMVTHFEKLGLKIEIVDIe--EIKDGw--RITFKRLYPDATNEIRELIGGKAFV 381 Pyrococcus abyssi GE5
Q57857       325 RVSEDFELIFDSEEDFDEFLDFMRKMKMVITIKNIekiDTEEGvkiKAVIGKIYNKTNDKIISYLNGTLWE 395 Methanocaldococcus janna...
WP_010884602 312 EIAEVFKVRVKKIETAYKMVTHFEKLGLRIEIVDIe--EMKGGw--RITFKRLYPDATEEIRELIGGKSFV 378 Pyrococcus horikoshii
WP_010876845 320 AAYEDTVIDVEDREAAEEFIRHLVRLGVSATLA-----DYRDG---RATIRRFYQSTTDRINNYLKGGLY- 381 Methanothermobacter ther...
WP_010878352 316 MVCEESELVFESPDVLELFKLHMKLLGVDFRI------EVLDGg--RVKLKRIMRSTSDRIRGILQGSTWR 378 Archaeoglobus fulgidus
WP_010866453 318 RLVEEFELVFANEVEAEEVIAYFASLGVHLEIAGVa--RGVDGv--RVAFRKPRKSEGEIARILETGISPL 384 Aeropyrum pernix
3QWU_A       301 KVYKTFTCKFRKKENAIALLELLSKTSKHIQVKERr--LEKEGdywRLEFDKVFLNMTgllghllsggivy 369 Aquifex aeolicus
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