1XRF


Conserved Protein Domain Family
pyrC_multi

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TIGR00857: pyrC_multi 
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dihydroorotase, multifunctional complex type
In contrast to the homodimeric type of dihydroorotase found in E. coli, this class tends to appear in a large, multifunctional complex with aspartate transcarbamoylase. Homologous domains appear in multifunctional proteins of higher eukaryotes. In some species, including Pseudomonas putida and P. aeruginosa, this protein is inactive but is required as a non-catalytic subunit of aspartate transcarbamoylase (ATCase). In these species, a second, active dihydroorotase is also present. The seed for this model does not include any example of the dihydroorotase domain of eukaryotic multidomain pyrimidine synthesis proteins. All proteins described by this model should represent active and inactive dihydroorotase per se and functionally equivalent domains of multifunctional proteins from higher eukaryotes, but exclude related proteins such as allantoinase. [Purines, pyrimidines, nucleosides, and nucleotides, Pyrimidine ribonucleotide biosynthesis]
Statistics
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PSSM-Id: 273302
Aligned: 10 rows
Threshold Bit Score: 498.121
Created: 7-Oct-2014
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1XRF_A        62 NLEGEFD----ILVE-NGKIKKID--KNILVPEAEIIDAKGLIVCPGFIDIHVHLRDPGQTYKEDIESGSRCAVAGGFTT 134 Aquifex aeolicus
O66990        17 NLEGEFD----ILVE-NGKIKKID--KNILVPEAEIIDAKGLIVCPGFIDIHVHLRDPGQTYKEDIESGSRCAVAGGFTT 89  Aquifex aeolicu...
P72934        17 GKETRVT----VIVR-GRAIVAVEddSYPIPADAAVIPGENLLLAPSLADLYSYSGEPGYEDRETLSQLVKTAIAGGFGD 91  Synechocystis s...
O28034        10 GEFVEAG----IEVE-NGRIKRIG----KLVEGKEVKG----VILPAGIDVHVHLRDFAEKRKETIETGTLSALHGGICL 76  Archaeoglobus f...
O57740        16 EKIIDGS----IGIE-DDKIAKFS--LRELKGDKKIKVEKGKIILPGLIDVHVHLRDFNESYKETIASGTKAAIHGGITT 88  Pyrococcus hori...
Q58885        12 NKIIEGD----ILIDeNGRIKKIA--K-DIKVDDEIIDIKNSLVIPGVIDAHVHFR-WGEEKKEDFLSGSLAGINGGVCF 83  Methanocaldococ...
Q9YFI5        15 DKMLEDA----CAVIsGERVERVHtgGFRGQPDLDLRGRS-SLALPGVIDMHVHLRGLKLSYKEDEVSGTAAAASGCVTL 89  Aeropyrum perni...
P71809        12 GEGERVD----VLVD-DGQIAQIGp-DLAIPDTADVIDATGHVLLPGFVDLHTHLREPGREYAEDIETGSAAAALGGYTA 85  Mycobacterium t...
AAA21268      15 GEKTQAD----IRVT-GETITAIG--KLDATDNETVIDAKGLLVSPGFVDLHVHFREPGGEKKETIETGAKAAGRGGYTT 87  Bacillus subtilis
WP_010876751  31 NCRVDRDltvnIGVD-DGKIVQIS--RGRIDASEK-IDLKGYFVLPGLIDAHVHFRDPGLEYKEDFRTGSMAAAHGGFST 106 Methanothermoba...
1XRF_A       135 IVCMPNTNPPIDNTTVVNYILQKSKSVG---------------------LCRVLPTGTITKGRKGKE---IADFYSLKEA 190 Aquifex aeolicus
O66990        90 IVCMPNTNPPIDNTTVVNYILQKSKSVG---------------------LCRVLPTGTITKGRKGKE---IADFYSLKEA 145 Aquifex aeolicu...
P72934        92 VAILPNTDPPLDQPQTLQWLKQRLNQIEgvnahhqppgdpqaenrpdsaPVQCHWWGSVTQGNQGKQ---LTEWGELDQA 168 Synechocystis s...
O28034        77 VVDQPNTKPPVDDAETYFRRMGKAEKSV---------------------YVDYALNLALTNSNHGKIgsiMRKISERYFV 135 Archaeoglobus f...
O57740        89 VFDMPNTKPPIMDEKTLKLRELIFKKKS---------------------YSDYALGFLIAGNEPAKA-----DFYKIFMG 142 Pyrococcus hori...
Q58885        84 AIDMPNNKPPITTKELFYKKLEDCKKDS---------------------KINVFLNFGVTENNYLGTv-eDAKAYKIFMV 141 Methanocaldococ...
