Conserved Protein Domain Family
ncs1
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TIGR00800: ncs1 
NCS1 nucleoside transporter family
The Nucleobase:Cation Symporter-1 (NCS1) Family (TC 2.A.39) The NCS1 family consists of bacterial and yeast transporters for nucleobases including purines and pyrimidines. Members of this family possess twelve putative transmembrane a-helical spanners (TMSs). At least some of them have been shown to function in uptake by substrate:H+ symport mechanism. [Transport and binding proteins, Nucleosides, purines and pyrimidines]
Links
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Statistics
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PSSM-Id: 273275
Aligned: 20 rows
Threshold Bit Score: 251.126
Created: 8-Oct-2014
Updated: 25-Oct-2021
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
P38196       118 RPVEAKRRT-WTWKQYIFFWISGSFNVNTWQISATGLQLg-LNWWQTWICIWVGYTFVAFFLILGSKVGNNYHISFPISS 195 Saccharomyces c...
Q01266         1 MPTVNKERN-MSSIAYFILWVGIAVQLVTPITAAQLYPA--LSPLQIIIACILGNLIVAILLTLLGDIGVRYGIPYAVYI 77  Pseudomonas sp....
AAA25848       1 MPTVNKERN-MSSIAYFILWVGIAVQLVTPITAAQLYPA--LSPLQIIIACILGNLIVAILLTLLGDIGVRYGIPYAVYI 77  Pseudomonas sp.
P94575        19 VPLGQEKRT-WKAMNFASIWMGCIHNIPTYATVGGLIAIg-LSPWQVLAIIITASLILFGALALNGHAGTKYGLPFPVII 96  Bacillus subtil...
CAA18904      46 LPVPVEGRT-WTTYNFSALWVGMAHNTASWTLASGLIAVg-MDWKQAVFTIALANLIVLAPMLLTGHAGPKYGIPFPVFA 123 Streptomyces co...
BAA30259       5 KPVKERIFD---FWSNFSIWFGADFGIAVIWAGALLTPY--LSLKQALAIIILGHLLGNAVMSLIAIEGQETGLPTMVLS 79  Pyrococcus hori...
P25525        10 GPVPQSARK--GVLALTFVMLGLTFFSASMWTGGTLGTG--LSYHDFFLAVLIGNLLLGIYTSFLGYIGAKTGLTTHLLA 85  Escherichia coli
P40039        72 EPITEDEKTdDSILNAASMWFSANMVLPAYAIGALGPMVfdLNFGQSVFVIIFFNLLGLVSVAFFSVFGAELGLRQMILS 151 Saccharomyces c...
P17064        75 EPVTEDEKTdDSILNAASMWFSANMVIASYALGALGPMVfgLNFGQSVLVIIFFNIMGLIFVAFFSVFGAELGLRQMILS 154 Saccharomyces c...
WP_001688483  18 LPKTQSQRT-WKTFNYFTLWIGSVHNVPNYVMVGGFFILg-LSTFSIMLAIILSAFFIAAVMVLNGAAGSKYGVPFAMIL 95  Escherichia coli

P38196       196 RVSFGIYFSIWIVINRV-VMACVWNSTLAYIGsqcvQLMLKAIFGTNLNTRIkdtiknpnlTNFEFMCFMVFWVACLpfl 274 Saccharomyces c...
Q01266        78 RASFGYLGAHIPGIVRA-VPAVFWFGFQTWMG----AYALDAIMEMLTGYSN---------LTLLIILFGVVQIINT--- 140 Pseudomonas sp....
AAA25848      78 RASFGYLGAHIPGIVRA-VPAVFWFGFQTWMG----AYALDAIMEMLTGYSN---------LTLLIILFGVVQIINT--- 140 Pseudomonas sp.
P94575        97 RASYGIYGANIPALLRA-FTAIMWLGIQTFAGstalNILLLNMWPGWGEIGGewni--lgiHLSGLLSFVFFWAIHLlvl 173 Bacillus subtil...
CAA18904     124 RASFGIRGANLPAVVRA-LVACGWFGIQTWIGgeaiYFLAGKLIGDGWTNAGtfg----ghAWTMWLSFAIFWALQVaii 198 Streptomyces co...
BAA30259      80 RGPLGGKGSILPSLLNY-LQLIGWTAIMLIVG----ARALDVIFPG-----------------TYFAWVIVLGVLVT--- 134 Pyrococcus hori...
P25525        86 RFSFGVKGSWLPSLLLG-GTQVGWFGVGVAMF------AIPVGKAT----G------------LDINLLIAVSGLLMtvt 142 Escherichia coli
P40039       152 RYLVGNIAARIFSFINF-IACIGWGIVNTVAS----SQVLNMVNPG--HQCP-----------LWAGCIVIIGATVIv-- 211 Saccharomyces c...
P17064       155 RYLVGNVTARIFSLINV-IACVGWGIVNTSVS----AQLLNMVNEGSGHVCP-----------IWAGCLIIIGGTVLv-- 216 Saccharomyces c...
WP_001688483  96 RASYGVRGALFPGLLRGgIAAIMWFGLQCYAGslacLILIGKIWPGFLTLGGdftl--lglSLPGLITFLIFWLVNVgig 173 Escherichia coli

