Conserved Protein Domain Family
livcs
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TIGR00796: livcs 
branched-chain amino acid uptake carrier
The Branched Chain Amino Acid:Cation Symporter (LIVCS) Family (TC 2.A.26) Characterized members of this family transport all three of the branched chain aliphatic amino acids (leucine (L), isoleucine (I) and valine (V)). They function by a Na+ or H+ symport mechanism and display 12 putative transmembrane helical spanners. [Transport and binding proteins, Amino acids, peptides and amines]
Links
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Statistics
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PSSM-Id: 273272
Aligned: 10 rows
Threshold Bit Score: 395.141
Created: 7-Oct-2014
Updated: 25-Oct-2021
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
AAC68156  19 GGSIFAMFFGAGNVVFPLALGHHFYYHTSY-ACLGMILTAVLTPLLGLFAMMLYSG-NYRSFFASIGRMPGMVLMVAILC 96  Chlamydia trachomat...
P37011    14 GFMTFALFVGAGNIIFPPMVGLQAGEHVWT-AAFGFLITAVGLPVLTVVALAKVGG-GVDSLSTPIGKVAGVLLATVCYL 91  Escherichia coli
P25185    13 GFMTFALFVGAGNIIFPPIVGLQSGPHVWL-AALGFLITAVGLPVITVIALAKVGG-SVDALSHPIGRYAGGLLAAVCYL 90  Pseudomonas aerugin...
P19072    13 GFMTFALFLGAGNIIFPPSAGMAAGEHVWS-AAFGFLLTGVGLPLLTVVALARVGG-GIGRLTQPIGRRAGVAFAIAVYL 90  Pseudomonas aerugin...
AAB47961  14 GLMLFALFFGAGNLIFPPMLGQLAGKNVWV-ANAGFLVTGVGLPLLAITAFVFSGKqNLQSLASRVHPVFGIVFTTILYL 92  Bacillus subtilis s...
AAC00400  14 GFMLFALFFGAGNMIYPPELGQAAGHNVWK-AIGGFLLTGVGLPLLGIIAIALTGK-DAKGLADKAHPVFGTIFTVVLYL 91  Bacillus subtilis
P54104    14 SSMLFGLFFGAGNLIFPAYLGEASGANLWI-SLLGFLITGVGLPLLAIASLGMTRSeGLLDLSGRVSHKYSYFFTCLLYL 92  Lactobacillus delbr...
P71345    11 GMMIFALFLGAGNIIFPPMEGFSSGQH-WTsASLGFVLTGVLMPFITLVVVAILGR--GEELTKDLPKWAGTGFLVILYL 87  Haemophilus influen...
AAC65254  10 SFMLFSFFFGAGNLILPPLLGKHAGTTLAT-ALLGFATSAVLIPIAGLITIAHAGG--IVPLSERVGKRFAHLYPAITLL 86  Treponema pallidum ...
AAC38146   9 WVYALRYVFWRRQSNFSSYLGLDRVNFLAR--HLAFVLTGIGLPLLGVIVGALDKE-GYIGALNKISPKFSILFLIIIYL 85  Staphylococcus aureus

AAC68156  97 IIGPFGGIPRTIAVSYDTLASLGDKh-pTLLPSLPWFSVFFCVLVYLFVCKLSKLIQWLGSVFSPVMLGTLAWLIIKGLL 175 Chlamydia trachomat...
P37011    92 AVGPLFATPRTATVSFEVGIAPLTG---DSALPLFIYSLVYFAIVILVSLYPGKLLDTVGNFLAPLKIIALVILSVAAIV 168 Escherichia coli
P25185    91 AVGPLFAIPRTATVSFEVGVVPLLG---ESGTALFVYSLAYFLLALAISLYPGRLLDTVGRFLAPLKILALAILGVAAFL 167 Pseudomonas aerugin...
P19072    91 AIGPLFATPRTAVVSFEMGVAPFTG---DGGVPLLIYTVAYFSVVLFLVLNPGRLVDRVGKVITPVLLSALLVLGGAAIF 167 Pseudomonas aerugin...
AAB47961  93 AIGPFFAIPRSGNVSFEIGVKPFLSn-dASPVSLIIFTILFFALACLLSLNPSKIIDIVGKFLTPIKLTFIGLLVAVALI 171 Bacillus subtilis s...
AAC00400  92 SIGPLFAIPRTGTVSYEIGAVPFLTg-vPERLSLLIFTLIFFGVTYYLALNPSKVVDRVGKILTPIKFTIILIIVLKAIF 170 Bacillus subtilis
P54104    93 TIGPFFAIPRSFTVPFETGISALLPsgmAKSTGLFIFSLIFFAIMLFFSLRPGQIMDWIGKFLTPAFLLFFFFIMIMALL 172 Lactobacillus delbr...
P71345    88 TIGSTFAMPRITNVAYEMAWLPLGLt-eNNANVRFVFSLIFNLIAMGFMISPNTIISSVGKFMTPALLVLLIAVAITVFI 166 Haemophilus influen...
AAC65254  87 VIGPALSIPRAGIVPFALAIAPLIHranTTLLAQLIYTTCFFIVSYWLCMRPHTLSNTLGKVLTPALLVLVLLLFLASFT 166 Treponema pallidum ...
AAC38146  86 TIGPLFAIPRTASTSFEMTITPIIHs--NSSIALFIFTIIYFIVVLYICLNPSKLIDRIGSLLTPLLLITILAMIIKGYL 163 Staphylococcus aureus

