2Z04,1B6S


Conserved Protein Domain Family
purK
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TIGR01161: purK 
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phosphoribosylaminoimidazole carboxylase, PurK protein
Phosphoribosylaminoimidazole carboxylase is a fusion protein in plants and fungi, but consists of two non-interacting proteins in bacteria, PurK and PurE. This model represents PurK, N5-carboxyaminoimidazole ribonucleotide synthetase, which hydrolyzes ATP and converts AIR to N5-CAIR. PurE converts N5-CAIR to CAIR. In the presence of high concentrations of bicarbonate, PurE is reported able to convert AIR to CAIR directly and without ATP. [Purines, pyrimidines, nucleosides, and nucleotides, Purine ribonucleotide biosynthesis]
Links
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Statistics
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PSSM-Id: 273473
Aligned: 14 rows
Threshold Bit Score: 447.17
Created: 8-Oct-2014
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
2Z04_A         3 TVGILGGGQLGWXTILEGRKLGFKFHVLEDKeNAPACRVAD-------RCFRTGQISEFVDSCDIITYEFEHIKDEVLEK 75  Aquifex aeolicus
P74724         7 TVGVIGGGQLAWMMAQEAPRLGLKLAVQTPGeSDPAVALADkvv--ltAIADGEGTRELAEHCGVITFENEFVDLPSLEK 84  Synechocystis s...
Q54975        11 HVGVIGGGQLAWMLAPAAQQLGMSLHVQTPNdHDPAVAIADqtv--laAVADAAATAKLAQACDVITFENEFVDLPALTE 88  Synechococcus e...
P96881        19 LVAMVGGGQLARMTHQAAIALGQNLRVLVTSaDDPAAQVTPnvv--igSHTDLAALRRVAAGADVLTFDHEHVPNELLEK 96  Mycobacterium t...
P15567         6 VVGILGGGQLGRMMVEAAHRLNIKCIILDAA-NSPAKQIDGgrehidaSFTDPDAIVELSKKCTLLTTEIEHINT---DA 81  Schizosaccharom...
P43850         9 TVYVLGNGQLGRMLRYAGAPLDIYVEPLAFNaPVFDl-----------P-EN-----------AIITAEIERWEKTPLTE 65  Haemophilus inf...
P09029         3 QVCVLGNGQLGRMLRQAGEPLGIAVWPVGLDaEPAAv-----------PFQQ-----------SVITAEIERWPETALTR 60  Escherichia col...
WP_004081519   3 kigiigggqlgkMMTLEAKKMGFYVIVLDPTpRSPAGQVADeqi--vaGFFDSERIEDLVKGSDVTTYDLEHIDVQTLKK 80  Thermotoga mari...
WP_031600234  14 vigiigggQLGKMMAVSAKQMGYKVAVVDPVkDSPCGQVADvei--taHYNDREAIRKLAEISDIITYEFENIDY---DA 88  Bacillus subtilis
AAA34407       5 TVGILGGGQLGRMIVEAANRLNIKTVILDAE-NSPAKQISNsndhvngSFSNPLDIEKLAEKCDVLTIEIEHVDVPTLKN 83  baker's yeast

