Conserved Protein Domain Family
hisAF_rel

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TIGR00734: hisAF_rel 
hisA/hisF family protein
This model models a family of proteins found so far in three archaeal species: Methanobacterium thermoautotrophicum, Methanococcus jannaschii, and Archaeoglobus fulgidus. This protein is homologous to phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase (HisA) and, with lower similarity, to the cyclase HisF, both of which are enzymes of histidine biosynthesis. Each species with this protein also encodes HisA. The function of this protein is unknown. [Unknown function, General]
Statistics
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PSSM-Id: 273240
Aligned: 3 rows
Threshold Bit Score: 300.684
Created: 8-Oct-2014
Updated: 25-Oct-2021
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q58114         1 MKIIPVIDLKDKIAVHGKSGNRDEYKPLESVICKSSNpIEVAKAYKERGAKTIYIADLNFIMGNGDNFDIIKEIDFIN-- 78  Methanocaldococ...
WP_010878216   1 MKVFFVVDIKSGKVVAGKGGERESYPPITAISRLVSS-DDALKVIEEIKPRFLYAADLDRIVGLGDNFSLLSKLSKRVee 79  Archaeoglobus f...
WP_010876307   2 LEIIPVIDLMDGIAVSGKSGEREKYRPLESVYSPSPDpVNIALSLRAAGARSIYIADLDAIEGTGSNLEAVRRVNHVLp- 80  Methanothermoba...
Q58114        79 KIVDIGVKSREDLETIKKVLnkddraIVATETLKDIELLKEKDi-------vVSLDFKNGNLLNYSLDEILSCVRDDTP- 150 Methanocaldococ...
WP_010878216  80 LIADCGFRSPEELEKLPFTP------VVGTETFDITQLDRKCY---------VSLDFKEKFLDASGKFESWEEVVKFLNs 144 Archaeoglobus f...
WP_010876307  81 VILDAGVR---DLETFHFMLefasrvVVATETLESTEELEEILrnyppertvVSVDVKDMRLHSRNLEIGLEELRDLLMg 157 Methanothermoba...
Q58114       151 -----LIILDISSVGTQRgVNAELIKYVLDKTNNPVYVGGGIKGMEDLELCYNLGVDAVLIATAIHKGVL 215 Methanocaldococcus jannas...
WP_010878216 145 fdlygLIVLPIHAVGAMK-PDLSVLTKTLELSEHPVMLGGGISGVEDLERLKEMGCSGVLVATAVHKGKI 213 Archaeoglobus fulgidus
WP_010876307 158 ye-vdIILLDIGSVGTSSgFNRELLELFRPLIER-VIPGGGVLPEEIPELEA-MGVRAALVGRALHEGMV 224 Methanothermobacter therm...
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