1A1S,1VLV,1AKM


Conserved Protein Domain Family
orni_carb_tr

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TIGR00658: orni_carb_tr 
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ornithine carbamoyltransferase
This family of ornithine carbamoyltransferases (OTCase) is in a superfamily with the related enzyme aspartate carbamoyltransferase. Most known examples are anabolic, playing a role in arginine biosynthesis, but some are catabolic. Most OTCases are homotrimers, but the homotrimers are organized into dodecamers built from four trimers in at least two species; the catabolic OTCase of Pseudomonas aeruginosa is allosterically regulated, while OTCase of the extreme thermophile Pyrococcus furiosus shows both allostery and thermophily. [Amino acid biosynthesis, Glutamate family]
Statistics
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PSSM-Id: 129743
View PSSM: TIGR00658
Aligned: 12 rows
Threshold Bit Score: 496.104
Threshold Setting Gi: 929866
Created: 7-Oct-2014
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1A1S_A         7 RDLLCLQDYTAEEIWTILETAKMFKIWQKIGKP------HRLLEGKTLAMIFQKPSTRTRVSFEVAMAHLGGHALYLNAQ 80  Pyrococcus furi...
P96108         8 RSLLTLLDFSPEEIRYLLDISKQVKMENRSKLR------TERFKGMTLAMIFEKRSTRTRLAFETAFAEEGGHPIFLSPN 81  Thermotoga mari...
O27495         2 KHLLSVCDMD--NVVDLLDLADDYKEGKIR---------EKILRGKTLAMIFEKSSTRTRVSFEVGAFQMGAQPLYLSAS 70  Methanothermoba...
O58457         8 RDLLCLQDYTPEEIWTILETAKMFKIWQKIGKP------HRLLEGKTLAMIFQKPSTRTRVSFEVAMAHLGGHALYLNAQ 81  Pyrococcus hori...
O29013         2 KHLLSMADLEKDELFEILKLAEKLKEERYKGVV------TDYLKNKSLAMIFELPSTRTRVSFEVAMTDLGGHALYLGWD 75  Archaeoglobus f...
Q58291         1 MHLLDLDVLSREDVLKIIEYGIYFKKNRRK--H------EKILEGKSVAILFEKPSTRTRMSFDIAVYELGGHPLIMNQN 72  Methanocaldococ...
Q55497         9 RDLLAIADLTIEEMKSLLQLAADLKSGVLKP--------H---CRKILGLLFYKASTRTRVSFTAAMYQLGGQVLDLNPS 77  Synechocystis s...
CAA58480     114 RHLISIKDLSDEEFRILVQRAQHFKNVFKANKTndfqsnHLKLLGRTIALIFTKRSTRTRISTEGAATFFGAQPMFLGKE 193 baker's yeast
P44770         8 RHLLSLVHHTEREIKYLLDLSRDLKRAKYAGTE------QQKLKGKNIALIFEKTSTRTRCAFEVAAYDQGAQVTYIDPN 81  Haemophilus inf...
1VLV_A        20 RSLLTLLDFSPEEIRYLLDISKQVKMENRSKLR------TERFKGMTLAMIFEKRSTRTRLAFETAFAEEGGHPIFLSPN 93  Thermotoga mari...
WP_010881110   3 RDFVDLWDLSPKEAWEIVKKTLKVKKGEEE--L------GKPLSGKTIALLFTKPSTRTRVSFEVGIYQLGGNSLFFQEK 74  Aquifex aeolicus
1AKM_A         6 KHFLKLLDFTPAELNSLLQLAAKLKADKKSGKE------EAKLTGKNIALIFEKDSTRTRCSFEVAAYDQGARVTYLGPS 79  Escherichia coli
1A1S_A        81 DLQLRRGETIADTARVLSRYVDAIMARVYDHKDVEDLAKYATVPVINGLSDFSHPCQALADYMTIWEKKG-T--IKGV-- 155 Pyrococcus furi...
P96108        82 DIHLGAKESLEDTARVLGRMVDAIMFRGYKQETVEKLAEYSGVPVYNGLTDEFHPTQALADLMTIEENFG-R--LKGV-- 156 Thermotoga mari...
O27495        71 DLQLGRGEPIADTARTLSRYVDGIMIRAISHSDVVELAGEASVPVINGLTDLEHPCQALADMQTIREKLG-G--FDG--- 144 Methanothermoba...
