3PUI


Conserved Protein Domain Family
CocE/NonD

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TIGR00976: CocE/NonD 
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putative hydrolase, CocE/NonD family
This model represents a protein subfamily that includes the cocaine esterase CocE, several glutaryl-7-ACA acylases, and the putative diester hydrolase NonD of Streptomyces griseus (all hydrolases). This family shows extensive, low-level similarity to a family of xaa-pro dipeptidyl-peptidases, and local similarity by PSI-BLAST to many other hydrolases. [Unknown function, Enzymes of unknown specificity]
Statistics
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PSSM-Id: 273375
Aligned: 8 rows
Threshold Bit Score: 528.989
Created: 8-Oct-2014
Updated: 22-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
3PUI_A        14 VPMRDGVRLAVDLYRPDADG------PVPVLLVRNPYDKFdvf--------------------------awSTQSTNWLE 61  Rhodococcus sp....
BAA01048      48 VEMRDGVKLATDIYLPVAKTeqekkdGFPTLVFRTPYNKD-------------------------------TYGKTEGPF 96  Brevibacillus l...
AAC26133      13 VEMRDGTVLRADVWRPAEGP------ASPAVLFRTPYGKSp-----------------------------lGLATLTPAQ 57  Streptomyces gr...
Q50598        34 VTMRDGVRIAIDLYLPAGLTsa---aRLPAILHQTRYYRSlqlrwplrml------------lggkplqhiAADKRRRRR 98  Mycobacterium t...
CAB53331      96 SADRSGTRLHADVLLPEGLKrk---eKVPVILSIGPYFAHagqtgpegw--------------srtgpsarFQDFIEGTD 158 Streptomyces co...
AAF42807      14 VPMRDGVRLAVDLYRPDADG------PVPVLLVRNPYDKFdvf--------------------------awSTQSTNWLE 61  Rhodococcus sp....
WP_010871701   1 MVTRDGIRLDSDLYYPNSGG------PWPALLMRQPYGRRla----------------------------sTLVYAHPHW 46  Synechocystis s...
WP_003911447  43 VPTRDGTLLRINVFRSAEGG------ARPVIASIHPYGKDalprrrgnrwtfspqyrmlrqpkpltfsaltGWEAPDPAW 116 Mycobacterium t...
3PUI_A        62 FVRDGYAVVIQDTRGLFASEGEFVPH--VDDEADAEDTLSWILEQAWCDGNVGMFGVSYLGVTQWQAAVSGVGGLKAIAP 139 Rhodococcus sp....
BAA01048      97 FAKRGYAVVVQDTRGRYKSEGEWNFV--FDDAKDGYDLIEWAAVQDFSTGKVGTMGLSYMAYTQYVLAESKPPHLVTMIP 174 Brevibacillus l...
AAC26133      58 CVDRGYAAVVQDTRGRFGSEGEWAPLdwSQEGPDGYDTVEWTAEQPWCDGNVAMAGTSYQAIVQWLAAMEKPPHLRAIAP 137 Streptomyces gr...
Q50598        99 FVASGYAWVDVDVRGSGASFGARVCEwsSDEIRDGAEIVDWIVRQPWCNGTVAALGNSYDGTSAELLLVNQHPAVRVIAP 178 Mycobacterium t...
CAB53331     159 LFDEGYAFVMVDLRGFGGSTGCLDWGg-PGEQADVKAAIDWAAKQPWSTGAVGMYGKSYDAVTGLIGNNLDQRALRAVVA 237 Streptomyces co...
AAF42807      62 FVRDGYAVVIQDTRGLFASEGEFVPH--VDDEADAEDTLSWILEQAWCDGNVGMFGVSYLGVTQWQAAVSGVGGLKAIAP 139 Rhodococcus sp....
WP_010871701  47 YAAQGYLVIIQDVRGRGSSEGEFDLF--AHEVEDGQDCLDWVSKLPQCEGSVATYGFSYQGMTQLYAAANHHPSLKTICP 124 Synechocystis s...
