3DH4


Conserved Protein Domain Family
sss
?
TIGR00813: sss 
Click on image for an interactive view with Cn3D
transporter, SSS family
The Solute:Sodium Symporter (SSS) Family (TC 2.A.21) Members of the SSS family catalyze solute:Na+ symport. The solutes transported may be sugars, amino acids, nucleosides, inositols, vitamins, urea or anions, depending on the system. Members of the SSS family have been identified in bacteria, archaea and animals, and all functionally well characterized members catalyze solute uptake via Na+ symport. Proteins of the SSS generally share a core of 13 TMSs, but different members of the family may have different numbers of TMSs. A 13 TMS topology with a periplasmic N-terminus and a cytoplasmic C-terminus has been experimentally determined for the proline:Na+ symporter, PutP, of E. coli. [Transport and binding proteins, Cations and iron carrying compounds]
Links
?
Statistics
?
PSSM-Id: 273282
Aligned: 21 rows
Threshold Bit Score: 285.351
Created: 7-Oct-2014
Updated: 25-Oct-2021
Structure
?
Program:
Drawing:
Aligned Rows:
Download Cn3D
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
3DH4_A    18 AGKSLPWWAVGASLIAANISAEQFIGMSGSGYSIG-----LAIASYEWMSAITLIIVGKYFLPIFIEKg-IYTIPEFVEK 91  Vibrio parahaemolyt...
P44963    39 GNRSMTGFVLAMTTASTYASASSFVGGPGAAYKYGlgwvlLAMIQVPVVWLALGALGKKFALLSRETN--ALTINDLFFY 116 Haemophilus influen...
P07117    38 GGRSLGPFVTALSAGASDMSGWLLMGLPGAVFLSGiseswIAIGLTLGAWINWKLVAGRLRVHTEYNNn-ALTLPDYFTG 116 Escherichia coli K-12
AAA26389  38 GGRSLGPFVTALSAGASDMSGWLLMGLPGAIFLSGiseswIAIGLTLGAWINWKLVAGRLRVHTEFNNn-ALTLPDYFTG 116 Rickettsia typhi
P45174    38 GGRRLGSFVTAMSAGASDMSGWLLMGLPGAVYLSGlvegwIAIGLTIGAYFNWLLVAGRLRVYTELNNn-ALTLPEYFHN 116 Haemophilus influen...
P39599    36 AGGGLTGVQNGLAIAGDYMSAASFLGIAGMIALYG-----FDGFFYSIGFLVAYLVVLYIVAEPLRNLg-KYTMADMIAA 109 Bacillus subtilis s...
AAC12270  61 ADRKMGCLPVALSLLATFQSAVAILGGPAEIYRFG-----TQYWFLGCSYFLGLLIPAHIFIPVFYRLh-LTSAYEYLEL 134 Norway rat
AAB39701  62 GGKKMQTLPIAISLVASQLSGIAIMSIPAESYTYG-----FNYIFVVLAMLVVIPILIYIIVPVFYENn-VSNCYEYLEM 135 fruit fly
P33413    51 AGRSVKTGLVAAAVVSSWIWCSTLLTSSTKEYADGi----FGGYAYAAGACFQIIAFAILAIKTKQMApnAHTYLELVRT 126 Saccharomyces cerev...
KFH99962  39 GSRSMGGIVLAMTLTATYISASSFIGGPGAAYKYGlgwvlLAMIQLPAVWLSLGILGKKFAILARRYN--AVTLNDMLFA 116 Escherichia coli

3DH4_A    92 RFNK--KLKTILAVFWISLYIFVNLTSVLYLGGLALETILGIPLMYSILGLALFALVYSIYGGLSAVVWTDVIQ--VFFL 167 Vibrio parahaemolyt...
P44963   117 RYKN--KYLVWLSSLALLLAFFAAMTVQFIGGARLLETTIGISYTQALLLFALTVGIYTFIGGFRAVVLTDTIQ--GTVM 192 Haemophilus influen...
P07117   117 RFEDksRILRIISALVILLFFTIYCASGIVAGARLFESTFGMSYETALWAGAAATILYTFIGGFLAVSWTDTVQ--ASLM 194 Escherichia coli K-12
AAA26389 117 RFEDksRVLRIISALVILLFFTIYCASGIVAGARLFESTFGMSYETALWAGAAATIIYTFIGGFLAVSWTDTVQ--ASLM 194 Rickettsia typhi
P45174   117 RFGSshKLLKLVSATIILVFLTIYCASGVVAGAKLFQNIFSVEYSTALWYGAAATIAYTFIGGFLAVSWTDTIQ--ATLM 194 Haemophilus influen...
P39599   110 RFKE--KKIRGVAALNTIAISTFYMIAQLVGAGALIKLLLGLDYTAAVLIVGVLMTIYVVFGGMIATSWVQIIK--AVLL 185 Bacillus subtilis s...
AAC12270 135 RFNK---AVRICGTVTFIFQMVVYMGVALYAPSLALNAVTGFDLWLSVLALGIVCNIYTALGGLKAVIWTDVFQ--TLIM 209 Norway rat
AAB39701 136 RFNK---RTRQLVTFFFVTNSFLMLPVYMFIPSLAFAQVTGMNIHLINVMVSSICIFYTMLGGIKAVVWTDVVQ--GAIM 210 fruit fly
P33413   127 RYGK---IGHGCYLFYAIATNILVTSMLLTSGSAVFSDLTGMNTIASCFLLPVGVVVYTLFGGIKATFLTDYMHtcVIII 203 Saccharomyces cerev...
KFH99962 117 RYQS--RLLVWLASLSLLVAFVGAMTVQFIGGARLLETAAGIPYETGLLIFGISIALYTAFGGFRASVLNDTMQ--GLVM 192 Escherichia coli