AAC68156 176 LPAHALPSES---VTFSKqQAFVTGLSEGFNTMDLLGAFFFCSIVLVSIqqlmvQQKHESSEEKPLEFHHIGKTekyklA 252 Chlamydia trachomat...
P37011   169 WPAGSISTAT---EAYQN-AAFSNGFVNGYLTMDTLGAMVFGIVIVNAA-----RSRGVTEARLLTRYTVWAGL-----M 234 Escherichia coli
P25185   168 WPAGPIGTAQ---PEYTQ-AAFSQGFVNGYLTMDTLAALVFGIVIVNAI-----RSRGVQSPRLITRYAIVAGL-----I 233 Pseudomonas aerugin...
P19072   168 APAGEIGSSS---GEYQS-APLVQGFLQGYLTMDTLGALVFGIVIATAI-----RDRGISDSRLVTRYSMIAGV-----I 233 Pseudomonas aerugin...
AAB47961 172 RPIGTIQAPS---KGYTS-QAFFKGFQEGYLTLDALVAFVFGIIIVNAL-----KEQGASTKKQLIVVCAKAAA-----I 237 Bacillus subtilis s...
AAC00400 171 TPMGGLGAVT---EAYKG-TPVFKGFLEGYKTMDALASIVFGVVVVNAV-----KSKGVTQSKALAAACIKAGV-----I 236 Bacillus subtilis
P54104   173 HPLGNYHAVKp-vGEYAS-APLISGVLAGYNTMDALAGLAFGIIVISSI-----RTFGVTKPEKVASATLKTGV-----L 240 Lactobacillus delbr...
P71345   167 SPLSEIQAPS---NAYENsHSLLIGLTSGYQTMDVLAAIAFGGIVARAL-----SAKNVTKTKDIVKYTISAGF-----V 233 Haemophilus influen...
AAC65254 167 PTLGPYLPAQ---GAYAThIPFSQGFLDGYLTTDALASLMFGNMILTYLh----RTRYTTAPFPPTPANTPADMrtvawI 239 Treponema pallidum ...
AAC38146 164 DFTVIVLERAmkhYIILIfQVLLKVYTRLFNNGMPWQQLLFQWMVVNAV-----KLTGITKTNQIFKQTLTAGL-----I 233 Staphylococcus aureus