WP_003911447 117 WTAQGFVVVNADSRGCGRSDGTGDLLs-HQEAEDTYDLVGWLADQAWSDGRVVMLGVSYLAISQYAVAALQPPALRAICP 195 Mycobacterium t...
3PUI_A       140 SMASADLYRAPWY-Gp-----------------gGALSVEALLGWSALIGTGLITsRSDA--RPEDAADFVQLAAILNDV 199 Rhodococcus sp....
BAA01048     175 LEGMSNPAEEVFF-Tg------------------GAMQLDRYLSWTLGQAVDTAR-RLDE--KNGNTVNQDKIKKALDDY 232 Brevibacillus l...
AAC26133     138 TMSTSAPFDAEQL-G-------------------GFLRLDHLTSWLGLTALEWVQrRAAAg-DPVDGAVVAEVVQLLTAP 196 Streptomyces gr...
Q50598       179 CFSLFDVYTDIAF-PggihaawftdtwgrynealDRNALHEVVGWWAKLPVTGMQpVQEDrdRSLRDGAIAAHRGNYDVH 257 Mycobacterium t...
CAB53331     238 QEPVWDMYQYIYS-N-------------------GVPRPNVTGTAGAYNSIASMPpMADD---DPRYQAAARYEESHPEC 294 Streptomyces co...
AAF42807     140 SMASADLYRAPWY-Gp-----------------gGALSVEALLGWSALIGTGLITsRSDA--RPEDAADFVQLAAILNDV 199 Rhodococcus sp....
WP_010871701 125 AMIAWDLYQDWAHeN-------------------GAFCLQNNLGWALQLATDSAKrRKDE--Q--TFRRLMRLAKSYDFS 181 Synechocystis s...
WP_003911447 196 WEGFTDAYRDLAF-P-------------------GGIRESGFTRLWSRGVRRRTR-------------------QTYDME 236 Mycobacterium t...
3PUI_A       200 AGAASVTPLAEQPLLGRLIPWVIdQVVDh-----PDNDESWQSISLFERLGGLATPALITAGWYD-G--FVGESLRTFVA 271 Rhodococcus sp....
BAA01048     233 EKWLNHMPRSKVAPLNQMIDWWK-EAMDh-----PEYDEYWKSISPQEQHDTWPVPTYHVGGWYD-I--LLNGTSKNYIG 303 Brevibacillus l...
AAC26133     197 EVPLRRWPLSTILDFEGFPGRLR------------DIFAGHVATVADYHLGEVGVPTFSVGGWYD-V--FSHGTIELHRA 261 Streptomyces gr...
Q50598       258 QIAGSLTFRDDVSASDPYRGQPDaRLEPigtpieSGSINLISPHNYWRDVQASGAAIYSYSGWFDgG--YAHAAIKRFLT 335 Mycobacterium t...
CAB53331     295 LTENSAGYRIS-----------------------DQRDPHWTSRDLARMARGSDTPLFVTQGFVEnN--TKPEEMEEYLD 349 Streptomyces co...
AAF42807     200 AGAASVTPLAEQPLLGRLIPWVIdQVVDh-----PDNDESWQSISLFERLGGLATPALITAGWYD-G--FVGESLRTFVA 271 Rhodococcus sp....
WP_010871701 182 GFQPAIPDRLGELAPDSFYHQWIsQPPE------ADYWQRRSPDQRWQIREKIDIPVLQIGGWFD-P--HLRGNWRLYAE 252 Synechocystis s...
WP_003911447 237 QMQEAHPLR-------------------------DDFWRSRVP-----DLSAIKVPMLVCGSFSD-NnlHSRGSIRAFTR 285 Mycobacterium t...
3PUI_A       272 VKDN---------------A-D--ARLVVGPWSHS-NLTGRNADRKFGIAATYPIQEAt-------tMHKAFFDRHLR-- 323 Rhodococcus sp....
BAA01048     304 ITENgpterylpalektvnI-QdtQKLLIGPWTHG-YPQTAVGTFNFPKADLSDVHNAgngadnwrlEQLRWFDYWLK-- 379 Brevibacillus l...
