4TR6


Conserved Protein Domain Family
dnan
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TIGR00663: dnan 
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DNA polymerase III, beta subunit
All proteins in this family for which functions are known are components of the DNA polymerase III complex (beta subunit). This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]
Links
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Statistics
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PSSM-Id: 273204
Aligned: 10 rows
Threshold Bit Score: 360.881
Created: 7-Oct-2014
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
4TR6_A         3 MKFTIQKDRLVESVQDVLKAVSSRTTIPILTGIKIVASDDG--VSFTGSDSDISIESFIpkeegdkeIVTIEQPGSIVLQ 80  Bacillus subtil...
P05649         1 MKFTIQKDRLVESVQDVLKAVSSRTTIPILTGIKIVASDDG--VSFTGSDSDISIESFIpkeegdkeIVTIEQPGSIVLQ 78  Bacillus subtil...
P43744         1 MQFSISRENLLKPLQQVCGVLSNRPNIPVLNNVLLQIEDYR--LTITGTDLEVELSSQTq-------LSSSSENGTFTIP 71  Haemophilus inf...
P29439         1 MKFTIQNDILTKNLKKITRVLVKNISFPILENILIQVEDGT--LSLTTTNLEIELISKIe-------IITKYIPGKTTIS 71  Buchnera aphidi...
P46387        13 LKFCLARESFASAVSWVAKYLPTRPTVPVLSGVLLTGSDSG--LTISGFDYEVSAEVQV--------AAEIASSGSVLVS 82  Mycobacterium l...
O83048         1 MKILCEKEAFLKEISTAQEVISNKKNTSIFSNVLLAAQGAL--LTIRATDTKVTFETSI--------PVNVLAEGTTTVF 70  Treponema palli...
P34029         1 MIVNIKRDKILDELLKVSRIISQKTLIPSLLGILIEVKKDK--ITFTTSDGDTSIKSEImg-----nDLNITRIGSVLIK 73  Spiroplasma citri
O25242         1 MKISVSKNDLENALRYLQAFLDKKDASSIASHIHLEVIKEK--LFLKASDSDIGLKSYIf-------TQSSDKEGVGTIN 71  Helicobacter py...
WP_002657061   5 TFFICETNQIMNEIEKAKGIILNRNMNDIWSALLIEVKKSN--LIIKSTDRNIFFESTIs--------IVSETDFKVLIN 74  Lyme disease sp...
P72856         1 MKLICRQSDLSSGLSLVSRAVSSRPTHPVLGNVLLEADADKnyLRLTAFDLSLGIQSSF--------TADVQQSGRITLP 72  Synechocystis s...

4TR6_A        81 ARFFSEIVKKLP---MATVEIEVQNQY------LtIIRSGKAE--FNLNGLDADEYPHLPQIEE----HHAIQIPTDLLK 145 Bacillus subtil...
P05649        79 ARFFSEIVKKLP---MATVEIEVQNQYl-----T-IIRSGKAE--FNLNGLDADEYPHLPQIEE----HHAIQIPTDLLK 143 Bacillus subtil...
P43744        72 AKKFLDICRTLSd--DSEITVTFEQDR------A-LVQSGRSR--FTLATQPAEEYPNLTDWQS----EVDFELPQNTLR 136 Haemophilus inf...
P29439        72 GRKILNICRTLSe--KSKIKMQLKNKK------M-YISSENSN--YILSTLSADTFPNHQNFDY----ISKFDISSNILK 136 Buchnera aphidi...
P46387        83 GRLLSDITRALP---NKPVHFYVDGNR------V-ALTCGSAR--FSLPTMAVEDYPTLPTLP-----DETGTLPSDVFA 145 Mycobacterium l...
O83048        71 CDKLVNVVSALP---TKEIELTLCEEQ------L-VITPPNKKisFQLRTLSHESFPCFPQNEG----GVSLAVPTSDLR 136 Treponema palli...
P34029        74 NKFIVEVIRKIE---DEFITLEVVEGN--------LIKIKANNfdSVLNTLNSADYPHLSFETE----GKEIIFTSTVLK 138 Spiroplasma citri
O25242        72 GKKFLDIISCLK---DSNIILETKDDS------L-AIKQNKSS--FKLPMFDADEFPEFPVIDP----KVSIEVNAPFLV 135 Helicobacter py...
WP_002657061  75 ASNFYDAVKAFSfykKIKIVFNENNSKleimgeL-NDEKEEYEdhLKEPTFSYEEIENYNYDMVnedyTFGIEIKQKSFK 153 Lyme disease sp...
P72856        73 AKLLNDIVSRLPd-gDITLAIDPDGDAgds-hlT-TITSESGR--FQIRGLDADDFPALPTVEG----VKPLLLPVATLN 143 Synechocystis s...

4TR6_A       146 NLIRQTVFAVSTSETRPILTGVNWK--VEQsELLCTATDSHRLALRKAK-----------LDIPEDRSYNVVIPGKSLTE 212 Bacillus subtil...
P05649       144 NLIRQTVFAVSTSETRPILTGVNWKv-EQS-ELLCTATDSHRLALRKAK-----------LDIPEDRSYNVVIPGKSLTE 210 Bacillus subtil...
P43744       137 RLIEATQFSMANQDARYFLNGMKFe--TEGnLLRTVATDGHRLAVCTIS-----------LEQELQN-HSVILPRKGVLE 202 Haemophilus inf...
P29439       137 EMIEKTEFSMGKQDVRYYLNGMLLe--KKDkFLRSVATDGYRLAIS-YT-----------QLKKDINFFSIIIPNKAVME 202 Buchnera aphidi...
P46387       146 EAIGQVAIAAGRDYTLPMLTGIRIE--ISGdTVVLAATDRFRLAVRELKw----------SVLSSDFEASVLVPAKTLVE 213 Mycobacterium l...
O83048       137 NMINHTVFAVSEDSTRHFINGVHVD--FQYgNIICVSTDGKRLAYIEKK-----------GESSPQSFSGVIVPTKILGI 203 Treponema palli...
P34029       139 EIISQTSFAIGEKEKRIVFNGLNIKtdQNNkELIITATDSFRLSCKKID-------------YSNNYNFDVIIPGKFINE 205 Spiroplasma citri
O25242       136 DAFKKIAPVIEQTSHKRELAGILMQfdQKHqTLSVVGTDTKRLSYTQLEk---------iSIHSTEEDISCILPKRALLE 206 Helicobacter py...
WP_002657061 154 KVINRIAFSAHLDESKNVLNGVYFSk-DEDsKLLLVSTNGHRMSICKT-------------EVIVEEDVNFIVPVKIFNF 219 Lyme disease sp...
P72856       144 EGLRGALFAASTDETKQVLTGVHIK--GSGdSLEFAATDGHRLAVVEAPtqiendegeavITGSDLADFAVTIPARALRE 221 Synechocystis s...

4TR6_A       213 LSKILDDNQELVDIVIt-------ETQVLFKAKNVLFFSRLLDGNYPDTTSLIPQDSKTEIIVNTKEFLQAIDRASLLAR 285 Bacillus subtil...
P05649       211 LSKILDDNQELVDIVIt-------ETQVLFKAKNVLFFSRLLDGNYPDTTSLIPQDSKTEIIVNTKEFLQAIDRASLLAR 283 Bacillus subtil...
P43744       203 LVRLLETNDEPAR-LQi------gTNNLRVHLKNTVFTSKLIDGRFPDYRRVLPRNATKIVEGNWEMLKQAFARASILSN 275 Haemophilus inf...
P29439       203 LLKLLNTQPQLLN-ILi------gSNSIRIYTKNLIFTTQLIEGEYPDYKSVLFKEKKNPIITNSILLKKSLLRVAILAH 275 Buchnera aphidi...
P46387       214 VAKAGTD-GSGVCLSLgagvgvgkDGLFGISGGGKRSTTRLLDAEFPKFRQLLPAEHTAVATIDVAELTEAIKLVALVAD 292 Mycobacterium l...
O83048       204 VNRKLTPEGSVTLCIT--------SQHVYFFFGGYKFSSVLIEGQFPNYKRVIPDHQERSFCVGRVELMEALKRVSLLVE 275 Treponema palli...
P34029       206 IGRLISEn----------------DQVSELLLIIINCKQKIIEGKYPDTSKVIRTSFNTSLTINNRAIIKIIERRSVLSN 269 Spiroplasma citri
O25242       207 ILKLFYEN-FSFKSd---------GMLAVIENEMHTFFTKLIDGNYPDYQKILPKEYISSFTLGKEEFKESIKLCSSLSS 276 Helicobacter py...
WP_002657061 220 LKHLMSGEGMVKIKFS--------DKKFYVEFDNYKIACSLINGNYPDYKSIIPKEQKNKSLVSLGILKDRLARVNLYVD 291 Lyme disease sp...
P72856       222 LERMVASQGNSDLVSLvv-----nDTQVIFELGDQRLTSRKLEGAYPAYDQLIPRQFSRTVTMERKRLITSLERVSVLAD 296 Synechocystis s...

