Conserved Protein Domain Family
topB

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TIGR01056: topB 
DNA topoisomerase III, bacteria and conjugative plasmid
This model describes topoisomerase III from bacteria and its equivalents encoded on plasmids. The gene is designated topB if found in the bacterial chromosome, traE on conjugative plasmid RP4, etc. These enzymes are involved in the control of DNA topology. DNA topoisomerase III belongs to the type I topoisomerases, which are ATP-independent. [DNA metabolism, DNA replication, recombination, and repair]
Statistics
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PSSM-Id: 273419
Aligned: 4 rows
Threshold Bit Score: 992.425
Created: 8-Oct-2014
Updated: 25-Oct-2021
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
AAF14809       1 MRLVLCEKPSQGRDIAKFLGATQR-GEGFLN------GPGVTVTWARGHLLETAEPEVYGEQYGKpWRTDVLPLLPQQWK 73  Salmonella ente...
P14294         1 MRLFIAEKPSLARAIADVLPKPHRkGDGFIEc-----GNGQVVTWCIGHLLEQAQPDAYDSRYAR-WNLADLPIVPEKWQ 74  Escherichia col...
AAC61961       2 NTLILCEKPSQAMDLSTVFAKKKK-QNGYMEisdeqlNVSGFLTWAVGHLVELKEPQEYDEKYKN-FSTYPILLEKDDFQ 79  Staphylococcus ...
WP_003246684   3 KTVVLAEKPSVGRDLARVLKCHKK-GNGYLE------GDQYIVTWALGHLVTLADPEGYGKEFQS-WRLEDLPIIPEPLK 74  Bacillales
AAF14809      74 LVVKADAKAQFAVINRLLK--QVDEVVIATDADREGEVIARELLDYCKFQG----RVFRLWMSALDDASIRSALADLWPS 147 Salmonella ente...
P14294        75 LQPRPSVTKQLNVIKRFLH--EASEIVHAGDPDREGQLLVDEVLDYLQLAPekrqQVQRCLINDLNPQAVERAIDRLRSN 152 Escherichia col...
AAC61961      80 FKVSDKTKDQFNNIKKIFKenKIDEVIIATDPAREGENIAYKILNQLKVTDk--vTIKRLWLTSKVESSIRKAFKNILPK 157 Staphylococcus ...
WP_003246684  75 LVVIKKTGKQFNAVKSQLTrkDVNQIVIATDAGREGELVARWIIEKANVRK----PIKRLWISSVTDKAIKEGFQKLRSG 150 Bacillales
AAF14809     148 SRTESLYYAGVGRSRADWLIGMNLTRLFTLLGREAGIGNVLSVGRVQTPTLAIVVKRDREIDNFVSKPYFEVIATMAVNG 227 Salmonella ente...
P14294       153 SEFVPLCVSALARARADWLYGINMTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPA 232 Escherichia col...
AAC61961     158 EKTYGFYKEGRARELSDWLVGINLSRHFTKISRELGNDGVIHIGRVSSPTLNMVYNRENNIKGFKGKKFYKVSATINKDE 237 Staphylococcus ...
WP_003246684 151 KEYENLYHSAVARAEADWIVGINATRALTTK-----FNAQLSCGRVQTPTLAMIAKREADIQAFTPVPYYGIRAAVDG-- 223 Bacillales
AAF14809     228 -VLFPSKWVPaa---qYCDEEKRCIQSGVAAQVVQLCRQTPtAAIINCQIERKKQSAPLAFSLSTLQQACSRHWGMPAQT 303 Salmonella ente...
P14294       233 dERFTAIWQPseacepYQDEEGRLLHRPLAEHVVNRISGQP-AIVTSYNDKRESESAPLPFSLSALQIEAAKRFGLSAQN 311 Escherichia col...
AAC61961     238 -QEVKTELKN-------KFDSEDELHEFLFENDITDLTQKG--LVTDIEKEIGYTMPPKFYDLSALQEDMNDKYKISAKR 307 Staphylococcus ...