AAC26133     262 VRALd-------------pV-AgrHELVVGPWVHSgQLPQVQGEVNTGPYGSAQGARLa-------dLHLDFFDRHLRpa 320 Streptomyces gr...
Q50598       336 VSTPg-------------------SHLILGPWNHT---GGWRVDPLRGLSRPDFDHDG---------ELLRFIDHHVK-- 382 Mycobacterium t...
CAB53331     350 NHRGp-------------------ERGWLGQWDHVrG-GDRVEDGRLAMGRAGWYDET-----------LSFYDQYLK-- 396 Streptomyces co...
AAF42807     272 VKDN---------------A-D--ARLVVGPWSHS-NLTGRNADRKFGIAATYPIQEAt-------tMHKAFFDRHLR-- 323 Rhodococcus sp....
WP_010871701 253 LERC---------------GiQ--QKMVVGPWGHF-PWGSRAGGQNYGESAISGVDQL----------QLAWFDHFLK-- 302 Synechocystis s...
WP_003911447 286 SGCG---------------H-A--R-----LYTHR----GGKWETFYSATALS--------------EQLKFLRDALA-- 322 Mycobacterium t...
3PUI_A       324 G--ETDALAGVPKVRLFVMG---IDEWRDETDWPLPDTAYTPFYLG-GSGAANTSTGGGTLSTSISG-TESADTYLYDPA 396 Rhodococcus sp....
BAA01048     380 G--IDNGIMDEDPVKLYIMKgenDGFWRTEKEWPIARTEYTNYYLHdGKSGTIDSLNDGILSTEKPKsGKKADSYLYDPK 457 Brevibacillus l...
AAC26133     321 G--GTTGRDSGGDVRYFLFG---DDAWHRAASWPPPEAVDAPWYLA----GPADGEEGGRLLPAPPReAPGHDAFTYDPE 391 Streptomyces gr...
Q50598       383 G--ADTGIGSEPPVHYFTMV---ENRWKSADTWPPP-ATTQSYYLS------ADR----QLRPDAPDcDSGADEYVVDQT 446 Mycobacterium t...
CAB53331     397 G--TRPTVRYPAYAVEDSTG-----AWRAQRTWPVT-ERTVTLPLGgGSYVDDGGASARAALTASGSpAPKAPPQPAGRW 468 Streptomyces co...
AAF42807     324 G--ETDALAGVPKVRLFVMG---IDEWRDETDWPLPDTAYTPFYLG-GSGAANTSTGGGTLSTSISG-TESADTYLYDPA 396 Rhodococcus sp....
WP_010871701 303 G---QEPRFNPAKLELFDLG---TKQWRYLTDLP---STQQSWFLQcSGLGTTQGSALTAKVPARSTe-EISDVWVHDPW 372 Synechocystis s...
WP_003911447 323 GssGSRSVRLEVREDRDTIT-----AVREETQWPLAGTRWRPMYLA-G---------PGLLATEPPp-TAGSIRFQTRSR 386 Mycobacterium t...
3PUI_A       397 DPVPSLGG-TLLFHNGDNGPADQRPIHDRDDVLCYSTEVLTDPVEVTGTVSARLFVSSSAVDTDFTAKLVDVFPDGRAIA 475 Rhodococcus sp....
BAA01048     458 NPTPTVGG-NISGTTPNDERGPQDQQGIEKDVLTYTTEVLNEDTEVTGPIKVKLWASTNAKDTDFAVKLTDVYPDGRSII 536 Brevibacillus l...
AAC26133     392 DPVPSHGGrVLQLGRLAAGPLNQAHLEDRPDVLCYTSEPLTEPLDAVGRQRLRLRFGSDAPATAVVAKLTDVHPDGRSLL 471 Streptomyces gr...
Q50598       447 AGTGERSR-WRSQVGIGGHVCYPDRKAQDAKLLTYTSAPLDHPLEVTGHVVVTLFITSTSSDGTFFVYLEDVDPRGRVAY 525 Mycobacterium t...