3DH4_A   168 VLGGFMTTYMAVSFIGG-TDGWFAGVSKMVD--AAPG-HFEMILDQSNPQYMNLPGiAVLIGGLWVanlyywgfnqyiIQ 243 Vibrio parahaemolyt...
P44963   193 IFGTIILLIGTIYALGG-VESAVNKLTEIDPdlVTPYgPNGMLDFQFMASFWILVC-FGVVGLPHT------------AV 258 Haemophilus influen...
P07117   195 IFALILTPVIVIISVGG-FGDSLEVIKQ--KsiEN---VDMLKGLNFVAIISLMGWgLGYFGQPHI------------LA 256 Escherichia coli K-12
AAA26389 195 IFALILTPVMVIVGVGG-FSESLEVIKQ--KsiEN---VDMLKGLNFVAIISLMGWgLGYFGQPHI------------LA 256 Rickettsia typhi
P45174   195 IFALILTPVFVLLSFAD-TAQFSAVLEQA-EaaVNKDfTDLFTSTTPLGLLSLAAWgLGYFGQPHI------------LA 260 Haemophilus influen...
P39599   186 MAGTLVISIIVFSKFGFsLNTMFEQMKTATPlgADFLnPGNKYKVPLETLSLNLALvLGTAGLPHI------------LI 253 Bacillus subtilis s...
AAC12270 210 FLGQLVVIIVGAAKVGG-LGHVWAVASQHGL--------ISGIELDPDPFVRHTFW-TLAFGGVFMmlslyg-vnqaqVQ 278 Norway rat
AAB39701 211 LLSVVAVGVLGTIRSGG-MFTVMERASDGGR---------FNFDFGLDPRIRMTFWgATMGGIFMWtghig--lnqscVQ 278 fruit fly
P33413   204 IVLVFAFKVYATSDVLGsPGKVYDLVREAAKr---HP-VDGNYQGEYMTMTSKSAGiLLIINLIGNfgtvf--ldngyWN 277 Saccharomyces cerev...
KFH99962 193 LIGTVVLLIGVVHAAGG-LSNAVQTLQTIDPqlVTPQgADDILSPAFMTSFWVLVC-FGVIGLPHT------------AV 258 Escherichia coli

3DH4_A   244 RTLAAKSVSEAQKGIVFAAFLKLIVPFLVVLPGIAAYVITsdpqlmasLGDIaatnlpsaaNADKAYPWLTQ-FLP--VG 320 Vibrio parahaemolyt...
P44963   259 RCMAFKDSKALHRGMLIGTIVLSIIMLGMHLAGALGRAVI--------PNLT---------VSDQVIPTLMIkVLP--PI 319 Haemophilus influen...
P07117   257 RFMAADSHHSIVHARRISMTWMILCLAGAVAVGFFGIAYFnd-----hPALAgav----nqNAERVFIELAQiLFN--PW 325 Escherichia coli K-12
AAA26389 257 RFMAADSHHSIVHARRISMTWMILCLAGAVAVGFFGIAYFnn-----nPALAgav----nqNSERVFIELAQiLFN--PW 325 Rickettsia typhi
P45174   261 RFMAADSVKSLIKARRISMGWMVLCLAGAIGIGLFAIPYFfa-----nPAIAgtv----nrEPEQVFIELAKlLFN--PW 329 Haemophilus influen...
P39599   254 RFYTVKDAKTARTSVVSATWIIGVFYIMTVFLGFGAAAFVg------fDAITaa-----dqAGNMAAPLLAKaLGG--DF 320 Bacillus subtilis s...
AAC12270 279 RYLSSHSEKAAVLSCYAVFPCQQVALCMSCLIGLVMFAYYkky--smsPQQEq-------aAPDQLVLYFVMdLLKdmPG 349 Norway rat
AAB39701 279 RIVSLPSYSHAKKSLIVSGLGFLIISFFNTISGIIMFARYyg----cdPMLAgl-----vsKPDKMMPFFVQdIMGhlAG 349 fruit fly
P33413   278 KAISASPAASLKAYAIGGLAWFAVPSLISLTMGLACLAVEtspnfptyPDPLtsf----qaNSGLVLPAAAIaIMG--KG 351 Saccharomyces cerev...
KFH99962 259 RCISYKDSKAVHRGIIIGTIVVAILMFGMHLAGALGRAVI--------PDLT---------VPDLVIPTLMVkVLP--PF 319 Escherichia coli

