2GAI


Conserved Protein Domain Family
topA_bact
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TIGR01051: topA_bact 
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DNA topoisomerase I, bacterial
This model describes DNA topoisomerase I among the members of bacteria. DNA topoisomerase I transiently cleaves one DNA strand and thus relaxes negatively supercoiled DNA during replication, transcription and recombination events. [DNA metabolism, DNA replication, recombination, and repair]
Links
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Statistics
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PSSM-Id: 273416
Aligned: 11 rows
Threshold Bit Score: 878.252
Created: 8-Oct-2014
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
2GAI_A         8 YIVVESPAKAKTIKSILG-NEYEVFASMGHIIDLPKS-----------------------------KFGVDLEKD--FEP 55   Thermotoga mar...
O83409        19 LVIVESPAKAQTIEKYLG-TQYVVRASMGHVIDLPKS-----------------------------RLAIDIEHD--FQP 66   Treponema pall...
P46799         8 YIVVESPAKAKTIKSILG-NEYEVFASMGHIIDLPKS-----------------------------KFGVDLEKD--FEP 55   Thermotoga mar...
P39814         5 LVIVESPAKAKTIERYLG-KKYKVKASMGHVRDLPKS-----------------------------QMGVDIEQN--FEP 52   Bacillus subti...
P06612         5 LVIVESPAKAKTINKYLG-SDYVVKSSVGHIRDLPTSgsaakksadststktakkpkkdergalvnRMGVDPWHN--WEA 81   Escherichia co...
P73810         4 LVIVESPTKARTIRNYLP-QDYRVEASMGHVRDLPASaeevpaa---------------ykdkswaNLGVNVEDH--FSP 65   Synechocystis ...
Q9ZDK2         3 LVIVESPAKAKTINKYLG-DEFKVIASFGHIRDLPSK-----------------------------KGSVLPDKN--FLM 50   Rickettsia pro...
P55991         4 LIIVESPAKAKTIKNFLD-KNYEVIASKGHVRDLSKF-----------------------------ALGIKIDETg-FTP 52   Helicobacter p...
P47368         5 LVVIESPNKVKTLKQYLPsDEFEIVSTVGHIREMVYKnfgfd-------------------entytPIWEDWTKNkqKNP 65   Mycoplasma gen...
WP_027480031  10 LVIVESPAKAKTIEKYLG-QGYAVESSVGHIRDLPRSaadipek---------------ykgqawaRLGLDVEHD--FQP 71   Deinococcus ra...
Q59567        20 LVIVESPTKARKLASYLG-SGYIVESSRGHIRDLPRAasdvpak---------------yksqpwaRLGVNVDAD--FEP 81   Mycobacterium ...

2GAI_A        56 EFAVIKGKEKVVEKLKDLAKK-GELLIASDMDREGEAIAWHIARVTNTLGRk------NRIVFSEITPRVIREAVKNPRE 128  Thermotoga mar...
O83409        67 EYITVRGRAQCLKELRTLSKQsLQVFLASDRDREGEAIAYHLAQSIQAYCDtp----iKRIVFNEITPHAIRAAIGHPVP 142  Treponema pall...
P46799        56 EFAVIKGKEKVVEKLKDLAKK-GELLIASDMDREGEAIAWHIARVTNTLGRk------NRIVFSEITPRVIREAVKNPRE 128  Thermotoga mar...
P39814        53 KYITIRGKGPVLKELKTAAKKaKKVYLAADPDREGEAIAWHLAHSLDLDLNs-----dCRVVFNEITKDAIKESFKHPRM 127  Bacillus subti...
P06612        82 HYEVLPGKEKVVSELKQLAEKaDHIYLATDLDREGEAIAWHLREVIGGDDAr-----ySRVVFNEITKNAIRQAFNKPGE 156  Escherichia co...
P73810        66 LYVIPKSKKKVVKELQTALKNaDEVILATDEDREGESISWHLLQLLQPKVPi------KRMVFHEITQEAIRSALENCRD 139  Synechocystis ...
Q9ZDK2        51 EYDISDKAGKYVDAIVKEARKaEVVYLATDPDREGESISWHVAEVIKEKNKvesddffKRVAFNEITKKAIMNAVANPRK 130  Rickettsia pro...
P55991        53 NYVVDKDHKELVKQIIELSKKaSITYIATDEDREGEAIGYHVACLIGGKLEs-----yPRIVFHEITQNAILNALKTPRK 127  Helicobacter p...
P47368        66 KQKHLLSKFEIIKSIKAKASDaQNIFLASDPDREGEAISWHVYDLLDQKDKak----cKRITFNEITKKAVVDALKQPRN 141  Mycoplasma gen...
WP_027480031  72 LYVVSPEKKQKVAQLRKLAAEaDEIILATDDDREGESIAWHLYQELKPKVPv------KRMVFHEITREAIQAAIAAPRQ 145  Deinococcus ra...
Q59567        82 LYIISPEKRSTVSELRGLLKDvDELYLATDGDREGEAIAWHLLETLKPRIPv------KRMVFHEITEPAIRAAAEHPRD 155  Mycobacterium ...

