1VDZ_A 4 KGRIIRVTGPLVVADGMKgAKMYEVVRVGELGLIGEIIRLEGDKAVIQVYEETAGVRPGEPVVGTGASLSVELGPGLLTS 83 Pyrococcus hori... AAC06375 4 KGEIYRVAGPVVTAIGLD-AKMYDLCKVGNEGLMGEVIQIVGDKTIIQVYEETGGVRPGEPCVTTGMSLAVELGPGLLSS 82 Methanosarcina ... Q48332 12 DGVIASVSGPVVTARGLD-ARMNDVVYVGDEGLMGEVIEIEGDLTTIQVYEETSGVGPGEPVESTGEPLTVDLGPGMMDA 90 Haloferax volca... P25163 10 TGEIESVSGPVVTATGLD-AQMNDVVYVGDEGLMGEVIEIEGDVTTIQVYEETSGIGPGQPVDNTGEPLTVDLGPGMLDS 88 Halobacterium s... O29101 9 VGEIYRISGPLVVAEGLK-ARMYDLCKVGEEGLMGEVVGLVGQKVLIQVYEDTEGVKPGDKVENTGMPLSVELGPGLIRN 87 Archaeoglobus f... O27036 4 EGRIIKIAGPVIIAEGMRgSQMYEMVKVGEDKLIGEIIELEGDTATIQVYEETAGIKPGETVERTGGPLSVELGPGILGS 83 Methanothermoba... AAB64416 1 MGRIIRVTGPLVVADGMKgSKMYEVVRVGEMGLIGEIIRLEGDKAVIQVYEETAGIRPGEPVEGTGSSLSVELGPGLLTS 80 Desulfurococcus... BAA23342 1 MGRIIRVTGPLVVADGMKgAKMYEVVRVGEMGLIGEIIRLEGDKAVIQVYEETAGIRPGEPVEGTGSSLSVELGPGLLTS 80 Thermococcus sp. CAB57737 3 NGRIVRINGPLVVADNMRnAQMYEVVEVGEPRLIGEITRIEGDRAFIQVYEDTSGIKPNEPVYRTGAPLSIELGPGLIGK 82 Sulfolobus solf... P09639 4 EGRVVRVNGPLVIADGMReAQMFEVVYVSDLKLVGEITRIEGDRAFIQVYESTDGVKPGDKVYRSGAPLSVELGPGLIGK 83 Sulfolobus acid... Q57670 4 VGKIIKIAGPVVVAEGMKgAQMYEVVKVGEEKLTGEIIQLHDDKAVIQVYEETSGIKPGEPVVGTGAPLSVELGPGMLRA 83 Methanocaldococ... P22662 4 KGEIYRVSGPVVTAIGLQ-AKMYDLVKVGNEGLMGEVIQILGPKTIIQVYEETAGIKPGEPCVSTGSSLSVELGPGLLSS 82 Methanosarcina ... WP_010865716 4 KGSIVRISGPLVVAEGMSgAQMYEMVYVGEDRLIGEITRIRGDRAFIQVYESTSGLKPGEPVVGTGAPLSVELGPGLLGT 83 Aeropyrum pernix
1VDZ_A 84 IYDGIQRPLEVIREKTG-D-------FIARGVTAPALPRDKKWHFIPK-AKVGDKVVGGDIIGEVPETSIIVHKIMVPPG 154 Pyrococcus hori... AAC06375 83 IYDGLQRPLHVLLERTG-G-------FIGRGVTADGLDHKKLWEFKPV-VKKGDGVIGGDVIGVVQETVNIEHKIMLPPD 153 Methanosarcina ... Q48332 91 IYDGVQRPLDVLESKMDsA-------FLDRGVDAPGIDLDEKWEFEPT-VSEGDEVAPGDVVGTVPETVTIEHKVMVPPD 162 Haloferax volca... P25163 89 IYDGVQRPLDVLEDEMG-A-------FLDRGVDAPGIDLDTDWEFEPT-VEAGDEVAAGDVVGTVDETVSIEHKVLVPPR 159 Halobacterium s... O29101 