3DH4_A   321 VKGVVFAALAAAIVSSLASMLNSTATIFTMDIYKEYISPD-SGDHKLVNVGRTAAVVALIIACL-IapMLGGIGQAFQYI 398 Vibrio parahaemolyt...
P44963   320 VAGIFLAAPMSAIMSTIDAQLIQSSSIFVKDLYLSAKPEAaKNEKKVSYFSSIITLILTALLIF-A--ALNPPDMIIWLN 396 Haemophilus influen...
P07117   326 IAGILLSAILAAVMSTLSCQLLVCSSAITEDLYKAFLRKHaS-QKELVWVGRVMVLVVALVAIA-L--AANPENRVLGLV 401 Escherichia coli K-12
AAA26389 326 IAGVLLSAILAAVMSTLSCQLLVCSSAITEDLYKAFLRKSaS-QQELVWVGRVMVLVVALIAIA-L--AANPDNRVLGLV 401 Rickettsia typhi
P45174   330 IAGILLSAILAAVMSTLSAQLLISSSSITEDFYKGFIRPNaS-EKELVWLGRIMVLVIAALAIW-I--AQDENSKVLKLV 405 Haemophilus influen...
P39599   321 LFAFVSAIAFATILAVVTGLVLSAASAFAHDIYSQIIRKGeATEKEQMKAARWASVAVSVLSILlA--IFAQSLNVAFLV 398 Bacillus subtilis s...
AAC12270 350 LPGLFVACLFSGSLSTISSAFNSLATVTMEDLIQPWFPQLtETRAIMLSRSLAFAYGLVCLGMA-Y--VSSHLGSVLQAA 426 Norway rat
AAB39701 350 MPGVFISCVFSAALSSLSATLNSLAGVVYFDYIKPRIRHTeA-RANWAMKLIVVVMGGYCILGG-F--MVQNFNSILQTV 425 fruit fly
P33413   352 GAVASLLMIFMAVTSAMSAELIAVSSVFTYDIYREYIDPRaSGKKLIYTSHVACIFFGLAMSGFsV--GLYYGGISMGYI 429 Saccharomyces cerev...
KFH99962 320 AAGIFLAAPMAAIMSTINAQLLQSSATIIKDLYLNIRPDQmQNETRLKRMSAVITLVLGALLLL-A--AWKPPEMIIWLN 396 Escherichia coli

3DH4_A   399 QEYTGLVSPGILAVFLLGLFWKKTTSKGAIIG--VVAS 434 Vibrio parahaemolyticus
P44963   397 LFAFGGLEAAFLWVIVLGIYWDKANAYGALSS--MIIG 432 Haemophilus influenzae Rd KW20
P07117   402 SYAWAGFGAAFGPVVLFSVMWSRMTRNGALAG--MIIG 437 Escherichia coli K-12
AAA26389 402 SYAWAGFGAAFGPVVLFSVMWSRMTRNGALAG--MIIG 437 Rickettsia typhi
P45174   406 EFAWAGFGSAFGPVVLFSLFWKRMTSSGAMAG--MLVG 441 Haemophilus influenzae Rd KW20
P39599   399 ALAFAVAASANLPLIVFTVFWKRFNASGALWG--SLTG 434 Bacillus subtilis subsp. subtilis str. 168
AAC12270 427 LSIFGMVGGPLLGLFCLGMFFPCANPLGAIVG--LLTG 462 Norway rat
AAB39701 426 VTITGINTGAVVGVFLLGMFVPRCNAKTAVTS--IIVS 461 fruit fly
P33413   430 YEMMGIIISSAVLPVVLTLCSKDMNLVAAVVSpiLGTG 467 Saccharomyces cerevisiae S288c
KFH99962 397 LLAFGGLEAVFLWPLVLGLYWERANAKGALSA--MIVG 432 Escherichia coli
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap