Conserved Protein Domain Family
lpxK
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TIGR00682: lpxK 
tetraacyldisaccharide 4'-kinase
Also called lipid-A 4'-kinase. This essential gene encodes an enzyme in the pathway of lipid A biosynthesis in Gram-negative organisms. A single copy of this protein is found in Gram-negative bacteria. PSI-BLAST converges on this set of apparent orthologs without identifying any other homologs. [Cell envelope, Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides]
Links
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Statistics
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PSSM-Id: 273216
Aligned: 5 rows
Threshold Bit Score: 382.975
Created: 7-Oct-2014
Updated: 25-Oct-2021
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q9Z823  28 WGWLGSLLSKVFAFLVACWNRFSWStpyRARSTVIsVGNIVVGGAGKTPTVLWLAEALRLRGYSCGVLSRGYKSqssRQK 107 Chlamydia pneumoniae
P27300  19 LSWLYGLVSGAIRLCYKLKLKRAWR---APVPVVV-VGNLTAGGNGKTPVVVWLVEQLQQRGIRVGVVSRGYGG---KAE 91  Escherichia coli K-12
P44491  17 FSLLFWLISQLRRALFSLGLKSSYR---APKPVII-VGNLSVGGNGKTPVVVWLMEELKKRGLRVGVISRGYGS---KSK 89  Haemophilus influenza...
O67572   9 FSYLYEKIINFRNTLYDKGFLKIKK---LPVPVIS-VGNLSVGGSGKTSFVMYLADLLKDK--RVCILSRGYKRkskGTL 82  Aquifex aeolicus VF5
Q9ZCL0  16 IAYLLLPISLIYQFLSYLRASLAYPv--ILPAQVIcVGNCSVGGTGKTQIVIYLAKLLKAKNVPFVIITKAYGS----HI 89  Rickettsia prowazekii...

Q9Z823 108 KLTVVDSKVHSASYVGDEPLLMAEKLpEGSVWVHKDRR--ISAARAAE-KFGILLLDDGLQYRKLHKDVEIAVVNGQDPL 184 Chlamydia pneumoniae
P27300  92 SYPLLLSADTTTAQAGDEPVLIYQRT-DAPVAVSPVRSdaVKAILAQHpDVQIIVTDDGLQHYRLARDVEIVVIDGVRRF 170 Escherichia coli K-12
P44491  90 TYPLFVTKNTNPIEGGDEPVLIAKRT-NAPVVISPNRQqaIELLLSQA-ECDIIISDDGLQHYQLQRDLEIVVMDAERAL 167 Haemophilus influenza...
O67572  83 IVSEYGNLKVSWEEAGDEPYLMAKLLpHVSVVASEDRYkgGLLALEKL-SPEVFILDDGFQHRKLHRDLNILLLKKKD-- 159 Aquifex aeolicus VF5
Q9ZCL0  90 KSTTIIQKGHTALEVGDEGIMLARYG---TVIAAKYVKdiLPLINELK--PDVIIVDDFLQNPYLHKDFTIVSVDSQRLF 164 Rickettsia prowazekii...

Q9Z823 185 GGRAFFPKGRLRDFPLRLKTVDAIIVNGGGKEAGtvvkrvSNApqIFVKPTIAsvVWTHNGERIPKEALRELrVgVFCGL 264 Chlamydia pneumoniae
P27300 171 GNGWWLPAGPMRERAGRLKSVDAVIVNGGVPRSG------EIP--MHLLPGQA--VNLRTGTRCDVAQLEHV-V-AMAGI 238 Escherichia coli K-12
P44491 168 GNGFVLPAGPLRELPSRLKSVDFVITNGGKNQYS------DAV--MRLVPHFA--INLKTNEKRQLNEFQSG-V-AIAGI 235 Haemophilus influenza...
O67572 160 LKDRLLPAGNLREPLKEIRRADALVLTYQEVEPFe----fFTGkpTFKMFREFccLLNSDFEEVPFDILKEReViAFSGL 235 Aquifex aeolicus VF5
Q9ZCL0 165 GNRFLIPAGPLRQNPKQVLDAADLIFLVSSNQDQ-------IP--NELTPYIDklINAQIVPSNNIDKNKNYf--AFSGI 233 Rickettsia prowazekii...

Q9Z823 265 GFPQGFLNMLREEGIHILGKYLLPDHaaitkKELNYFCQQMAMRQGQGLLCTEKDSVKLPRLSGEVSl-LPIAKVEMRLS 343 Chlamydia pneumoniae
P27300 239 GHPPRFFATLKMCGVQPEKCVPLADH-----QSLNHADVSALVSAGQTLVMTEKDAVKCRAFAEENWwyLPVDAQLSGDE 313 Escherichia coli K-12
P44491 236 GNPQRFFTMLEKLGIQLKQTQAFQDH-----QHFEASQLEKLAEN-QPLFMTEKDAVKCQSFAKDNWwyVPVDAEIIEAE 309 Haemophilus influenza...
O67572 236 GDNGQFRKVLKNLGIKVKEFMSFPDH-------Y--DYSDFTPEEGEIYLTTPKDLIKLQGYENVFAlnFKVKLEREEKL 306 Aquifex aeolicus VF5
Q9ZCL0 234 GNPQRFFLTLENYRLNIVGYKIFPDHyn-ylQADLENLYSLAKEHNAILITTRKDYVKFNYLNDEIIc-LDVELSINNPD 311 Rickettsia prowazekii...

Q9Z823 344 vn---qDdtlSLLNMIEQIHKN 362 Chlamydia pneumoniae
P27300 314 ------P---AKLLTQLTLLAS 326 Escherichia coli K-12
P44491 310 kqrenlPhfwAKIDKLVEQYRN 331 Haemophilus influenzae Rd KW20
O67572 307 k---------KLIYRIFY---- 315 Aquifex aeolicus VF5
Q9ZCL0 312 ----------LLNEKIFKKAKI 323 Rickettsia prowazekii str. Madrid E
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