1GSO,2QK4,2YW2,2XD4


Conserved Protein Domain Family
purD

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TIGR00877: purD 
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phosphoribosylamine--glycine ligase
Alternate name: glycinamide ribonucleotide synthetase (GARS). This enzyme appears as a monofunctional protein in prokaryotes but as part of a larger, multidomain protein in eukaryotes. [Purines, pyrimidines, nucleosides, and nucleotides, Purine ribonucleotide biosynthesis]
Statistics
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PSSM-Id: 273315
Aligned: 17 rows
Threshold Bit Score: 543.826
Created: 7-Oct-2014
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1GSO_A    3 MKVLVIGNGGREHALAWKAAQ-SPLVETVFVAPGNAGTALEPALQNVAIGVT------DIPALLDFAQNEKIDLTIVGPE 75  
O29108    1 MKVLVVDAGGRGNAIAHAFSR-SEQVKEIYIAPGNGGSEFFEKCKIAELDGKkipsirAIDEIVRFAKKCEVDLAYIGPE 79   Archaeoglobus fulgi...
O25817    7 YNVLIVGNKGREYALAQRLQQ-DERVNALYFCLGNGGTQDLGENLECEH----------YEHIVELALKKQIHLAIISEE 75   Helicobacter pylori...
P22102    3 ARVLIIGSGGREHTLAWKLAQ-SHHVKQVLVAPGNAGTACSEKISNTAISIS------DHTALAQFCKEKKIEFVVVGPE 75   human
P74232    1 MKVAVIGSGGREHTLAWSLVR-SPEVSHCYCLPGNGGTAGLPKTENVAIAVD------QLGEICEFCQTEKINLVVVGPE 73   Synechocystis sp. P...
P71827    1 MRVLVIGSGAREHALLLALGK-DPQVSGLIVAPGNAGTARIAEQHDVDITSA--------EAVVALAREVGADMVVIGPE 71   Mycobacterium tuber...
Q58347    1 MKILLIGGGARESAIAHALKKnEEVKLYTLMKNKNPGIARLSEEIKLAKETD-------LDAVKEFAEKVKPDLAVIGPE 73   Methanocaldococcus ...
O27494    1 MKILVVGTGAREHAICSALA--DEATIYSVMGNRNPGISRLAGNSLLLLKLT-------PKVVR-FASEKGVDMAFIGPE 70   Methanothermobacter...
P07244    2 LNILVLGNGAREHVLVTKLAQ-SPTVGKIYVAPGNGGTATMDPSRVINWDITpd--vaNFARLQSMAVEHKINLVVPGPE 78   Saccharomyces cerev...
2QK4_A   25 aRVLIIGSGGREHTLAWKLAQ-SHHVKQVLVAPGNAGTACSEKISNTAISIS------DHTALAQFCKEKKIEFVVVGPE 97   human
1GSO_A   76 APLVKGVVDTFRAAGLKIFGPTAGAAQLEGSKAFTKDFLARHKIP-TAEYQNFTEV-EPALAYLREKGAP-----IVIKA 148 
O29108   80 EPLSLGLVDRLEEEGIPAVGPKKEATILEASKCWAKDFLKRIGVP-IPEYANFDNP-EEAKEYIREKFNNg----IVVKA 153  Archaeoglobus fulgi...
O25817   76 EFLVLGLTEMLEKAGILVFGASKEAAKLEASKSYMKAFVKECGIK-SASYFETNDL-KEALSYIQNASFPl----VIKAL 149  Helicobacter pylori...
P22102   76 APLAAGIVGNLRSAGVQCFGPTAEAAQLESSKRFAKEFMDRHGIP-TAQWKAFTKP-EEACSFILSADFPa----LVVKA 149  human
P74232   74 LPLTLGLTDQLQALGIKVFGPTKAGAELEASKSWTKQLLIEAGVP-TAFGETFTEP-APAQAYATKMGAP-----IVVKA 146  Synechocystis sp. P...
P71827   72 VPLVLGVADAVRAAGIVCFGPGKDAARIEGSKAFAKDVMAAAGVR-TANSEIVDSP-AHLDAALDRFGPPagdpaWVVKD 149  Mycobacterium tuber...
Q58347   74 APLGEGVVDLLEEMGISAVGPKKLAAQIETNKEFMRNLFKKYNIKgSLMYKAFEEYgEELESFIDELTEKgi--kAVVKP 151  Methanocaldococcus ...
O27494   71 AHLEAGLVDALEEAGIPSVGPTRDAARIETDKSFMRKLFEDYRIPgSITYRVFSDP-EELREFMEDFDSe-----AVVKP 144  Methanothermobacter...
P07244   79 LPLVNGITSVFHSVGIPVFGPSVKAAQLEASKAFSKRFMSKHNIP-TASYDVFTNP-EEAISFLQAHTDKa----FVIKA 152  Saccharomyces cerev...