2Z04_A        76 CES-----KLIPNPQALYVKKSRIREKLFLKKHGFPVPEFLVi---kRDEIIDAlksfkLPVVIKAEKLGYDGKGQYRIK 147 Aquifex aeolicus
P74724        85 LAQqg--iTFHPRLDALAPLLDKWEQRHFLQNLGLPVPDFWAle--sLPAQLPD-----FPWVLKARRHGYDGQGTQIIN 155 Synechocystis s...
Q54975        89 LEEtg--vRFRPRPAAIASLLDKLDQRQLLTRLGLPTPRFLAia--aATATESEltalgFPVVLKQRRHGYDGKGTQVLR 164 Synechococcus e...
P96881        97 LVAdg--vNVAPSPQALVHAQDKLVMRQRLAAAGVAVPRYAGik--dPDEIDVFaarvdAPIVVKAVRGGYDGRGVRMAR 172 Mycobacterium t...
P15567        82 LAAvtksvAVEPSPATLRCIQDKYLQKQHLQVFKIALPEFCda--pdQESVEKAgqefgYPFVLKSKTLAYDGRGNYVVH 159 Schizosaccharom...
P43850        66 LLGn---hKNFVNQHIFGLLADRFTQKSLLDELNLSTSPWCLlk--dKNQWNDLfqtvgEKVVVKRRTGGYDGRGQWIIR 140 Haemophilus inf...
P09029        61 ELAr---hPAFVNRDVFPIIADRLTQKQLFDKLHLPTAPWQLla--eRSEWPAVfdrlgELAIVKRRTGGYDGRGQWRLR 135 Escherichia col...
WP_004081519  81 LYNeg--yKIHPSPYTLEIIQDKFVQKEFLKKNGIPVPEYKLv-----kDLESDvrefgFPVVQKARKGGYDGRGVFIIK 153 Thermotoga mari...
WP_031600234  89 LHWlkdhaYLPQGSELLLITQNRETEKKAIQSAGCEVAPYSIvk--tKNELKQAvqelgLPAVLKTCRGGYDGKGQFVIK 166 Bacillus subtilis
AAA34407      84 LQVkhpklKIYPSPETIGLIQDKYIQKEHLIKNGIAVTQSVPveqasETSLLNVgrdlgFPFVLKSRTLAYDGRGNFVVK 163 baker's yeast

2Z04_A       148 KLEDANQVVKNHdKEe--SFIIEEFVKFEAEISCIGVRDREGKTYFYPQPFNKHEE--GILIYNYVPY-A----K---LK 215 Aquifex aeolicus
P74724       156 SPADLPDLSKAP-PG---SWMVESFVPYERELAVIGVRNARGEMEIYPVVETKQID--QVCRWVVAPA-PidaaI---AA 225 Synechocystis s...
Q54975       165 SLAELQQALQSY-GDt--PLLLEEFIPFEQELAVMVARSQSGAIATFPVVQTHQQN--QVCRWVVAPA-AipgaL---QK 235 Synechococcus e...
P96881       173 DVADARDFAREC-LAdgvAVLVEERVDLRRELSALVARSPFGQGAAWPVVQTVQRD--GTCVLVIAPApAlpddL---AT 246 Mycobacterium t...
P15567       160 QPSEIPTAIKAL-GDr--PLYVEKFVPFSMEIAVMVVRSLDGKVYAYPTTETIQKD--NVCHLVYAPA-RlpfsI---QQ 230 Schizosaccharom...
P43850       141 DENRADITDDLF-G----EVIAEKFIPFDYEVSIVGARFKNGEKRFYPVTHNLQQN--GILRYSVVDC-AfpqqSvqqK- 211 Haemophilus inf...
P09029       136 ANETEQLPAECY-G----ECIVEQGINFSGEVSLVGARGFDGSTVFYPLTHNLHQD--GILRTSV----AfpqaNaqqQA 204 Escherichia col...
WP_004081519 154 NEKDLENAIKg-------ETYLEEFVEIEKELAVMVARNEKGEIACYPVVEMYFDEdaNICDTVIAPA-RieekY---SK 222 Thermotoga mari...
WP_031600234 167 EEAQMEQAAALL-EHg--TCILESWVSFKMELSVIVVRSVNGEISTFPTAENIHHN--NILFQSIVPA-RvekgI---QQ 237 Bacillus subtilis
AAA34407     164 NKEMIPEALEVL-KDr--PLYAEKWGPFTKELAVMIVRSVNGLVFFYPIVETIHKD--NICDLCYAPA-RvpdsV---QL 234 baker's yeast

