Conserved Protein Domain Family
nst

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TIGR00803: nst 
UDP-galactose transporter
The 10-12 TMS Nucleotide Sugar Transporters (TC 2.A.7.10)Nucleotide-sugar transporters (NSTs) are found in the Golgi apparatus and the endoplasmic reticulum of eukaryotic cells. Members of the family have been sequenced from yeast, protozoans and animals. Animals such as C. elegans possess many of these transporters. Humans have at least two closely related isoforms of the UDP-galactose:UMP exchange transporter.NSTs generally appear to function by antiport mechanisms, exchanging a nucleotide-sugar for a nucleotide. Thus, CMP-sialic acid is exchanged for CMP; GDP-mannose is preferentially exchanged for GMP, and UDP-galactose and UDP-N-acetylglucosamine are exchanged for UMP (or possibly UDP). Other nucleotide sugars (e.g., GDP-fucose, UDP-xylose, UDP-glucose, UDP-N-acetylgalactosamine, etc.) may also be transported in exchange for various nucleotides, but their transporters have not been molecularly characterized. Each compound appears to be translocated by its own transport protein. Transport allows the compound, synthesized in the cytoplasm, to be exported to the lumen of the Golgi apparatus or the endoplasmic reticulum where it is used for the synthesis of glycoproteins and glycolipids.
Statistics
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PSSM-Id: 129885
View PSSM: TIGR00803
Aligned: 10 rows
Threshold Bit Score: 183.71
Threshold Setting Gi: 1041825
Created: 8-Oct-2014
Updated: 2-Oct-2020
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
P40004     94 NISIPIHIVFRCFGTVITMFTCWLLNGRKYT-KIQILSTLFLTIGAIIASLFKDADFRYQDLKLQAWKIGSDQSVD---- 168 Saccharomyces cere...
BAA95615  114 KLAVPSLIYTLQNNLQYVAISNLPAATFQVTyQLKILTTALFSVLMLNRSLSRLQWASLLLLFTGVAIVQAQQAGGgg-p 192 human
AAC39260   86 KLAIPSGIYTLQNNLLYVALSNLDAATYQVTyQLKILTTALFSVSMLSKKLGVYQWLSLVILMTGVAFVQWPSDSQelds 165 dog
P87041     97 KLAIPAFLYTCQNNLQYVAAGNLTAASFQVTyQLKILTTAIFSILLLHRRLGPMKWFSLFLLTGGIAIVQLQNLNSd--- 173 Schizosaccharomyce...
O08520     90 KLSVPSLVYAVQNNMAFLALSNLDAAVYQVTyQLKIPCTALCTVLMLNRTLSKLQWVSVFMLCGGVILVQWKPAQAt--- 166 Chinese hamster
P40107    108 yLAVPIYTIFKNLTIILIAYGEVLFFGGSVT-SMELSSFLLMVLSSVVATWGDQQAVAAKAASLAEGAAGAVAS------ 180 Saccharomyces cere...
P40027    103 yLAVPIYTIFKNLTIILIAYGEVLFFGGKVT-SMELTSFIMMVLSSVVATWGDQQAIAIKASSLEDLDQELVESTI---- 177 baker's yeast
AAC46914   97 TMSVAAQTILKNLAVVLIALGDKFLYGKAQT-PMVYFSFALMILGSLLGAKGDKWVTAWGLVWTFLNIVSTVSYT----- 170 Leishmania donovani
AAC49313   93 DISVPIHIIIRCSGTTLTMIIGWAVCNKRYS-KLQVQSAIIMTLGAIVASLYRDKEFSMDSLKLNTDSVGMTQKS----- 166 Kluyveromyces lactis
NP_498930 122 KMSVPSFAYALQNNLDFVGLSNLDAGLYQVTtQLKVVSTAFFMMLFLGRKFSTRRWMAITLLMFGVAFVQMNNVSAse-a 200 Caenorhabditis ele...
P40004    169 LTFIFg--ICILVLSSFTSSLLSAYNERTYQKYGKHWKENI-FYSHFLSLPLFLFSRKqliheYRVMRKSERILCSNFGG 245 Saccharomyces cere...