88 IYDGVQRPLPVLKEVSG-D-------FIGRGIEAPGLDRKAKWEFKPL-VKKGEKVKPGEIIGTVQETEVVEQKILVPPN 158 Archaeoglobus f... O27036 84 IFDGIQRPLENIKALTG-D-------YIERGVDVPSLPKDKKWTFKPT-AREGQMVKGGDIIGEVEETSSITHRIMIPPN 154 Methanothermoba... AAB64416 81 MYDGIQRPLEKLRELSG-D-------FIARGLTAPALPRDKKWHFTPT-VKVGDKVTGGDILGVVPETSIIEHKILVPPW 151 Desulfurococcus... BAA23342 81 MYDGIQRPLDVLRQLSG-D-------FIARGLTAPALPRDKKWHFTPK-VKVGDKVVGGDILGVVPETSIIEHKILVPPW 151 Thermococcus sp. CAB57737 83 IFDGLQRPLDSIKELTKsP-------FIARGIKVPSIDRKTKWHFVPK-VKKGDKVEGGSIIGIVNETPLVEHRILVPPY 154 Sulfolobus solf... P09639 84 IYDGLQRPLDSIAKVSNsP-------FVARGVSIPALDRQTKWHFVPK-VKSGDKVGPGDIIGVVQETDLIEHRILIPPN 155 Sulfolobus acid... Q57670 84 MYDGIQRPLTAIEEKTG-Si------FIPRGVDVPALPRDIKWEFKPV-VNEGDYVEEGDIIGTVDETPSIVHKILVPIG 155 Methanocaldococ... P22662 83 IYDGVQRPLHVLLEKMG-S-------FIQRGVSADGLDHKKLWDFKPI-VKKGDSVKGGDVIGVVQETVNIEHKIMVPPD 153 Methanosarcina ... WP_010865716 84 IYDGVQRPLPIIAEKVA-EvdprrrmFVERGIQAPPLPRDRKFHFKPEpLKEGDKVEGGDALGRVPETSLIEHVVMVPPG 162 Aeropyrum pernix
1VDZ_A 155 IEG-EIVEIAeEGDYTIEEVIAKVKtpSGe-Ik-ELKMYQRWPVRVKRPYKEKLPPEVPLITGQRVIDTFFPQAKGGTAA 231 Pyrococcus hori... AAC06375 154 ISG-TVSDIR-SGSFTVVDTICTLT--EG--P--ELQMMQRWPVRKPRPVKRKLTPEKPLVTGQRILDGLFPVAKGGTAA 225 Methanosarcina ... Q48332 163 FGGgEVVAVE-EGEFSVTEAVVELD--SG--E--EITMHQEWPVRQARPAAEKKTPREPLVSGQRILDGLFPIAKGGTAA 235 Haloferax volca... P25163 160 SDGgEVVAVE-SGTFTVDDTVVELD--TG--E--EIQMHQEWPVRRQRPTVDKQTPTEPLVSGQRILDGLFPIAKGGTAA 232 Halobacterium s... O29101 159 VKEgVIAEIY-EGSFTVEDTIAVLE--DG--T--ELKLYHKWPVRIPRPYVEKLPPVVPLITGQRILDTFFPVAKGGTAA 231 Archaeoglobus f... O27036 155 VEG-KLTMIApQGEYTVLDDIAEVEteSGt-E--KIQMLQKWPVRKGRPYKKKLDPDVPLVTGQRAQDTFFSVAKGGTAA 230 Methanothermoba... AAB64416 152 VEG-EIVEIAeEGDYTVEEVIAKVKkpDGsiE--ELKMYHKWPVRVKRPYKNKLPPEVPLITGQRTIDTFFSIAKGGTAA 228 Desulfurococcus... BAA23342 152 VEG-EIVEIAeEGDYTVEEVIVKVKkpDGtiE--ELKMYHRWPVRVKRPYKQKLPPEVPLITGQRTIDTFFSQAKGGTAA 