2QK4_A   98 APLAAGIVGNLRSAGVQCFGPTAEAAQLESSKRFAKEFMDRHGIP-TAQWKAFTKP-EEACSFILSADFPa----LVVKA 171  human
1GSO_A  149 DGLAAGKGVIVA----MTLEEAEAAVHDMLAGN-AfgDAGHRIVIEEFLDGEEASFIVMVDGEHVLPMATSQDHKRVGDK 223 
O29108  154 DGLAAGKGVYVC----DSVEEALRAVDEIMVQKkFg-EAGNRIVVEERLRGIEVAFTAMTDGKTVKPFGHARDYKRAFDS 228  Archaeoglobus fulgi...
O25817  150 N-----KNTSIV----YQEEEAIKILEDAFKQ------SNEPVIIEPFLEGFELSVTALIANDDFILLPFCQNYKRLLEG 214  Helicobacter pylori...
P22102  150 SGLAAGKGVIVA----KSKEEACKAVQEIMQEKaFg-AAGETIVIEELLDGEEVSCLCFTDGKTVAPMPPAQDHKRLLEG 224  human
P74232  147 DGLAAGKGVIVA----QTSAEATTAIAELFDQG------FEKIVVEEFLPGEEVSVLALCDGKTVIPLLPAQDHKRIGEG 216  Synechocystis sp. P...
P71827  150 DRLAAGKGVVVT----ADRDVARAHGAALLEAG-------HPVLLESYLDGPEVSLFCVVDRTVVVPLLPAQDFKRVGED 218  Mycobacterium tuber...
Q58347  152 VGLTGGKGVKVVgeqlKDNEEAKKYAKEIFETG-L--GGG-KVLIEEKLEGVEFTLHGFVDGDTIKFTPFVQDHPHALEG 227  Methanocaldococcus ...
O27494  145 VGLTGGKGVKIVgehlRDNMEALKYATEVIEKR-I--GGHPSVVIEERVVGEEFTVQAFSDGEHIVPMPAVQDHPHAYEG 221  Methanothermobacter...
P07244  153 DGIAAGKGVIIP----SSIDESVQAIKDIMVTKqFgeEAGKQVVIEQFLEGDEISLLTIVDGYSHFNLPVAQDHKRIFDG 228  Saccharomyces cerev...
2QK4_A  172 SGLAAGKGVIVA----KSKEEACKAVQEIMQEK-AfgAAGETIVIEELLDGEEVSCLCFTDGKTVAPMPPAQDHKRLLEG 246  human
1GSO_A  224 DT-------------------------------GPNTGGMGAYSPAP---VVTDDVHQRTMERIIWPTVKGMAAEgntYT 269 
O29108  229 DDieglrdfyigltkkfytkaqieqlyregkliNPNTGGMGAVSPHP---AVTEEVEQRIMEMVVEPIIENFDKE---FK 302  Archaeoglobus fulgi...
O25817  215 Dn-------------------------------GVNTGGMGAIAPAN---FFSNELEEKIKNHIFKPTLEKLQADntpFK 260  Helicobacter pylori...
P22102  225 DG-------------------------------GPNTGGMGAYCPAP---QVSNDLLLKIKDTVLQRTVDGMQQEgtpYT 270  human
P74232  217 DQ-------------------------------GLNTGGMGAYCPAP---IAPPAVIDQVQKQILQPTANALAKRgidYR 262  Synechocystis sp. P...
P71827  219 DT-------------------------------GLNTGGMGAYAPLP---WLPDNIYREVVSRIVEPVAAELVRRgssFC 264  Mycobacterium tuber...
Q58347  228 DE-------------------------------GSITGGMGSYSCPDhklPFMTEEDVKLAKEIMEETVKALKEEvggYK 276  Methanocaldococcus ...
O27494  222 DQ-------------------------------GPITGGMGSYSDSDgllPFLTQKDYEDAVEIMQRTVDAIRKEtgpYR 270  Methanothermobacter...
P07244  229 DK-------------------------------GLNTGGMGAYAPAP---VATPSLLKTIDSQIVKPTIDGMRRDgmpFV 274  Saccharomyces cerev...
2QK4_A  247 DG-------------------------------GPNTGGMGAYCPAP---QVSNDLLLKIKDTVLQRTVDGMQQEgtpYT 292  human
1GSO_A  270 GFLYAGLMIDKQGn-----PKVIEFNCRFGDLETQPIMLRMK--SDLVELCLAACESKLD-EKTSEWDERASLGVVMAA- 340 
O29108  303 GVLYPVIMLVEENge--liPKVLEINVRDCDPGAEAKLPRLK--SDMAEISMAVVEGRLD-EVEMRFSSDYCVAVCAVSg 377  Archaeoglobus fulgi...
O25817  261 GVLLAEIVIIEEKgv--lePYLLDFSVRFKDIECQTILPLLE--SSLLDLCLATAKGELH-SLELVFSKEFVMSVALVSr 335  Helicobacter pylori...
