4BEW


Conserved Protein Domain Family
ATPase-IIA1_Ca

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TIGR01116: ATPase-IIA1_Ca 
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sarco/endoplasmic reticulum calcium-translocating P-type ATPase
This model describes the P-type ATPase responsible for translocating calcium ions across the endoplasmic reticulum membrane of eukaryotes, and is of particular importance in the sarcoplasmic reticulum of skeletal and cardiac muscle in vertebrates. These pumps transfer Ca2+ from the cytoplasm to the lumen of the endoplasmic reticulum. In humans and mice, at least, there are multiple isoforms of the SERCA pump with overlapping but not redundant functions. Defects in SERCA isoforms are associated with diseases in humans. The calcium P-type ATPases have been characterized as Type IIA based on a phylogenetic analysis which distinguishes this group from the Type IIB PMCA calcium pump modelled by TIGR01517. A separate analysis divides Type IIA into sub-types, SERCA and PMR1, the latter of which is modelled by TIGR01522. [Transport and binding proteins, Cations and iron carrying compounds]
Statistics
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PSSM-Id: 273452
Aligned: 6 rows
Threshold Bit Score: 1461.92
Created: 8-Oct-2014
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
4BEW_A         53 VIEQFEDLLVRILLLAACISFVLawfee----geetITAFVEPFVILLILIANAIVGVWQERNAENAIEALKEYEPEMGK 128  rabbit
P54209         76 ILKQFDDLLVKILLGAAIVDFIIaise-----gesiQSGLIEPMVILLILVANATVGVVTERNAEKAIEQLKSYEADDAT 150  Dunaliella bi...
CAA76764       59 IKEQFEDNLVRILLLAAVISFVIsqfedh--edshaVPPWVEPCVIFTILILNAAVGIWQDLDAERAIEALKDLQSPHAM 136  Paramecium te...
AAC47505       72 VVGQFEDTLVRILLLAAFVSFCLavl-------ennVMDLVEPFIILLILTLNAIVGVWQEDRAEKAIDALKTSFLKQLL 144  Leishmania am...
XP_002440489   72 LLDQFEDTLVRILLAAAAVSFVLalssstasgsaptLAAFVEPLVIFLILVVNAAVGVWQEANAERALDALREIQSHHAA 151  sorghum
NP_733765      53 VIEQFEDLLVRILLLAACISFVLawfee----geetITAFVEPFVILLILVANAIVGVWQERNAENAIEALKEYEPEMGK 128  human
4BEW_A        129 VYRADR----KsvqrikARDIVPGDIVEVAVGDKVPADIRILSI--KstT--LRVDQSILTGESVSVIKHTEPVPDPRAV 200  rabbit
P54209        151 VLRNGQlqliP------SADIVPGDIVELAVGNKVPADTRVSHI--Y--TtsLKIDQSLLTGESQAVEKHTEVVHNEQAV 220  Dunaliella bi...
CAA76764      137 VLRDGE----Wtq--ieAKDLVIGDIVEIKQGDRIPADLRMVEL--K--TitLKTDQSILTGEVNPVNKVTDSVQKDKAA 206  Paramecium te...
AAC47505      145 LFVRVCr---W------QENLVPGDIVEVAVGDRVAADVRLLTL--EstT--LRVDQSILNGESVEAMKQVESVRGNRER 211  Leishmania am...
XP_002440489  152 VLRDGG----Wvpa-lpARDLVPGDVVQLRVGDKVPADMRVARLltS--T--LRLEQGSLTGETASVNKTSRAVPVEDAD 222  sorghum
NP_733765     129 VYRQDR----KsvqrikAKDIVPGDIVEIAVGDKVPADIRLTSI--KstT--LRVDQSILTGESVSVIKHTDPVPDPRAV 200  human
4BEW_A        201 NQDKKNMLFSGTNIAAGKALGIVATTGVSTEIGKIRDQMAATEQD----KTPLQQKLDEFGEQLSKVISLICVAVWLINI 276  rabbit
P54209        221 YQDKLNMLFSGTLVVAGRARGIVVGTGSNTAIGKIRDAMGVEEDV----VTPLKAKLDEFGALLSKVIAGICVLVWVVNI 296  Dunaliella bi...
CAA76764      207 VQDKINFLFSGTLVSNGTAIGVVCNTGMRTEIGKIQKEVQDAAKEksedDDPLSKRLDEFGDKLAKYVTYICIICWVMNI 286  Paramecium te...
AAC47505      212 FPS--SMVYRGTAVVYGKARGVVVRTGTSTEMGFIERDVREQEET----KTPLQLKLDEFGVLLSGVIGYICLFVFVANL 285  Leishmania am...