CAB53331     469 DMENAPATeQPAPAGLAAELAKRQRAGEVASSFFVWSKPLKSTTRVTGTPRVSLTARG---AGNVMLKLYDVAPDGTAVM 545 Streptomyces co...
AAF42807     397 DPVPSLGG-TLLFHNGDNGPADQRPIHDRDDVLCYSTEVLTDPVEVTGTVSARLFVSSSAVDTDFTAKLVDVFPDGRAIA 475 Rhodococcus sp....
WP_010871701 373 RPVPSLGG--HSGY--PQGVKERSTIDDRSDVVTYTSEPLQKSLTICGVPQIFLTLESDRPSFDVAVSLSQFRVTGEVWA 448 Synechocystis s...
WP_003911447 387 AAAFNWTIpEDIELTGPMAARLWVQLDGCDDANLFVGVEKWRDGQFVAFEGSYGWGRDRVTTGWQRVSLRELDPELSQPW 466 Mycobacterium t...
3PUI_A       476 LCDGIVRMRYRETLVNptl-----------------ieaGEIYEVAIDMLATSNVFLPGHRIMVQVSSSNFPKYDRNSNT 538 Rhodococcus sp....
BAA01048     537 IQDSIIRGRYHESREKetl-----------------lepGKIYEFTIDLGSTANIFKKGHRIRVDVSSSNYPRFDNNPNT 599 Brevibacillus l...
AAC26133     472 VAEASLRLEAEGDGPR-----------------------DEPYDADLLLGDTAWRFAPGHRLRVHVTSSNFPHLDRHPNI 528 Streptomyces gr...
Q50598       526 ITEGQLRAIHRRLSDGpppyrqvvpyrtfasgdawplvpGEIARLTFDLLPTSYLFQPGHRIRIAIAGADASHFAILPGC 605 Mycobacterium t...
CAB53331     546 FDEQVSLVKSGRMS--------------------------------VDLKATDWTLAAGHVLAVEIGSIQTGSWRDTPSG 593 Streptomyces co...
AAF42807     476 LCDGIVRMRYRETLVNptl-----------------ieaGEIYEVAIDMLATSNVFLPGHRIMVQVSSSNFPKYDRNSNT 538 Rhodococcus sp....
WP_010871701 449 LSQGYCTSCKQTAN------------------------------LEICLQAICVTLSPGDCLRISLAGASFPAYPVNPGT 498 Synechocystis s...
WP_003911447 467 EPVPACARPRPVTA-------------------------GEVVAVDVALGPSATLFRAGEQLRLVVGGRWLSPRNPLTGQ 521 Mycobacterium t...
3PUI_A       539 GGVIAr-----------eQLEEMCTAVNRIHRGPEHPSHIVLPIIKR 574 Rhodococcus sp. MB1 'Bresler 1999'
BAA01048     600 GHKFG-------------NDAAMKTAKNTIYHDSEHPSHIILPIIPN 633 Brevibacillus laterosporus
AAC26133     529 PGPVG-------------EAEHCRTARQSVWYGGPYESVLRLSTLPA 562 Streptomyces griseus subsp. griseus
Q50598       606 APTVR------------------------VYRSRMHASRIDLPVIQP 628 Mycobacterium tuberculosis
CAB53331     594 ETVEVkgarlglaldnpaDDVATAGDRSPYLDTYLRQYTVSLPAGPG 640 Streptomyces coelicolor A3(2)
AAF42807     539 GGVIAr-----------eQLEEMCTAVNRIHRGPEHPSHIVLPIIKR 574 Rhodococcus sp. MB1 'Bresler 1999'
WP_010871701 499 GQQAVl-----------aNLVDQQIITLALVTDGPTQNHLLLPILSG 534 Synechocystis sp. PCC 6803
WP_003911447 522 FPAAYp---------------RPPRGRVTLHWGPRYDAHLLIPEVPG 553 Mycobacterium tuberculosis
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