AAC68156 253 MSFLLAAALLSLVYLGfa----fcAARHAGALIDVQRGQILGRISALVVGP-NSFLTGLSVFLACLTTAIAATGIFADFI 327 Chlamydia trachomat...
P37011   235 AGVGLTLLYLALFRLG--------SDSASLVDQSANGAAILHAYVQHTFGGgGSFLLAALIFIACLVTAVGLTCACAEFF 306 Escherichia coli
P25185   234 AGVGLVLVYVSLFRLG--------AGSHAIAADASNGAAVLHAYVQHTFGSlGSSFLAGLIALACLVTAVGLTCACAEYF 305 Pseudomonas aerugin...
P19072   234 AATGLSLVYLALFYLG--------ATSQGIAGDAQNGVQILTAYVQQTFGVsGSLLLAVVITLACLTTAVGLITACGEFF 305 Pseudomonas aerugin...
AAB47961 238 AAVLLAVMYTALSYMG--------ASSVEELGILENGAEVLAKVSSYYFGSyGSILLGLMITVACLTTSVGLITACSSFF 309 Bacillus subtilis s...
AAC00400 237 AALGLTFIYVSLAYLG--------ATSTNAIGPVGEGAKILSASSHYLFGSlGNIVLGAAITVACLTTSIGLVTSCGQYF 308 Bacillus subtilis
P54104   241 TCLLMAVIYAITALVG--------AQSRTALGLAANGGEALSQIARHYFPGlGAVIFALMIFVACLKTAIGLITACSETF 312 Lactobacillus delbr...
P71345   234 SVILLAGLYFSLFYLG--------ATSAAVAEGATNGGQIFSRYVNVLFGSaGTWIMAGIIVLASLTTLVGVTSASADYF 305 Haemophilus influen...
AAC65254 240 AGVMLFFTYGVLAHLG--------ALSARQLPHTVNGAHILASVSRHLFGKaGIALLGLIFTIACLTTCAGLLVCVSEYF 311 Treponema pallidum ...
AAC38146 234 AAVALIFIYISLGYIGnhmpvsdmTLDQLKSKDRNIGTYLLTTMASTGFGSfGKYLLGIIVALRCLTTACGLIVAVSEYF 313 Staphylococcus aureus

AAC68156 328 ARVVSsqkMSYSNALIVTLVPTYLVSILSFENISKILIPILEMSYPALIALTCGVIAKKLWDFPHAKTLFYLVFALTILY 407 Chlamydia trachomat...
P37011   307 AQYVP---LSYRTLVFILGGFSMVVSNLGLSQLIQISVPVLTAIYPPCIALVVLSFTRSWWHNSSRVIAPPMFISLLFGI 383 Escherichia coli
P25185   306 CQRLP---LSYRSLVIILAGFSFIVSNLGLTKLIQVSIPVLTAIYPPCIVLVALSFCIGLWHSATRILAPVMLVSLAFGV 382 Pseudomonas aerugin...
P19072   306 SDLLP---VSYKTVVIVFSLFSLLVANQGLTQLISLSVPVLVGLYPLAIVLIALSLFDRLWVSAPRVFVPVMIVALLFGI 382 Pseudomonas aerugin...
AAB47961 310 HELFPn--ISYKKIAVVLSVFSTVVANIGLTQLIKVSMPVLLTMYPIAISLIFLTFLHSVFKGKTEVYQGSLLFAFIISL 387 Bacillus subtilis s...
AAC00400 309 SKLIPa--LSYKIVVTIVTLFSLIIANFGLAQIIAFSVPILSAIYPLAIVIIVLSFIDKIFKERREVYIACLIGTGLFSI 386 Bacillus subtilis
P54104   313 AEMFPk-tLSYNMWAIIFSLLAFGIANVGLTTIISFSLPVLMLLYPLAISLILLALTSKLFDFKQVDYQIMTAVTFLCAL 391 Lactobacillus delbr...
P71345   306 SKFSVr--FSYPFWAALFTAMTITVSQYGLTDLLRITIPALLLIYPVAIVLVLLQFLRKKLPSIKFTYNSTLLVTVCFSL 383 Haemophilus influen...
AAC65254 312 HKRAPr--VSYLCWIRLFTISSFALANTGLERILAYGTPLLMILYPISLVLIGISHLERLIRIPRAAYRLTVWSAGTLST 389 Treponema pallidum ...
AAC38146 314 HKIVPk--VSYKAFVLVFILMSFIIANQGLNAVISMSIPVLSIVYPVAITVVLLILIAKFIPTKRISQQIPVIIVFILSI 391 Staphylococcus aureus

AAC68156 408 KLSV 411 Chlamydia trachomatis D/UW-3/CX
P37011   384 LDGI 387 Escherichia coli
P25185   383 LDAL 386 Pseudomonas aeruginosa PAO1
P19072   383 VDGL 386 Pseudomonas aeruginosa PAO1
AAB47961 388 FDGL 391 Bacillus subtilis subsp. subtilis str. SMY
AAC00400 387 LDGI 390 Bacillus subtilis
P54104   392 GDFF 395 Lactobacillus delbrueckii subsp. lactis
P71345   384 CDSL 387 Haemophilus influenzae Rd KW20
AAC65254 390 CAVG 393 Treponema pallidum subsp. pallidum str. Nichols
AAC38146 392 FSVI 395 Staphylococcus aureus
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