228 Thermococcus sp. CAB57737 155 VHG-TLKEVVaEGDYTVEDPIAIVDm-NGdeV--PVKLMQKWPVRIPRPFKEKLEPTEPLLTGTRVLDTIFPIAKGGTAA 230 Sulfolobus solf... P09639 156 VHG-TLKELArEGDYTVEDVVAVVDm-NGdeI--PVKMYQKWPVRIPRPYKEKLEPVEPLLTGIRVLDTVFPIAKGGTAA 231 Sulfolobus acid... Q57670 156 VKG-KIVEIK-EGKFTVEETVAVVEt-ENg-ErkEITMMQKWPVRKPRPYKEKLPPEIPLITGQRVEDTFFTLAKGGTAA 231 Methanocaldococ... P22662 154 ISG-TISDIK-SGNFTVVDTICTLT--DG--T--ELQMMQRWPVRRPRPVKAKLTPTRPLVTGMRILDGLFPVAKGGTAA 225 Methanosarcina ... WP_010865716 163 IRG-RLKWLAsEGDYSVEDTIAVVEr-DGrdV--EIRMHQRWPVRIPRPFKEKLEPQLPLITGVRIIDTFFPMAKGGTGA 238 Aeropyrum pernix
1VDZ_A 232 IPGPFGSGKTVTQHQLAKWSDAQVVIYIGCGERGNEMTDVLEEFPKLKDPKTGKPLMERTVLIANTSNMPVAAREASIYT 311 Pyrococcus hori... AAC06375 226 IPGPFGSGKTVTQQQLSKWSDTEIVVYIGCGERGNEMADVLWEFPELEEPQTGRPLMERTILVANTSNMPVAAREASVYT 305 Methanosarcina ... Q48332 236 IPGPFGSGKTVTQHQLAKWADADIVVYVGCGERGNEMTEVIEDFPELDDPKTGNPLMARTCLIANTSNMPVAARESCIYT 315 Haloferax volca... P25163 233 IPGPFGSGKTVTQQSLAKFADADIVVYIGCGERGNEMTEVIEDFPELPDPQTGNPLMARTTLIANTSNMPVAGRESCIYT 312 Halobacterium s... O29101 232 IPGPFGSGKTVTQHQLAKWSDAQIVVYIGCGERGNEMTEVLEEFPELEDPRTGKPLMERTVLVANTSNMPVAAREASVYT 311 Archaeoglobus f... O27036 231 IPGPFGSGKTVTQQQLAKWADADIIVYVGCGERGNEMTEVLKEFPELEDPKTGNPLMDRTVLIANTSNMPVAAREACVYT 310 Methanothermoba... AAB64416 229 IPGPFGSGKTVTQHQLAKWSDAQVVVYIGCGERGNEMTDVLEEFPKLKDPKTGKPLMERTVLIANTSNMPVAAREASIYT 308 Desulfurococcus... BAA23342 229 IPGPFGSGKTVTQHQLAKWSDAQVVVYIGCGERGNEMTDVLEEFPKLKDPKTGKPLMERTVLIANTSNMPVAAREASIYT 308 Thermococcus sp. CAB57737 231 IPGPFGSGKTVTLQSLAKWSAAKIVIYVGCGERGNEMTDELRQFPSLKDPWTGRPLLERTILVANTSNMPVAAREASIYV 310 Sulfolobus solf... P09639 232 IPGPFGSGKTVTLQSLAKWSAAKVVIYVGCGERGNEMTDELRSFPKLKDPWTGKPLLLRTILVANTSNMPVAARESSIYV 311 Sulfolobus acid... Q57670 232 IPGPFGSGKTVTQHQLAKWSDADVVVYIGCGERGNEMTEVIEEFPHLEDIRTGNKLMDRTVLIANTSNMPVAAREASVYT 311 Methanocaldococ... P22662 226 IPGPFGSGKTVTQQSLAKWSDTEIVVYIGCGERGNEMADVLSEFPELEDPQTGRPLMERTVLIANTSNMPVAAREASVYT 305 Methanosarcina ... WP_010865716 239 VPGGFGTGKTVTLHSLAQWSEARVVIYIGCGERGNEMTEVLERFPQYKDPWTGKPLMDRTVLIANTSNMPVAAREASIYV 318 Aeropyrum pernix