4TR6_A       286 EGRNNVVKLSAKPaESIEISSNSPE--IGKVVEAIVADqIEGE-ELNISFSPKYMLDALKVLEGAEIRVSFTGAMRPFLI 362 Bacillus subtil...
P05649       284 EGRNNVVKLSAKPaESIEISSNSPE--IGKVVEAIVADqIEGE-ELNISFSPKYMLDALKVLEGAEIRVSFTGAMRPFLI 360 Bacillus subtil...
P43744       276 ERARSVRLSLKEN--QLKITASNTE--HEEAEEIVDVN-YNGE-ELEVGFNVTYILDVLNALKCNQVRMCLTDAFSSCLI 349 Haemophilus inf...
P29439       276 EKFCGIEIKIENG--KFKVLSDNQE--EETAEDLFEID-YFGE-KIEISINVYYLLDVINNIKSENIALFLNKSKSSIQI 349 Buchnera aphidi...
P46387       293 R-GAQVRMEFGDG--ILRLSAGADD--VGRAEEDLAVA-FTGE-PLTIAFNPNYLTDGLASVHSERVSFGFTTPSKPALL 365 Mycobacterium l...
O83048       276 QKSHRIFITIQQGlLTLSSKAHTQEneIGDAQEEIACA-YTGE-SEVIALNYLYLEEPLKVFTSKEVQVEFTDPAKALTL 353 Treponema palli...
P34029       270 ETMTTIVTLKIKE-QKVLVTSFTQE--IGNTEEEIRDFkVEGT-DQIIAFNSKYILDALKAFKTKEITIKMIDERKPLII 345 Spiroplasma citri
O25242       277 T---IKLTLEKNN--ALFESLDSEHseTAKTSVEIEKG-LDIEkAFHLGVNAKFFLEALNALGTTQFVLRCNEPSSPFLI 350 Helicobacter py...
WP_002657061 292 KSRKLVLTFSELQlKLLGEDLITGR--KGEFFIKDPNYlYDGA-DEVMAINISYFVEAISVFETSKIEIQFNSGNVLKLS 368 Lyme disease sp...
P72856       297 QKNNLVTFTLQSPgNQLQLAVEAQD--LGHGEESMGAE-IIGE-GGQIAFNIKYLMDGLKALPSNDIQMQLNEGNQPVIF 372 Synechocystis s...

4TR6_A       363 RTPNDET---------------IVQLILPVRT 379 Bacillus subtilis subsp. subtilis str. 168
P05649       361 RTPNDET---------------IVQLILPVRT 377 Bacillus subtilis subsp. subtilis str. 168
P43744       350 ENCEDSS---------------CEYVIMPMRL 366 Haemophilus influenzae Rd KW20
P29439       350 EAENNSS---------------NAYVVMLLKR 366 Buchnera aphidicola str. Sg (Schizaphis graminum)
P46387       366 RPTSNDDvhpthdgpfpalptdYVYLLMPVRL 397 Mycobacterium leprae TN
O83048       354 RAVPNTD---------------CFHIIMPMQT 370 Treponema pallidum subsp. pallidum str. Nichols
P34029       346 TANDDQT---------------LQQLVLPIRS 362 Spiroplasma citri
O25242       351 QESLDEKqshl--------nakISTLMMPITL 374 Helicobacter pylori 26695
WP_002657061 369 EPENFNF----------------THLIMPMSL 384 Lyme disease spirochete
P72856       373 TPLGGLK---------------MTYLVMPVRL 389 Synechocystis sp. PCC 6803 substr. Kazusa
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