XP_002440489  223 IQAKECMVFAGTTVVNGAALCIVARTGMATEIGAIHAQIHQASQEe--dDTPLKKKLNEFGEALTKIIGLICALVWLINV 300  sorghum
NP_733765     201 NQDKKNMLFSGTNIAAGKAMGVVVATGVNTEIGKIRDEMVATEQE----RTPLQQKLDEFGEQLSKVISLICIAVWIINI 276  human
4BEW_A        277 GHFNdpvhgg--------swirgAIYYFKIAVALAVAAIPEGLPAVITTCLALGTRRMAKKNAIVRSLPSVETLGCTSVI 348  rabbit
P54209        297 NRFNdpalg---------gwfqgAIHYFKIAVALAVAAIPEGLPAVVTTCLALGTRKMARHNAIVRTLPSVETLGCTTVI 367  Dunaliella bi...
CAA76764      287 GNFSdpayg---------gtimgALYYFKVAVALAVAAIPEGLPAVITTCLALGARRMAKQKAIVRKLPKVQTLGCTTII 357  Paramecium te...
AAC47505      286 LHWFrthtpttee-swferyiqpTVHSLKVAVALAVAAIPEGLPAVVTTCLALGARKMARHNALVRDLPSVETLGRCTVI 364  Leishmania am...
XP_002440489  301 KYFLtfdlqggwvprnvkfsfekCTYYFEIAVALAVAAIPEGLPAVITTCLALGTRKMAAKNALVRKLPSVETLGCTTVI 380  sorghum
NP_733765     277 GHFNdpvhgg--------swirgAIYYFKIAVALAVAAIPEGLPAVITTCLALGTRRMAKKNAIVRSLPSVETLGCTSVI 348  human
4BEW_A        349 CSDKTGTLTTNQMSVCKMFIIDkvdgdfcslNEFSITGSTYAPEGEVLKNdkpirs---gqfdgLV-------------- 411  rabbit
P54209        368 CSDKTGTLTTNQMSVIKVAAVQsss---sqlAEFDVTGTTFSPEGMVLGPggvvlrq-padtpcLA-------------- 429  Dunaliella bi...
CAA76764      358 CSDKTGTLTTNEMCVKELVLLTgqea--sslQVFPVEGTSYHP-EGKIDG--------------LEskllkgndlsgnlk 420  Paramecium te...
AAC47505      365 CSDKTGTLTTNMMSVSEVVTMEpsg----kaHEYCLHDSRFNVVAASVSHrgtpagdvlgndaaLD-------------- 426  Leishmania am...
XP_002440489  381 CSDKTGTLTTNKMSVAKLVAIGdss---qevRSFKVDGTSYDPQDGKIHDwpags-----idanLE-------------- 438  sorghum
NP_733765     349 CSDKTGTLTTNQMSVCRMFILDrvegdtcslNEFTITGSTYAPIGEVHKDdkpvnc---hqydgLV-------------- 411  human
4BEW_A        412 ELATICALCNDSSLDFNETKgvYEKVGEATETALTTLVEKMNVFNTEVRNLSKVERANACNSVI----Rql----mkKE- 482  rabbit
P54209        430 HAAQCAALCNDSQVFVAQKTgtLQRIGESTEIALRVFAEKIGLPSSIRPDRPISRSQFGTNNFW----Qed----veRL- 500  Dunaliella bi...
CAA76764      421 RLCQSMALCNESKLYMDKGR--VQRSGLPTEAALKVLVEKIG----KYDKSFNGRPILDAPQQY----NdkivnefaKR- 489  Paramecium te...
AAC47505      427 MVATIATLCSDASLIFGTRSaeVEKVGDATEAALLVMSEKLYHSAAWNGVDGARLPADRCRSLK----K--------KLw 494  Leishmania am...
XP_002440489  439 TIAKVAAVCNDANVALSSQQ--YVATGMPTEAALKVLVEKMGLPGGKNGLSLDPSETLGCCKWW----Nnv----akRI- 507  sorghum
NP_733765     412 ELATICALCNDSALDYNEAKgvYEKVGEATETALTCLVEKMNVFDTELKGLSKIERANACNSVIkqlmK--------KE- 482  human
4BEW_A        483 ---FTLEFSRDRKSMSVYC-----SpakssraavGNKMFVKGAPEGVIDRCNYVR--VGtTR-VPMTGPVKEKILSVIKE 551  rabbit
P54209        501 ---ALLEFSRDRKMMSVLV-----Kgs-----drQHNIWSKGAPEFVLRKCSHVLanNG-EGaVPLTDNMRQAILSDMQA 566  Dunaliella bi...
CAA76764      490 ---ATLXFTRDRKSMSVLAssqneK---------GNVLFIKGAPDYLLEKSTMIL--NSdGVaVPLKAQDKNQLLTIVKN 555  Paramecium te...