WP_003246684 224 ---MTLTWQD------KKSKQTRTFNQDVTSRLLKNLQGKQ-AVVAELKKTAKKSFAPALYDLTELQRDAHKRFGFSAKE 293 Bacillales
AAF14809     304 VLDIAQKLYETHKLTTYPRTDCGYLPLSMREEIPQVLSAVVGTDPALQPv-VASLDTQFVSRIWNDKKITAHHGIIPTKH 382 Salmonella ente...
P14294       312 VLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPDLLP--QPVVDPDIRNRCWDDKKVDAHHAIIPTAR 389 Escherichia col...
AAC61961     308 TLEIAQTLYEK-KLITYPRTDSRYITEDEKEMLLENIDYLKEITKINLN------NELTNNSLINPSKIEDHYAILITGN 380 Staphylococcus ...
WP_003246684 294 TLSVLQKLYEQHKLVTYPRTDSRFLSSDIVPTLKDRLEGMEVKPYAQYVsqIKKRGIKSHKGYVNDAKVSDHHAIIPTEE 373 Bacillales
AAF14809     383 TGDLSkLSDAERNVYQLVRLHYLAQFLPQMEIDVTEATFNIGGQLFRTRGNVLVKPGWKSLFGKMSEDDEDNTg-eTTLP 461 Salmonella ente...
P14294       390 SSAIN-LTENEAKVYNLIARQYLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDG---TPLP 465 Escherichia col...
AAC61961     381 DFNKVdLKEEEINVYKSILQNVAMNFMDKEQYETTTIEIAVKKLMFEVKGKIIQDNGFKALLNKQKTSEET-------IP 453 Staphylococcus ...
WP_003246684 374 PLVLSsLSDKERKLYDLIAKRFLAVLMPAFEYEETKVIAEIGGETFTAKGKTVQSQGWKAVYDMAEEDDEQEDdrdQTLP 453 Bacillales
AAF14809     462 AMQAGQVCQVQGAEQKVLQTKPPAPYNDGTLIAAMTNAAAFVT--DAALKKVLKENAGIGTEATRAGIIDTLLKRGFLVR 539 Salmonella ente...
P14294       466 VVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQ--DKDLKKILRATDGLGTEATRAGIIELLFKRGFLTK 543 Escherichia col...
AAC61961     454 NFEKNEEVDIE-LDLLEKETTPPKRYTEKTLLKAMANPIETLE--DEGLKSTLKEVKGLGTPATRADIIENLKKNKYIQV 530 Staphylococcus ...
WP_003246684 454 ALQKGDTLAVRTLTETSGQTKPPARFNEGTLLSAMENPSAFMQgeEKGLVKTLGETGGLGTVATRADIIEKLFNSFLIEK 533 Bacillales
AAF14809     540 EKKTLKSTPLGRNLVDVLP-GTLTNPGLTALWEQMLDEVAAGRVSLDDFMAKQSQWVSQLVAQGRSQPLTMQAPPSPPCp 618 Salmonella ente...
P14294       544 KGRYIHSTDAGKALFHSLP-EMATRPDMTAHWESVLTQISEKQCRYQDFMQPLVGTLYQLIDQAKRTPVRQFRGIVAPG- 621 Escherichia col...
AAC61961     531 QKNKIYITKNGILACLLLEgHLLSKPDLTGQWEKYLNGISKGEKDDDSFINTINEMIKKTINEEVKNKESIQKVAKEKVs 610 Staphylococcus ...
WP_003246684 534 KGQDIFITSKGKQLLQLVP-EDLKSPALTAEWEQKLSAIAAGKLKSAVFIKDMKAYAHQTVKEIKNSSQTFRHDNITGTa 612 Bacillales
AAF14809     619 v------------------------cGGKTLQRNGKSGLFWGCLKYPECKGIVNNGNK 652 Salmonella enterica subsp. enterica s...
P14294       622 --------------------------SGGSADKKKAAPRKRSAKKSPPADEVGSGAIA 653 Escherichia coli K-12
AAC61961     611 -------------------------tNNIAKCPACDNGYLIDRKGFYGCTEYNNGCEF 643 Staphylococcus aureus
WP_003246684 613 cpecgkmmlkvngkrgtmlvcqdrecGSRKTIARKTNARCPNCHKRMELRGQGEGQTF 670 Bacillales
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