O58457        82 DLQLRRGETIADTARVLSRYVDAIMARVYAHKDVEDLAKYASVPVINGLSDFSHPCQALADYMTIWEKKG-T--IKGV-- 156 Pyrococcus hori...
O29013        76 ELQLGRGEPIKDTARVLSRYVHAVMMRVREHSTIEEFARYSTVPVINGLSNLEHPCQVIADLLTIYEYRG-D--FKDV-- 150 Archaeoglobus f...
Q58291        73 EIHLGKKESIKDTAKVMGRYVDTIVARVYKHRHLEEMAKYSSVPVINALSDLAHPCQILADLMTIKEYKG-K--FKGL-- 147 Methanocaldococ...
Q55497        78 VTQVGRGEPIQDTARVLDRYIDILAVRTFKQTDLQTFADHAKMPIINALSDLEHPCQILADLQTIKECFG-K--LEGL-- 152 Synechocystis s...
CAA58480     194 DIQLGVNESFYDTTKVVSSMVSCIFARVNKHEDILAFCKDSSVPIINSLCDKFHPLQAICDLLTIIENFNiS--LDEVnk 271 baker's yeast
P44770        82 SSQIGHKESMKDTARVLGRMYDGIEYRGFKQSIVQELADYAGVPVFNGLTDEFHPTQMLADVLTMIEHCDkP--LSEI-- 157 Haemophilus inf...
1VLV_A        94 DIHLGAKESLEDTARVLGRMVDAIMFRGYKQETVEKLAEYSGVPVYNGLTDEFHPTQALADLMTIEENFG-R--LKGV-- 168 Thermotoga mari...
WP_010881110  75 ELQVSRGEDVRDTARTLSKYVDGVIVRNHSHTWLKEFANFASVPVINALTNMSHPCQILSDVFTLYEHYGeE--LKNL-- 150 Aquifex aeolicus
1AKM_A        80 GSQIGHKESIKDTARVLGRMYDGIQYRGYGQEIVETLAEYASVPVWNGLTNEFHPTQLLADLLTMQEHLP-GkaFNEM-- 156 Escherichia coli
1A1S_A       156 ------KVVYVGDG-NNVAHSLMIAGTKLGADVVVATPEGYEPDEKVIKWAEQNAAESG-GSFELLHDPVKAVKDADVIY 227 Pyrococcus furi...
P96108       157 ------KVVFMGDTrNNVATSLMIACAKMGMNFVACGPEELKPRSDVFKRCQEIVKETD-GSVSFTSNLEEALAGADVVY 229 Thermotoga mari...
O27495       145 ------RLVFVGDG-NNVCHSLLLITATLGMDMDVACPPGYEPDPGIREMAGKIADETG-SRIRVIHDPSEAVRGADVVY 216 Methanothermoba...
O58457       157 ------KVVYVGDG-NNVCHSLMIAGTKLGADVVVATPEGYEPDKKVIKWAEQNAAESG-GSFELLHDPVKAVKDADVIY 228 Pyrococcus hori...
O29013       151 ------TLAWVGDG-NNVCNSMILAAALTGMKMVISTPENYDPNPEIVKKA----EEMG-AKLRFVRDPKEAVKEADVIY 218 Archaeoglobus f...
Q58291       148 ------KIAYLGDG-NNVCNSLILGSALVGMDTYVGTPKGYEPNAKVVLKAKEIINNYGeGSLTLTNDPIEAAEDADVLY 220 Methanocaldococ...
Q55497       153 ------TVTYLGDG-NNVAHSLILGGVMMGMTVRVATPKNYEPLAEIVQQAQQ-IAAPG-GKVELTDDPKAAAQGSHILY 223 Synechocystis s...
CAA58480     272 ginsklKMAWIGDA-NNVINDMCIACLKFGISVSISTPPGIEMDSDIVDEAKKVAERNG-ATFELTHDSLKASTNANILV 349 baker's yeast
P44770       158 ------SYVYIGDArNNMGNSLLLIGAKLGMDVRICGPKALLPEANLVEMCEKFAKESG-ARITVTEDIDKAVKGVDFIH 230 Haemophilus inf...
1VLV_A       169 ------KVVFMGDTrNNVATSLMIACAKMGMNFVACGPEELKPRSDVFKRCQEIVKETD-GSVSFTSNLEEALAGADVVY 241 Thermotoga mari...
