1HV9,2V0H,3FOQ


Conserved Protein Domain Family
glmU

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TIGR01173: glmU 
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UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase
This protein is a bifunctional enzyme, GlmU, which catalyzes last two reactions in the four-step pathway of UDP-N-acetylglucosamine biosynthesis from fructose-6-phosphate. Its reaction product is required from peptidoglycan biosynthesis, LPS biosynthesis in species with LPS, and certain other processes. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan, Cell envelope, Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides, Central intermediary metabolism, Amino sugars]
Statistics
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PSSM-Id: 273482
Aligned: 18 rows
Threshold Bit Score: 580.386
Created: 8-Oct-2014
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1HV9_A         6 MSVVILAAGKGTRMYSDLPKVLHTLAGKAMVQHVIDAANELGAAHVHLVYGHGGDLLKQALKD------D-N---LNWVL 75  Escherichia coli
WP_010893657   7 LHIVILAAGEGKRMKSALPKVLHPIAGKPMLAHVITAAQALTPDAIHVVYGHAGNQVRAAFAD------QtD---LHWVE 77  Xylella fastidiosa
WP_003226732   4 RFAVVLAAGQGTRMKSKLYKVLHPVCGKPMVEHVVDEALKLSLSKLVTIVGHGAEEVKKQLGD------K-S----EYAL 72  Bacillus subtilis
WP_010887454  11 LDVVILAAGQGTRMNSALPKVLHPVAGRPMVAWAVKAARDLGARKIVVVTGHGAEQVEAAVQQ------P-G---VAFAR 80  Deinococcus rad...
WP_004082105   1 MRALVLAAGKGTRMKSKIPKVLHPLSGRPMIEWVIETAGKVA-QKVGVVLGFEAELVRKALPE------W-----VDVFV 68  Thermotoga mari...
WP_009873988   6 IIIVILAAGKGTRMKSNHPKVLHFLGGKTILEHVIETAQSIKPKKIILVYSDQKKPVLSNIYN------I-P---IQWII 75  Buchnera aphidi...
WP_010874079   2 VAVAVLAAGKGTRMKSDLPKVLHQLGGYSLVERVLQSCRPLAPERQILIVGYQAAAVESSLAG------RsD---VEFVE 72  Synechocystis s...
3FOQ_A        15 TAVLVLAAGPGTRMRSDTPKVLHTLAGRSMLSHVLHAIAKLAPQRLIVVLGHDHQRIAPLVGEladtlgR-T---IDVAL 90  Mycobacterium t...
WP_010880361   1 MRAVILAAGLGTRFKSEKPKVLHEILGKPMLWYVITNVRNGRIDDIAVVVGHKAQEVMEAFKN------E-N---LKFFI 70  Aquifex aeolicus
WP_000953691   2 LSVIILAAGKGTRMHSSLPKTLHTICGEPMLFYILEVAFSISN-DVHLVLHHQQERIKEAVSK------R-FkgvIFHAQ 73  Helicobacter py...
1HV9_A        76 QAEQL-G-TGHAMQQAA--PFFA-DD--E-DILMLYGDVPLISVETL---QRLRDAKPQ--G-----G--IGLLTVKLDD 135 Escherichia coli
WP_010893657  78 QAQQL-G-TGHAVKQTM--SAIP-NA--A-NVLVLYGDVPLIRAETL---KRLPRAST---------P--IAVLVTELAN 135 Xylella fastidiosa
WP_003226732  73 QAKQL-G-TAHAVKQAQ--PFLA-DEk-G-VTIVICGDTPLLTAETM---EQMLKEHTQ--Re---aK--ATILTAVAED 135 Bacillus subtilis
WP_010887454  81 QERQL-G-TGDAFLSGA--SALT-EG--GaDILVLYGDTPLLRPDTL---RELVASHRE--Q-----GsaMTVLTGELPD 143 Deinococcus rad...