1VDZ_A 312 GITIAEYFRDMGYDVALMADSTSRWAEALREISGRLEEMPGEEGYPAYLASKLAEFYERAGRVVTLGSDyrVGSVSVIGA 391 Pyrococcus hori... AAC06375 306 GMTLAEYFRDMGYDVSLMADSTSRWPEAMREISSRLEEMPGEEGYPAYLSARLAEFYERAGVAETLCGE--KGSITAIGA 383 Methanosarcina ... Q48332 316 GITIAEYYRDMGYDVALMADSTSRWAEAMREISSRLEEMPGEEGYPAYLAARLSEFYERAGYFTTVNGE--EGSVSVIGA 393 Haloferax volca... P25163 313 GITIAEYYRDMGYDVALMADSTSRWAEAMREISSRLEEMPGEEGYPAYLAARLSEFYERAGYFENFNGT--EGSISVIGA 390 Halobacterium s... O29101 312 GITIAEYFRDMGYDVAIQADSTSRWAEAMREISGRLEEMPGEEGYPAYLASRLAEFYERAGRVKTLAGN--IGSVTVVGA 389 Archaeoglobus f... O27036 311 GITIAEYFRDMGYDVALMADSTSRWAEAMREISGRLEEMPGEEGYPAYLASRLAQFYERAGRVTTIGSEdkIASVSVVGA 390 Methanothermoba... AAB64416 309 GITIAEYFRDQGYDVALMADSTSRWAEALREISGRLEEMPGEEGYPAYLASKIAEFYERAGRVVTLGSEprVGSVSVIGA 388 Desulfurococcus... BAA23342 309 GITIAEYFRDQGYDVALMADSTSRWAEALREISGRLEEMPGEEGYPAYLASKIAEFYERAGRVITLGSDerVGSVSVIGA 388 Thermococcus sp. CAB57737 311 GITMAEYFRDQGYDTLLVADSTSRWAEALRDLGGRMEEMPAEEGFPSYLPSRLAEYYERAGRVKTIGNPerFGSVTVASA 390 Sulfolobus solf... P09639 312 GVTMAEYFRDQGYDVLLVADSTSRWAEALRDLGGRMEEMPAEEGFPSYLPSRLAEYYERAGRVIALGNPerYGSVTIASA 391 Sulfolobus acid... Q57670 312 GITIAEYFRDMGYGVLLTADSTSRWAEAMREISGRLEEMPGEEGYPAYLASRLAQFYERAGRVITLGKDnrQGFVCIVGA 391 Methanocaldococ... P22662 306 GITIAEYYRDMGLDVSLMADSTSRWAEAMREISSRLEEMPGEEGYPAYLSARLAEFYERAGVAESLCGE--TGSITVIGA 383 Methanosarcina ... WP_010865716 319 GITIAEYYRDMGYDVLLVADSTSRWAEALREIAGRLEEMPAEEGYPSYLASRLAEFYERAGRVKALGSPerSGSVTVVGA 398 Aeropyrum pernix