2Z04_A       216 EAEEITKRLXeLLDIVGVFTVEFFLL---KDG-----RVLINEFAPRVHNTGHWTLDGAYTSQFENLLRAITEXPLGS-- 285 Aquifex aeolicus
P74724       226 TAQDYCRRILnHLDYVGILAIEFFLLpasTQTptpeqRLLVNELAPRTHNSGHFSLDACHTSQFALQLQAVTGQTLGS-- 303 Synechocystis s...
Q54975       236 AVAAIARTLVeTVDYVGVAGIELF-----QQGd----RLWVNEIAPRTHNSGHYSLDACQTSQFEQQLRAIADLPLGS-- 304 Synechococcus e...
P96881       247 AAQRLALQLAdELGVVGVLAVELFET---TDG-----ALLVNELAMRPHNSGHWTIDGARTSQFEQHLRAVLDYPLGD-- 316 Mycobacterium t...
P15567       231 RAQTLAMDAVrTFEGAGIYGVEMFVL---QDGe----TILLNEIAPRPHNSGHYTIEACPTSQFEAHLRAICGLPFSEin 303 Schizosaccharom...
P43850       212 QAETMLGKIMdKLGYVGVMAMECFVV---GDK------LLINELAPRVHNSGHWTQLGCSISQFELHLRALLNLPTPE-- 280 Haemophilus inf...
P09029       205 QAEEMLSAIMqELGYVGVMAMECFVT---PQG------LLINELAPRVHNSGHWTQNGASISQFELHLRAITDLPLPQ-- 273 Escherichia col...
WP_004081519 223 IAREIATSVVeALEGVGIFGIEMFLT---KQG-----EILVNEIAPRPHNSGHYTIEACVTSQFEQHIRAIMNLPLGS-- 292 Thermotoga mari...
WP_031600234 238 KAADLAVKLAdELNLVGPLAVEMFLT---EDG-----ELLVNELAPRPHNSGHYTLDLCETSQFEQHIRAVCGLPLGK-- 307 Bacillus subtilis
AAA34407     235 KAKLLAKMQS-NFSRLWYIGVEMFYL---ETG-----ELLINEIAPRPHNSGHYTIDACVTSQFEAHLRSILDLPMPKnf 305 baker's yeast

2Z04_A       286 TELKLP---SGXVNILGKS-----YE---EIPL-KEILSVEGAKLYWYGK-EKKPRRKVGHVNVVGRS 340 Aquifex aeolicus
P74724       304 SALRCGq--AVMVNLLGYEvs--tGD---YQQQlDKLAALPHSHVHWYGKgDCRPGRKLGHVTLLNPD 364 Synechocystis sp. PCC 6803 ...
Q54975       305 TALQWPg--ALMVNLLGFEdh--qSG---YAELrQQLAALPGACLYWYGKtESKPGRKLGHITLPLSG 365 Synechococcus elongatus PCC...
P96881       317 SDAVVPv--TVMANVLGAAqppamSV---DERLhHLFARMPDARVHLYGKaE-RPGRKVGHINFLGSD 378 Mycobacterium tuberculosis
P15567       304 TQLSTStthALMVNILGTDd---pDY---VSKIaKRSLSIPGATLHLYGKaESRKGRKMGHVTIISDS 365 Schizosaccharomyces pombe 9...
P43850       281 LQTFAP---SVMINLIGTN----------HNPKwLN---IPFAQLHWYGK-EVRIGRKVGHINLSHPN 331 Haemophilus influenzae Rd KW20
P09029       274 PVVNNP---SVMINLIGSD----------VNYDwLK---LPLVHLHWYDK-EVRPGRKVGHLNLTDSD 324 Escherichia coli K-12
WP_004081519 293 TELLIP---AVMVNLLGEEg----YYgkpALIGlEEALAIEGLSLHFYGKkETRPYRKMGHFTVVDRD 353 Thermotoga maritima
WP_031600234 308 TDLLKP---GMMVNLLG-------DE---VKLVeEDPELLKEAKLYIYGKhEIKKGRKMGHITFMKQP 362 Bacillus subtilis
AAA34407     306 TSFSTIttnAIMLNVLGDKht--kDK---ELETcERALATPGSSVYLYGK-ESRPNRKVGHINIIASS 367 baker's yeast
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