WP_004082105  69 QGEQL-G-TAHAVMCAK--DFIE-PG--D-DVLILYGDVPLISENTL---KRMIEEHRK--G-----Ad-VTILVADLED 129 Thermotoga mari...
WP_009873988  76 QKKPQ-G-TGHAILLAI--KKIS-DN--T-EILVLYGDVPFISPVSI---KKLQKSKKQ--S-----K--ISLLTAKVKN 135 Buchnera aphidi...
WP_010874079  73 QREQL-G-TGHAIQQLL--PCLQdYQ--G-DLLVLNGDAPLLRSETL---ENLLATHQRhgN-----A--ATLLTAHLPD 135 Synechocystis s...
3FOQ_A        91 QDRPL-G-TGHAVLCGL--SALP-DDyaG-NVVVTSGDTPLLDADTL---ADLIATHRAvsA-----A--VTVLTTTLDD 154 Mycobacterium t...
WP_010880361  71 QENPK-GgTADAVLAAK--DFFSsYE--G-YVLIINGDSPLVSGETIrnmQQFIHMVRT--YegiklG--GVVLTTHLPD 140 Aquifex aeolicus
WP_000953691  74 IVEKYsG-TGGAIMQENktPIPT-QH--E-RVLILNADMPLITKDAL---TPLLESH-N--N-----A--IGLL--HLAD 133 Helicobacter py...
1HV9_A       136 PTGYGRITREN--GKVTGIVEHKDATDEQRQIQEINTGILIANGADMKRWLAKLTNNNAQGEYYITDIIALAYQEGREIV 213 Escherichia coli
WP_010893657 136 PAGYGHIVRNSe-GKVAAIIEDKDADEEQRRIHTVNTGILCAESTALRRWLSKLSNTNMQGEYYLTDIFASATADLTPAN 214 Xylella fastidiosa
WP_003226732 136 PTGYGRIIRSEn-GAVQKIVEHKDASEEERLVTEINTGTYCFDNEALFRAIDQVSNDNAQGEYYLPDVIEILKNEGETVA 214 Bacillus subtilis
WP_010887454 144 ATGYGRIVRGEg-GAVERIVEQKDASDAEKAIGEFNSGVYVFDERA-PELARRIGNDNKAGEYYLTDLLGLYRAGGATVR 221 Deinococcus rad...
WP_004082105 130 PSGYGRVIQD---GDKYRIIEDTDLPEELKSVTTINTGFYVFSGDFLLRALPEIKNENAKGEYYLTDAVNFA----EKVR 202 Thermotoga mari...
WP_009873988 136 PNGYGRILRKK--GKVISIIEDQDASNEQKNIKEIYSGIFIAQSKDLTRWLKKIDKKNEKQEFYATDIIALAHLEGSFIK 213 Buchnera aphidi...
WP_010874079 136 PKGYGRVFCNGd-NRVTQIVEDRDCNAAQRQNHRVNGGIYCFHWPRLAAALPKLSANNDQKEYYLTEVVDYL----DQVM 210 Synechocystis s...
3FOQ_A       155 PFGYGRILRTQd-HEVMAIVEQTDATPSQREIREVNAGVYAFDIAALRSALSRLSSNNAQQELYLTDVIAILRSDGQTVH 233 Mycobacterium t...
WP_010880361 141 PTGYGRIIKEEgtDRIIRIVEEKDATPEEKAITEINAGTYIFYAPYLLEALYRIKPSPVTGELYLTDVIEYMVNKGYEVR 220 Aquifex aeolicus
WP_000953691 134 PKGYGRVILEN--HQVKKIVEEKDANDEEKTIKSVNAGVYFFERKFLERYLPKLHDQNAQKEYYLTDLIALGIKGNEKI- 210 Helicobacter py...