1VDZ_A 392 VSPPGGDFSEPVVQNTLRVVKVFWALDADLARRRHFPAINWLTSYSLYVDAVKDWWHKNIDPEWKAMRDKAMALLQKESE 471 Pyrococcus hori... AAC06375 384 VSPPGGDFSEPVTQNTLRIVKVFWALDAKLSQKRHFPAINWLNSYSLYKEDLNDWFTENVAPDYVPMRERAMDMLQTESE 463 Methanosarcina ... Q48332 394 VSPPGGDFSEPVTQNTLRIVKTFWALDADLAERRHFPAINWNESYSLYQEQLDPWFVENVEDDWAEERQWAVDVLDEENE 473 Haloferax volca... P25163 391 VSPPGGDFSEPVTQNTLRIVKTFWALDSDLAERRHFPAINWDESYSLYKDQLDPWFTDNVVDDWAEQRQSAVDILDEESE 470 Halobacterium s... O29101 390 VSPPGGDFSEPVTQNTLRIVKVFWALDAKLAARRHFPAINWLQSYSLYVDTLKDWFAENVSEEWNELRRWAMEVLQEEAN 469 Archaeoglobus f... O27036 391 VSPPGGDLSEPVTQNTLRICKVFWALDASLADKRHFPSIDWLQSYSLYIDSVQEWWASNVDPEWRKFRDEAMALLQKEAE 470 Methanothermoba... AAB64416 389 VSPPGGDFSEPVVQNTLRVVKVFWALDADLARRRHFPAINWLRSYSLYLDSIQDWWHKNVDPEWRKMRDTAMALLQKEAE 468 Desulfurococcus... BAA23342 389 VSPPGGDFSEPVVQNTLRVVKVFWALDADLARRRHFPAINWLRSYSLYVDAIQDWWHKNVDPEWRKMRDTAMALLQKEAE 468 Thermococcus sp. CAB57737 391 VSPPGGDFTEPVTSQTLRFVKVFWPLDVSLAQARHYPAINWLQGFSAYVDLVANWWNTNVDPKWREMRDMMVRTLIREDE 470 Sulfolobus solf... P09639 392 VSPPGGDFTEPVTSNTLRFVRVFWPLDVSLAQARHYPAINWIQGFSAYVDLVAQWWHKNVDPNWKEMRDTMMKVLIREDE 471 Sulfolobus acid... Q57670 392 VSPPGGDFSEPVTSNTLRIVKVFWALDANLARRRHFPAINWLQSYSLYIDDVTEWWNTNTGPDWRQLRDEAMSLLQKEAE 471 Methanocaldococ... P22662 384 VSPPGGDFSEPVTQNTLRIVKVFWALDAKLSQRRHFPAINWLNSYSLYKDSLNDWFADNVAPDYVPLRERAMEMLQTESE 463 Methanosarcina ... WP_010865716 399 VSPPGGDFSEPVTSHTTRFIRVFWALDTKLAYSRHYPAINWLMSYSAYVDLVTQWWHENVDKRWREYRDEAMDILLRESE 478 Aeropyrum pernix
1VDZ_A 472 LQEIVRIVGPDALPERERAILLVARMLREDYLQQDAFDEVDTYCPPEKQVTMMRVLLNFYDKTMEAINRGVPLEEIAKLP 551 Pyrococcus hori... AAC06375 464 LQEIVQLVGSDALPEEQQLLLEITRMIREIFLQQNAFHPIDTYSPFEKQYKIMKAIMKWGDAAMDALKSGVPSSEILKIE 543 Methanosarcina ... Q48332 474 LQEIVQLVGKDALPEDQQLTLEIARYLREAYLQQNAFHPTDTYCSPEKTYGILTAIHAFNDEAFKALEAGVPVEEIQAIE 553 Haloferax volca... P25163 471 LEEIVQLVGKDALPEDQQLTLEVARYIREAWLQQNALHDVDRYCPPEKTYAILSGIKTLHEESFEALDAGVPVEEITSID 550 Halobacterium s... O29101 470 LQEIVQLVGSDALPESQRVLLEVARIIREVYLIQYAYHPVDTYCSVQKQYDMLKAIKQINDWFYQALEAGKTIDEIAGVE 549 Archaeoglobus f... O27036 471 LQEIVQLVGPDALPDRERITLETTRMIREDFLQQNAYHEVDTYCSPSKQFEMLRTIIMFHRNATAALEKGAPAADIISLP 