P38196       275 wFPPDKLRHIFALKSAITPFAAFGFLIWTLCKAKgHLALGSLN--DnggaiSKTVLAWSVIRAIMSALDNFSTLILNAPD 352 Saccharomyces c...
Q01266       141 -AMGMEAITKFEWLASPSILIIGIILQVYIMKQH-HLTFSEIF--S-----HGGDGGVSMGYAVVVMMGTYITMALNAPD 211 Pseudomonas sp....
AAA25848     141 -AMGMEAITKFEWLASPSILIIGIILQVYIMKQH-HLTFSEIF--S-----HGGDGGVSMGYAVVVMMGTYITMALNAPD 211 Pseudomonas sp.
P94575       174 hHGMESIKRFEVWAGPLVYLVFGGMVWWAVDIAGgLGPIYSQP--Gkf--hTFSETFWPFAAGVTGIIGIWATLILNIPD 249 Bacillus subtil...
CAA18904     199 yRGMETIRRFENWAAPFVLVGAFVMLWWMADKAGgFGPLFDQP--Srl--gWGGDFWKLFWPSLMGMIGFWSTLSLNIPD 274 Streptomyces co...
BAA30259     135 -VWTLVGPERWGWLEKLSVILLAILSGWLLYVIFsKYSFSELW--N-----KPGTGGLPLLIALDLVIAMPLSWAPTIAD 206 Pyrococcus hori...
P25525       143 vFFGISALTVLSVIAVPAIACLGGYSVWLAVNGMgGLDALKAV--V-------PAQPLDFNVALALVVGSFISAGTLTAD 213 Escherichia coli
P40039       212 tFFGYGVIHAYEKWAWVPNFAVFLVIIARLARSK-KFVLGEWT--S------GPTTAGNVLSFGSTVYGFAAGWTTYAAD 282 Saccharomyces c...
P17064       217 tFFGYSVIHAYEKWSWVPNFAVFLVIIAQLSRSG-KFKGGEWV--G------GATTAGSVLSFGSSIFGFAAGWTTYAAD 287 Saccharomyces c...
WP_001688483 174 fGGGKVLNKFTAILNPCIYIVFGGMAIWAISLVg-IGPIFDYIpsGi---qKAENGGFLFLVGINAVVAVWAAPAVSASD 249 Escherichia coli

P38196       353 FTRFGKTYKSSVYS-QLIALPVCYAIISLIGILSV 386 Saccharomyces cerevisiae S288c
Q01266       212 FTRFLKTKTGSSEP-NWWKVNKGSFWAHTFGLIGS 245 Pseudomonas sp. NS671
AAA25848     212 FTRFLKTKTGSSEP-NWWKVNKG------------ 233 Pseudomonas sp.
P94575       250 FTRFAETQKEQIKG-QFYGLPGTFALFAFASITVT 283 Bacillus subtilis subsp. subtilis str. 168
CAA18904     275 FTRYGKSQRAQTRG-QALGLPTTMTLFAFLSVMVT 308 Streptomyces coelicolor A3(2)
BAA30259     207 YSRFAKSKSDAAWG-TYLGHLAGSAFCYFLGALSN 240 Pyrococcus horikoshii OT3
P25525       214 FVRFGRNAKLAVLV-AMVAFFLGNSLMFIFGAAGA 247 Escherichia coli
P40039       283 YTVYMPR-KTNKYKiFFSLVVGLATPLYFTMILGA 316 Saccharomyces cerevisiae S288c
P17064       288 YTVYMPK-STNKYKiFFSLVAGLAFPLFFTMILGA 321 Saccharomyces cerevisiae S288c
WP_001688483 250 FTQNAHSFREQALG-QTLGLVVAYILFAVAGVCII 283 Escherichia coli
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