1HV9_A       214 AVHPQRLSEVEGVNNRLQLSRLERVYQSEQAEKLLLAGVMLRDPARFDLRGTLTHGRDVEIDTNVIIEGNVTLGHRVKIG 293 Escherichia coli
WP_010893657 215 MIMVTDAREVEGVNDLWQLTQLERAWQIRAARALCLQGARVADPARLDQRGTIRIGQNVHIDIDVVLEGEIELGDNVVIG 294 Xylella fastidiosa
WP_003226732 215 AYQTGNFQETLGVNDRVALSQAEQFMKERINKRHMQNGVTLIDPMNTYISPDAVIGSDTVIYPGTVIKGEVQIGEDTIIG 294 Bacillus subtilis
WP_010887454 222 AFRLSDPDEVLGANDRAGLTQLEATLQRRINEGHLKAGVSISLPGTVLIEDTVEIGRDVVIEPGALLRGQTRIAGGAVIG 301 Deinococcus rad...
WP_004082105 203 VVRTDDLLEITGVNTRKTLVWLEEQLRMRKIEELLENGVTILDPATTYIHYSVEIGMDTVIYPMTFIEGKSRVGENCEIG 282 Thermotoga mari...
WP_009873988 214 TIEPLNYEEILGINNKLQLSNLEKIFQKKQINKLLINGVTIKDPSHFIFRGTLQHGQNVEIDTGVILENNVILGDDVKIG 293 Buchnera aphidi...
WP_010874079 211 AVDVDDYLEINGINDRKQLAAANDILQNRIKDDWMAQGITLINPDSITIDDTVVLEADVIIEPNTHLRGKTVIGRGSRIG 290 Synechocystis s...
3FOQ_A       234 ASHVDDSALVAGVNNRVQLAELASELNRRVVAAHQLAGVTVVDPATTWIDVDVTIGRDTVIHPGTQLLGRTQIGGRCVVG 313 Mycobacterium t...
WP_010880361 221 SFMAKEPTEALGVNTRWDLALVENVIKLKIARYWAERGVTVHYPETVWIEPDVSIEPDVEIFPDVMLKGKTKIKKGSVIG 300 Aquifex aeolicus
WP_000953691 211 DAIFLEEECFLGVNSQTERAKAEEIMLERLRKNAMDLGVVMQLPSSIYLEKGVSFKGECVLEQGVRLIGN---------- 280 Helicobacter py...
1HV9_A       294 TGCVIKNSVIGDDCEISpYTVVEDANLAAACTIGPFARLRPGAELLEGAHVGNFVEMKKARLGKGSKAGHLTYLGDAEIG 373 Escherichia coli
WP_010893657 295 PFVRLKNVKLGPGTKVHaHCDLEGVTTTGSALIGPFARLRPGTMLADGVHIGNFVETKNTSIGADSKANHLTYLGDAQIG 374 Xylella fastidiosa
WP_003226732 295 PHTEIMNSAIGSRTVIK-QSVVNHSKVGNDVNIGPFAHIRPDSVIGNEVKIGNFVEIKKTQFGDRSKASHLSYVGDAEVG 373 Bacillus subtilis
WP_010887454 302 AYSVITDSVIHERAVIKaHSVLEQAEVGAGSDVGPFARLRPGSVLGEGVHIGNFVETKNARLDAGVKAGHLAYLGDVEIG 381 Deinococcus rad...
WP_004082105 283 PMTRIVDCEIGNNVKIT-RSECFKSVIEDDVSVGPFARLREGTILKKSSKIGNFVEIKKSTIGEGTKAQHLSYIGDAFVG 361 Thermotoga mari...
WP_009873988 294 PGCIIRNSSIDSNTNIQaYTIIENSKIGKGCIIGPFAHLRSNTLLDRNVHIGNFVETKDTFIKNESKVKHLSYLGNSEIG 373 Buchnera aphidi...
WP_010874079 291 PGSLIEDSIVGSDASVL-FSVVSQSQIGDGCRLGPYSHVRGEADIQANCRIGNFVEVKKSVIGAQSNVAHLSYLGDAMLG 369 Synechocystis s...