BAA95615  193 RPLDQ---NPGAGLAAVVASCLSSGFAGVYFEKILKGSSGS-VWLRNLQLGLFGTALG-----LVGLWWAEGTAVATRGF 263 human
AAC39260  166 KELSAg--SQFVGLMAVLTACFSSGFAGVYFEKILKETKQS-VWIRNIQLGFFGSIFG-----LMGVYIYDGELVSKNGF 237 dog
P87041    174 DQMSAgpmNPVTGFSAVLVACLISGLAGVYFEKVLKDTNPS-LWVRNVQLSFFSLFPC-----LFTILMKDYHNIAENGF 247 Schizosaccharomyce...
O08520    167 KVVVEq--SPLLGFGAIAIAVLCSGFAGVYFEKVLKSSDTS-LWVRNIQMYLSGIVVT-----LVGTYLSDGAEIKEKGF 238 Chinese hamster
P40107    181 --FNPg--YFWMFTNCITSALFVLIMRKRIKLTNFKDFDTM-FYNNVLALPILLLFS------FCVEDWSSVNLTNNFS- 248 Saccharomyces cere...
P40027    178 FVLNPg--YLWMFTNCISSALFVLIMRKRIRLTNFKDYDTM-FYNNVLALPLLLVFS------FIMEDWSTKNLSVNLS- 247 baker's yeast
AAC46914  171 -LYMKavlGSVSNSIGRYGPVFYNNLLSLPFFLIMGVGDIMpFSAAIGDTTTFGKLVLt----FSVLVSSVMTFSVFWCM 245 Leishmania donovani
AAC49313  167 ---MFg--IFVVLVATALMSLLSLLNEWTYNKCGKHWKETL-FYSHFLALPLFMLGYTrlrdeFRDLLISSDSMDIPIV- 239 Kluyveromyces lactis
NP_498930 201 NTKREtaeNYIVGLSAVLATCVTAGFAGVYFEKMLKDGGSTpFWIRNMQMYSCGVIS------ASIACLTDFSRISDKGF 274 Caenorhabditis ele...
P40004    246 KILVPREETLLLFNVLTQYFCVKGVNILASKTnalTLSITLLVRKFISLLLS-VRLFDNNLSYTGYIGVYLVFFGAFIY 323 Saccharomyces cerev...
BAA95615  264 FFGYTPAVWGVVLNQAFGGLLVAVVVKYADNI---LKGFATSLSIVLSTVAS-IRLFGFHVDPLFALGAGLVIGAVYLY 338 human
AAC39260  238 FQGYNRLTWIVVILQALGGLVIAAVIKYADNI---LKGFATSLSIILSTLISyFWLQDFVPTSVFFLGAILVITATFLY 313 dog
P87041    248 FFGYNSIVWLAILLQAGGGIIVALCVAFADNI---MKNFSTSISIIISSLAS-VYLMDFKISLTFLIGVMLVIAATFLY 322 Schizosaccharomyces...
O08520    239 FYGYTYYVWFVIFLASVGGLYTSVVVKYTDNI---MKGFSAAAAIVLSTIAS-VMLFGLQITLSFAMGALLVCISIYLY 313 Chinese hamster
P40107    249 -NDSLTAMIISGVASVGISYCSGWCVRVTSST---TYSMVGALNKLPIALSG-LIFFDAPRNFLSILSIFIGFLSGIIY 322 Saccharomyces cerev...
P40027    248 -ADSLAAMVISGLMSVGISYCSGWCVRVTSST---TYSMVGALNKLPIALAG-LVFFDAPKNFLSFFSIFLGFLSGLLY 321 baker's yeast
AAC46914  246 SITSPTTMSVVGSLNKIPLTFLGMLVFHQFPTatgYLGIMIALSAGFLYTHLnIRANRAKASSDTEHQMQQAGKTTAES 324 Leishmania donovani
AAC49313  240 KLPIATKLFMLIANNVTQFICIKGVNMLASNTdalTLSVVLLVRKFVSLLLS-VYIYKNVLSVTAYLGTITVFLGAGLY 317 Kluyveromyces lactis
NP_498930 275 FFGYTDKVWAVVILLGVGGLYISLVMRYLDNL---YKSMASAVSIILVVVLSmLIFPDIFIGMYFVLGTICVVLAVLLY 350 Caenorhabditis elegans
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