2GAI_A       129 IDMKKVRAQLARRILDRIVGYSLSPVLWRNFKSNLSAGRVQSATLKLVCDREREILRFVPKKYHRITV------------ 196  Thermotoga mar...
O83409       143 IDTAKVNAQKARRVLDRLVGYHLCPLLWHKVKNGLSAGRVQSVALRLICEREVEVKRFVPEEYWTVEGtfek-------d 215  Treponema pall...
P46799       129 IDMKKVRAQLARRILDRIVGYSLSPVLWRNFKSNLSAGRVQSATLKLVCDREREILRFVPKKYHRITv------------ 196  Thermotoga mar...
P39814       128 INMDLVDAQQARRILDRLVGYKISPILWKKVKKGLSAGRVQSVALRLIIDREKEINDFKPEEYWTIDGtflk-------g 200  Bacillus subti...
P06612       157 LNIDRVNAQQARRFMDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDAsttt------ps 230  Escherichia co...
P73810       140 IDENLVHAQETRRILDRLVGYTLSPLLWKKIAWGLSAGRVQSVAVRLIVQRERARRAFKTAGYWDLKAeleq-------n 212  Synechocystis ...
Q9ZDK2       131 LDTNLVNAQQARRALDYLVGFTLSPLLWRKLPGCKSAGRVQSVALRLICDREDEIERFKSEEYWDISLkmqn------sn 204  Rickettsia pro...
P55991       128 IDMSKVNAQQARRFLDRIVGFKLSSLIASKITKGLSAGRVQSAALKLVIDKEREIKAFKPLTYFTLDAyf---------- 197  Helicobacter p...
P47368       142 IDLNWVESQFARQILDRMIGFRLSRLLN-SYLQAKSAGRVQSVALRFLEEREKEIAKFVPRFWWTVDVllnkennqkvvc 220  Mycoplasma gen...
WP_027480031 146 IDRNLVEAQEARRAVDRLYGYEVSPVLWRKVAPKLSAGRVQSVATRMLVERERERMRFVAATWWDVVVtaqalt--aqag 223  Deinococcus ra...
Q59567       156 LDIDLVDAQETRRILDRLYGYEVSPVLWKKVAPKLSAGRVQSVATRIIVARERDRMAFRSAAYWDILAkldasvsdpdaa 235  Mycobacterium ...

2GAI_A       197 --NFDGLTAEIDVKEKKF----------------------FDAETLKEIQSIDELVVEEKKVSVKKFAPPEPFKTSTLQQ 252  Thermotoga mar...
O83409       216 kkSFSALLILIQGKKAVFks-------------------kQEATSAIGLFSQSEARVSQIRSFEKNVRPKQPFTTSTLQQ 276  Treponema pall...
P46799       197 --NFDGLTAEIDVKEKKF----------------------FDAETLKEIQSIDELVVEEKKVSVKKFAPPEPFKTSTLQQ 252  Thermotoga mar...
P39814       201 qeTFEASFFGKNGKKLPLns-------------------eADVKEILSQLKGNQYTVEKVTKKERKRNPALPFTTSTLQQ 261  Bacillus subti...
P06612       231 geALALQVTHQNDKPFRPvn-------------------kEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQ 291  Escherichia co...
P73810       213 knpFQAKLMTLGGTKLANgsdfdpntgallpdkqvvvldeAQAIALKERLTGKPWAVVNTEEKPGVRKPSPPFTTSTLQQ 292  Synechocystis ...
Q9ZDK2       205 ndLFTAKLTHVNDQKLKKfsi----------------ineKEAKDLTQKLKLQKFYVEKIEKKQQKRQPQPPFITSSLQQ 268  Rickettsia pro...
P55991       198 esHLEAQLISYKGNKLKAqel----------------ideKKAQEIKNELEKESYAISSIVKKSKKSPTPPPFMTSTLQQ 261  Helicobacter p...
P47368       221 anKSIPLVLREINPELSAslkldfeaae--nvsgidflneASATRFANQLTGEYEVYFIDEPKIYYSSPNPVYTTASLQK 298  Mycoplasma gen...
WP_027480031 224 eqTFPARLTEVQGERLAAgkdfdpltgqlrpgagvrllgeAEALAISEGLKGQTLKVLTAEEKPFTSRPPAPFITSTLQQ 303  Deinococcus ra...
Q59567       236 ppTFSARLTAVAGRRVATgrdfdslgtlr-kgdevivldeGSATALAAGLDGTQLTVASAEEKPYARRPYPPFMTSTLQQ 314  Mycobacterium ...

2GAI_A       253 EAYSKLGFSVSKTMMIAQQLYEGvetk-dghiAFITYMRTDSTRVSDYAKEEARNLITEVFGEEYVGSKRe--RRKSNAK 329  Thermotoga mar...
O83409       277 CAANRLGFTSRKTMQVAQQLYEGvslg-thrvGLITYMRTDSVRVSEAAVKEVRAWIATHFSDALPGTPN---RYAAKGK 352  Treponema pall...
P46799       253 EAYSKLGFSVSKTMMIAQQLYEGvetk-dghiAFITYMRTDSTRVSDYAKEEARNLITEVFGEEYVGSKRe--RRKSNAK 329  Thermotoga mar...
P39814       262 EAARKLNFRAKKTMMIAQQLYEGidlgregtvGLITYMRTDSTRISNTAVDEAAAFIDQTYGKEFLGGKRk--PAKKNEN 339  Bacillus subti...
P06612       292 AASTRLGFGVKKTMMMAQRLYEa---------GYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPESPn--QYASKEN 360  Escherichia co...
P73810       293 EANRKLGISARDTMRVAQKLYEE---------GYITYMRTDSVHLSDQAVTAARNCVQQMYGKEYLSPQPk--QYTTKSK 361  Synechocystis ...
Q9ZDK2       269 EAARKLGFSAKKTMQIAQKLYEGvdig-ketiGLITYMRTDGVTLSNDAIADIRKLIDKNYGNQYLPIKPr--IYQSKVK 345  Rickettsia pro...
P55991       262 SASSLLGFSPTKTMSIAQKLYEGvatp-qgvmGVITYMRTDSLNIAKEALEEARNKILKDYGKDYLPPKAk--VYSSKNK 338  Helicobacter p...
P47368       299 DAINKLGWSSKKVTMVAQRLYEGisvn-gkqtALISYPRTDSIRISNQFQSECEKYIEKEFGSHYLADKNklkRHKKDEK 377  Mycoplasma gen...
WP_027480031 304 EGSRKLRMSAQTTMRTAQRLYEG---------GYITYMRTDSTNLSSEAVNAARGQVKDMYGAPYLSPQPr--VYAKKSK 372  Deinococcus ra...
Q59567       315 EASRKLRFSAERTMSIAQRLYEN---------GYITYMRTDSTTLSESAINAARTQARQLYGDEYVAPAPr--QYTRKVK 383  Mycobacterium ...

2GAI_A       330 -IQDAHEAIRPT-NVFMTPEEAGKYLNS---DQKKLYELIWKRFLASQMKPSQYEETRFVLRTkdG--------KYRFKG 396  Thermotoga mar...
O83409       353 -SQDAHEAIRPT-YVAHTPERIKAHLTR---DQIRLYTLIWERFVASQMTDARVRSLTFEITA--G--------PAVFSA 417  Treponema pall...
P46799       330 -IQDAHEAIRPT-NVFMTPEEAGKYLNS---DQKKLYELIWKRFLASQMKPSQYEETRFVLRTkdG--------KYRFKG 396  Thermotoga mar...
P39814       340 -AQDAHEAIRPT-SVLRKPSELKAVLGR---DQMRLYKLIWERFVASQMAPAVLDTMSVDLTN--N--------GLTFRA 404  Bacillus subti...
P06612       361 -SQEAHEAIRPS-DVNVMAESLKD-MEA---DAQKLYQLIWRQFVACQMTPAKYDSTTLTVGA--G--------DFRLKA 424  Escherichia co...
P73810       362 gAQEAHEAIRPAgTEFRIPNQTG--LKD---RELALYELIWKRTVACQMADARITQLSVLLKVedA----------EFRA 426  Synechocystis ...
Q9ZDK2       346 nAQEAHEAIRPT-NITYTPDSLKQKLEK---DYYKLYELIWHRTIACQMENVIMDLVIANLASenK--------EYLAKA 413  Rickettsia pro...
P55991       339 nAQEAHEAIRPT-SIILEPNALKDYLKP---EELRLYTLIYKRFLASQMQDALFESQSVVVACekG----------EFKA 404  Helicobacter p...
P47368       378 iIQDAHEGIHPT-YITITPNDLKNGVKR---DEFLLYRLIWIRTVASLMADAKTSRTIVRFINqkN----------KFYT 443  Mycoplasma gen...
WP_027480031 373 nAQEAHEAIRPAgSTFRTPEQLRGELSG---DEWRLYDLIWKRTVASQMSDARGRSLRVRLGGqtAsgqtadsvPVVLNA 449  Deinococcus ra...
Q59567       384 nAQEAHEAIRPAgETFATPDAVRRELDGpniDDFRLYELIWQRTVASQMADARGMTLSLRITGmsGh------qEVVFSA 457  Mycobacterium ...

2GAI_A       397 TVLKKIFDGYEKVWKTER----------NTGEFP-FEEGESVKPVVVKIEEQETKPKPRYTEGSLVKEMERLGIGRPSTY 465  Thermotoga mar...
O83409       418 TETQVIEQGFYRVLKMLSpk------dlSKAVLPpTKEGEVVALHNVQSVQHFTQGPVRYTDASIVKMLEEKGIGRPSTY 491  Treponema pall...
P46799       397 TVLKKIFDGYEKVWKTER----------NTGEFP-FEEGESVKPVVVKIEEQETKPKPRYTEGSLVKEMERLGIGRPSTY 465  Thermotoga mar...
P39814       405 NGSKVKFSGFMKVYVEGKddq----meeKDRMLPdLQEGDTVLSKDIEPEQHFTQPPPRYTEARLVKTLEERGIGRPSTY 480  Bacillus subti...
P06612       425 RGRILRFDGWTKVMPALRkg-------dEDRILPaVNKGDALTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTY 497  Escherichia co...
P73810       427 AGKRIDFPGYFRAYVEGSddpda-alenQEVILPpLKVGDRPNCREIDTVGHETQPPARYTEASLVKTLESEGVGRPSTY 505  Synechocystis ...
Q9ZDK2       414 NGSIIAFDGFYKVYRESLdde----deeDNKMLPpLKEQEHIKTKEVIPNKHFTEPPPRYSEASLVKKLEELGIGRPSTY 489  Rickettsia pro...
P55991       405 SGRKLLFDGYYKILGNd----------dKDKLLPnLKENDPIKLEKLESNAHVTEPPARYSEASLIKVLESLGIGRPSTY 474  Helicobacter p...
P47368       444 SSKSLLFDGYQRLYEEIKpnt----kdeLYIDLSkLKIGDKFSFEKISVNEHKTNPPPRYTQASLIEELEKSNIGRPSTY 519  Mycoplasma gen...
WP_027480031 450 SGRTIDFPGFLRAYVEGSddpaa-aledRDTPLPpLKAGDAVRAQDVKAEDHETQPPARYTEASLVQALEGAGIGRPSTY 528  Deinococcus ra...
Q59567       458 TGRTLTFPGFLKAYVETVdelvggeaddAERRLPhLTPGQRLDIVELTPDGHATNPPARYTEASLVKALEELGIGRPSTY 537  Mycobacterium ...