550 Methanothermoba... AAB64416 469 LQEIVRIVGPDALPDREKAILIVTRMLREDYLQQDAFDEVDTYCPPKKQVTMMRVILNFYERTMEAVDRGVPVDEIAKLP 548 Desulfurococcus... BAA23342 469 LQEIVRIVGPDALPDREKAILIVTRMLREDYLQQDAFDEVDTYCPPKKQVTMMRVILNFYEKTMQAVDRGVPVDEIAKLP 548 Thermococcus sp. CAB57737 471 LRQIVRLVGPESLAEKDKLILETARLIKEAFLKQNAYDDIDAFSSPQKQARIMRLIYLFNTYASKLVERGIPTKKIVDSM 550 Sulfolobus solf... P09639 472 LRQIVRLVGPEELAEKDKLVLEAAKLIKDAFLKENAYDDIDAFSSPQKQVRIMRLIYIFYNQSQDLISKGVPLKKILDKV 551 Sulfolobus acid... Q57670 472 LQEIVQLVGPDALPDRERVILEVARMLREDFLQQDAFDEVDTYCPPMKQYLMLKIIMTFYQEALKAVERGVEPAKILGVS 551 Methanocaldococ... P22662 464 LQEIVQLVGSDALPDDQQLLLEITRMLREIFLQQNAFHPVDAYSPFDQQYKILKAIMKWGDAAMDALKSGVPVTEIIKLE 543 Methanosarcina ... WP_010865716 479 LQEIVRLVGTEGLDEKDKMVLETARLIKDGFLKQNAFDPIDAFATPQKQFRLLKMIMDIHRKSLELIEKGVTTQQILQAL 558 Aeropyrum pernix
1VDZ_A 552 --VREEIGRMKFERDvskIRSLIDKTNEQFEELFK 584 Pyrococcus horikoshii AAC06375 544 --SKDSLPKVKYEEN---FEDSLNAVLAKMDKEFA 573 Methanosarcina mazei Go1 Q48332 554 --AAPRLNRIGVQED---WEAYIEDLKAEITEQLR 583 Haloferax volcanii DS2 P25163 551 --AAPRLNRLGTTPDd-eHEAEVAEIKQQITEQLR 582 Halobacterium salinarum O29101 550 --GLEEFARAKFEED---YKPAMEAALEKIRKNLL 579 Archaeoglobus fulgidus DSM 4304 O27036 551 --VKEDIGRMKYIPEeefP-ARIKEIQERIVKECS 582 Methanothermobacter thermautotrophicus str. Delta H AAB64416 549 --VREKIGRMKFEPDiekIRALIDETNEQFEELFK 581 Desulfurococcus sp. SY BAA23342 549 --VREKIGRMKFEPDvekVRALIDETNQQFEELFK 581 Thermococcus sp. CAB57737 551 gqLLPEIIRSKAAIKn-dELNRYDELERKLITVFE 584 Sulfolobus solfataricus P2 P09639 552 gpIEPEIIRIKYTIKn-dELNKIDEIENKLKATFD 585 Sulfolobus acidocaldarius Q57670 552 --VKQDIARMKYIPHdefINVKSKEIMEKIKNELG 584 Methanocaldococcus jannaschii DSM 2661 P22662 544 --SKNVLAKVKYEEK---FDESMNAVLAQMDKEFA 573 Methanosarcina barkeri WP_010865716 559 grLYIDIVKAKFTIPn-dQLEKIDEIRDRALKALD 592 Aeropyrum pernix
Jiyao W et al.(2023). "The conserved domain database in 2023.",