P22102  271 GILYAGIMLTKNG------PKVLEFNCRFGDPECQVILPLLK--SDLYEVIQSTLDGLLCtSLPVWLENHTALTVVMAS- 341  human
P74232  263 GVLYAGLMVSPTGe-----IKVLEYNCRFGDPETQAVLPLLA--TPLEKVLMACVEQNLEqLGPLQWHSGNAVCVVVAA- 334  Synechocystis sp. P...
P71827  265 GLLYVGLAITARG------PAVVEFNCRFGDPETQAVLALLE--SPLGQLLHAAATGKLAdFGELRWRDGVAVTVVLAA- 335  Mycobacterium tuber...
Q58347  277 GILYGQFMLTKEG------PKIIEYNARFGDPEAMNLLAILK--NDFLEVCEAIVNKKLKd-IDVEFENKATVCKYVVP- 346  Methanocaldococcus ...
O27494  271 GILYGQFMLSADG------PKLIEYNARFGDPEAMNVLPLLE--SSMLEICEGIVDGNLK---SASFMNLATVCKYLVP- 338  Methanothermobacter...
P07244  275 GVLFTGMILVKDSktnqlvPEVLEYNVRFGDPETQAVLSLLDdqTDLAQVFLAAAEHRLDsVNIGIDDTRSAVTVVVAA- 353  Saccharomyces cerev...
2QK4_A  293 GILYAGIMLTKNG------PKVLEFNCRFGDPECQVILPLLK--SDLYEVIQSTLDGLLCtSLPVWLENHTALTVVMAS- 363  human
1GSO_A  341 ---------GGYPGDYRTGDVIHgl-pLEEVAGGKVFHAGT--KlADDEQVVTNGGRVLCVTALGHTVAEAQKRAYALMT 408 
O29108  378 alkgreglkPGYPADHYTSQPITg---IEEAMKEAIIYANG--I-AKTNGYVTTGGRVLTVVGMGQSIEEARSKAYSALE 451  Archaeoglobus fulgi...
O25817  336 ny-----ptSSSPKQTLYIDPVD-------EKKGHLILGEV--E-QDNGVFESSGGRVIFAIGRGKSLLEARNHAYEIAQ 400  Helicobacter pylori...
P22102  342 ---------KGYPGDYTKGVEITgf-pEAQALGLEVFHAGt--A-LKNGKVVTHGGRVLAVTAIRENLISALEEAKKGLA 408  human
P74232  335 ---------GGYPGSYRKGDEINgl-aEAEAQDVKVFHAGt--E-LKEGKVLTNGGRVLGVTALGKDLSTAIATAYRGVE 401  Synechocystis sp. P...
P71827  336 ---------ENYPGRPRVGDVVVg----SEAEG--VLHAGt-tR-RDDGAIVSSGGRVLSVVGTGADLSAARAHAYEILS 398  Mycobacterium tuber...
Q58347  347 ---------KGYPDNPVRGEPITvdeeAIKKTGAILHYASv--N-EDNGSLYMTGSRAVAVVGVADTIEEAERIAEEATK 414  Methanocaldococcus ...
O27494  339 ---------EGYPESGVAGAEIKvdekKIEDMGVITYYAAv--N-QEDDHIYTSSSRALALVAPADDIYSAEELCEEATA 406  Methanothermobacter...
P07244  354 ---------GGYPESYAKGDKITld-tDKLPPHTQIFQAGTkyD-SATDSLLTNGGRVLSVTSTAQDLRTAVDTVYEAVK 422  Saccharomyces cerev...
2QK4_A  364 ---------KGYPGDYTKGVEITgf-pEAQALGLEVFHAGT--A-LKNGKVVTHGGRVLAVTAIRENLISALEEAKKGLA 430  human
1GSO_A  409 DIHWDDCFCRKDIGWRAIE 427 
O29108  452 KISFPGMRYRRTIGLDVPE 470  Archaeoglobus fulgidus DSM 4304
O25817  401 KVHFEGMFYRKDIGFKVLD 419  Helicobacter pylori 26695
P22102  409 AIKFEGAIYRKDVGFRAIA 427  human
P74232  402 QIDFDGMYYRRDIGHKAL- 419  Synechocystis sp. PCC 6803 substr. Kazusa
P71827  399 SIRLPGGHFRSDIGLRAAE 417  Mycobacterium tuberculosis
Q58347  415 YIKGE-VYHRSDIGKKELI 432  Methanocaldococcus jannaschii DSM 2661
O27494  407 HVKGR-LYHRRDIGTRELV 424  Methanothermobacter thermautotrophicus str. Delta H
P07244  423 CVHFQNSYYRKDIAYRAFQ 441  Saccharomyces cerevisiae S288c
2QK4_A  431 AIKFEGAIYRKDIGFRAIa 449  human
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