2GAI_A       466 ASTIKLLLNRGYIKKIRGYLYPTIVGSVVMDYLEKKYSDVVSVSFTAEMEKDLDEVEQGKKTDKIVLREFYESFSSVFD- 544  Thermotoga mar...
O83409       492 APTISVLLDRYYVTRIQKQLMPTPLGKVISDLLTTYFHDVVDVSFTARMESKLDEVEEDKIKWNCVIADFYPAFSEKVSt 571  Treponema pall...
P46799       466 ASTIKLLLNRGYIKKIRGYLYPTIVGSVVMDYLEKKYSDVVSVSFTAEMEKDLDEVEQGKKTDKIVLREFYESFSSVFD- 544  Thermotoga mar...
P39814       481 APTLDTIQRRGYVALDNKRFVPTELGQIVLDLIMEFFPEIINVEFTAKMERDLDHVEEGNTEWVKIIDNFYTDFEKRVKk 560  Bacillus subti...
P06612       498 ASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDk 577  Escherichia co...
P73810       506 ASIIGTIIDRGYVQMRSKALTPTFTAFAVVSLLESHFPDLVDTGFTSRMEQKLDEIAIGKTQWLPYLQGFFLGESGlen- 584  Synechocystis ...
Q9ZDK2       490 ASILSVLQDRKYVALEKKRFIPEELGRLVTVFLVGFFKKYVEYDFTAGLENELDEIAAGKLEWKTALNNFWRGFNHNIEs 569  Rickettsia pro...
P55991       475 APTISLLQNRDYIKVEKKQISALESAFKVIEILEKHFEEIVDSKFSASLEEELDNIAQNKADYQQVLKDFYYPFMDKIEa 554  Helicobacter p...
P47368       520 NTMASVNLERGYANLVNRFFYITELGEKVNNELSKHFGNVINKEFTKKMEKSLDEIAENKVNYQEFLKQFWTNFKSDVKl 599  Mycoplasma gen...
WP_027480031 529 ASILGTIQDRGYALKKGTALVPSWTAFATSALLEHHFGTLVDYDFTAKMEEDLDEIAGGREHRVPYLRRFYLGEEGegma 608  Deinococcus ra...
Q59567       538 SSIIKTIQDRGYVHKKGSALVPSWVAFAVTGLLEQHFGRLVDYDFTAAMEDELDEIAAGNERRTNWLNNFYFGGDHGVPd 617  Mycobacterium ...

2GAI_A       545 -------------RNDRIVVDf---PTNQKCS-CGK-EMRLSFGKYG--FYLKC------------ECGKTRSVK 587  Thermotoga maritima...
O83409       572 vm--------kdlNSMRGVFDe---KTDVVCSqCGD-TMVKKLGRFG--FFLACgk--------fpECRNTQPVP 624  Treponema pallidum ...
P46799       545 -------------RNDRIVVDf---PTNQKCS-CGK-EMRLSFGKYG--FYLKC------------ECGKTRSVK 587  Thermotoga maritima...
P39814       561 ae---------seMKEVEIEPe---YAGEDCElCSS-PMVYKMGRYG--KFLACsn--------fpDCRNTKPIV 612  Bacillus subtilis s...
P06612       578 aek------dpeeGGMRPNQMv---LTSIDCPtCGR-KMGIRTASTG--VFLGCsgyal---ppkeRCKTTINLV 637  Escherichia coli K-12
P73810       585 ----------qvkVRQDQIDP----AIAKAIElENL-AAKVKIGKFG--PYIEIpqge-----eiiTASIPQDLT 637  Synechocystis sp. P...
Q9ZDK2       570 vneqkiteiinylQKALDYHLfgedKESKVCPsCKTgQLSLKLGKFG--AFLACsn--------ypECTFKKSIV 634  Rickettsia prowazek...
P55991       555 -------------GKKNIISQkvheKTGQSCPkCGG-ELVKKNSRYG--EFIACnn--------ypKCKYVKQTE 605  Helicobacter pylori...
P47368       600 ------------aENSIQKVKkekeLVERDCPkCNQ-PLVYRYTKRGneKFVGCsd--------fpKCKYSEFSN 653  Mycoplasma genitali...
WP_027480031 609 l-------kplieRQMGEIDArgiaTIKVP-KlEGS-GIEVRVGRYG--PYMQRge---------dKANLPEGMT 663  Deinococcus radiodu...
Q59567       618 svarsgglkklvgINLEGIDArevnSIKLFDDtHGR-PIYVRVGKNG--PYLERlvagdtgeptpqRANLSDSIT 689  Mycobacterium tuber...
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