WP_010881110 151 ------KVAYVGDG-NNVCNTLMVGAGMFGLKLFVATPEGYEPNSYYYKKALEFSKENG-GSVELTNNPVESVKDADVVY 222 Aquifex aeolicus
1AKM_A       157 ------TLVYAGDArNNMGNSMLEAAALTGLDLRLVAPQACWPEAALVTECRALAQQNG-GNITLTEDVAKGVEGADFIY 229 Escherichia coli
1A1S_A       228 TDVWASMGQ-EAEAEERRKIFRPFQVNKDLVKHA-KPDYMFMHCLPAHR-------------------GEEVTDDVIDSP 286 Pyrococcus furi...
P96108       230 TDVWASMGE-EDKEKERMALLKPYQVNERVMEMTgKSETIFMHCLPAVK-------------------GQEVTYEVIEGK 289 Thermotoga mari...
O27495       217 TDVWVSMGY-EDEAEDRLEVFRPYQVNMELMELA-APEAIFMHCLPAVR-------------------GQETTAEVIDGP 275 Methanothermoba...
O58457       229 TDVWASMGQ-EAEAEERRKIFRPFQVNKDLVKHA-KSDYMFMHCLPAHR-------------------GEEVTDDVIDSP 287 Pyrococcus hori...
O29013       219 TDVWTSMGQ-EAEKEARLKAFQPYQVSDELLKFS-KDDVVVMHCLPAHR-------------------GEEITDEVMEGK 277 Archaeoglobus f...
Q58291       221 TDVWISMGD-DKDKEEVLKIFPPFQINSKLLEYA-KDDVIVMHCLPANR-------------------GYEITDDVIDGE 279 Methanocaldococ...
Q55497       224 TDVWASMGQ-EDLADSRIPIFQPYQINQELLALA-DPEAIVLHCLPAHR-------------------GEEITDAVMEGP 282 Synechocystis s...
CAA58480     350 TDTFVSMGE-EFAKQAKLKQFKGFQINQELVSVA-DPNYKFMHCLPRHQ--------------------EEVSDDVFYGE 407 baker's yeast
P44770       231 TDVWVSMGEpLETWGERIKLLLPYQVTPELMKRTgNPKVKFMHCLPAFHnsetkvgrqiaekypelanGIEVTEEVFESP 310 Haemophilus inf...
1VLV_A       242 TDVWASMGE-EDKEKERMALLKPYQVNERVMEMTgKSETIFMHCLPAVK-------------------GQEVTYEVIEGK 301 Thermotoga mari...
WP_010881110 223 TDVWVSMGE-ENKN---IEAFLPYQVNEKLLSFA-KSSVKVMHCLPAKK-------------------GQEITEEVFEKN 278 Aquifex aeolicus
1AKM_A       230 TDVWVSMGEaKEKWAERIALLREYQVNSKMMQLTgNPEVKFLHCLPAFHddqttlgkk-maeefglhgGMEVTDEVFESA 308 Escherichia coli
1A1S_A       287 NSVVWDQAENRLHAQKAVLALVMG 310 Pyrococcus furiosus
P96108       290 QSRVWDEAENRKHTIKAVMIATLL 313 Thermotoga maritima MSB8
O27495       276 HSVVWDQAENRLHAQKAIMHWLMG 299 Methanothermobacter thermautotrophicus str. Delta H
O58457       288 NSVVWDEAENRLHAQKAVLALLLG 311 Pyrococcus horikoshii OT3
O29013       278 HSIVFDQAENRLHAQKAILLKLLG 301 Archaeoglobus fulgidus DSM 4304
Q58291       280 HSVVYDEAENRLHVQKGVFKFIFE 303 Methanocaldococcus jannaschii DSM 2661
Q55497       283 QSRLWDQAENRMHAQKALMVALLG 306 Synechocystis sp. PCC 6803 substr. Kazusa
CAA58480     408 HSIVFEEAENRLYAAMSAIDIFVN 431 baker's yeast
P44770       311 MNIAFEQAENRMHTIKAVMVASLA 334 Haemophilus influenzae Rd KW20
1VLV_A       302 QSRVWDEAENRKHTIKAVMIATLl 325 Thermotoga maritima
WP_010881110 279 ADFIFTQAENRLHTQKTLMEFLFR 302 Aquifex aeolicus
1AKM_A       309 ASIVFDQAENRMHTIKAVMVATLS 332 Escherichia coli
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