AAC47505      495 lkkATLEFTRSRKSMSVCC-----Ts-------tRHSLFVKGAPEEILKRCTRIM--FKdGRiSPLTPKMVNTVTANIDR 560  Leishmania am...
XP_002440489  508 ---ATLEFDRTRKSMGAIV-----Kts-----sgSNALLVKGAVETLLERSSHIQ--LKdGSvVPLDDKAKKTVLASLHE 572  sorghum
NP_733765     483 ---FTLEFSRDRKSMSVYC-----Tpnkp-srtsMSKMFVKGAPEGVIDRCTHIR--VG-STkVPMTSGVKQKIMSVIRE 550  human
4BEW_A        552 W--GTgrDTLRCLALATR------------Dtppkreemvl---------ddssrfmeyETDLTFVGVVGMLDPPRKEVM 608  rabbit
P54209        567 F--GSr-QALRCLALAFKsvpttttkldysD----------------------------ESGLTFIGLLGMHDPPRPECR 615  Dunaliella bi...
CAA76764      556 L--AE--KGLRTLAICVQ------------Rcgqlseydgpkhpa-hnllvdtnnynhlESKPIIIGVVALQDPPRPEVK 618  Paramecium te...
AAC47505      561 M--SGteEALRCIAFAFR------------Pipdpkqldl----------sdpakfeaiDSHLTWGGVFGILDPPRREVA 616  Leishmania am...
XP_002440489  573 M--ST--KALRCLGFAYK------------EdlaefatydgenhpahkllldpanyaaiETDLIFAGLVGLRDPPREEVY 636  sorghum
NP_733765     551 WgsGS--DTLRCLALATH------------Dnplrreemhl---------edsanfikyETNLTFVGCVGMLDPPRIEVA 607  human
4BEW_A        609 GSIQLCRDAGIRVIMITGDNKGTAIAICRRIGIF--------Genee--------vadrA-------YTGREFDDLPLAE 665  rabbit
P54209        616 SALSTCHNAGIKVIMVTGDNKGTAEAVARQVGAL--------SpstalagsddednlgiS-------YTGREFEEMGALG 680  Dunaliella bi...
CAA76764      619 RSIEKCREAGISVIMITGDIKETAQSIAMQIGILhnqsqfptH----------------S-------FTGMEFSTMGEEK 675  Paramecium te...
AAC47505      617 DAIAKCRTAGIRVIVITGDKKETAEAVCRRIGLM--------S----------------SeptkglsFTGYELDQMTPAQ 672  Leishmania am...
XP_002440489  637 DAIEDCRAAGIRVMVITGDNKETAEAICREIGVF--------Spded--------itfkS-------LTGKEFMALEDKK 693  sorghum
NP_733765     608 SSVKLCRQAGIRVIMITGDNKGTAVAICRRIGIF--------Gqded--------vtskA-------FTGREFDELNPSA 664  human
4BEW_A        666 qrea------crrACCFARVEPSHKSKIVE-Yl-QSYDEITAMTGDGVNDAPALKKAEIGIAMG-SGTAVAKTASEMVLA 736  rabbit
P54209        681 qaaa------trnLVVLSRVEPMHKLRLVE-Ll-KAQGHVVAMTGDGVNDAPALLRADIGIAMG-SGTAVAKHAADMVLG 751  Dunaliella bi...
CAA76764      676 qnkvleqvigrpsGLVFSRTDPSHKRELVK-LltGQLNQIAAMTGDGVNDAPALKQASIGIAMGiSGTEVAKEASDMILA 754  Paramecium te...
AAC47505      673 rraa------vssAVLFSRTDPSHKMQLVN-Ll-QEQKLICAMTGDGVNDSPALKKADIGIAMG-SGTEVAKAASKLVLA 743  Leishmania am...
XP_002440489  694 tllr------gkgGLLFSRAEPRHKQEIVR-Ll-KEDGEVVAMTGDGVNDAPALKLADIGIAMGiTGTEVAKEASDMVLA 765  sorghum
NP_733765     665 qrda------clnARCFARVEPSHKSKIVEfL--QSFDEITAMTGDGVNDAPALKKAEIGIAMG-SGTAVAKTASEMVLA 735  human
4BEW_A        737 DDNFSTIVAAVEEGRAIYNNMKQFIRYLISSNVGEVVCIFLTAALGLpEALIPVQLLWVNLVTDGLPATALGFNPPDLDI 816  rabbit
P54209        752 DDNFATIVFAVAEGRVIFNNTKQFIRYMISSNIGEVVAIFLAALLGLpEVLTPVQLLWVNLVTDGLPATALGFNRADKDM 831  Dunaliella bi...