3FOQ_A       314 PDTTLTDVAVGDGASVV-RTHGSSSSIGDGAAVGPFTYLRPGTALGADGKLGAFVEVKNSTIGTGTKVPHLTYVGDADIG 392 Mycobacterium t...
WP_010880361 301 KGSVIKDSLVEENVIVReYSVIENSEIKKRAVVGPFARIRNESVIGEEAEIGNFVEVKKSSIGKGVKAKHLAYIGDATVG 380 Aquifex aeolicus
WP_000953691 281 --CLIENARI------KaYSVIEESQII-NSSVGPFAHARPKSVICD-SHVGNFVETKNAKLQ-GTKAGHLSYLGDCEIG 349 Helicobacter py...
1HV9_A       374 DNVNIGAGTITCNYDGANKFKTIIGDDVFVGSDTQLVAPVTVGKGATIAAGTTVTRNVGENALAISRVPQTQKEGWRRPV 453 Escherichia coli
WP_010893657 375 TKVNIGAGTITCNYDGINKSITLIGDGAFIGSHSALIAPVSVGAGATLGAGTVLTHDAPAHQLTVARSRQTTLDSWQRPK 454 Xylella fastidiosa
WP_003226732 374 TDVNLGCGSITVNYDGKNKYLTKIEDGAFIGCNSNLVAPVTVGEGAYVAAGSTVTEDVPGKALAIARARQVNKDDYVKNI 453 Bacillus subtilis
WP_010887454 382 AETNVGAGTIVANFDGLNKHQSKVGAGVFIGSNTTLIAPRVVGDAAFIAGGSAIHDDVPEGAMAVARGKQRNIEGWARRY 461 Deinococcus rad...
WP_004082105 362 KNVNVGAGTITCNYDGKKKNPTFIEDGAFIGSNSSLVAPVRIGKGALIGAGSVITEDVPPYSLGLGRARQVVKEGWVLKK 441 Thermotoga mari...
WP_009873988 374 SKVNIGAGSITCNYDGANKFKTIIGDNVLVGSNTQLIAPIKIAKNTTIAAGTTVTKDVNTPCLVYNTKEQKYKKNWMRSK 453 Buchnera aphidi...
WP_010874079 370 QRVNVGAGTITANYDGVSKHATVIGSGTKTGANSVFVAPVQVGEGVTVAAGSVINRDVPAGSLAIARPRQRIIDNWQVPP 449 Synechocystis s...
3FOQ_A       393 EYSNIGASSVFVNYDGTSKRRTTVGSHVRTGSDTMFVAPVTIGDGAYTGAGTVVREDVPPGALAVSAGPQRNIENWVQRK 472 Mycobacterium t...
WP_010880361 381 ENTNIGAGTVFANYDGKRKYESYVGKSAFIGSNSLLIAPIRVGDWAYIAGGSVVNKDIPEGALAVSRPELKIFEGRGKKK 460 Aquifex aeolicus
WP_000953691 350 KNTNVGAGVITCNYDGKKKHQTIIGENVFIGSDSQLVAPINIGSNVLIGSGTTITKDIPSGSLSLSRTPQTNIENGYFKF 429 Helicobacter py...
1HV9_A       454 KK 455 Escherichia coli
WP_010893657 455 KK 456 Xylella fastidiosa
WP_003226732 454 HK 455 Bacillus subtilis
WP_010887454 462 Wa 463 Deinococcus radiodurans
WP_004082105 442 RK 443 Thermotoga maritima
WP_009873988 454 KI 455 Buchnera aphidicola
WP_010874079 450 AP 451 Synechocystis sp. PCC 6803
3FOQ_A       473 RP 474 Mycobacterium tuberculosis
WP_010880361 461 lq 462 Aquifex aeolicus
WP_000953691 430 FK 431 Helicobacter pylori
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