Q9YFI5        90 VADMPNTQPPLRTPEALREKLASLEAGA---------------------KVDYTVYAGVPRSYG--------EAVEMASM 140 Aeropyrum perni...
P71809        86 VFAMANTNPVADSPVVTDHVWHRGQQVG---------------------LVDVHPVGAVTVGLAGAE---LTEMGMMNAG 141 Mycobacterium t...
AAA21268      88 VAAMPNTRPVPDTKEQMEWVQNRIKETS---------------------CVRVLPYASITIRQIGDE---MTNFEALKEA 143 Bacillus subtilis
WP_010876751 107 VLDMPNTVPPADNAAEFERKIRIGERKS---------------------VVDFGLHAGFRSVSDVKGilrFMPASFKVFM 165 Methanothermoba...
1XRF_A       191 GCVA--FTDDGSPVMDSSVMRKALELASQLGVPIMDHCEDDKLAYG--VINEGEVSALLGLSSRAPEAEEIQIARDGILA 266 Aquifex aeolicus
O66990       146 GCVA--FTDDGSPVMDSSVMRKALELASQLGVPIMDHCEDDKLAYG--VINEGEVSALLGLSSRAPEAEEIQIARDGILA 221 Aquifex aeolicu...
P72934       169 GVIG---FSDGGAIQDWRLLQRALEYGAIAGKPLALVPLNLSLRGNg-VMREGPLAIQLGLPPDPVMSEAAVIASLLELL 244 Synechocystis s...
O28034       136 PAVGevFIQHDSEDLQIDYETLSSVYKRFEGVVFTIHAEDPAYVARgsPNFVF----------RRREAEVLAVERLVELG 205 Archaeoglobus f...
O57740       143 ASTGgiYSKNFEEDYKKAPDIVS------------VHAEEYELINR----YPE----------RPPIVEVVAIKKALQAS 196 Pyrococcus hori...
Q58885       142 KSVGdlFIEDYSKLKDILNQNKL----------FCIHAEHKDVINEnlKKYQLNS-WIDHCKIRDEKSEVEAVKEVIKNL 210 Methanocaldococ...
Q9YFI5       141 GIAG--FKIYPEDLVNLDSIKNVLEAAEEAGILVVLHPESHDMFAGpdYGWLRR-------VARPCHAEAASVELLHDAA 211 Aeropyrum perni...
P71809       142 AAQVrmFSDDGVCVHDPLIMRRALEYATGLGVLIAQHAEEPRLTVGa-VAHEGPMAARLGLAGWPRAAEESIVARDALLA 220 Mycobacterium t...
AAA21268     144 GAFA--FTDDGVGIQTAGMMYEAMKRAAAIDKAIVAHCEDNSLIYGg-SVHEGTFSKANGLNGIPSVCESVHIARDVLLL 220 Bacillus subtilis
WP_010876751 166 DLTGisTVDGLFRELKDLSAP----------VPVTVHCENRDVVMKsmKELKDRSDPSAYALARPPLAEEVSVAEVLALS 235 Methanothermoba...
1XRF_A       267 QRTGGH------VHIQHVSTKLSLEIIEFFKEK--GVKITCEVNPNHLLFTEREVLN--------SGANARVNPPLRKKE 330 Aquifex aeolicus
O66990       222 QRTGGH------VHIQHVSTKLSLEIIEFFKEK--GVKITCEVNPNHLLFTEREVLN--------SGANARVNPPLRKKE 285 Aquifex aeolicu...
P72934       245 PHYGTP------VHFMRISTARGVELIVQAKSQ--GLNCTASVNWHHLLLSNEAIAHglpphtphYDPNLRFDPPLGNEG 316 Synechocystis s...
O28034       206 K-----------FHFCHISTKDSAKEILNSNS-------TYEVTPHHMLLSVEDYGR--------LGNLVNVNPPLRERE 259 Archaeoglobus f...
O57740       197 KKMKKP------LHICHVSTKDGLKEILKANIPw----vSFEVTPHHLFLTRRDYER--------S-KLLKVYPPLRDEE 257 Pyrococcus hori...
Q58885       211 KIIDRQsnkkphVHFCHISTKEALYLIKKVRQElkNIKITVEVTPHHIYLNKDMAEE--------LKGFGKFNPPLREKD 282 Methanocaldococ...
Q9YFI5       212 RECGCK------PR-VHITHASCPATVVESKKR----GFTVDVTPHHLFLSEEEVAGp-------THSWGKVNPPLRGVG 273 Aeropyrum perni...
P71809       221 RDAGAR------VHICHASAAGTVEILKWAKDQ--GISITAEVTPHHLLLDDARLAS--------YDGVNRVNPPLREAS 284 Mycobacterium t...