CAA76764      755 DDNFATIVRAVEEGRAIYQNMKGFIRYMISSNIGEVVSIFTSSALGIpDGFNSIQLLWVNLVTDGLPATALSFNPPDPDV 834  Paramecium te...
AAC47505      744 DDNFATVVKAVHEGRTIFNNTKQFIRYLISSNIGEVACVLATDCLAC-QKHSADQLLWVNLVTDGLPATACWVQTPPIQT 822  Leishmania am...
XP_002440489  766 DDNFSTIVSAVGEGRSIYNNMKAFIRYMISSNIGEVASIFLTSALGIpEGLIPVQLLWVNLVTDGPPATALGFNPPDKDI 845  sorghum
NP_733765     736 DDNFSTIVAAVEEGRAIYNNMKQFIRYLISSNVGEVVCIFLTAALGFpEALIPVQLLWVNLVTDGLPATALGFNPPDLDI 815  human
4BEW_A        817 MDRPPRSPKE-PLISGWLFFRYMA---------IGGYVGaatvgaaawwfmYAEDGPGV-------------------T- 866  rabbit
P54209        832 MARGPRRVDD-PIVNGWLFLRYLI---------IGMYVG------------IVTVYGFI-------------------W- 869  Dunaliella bi...
CAA76764      835 MQKPPRKHDE-PIITEYVFVRYCV---------VGTYVG------------LATVFVFI-------------------Y- 872  Paramecium te...
AAC47505      823 LWNRHRGEETsPLSTGWLFFRYMV---------VGVYVG------------LATVAGFV-------------------W- 861  Leishmania am...
XP_002440489  846 MKKPPRRSDD-SLITPWILFRYLIiglyvgiatVGIFVI------------WYTHGSFMgidltgdghtlvsysqlsnWg 912  sorghum
NP_733765     816 MNKPPRNPKE-PLISGWLFFRYLA---------IGCYVGaatvgaaawwfiAADGGPRV-------------------S- 865  human
4BEW_A        867 ----Yhqlthfmqctedh--------------------------phfegldceifeaPEPm-TMALSVLVTIEMCNALNS 915  rabbit
P54209        870 ----Wyisfpeggnmtwsqlthf----------------qacasqpggakdcevfhsKHPt-TISMSVLVVVEMFNALNN 928  Dunaliella bi...
CAA76764      873 ----YylgyewagdghpvvtfhqlrnwaechhwegfkvanfdkydfskdpclyfswgKQKasTLSLSVLVVIEMFNALNA 948  Paramecium te...
AAC47505      862 ----Wfltngftmadlvsft----------------------tctdmsnpkcavlanPQTarAIALSILVVVEMLNALNA 915  Leishmania am...
XP_002440489  913 qcssWdnftaspftagtkt-------------------------ftfddpcdyfhtgKVKatTLSLSVLVAIEMFNSLNA 967  sorghum
NP_733765     866 ----Fyqlshflqckedn--------------------------pdfegvdcaifesPYPm-TMALSVLVTIEMCNALNS 914  human
4BEW_A        916 LSENQSLMRMPPWVNIWLLGSICLSMSLHFLILYVDpLPMIFKLKAL-------------------DLTQWLMVLKISLP 976  rabbit
P54209        929 LSEDSSLLRIPPWDNKWLVGAIATSMALHFGILYTG-ASAMFGVTGL-------------------SFAEWTMVIKLSAP 988  Dunaliella bi...
CAA76764      949 LSEDGSLLKVGVFANPYLILAIFGTMTLHCMICYVPlFENIFNTVPL-------------------SLQDWILIIGVSAP 1009 Paramecium te...
AAC47505      916 LSENQSLVVIRPSTNKWLIAAICSSIALHLTIMYIPfFSRLFGVTPLgvdadvvatanswdvllptDFTDWKTVLVLSIP 995  Leishmania am...
XP_002440489  968 LSEDSSLLTMPPWVNPWLLVAMSVSFGLHFLILYVPfLATVFGIVPL-------------------SLNEWLLVLLVALP 1028 sorghum
NP_733765     915 LSENQSLLRMPPWENIWLVGSICLSMSLHFLILYVEpLPLIFQITPL-------------------NVTQWLMVLKISLP 975  human
4BEW_A        977 VIGLDEILKFIAR 989  rabbit
P54209        989 VILVDEIMKAWSR 1001 Dunaliella bioculata
CAA76764     1010 VVLVDEVLKFFSR 1022 Paramecium tetraurelia
AAC47505      996 VIFLDELLKLFSR 1008 Leishmania amazonensis
XP_002440489 1029 VVLIDEVLKFVGR 1041 sorghum
NP_733765     976 VILMDETLKFVAR 988  human
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