AAA21268     221 -GANCH------YHVCHISTKESVRVVRDAKKA--GIRVTAEVSPHHLLLCDEDIPG--------LDTNYKMNPPLRSPE 283 Bacillus subtilis
WP_010876751 236 IHHEHP------VHICHLSTVKALQLVEPFREY-----VTCEVTPHHLLLDSGAFRR--------FGTMVKTNPPLRPPE 296 Methanothermoba...
1XRF_A       331 DRLALIEGVKRGIIDCFATDHAPHQTFEK-ELVEFAMPGIIGLQTALPSALELYRKG--IISLKKLIEMFTINPARIIGV 407 Aquifex aeolicus
O66990       286 DRLALIEGVKRGIIDCFATDHAPHQTFEK-ELVEFAMPGIIGLQTALPSALELYRKG--IISLKKLIEMFTINPARIIGV 362 Aquifex aeolicu...
P72934       317 DRLALIEGVKSGVIDAIAVDHQAFTYEEKtQTFAETPPGAIGYELVLPCLWQGLVEKn-LITPMALWRALSTNPRRCLGL 395 Synechocystis s...
O28034       260 DVEWLFRNFH--RIDVLASDHAPHTLEDK----EAGASGFPGVETMYPLFVNLASKG--YISFKTLVEKIASNPARIFGF 331 Archaeoglobus f...
O57740       258 DRRYLWENLK--SIPIIASDHAPHTLEDK----EAGAAGLPGLETEVALLLDAVNKG--MITIWDIVAKMSINPARIFKI 329 Pyrococcus hori...
Q58885       283 DNIALIKGIVNKDVDIIASDHAPHLLEDKlKNVKNCPSGIPGIETIVPLTLNLVNKG--LISLFDAIRVLSKNPAKIFNI 360 Methanocaldococ...
Q9YFI5       274 ERSLLTQLTIEGLVDAIASDHAPHSTWEKwMHPAIAPPGFPWLEWWPGFTAARLMRA---VGLERFYSMVSQTPSTILGV 350 Aeropyrum perni...
P71809       285 DAVALRQALADGIIDCVATDHAPHAEHEKcVEFAAARPGMLGLQTALSVVVQTMVAPg-LLSWRDIARVMSENPACIARL 363 Mycobacterium t...
AAA21268     284 DRAALIEGLLDGTIDFIATDHAPHTEEEKnTEMKLAPFRNCRLRNSIPASLHTLCQKwqLVTEAADLTYMTIKPCEAFGL 363 Bacillus subtilis
WP_010876751 297 SR--IYPEFLD-RINIIGTDHAPHGIEEKrKGIWDAPPGIPNLEVVLKLLLTLVSKG--RMSLSTIRRMLAEEPARIFGL 371 Methanothermoba...
1XRF_A       408 DLg--TLKLGSPADITIFDPNKEWILNEETNLSKSRNTPLWGKVLKGKVIYTIKDGKMVYKD 467 Aquifex aeolicus
O66990       363 DLg--TLKLGSPADITIFDPNKEWILNEETNLSKSRNTPLWGKVLKGKVIYTIKDGKMVYKD 422 Aquifex aeolicus VF5
P72934       396 PEv---sNSR-----ILFDPDQAWTLKRGTLQTSAYNSPWWNHSLK---------GRVVAWE 440 Synechocystis sp. PCC 6803 substr...
O28034       332 KGy-gEIEVGNYANFAVFDLKKVDEIRAERLHSKCGWTPFEGFEAV-FPDKVYLRGKELLEN 391 Archaeoglobus fulgidus DSM 4304
O57740       330 KNk--gWEEGKDADLIVVDMKKEWTIKAENFYTKANWTPYEGWKVKGKVIMTILRGEVVMED 389 Pyrococcus horikoshii OT3
Q58885       361 NNk---IEEGNLANLTIIDLKKEGKINAELFKSKAKFSPFDGWEVKGFPIYTVINGTLYEAY 419 Methanocaldococcus jannaschii DSM...
Q9YFI5       351 GDr--CLWDGCPATISVLQLERTRVYHKG--YTKALYTPVLGMESFD-CAATVIRGKIAYTA 407 Aeropyrum pernix K1
P71809       364 PDqgrPLEVGEPANLTVVDPDATWTVTGADLASRSANTPFESMSLPATVTATLLRGKVTARD 425 Mycobacterium tuberculosis
AAA21268     364 Py--gTLQTGQAADITLIDLEKEAVIDKETFLSKGKNTPFNGISCTGWPVATIAAGKLAYEE 423 Bacillus subtilis
WP_010876751 372 RSk-gRIAEGMDADFTVIDLKETGRIRSDEFYSKAHYTPFEGFSYTGGPVMTIVRGRAVMRD 432 Methanothermobacter thermautotrop...
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