3W2X,4LND,1AKO,2VOA


Conserved Protein Domain Family
xth
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TIGR00633: xth 
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exodeoxyribonuclease III (xth)
All proteins in this family for which functions are known are 5' AP endonucleases that funciton in base excision repair and the repair of abasic sites in DNA.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]
Links
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Statistics
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PSSM-Id: 273186
Aligned: 22 rows
Threshold Bit Score: 325.388
Created: 7-Oct-2014
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
3W2X_A         7 LKIISWNVNGLRAVHRKGf---------LKWFMEEKPDILCLQEIKAAP-EQLPRKLR----HVEGYRSFFTPAEr---k 69  Methanothermoba...
BAA19649       1 MKIMSFNINGLRARPHQL----------EEIINKYQPDVLGLQEIKVSD-EVFPYDLV----DHLGYHVNHFGQK----- 60  Aggregatibacter...
P44318         1 MKFISFNINGLRARPHQL----------EAIIEKYQPDVIGLQEIKVAD-EAFPYEIT----ENLGYHVFHHGQK----- 60  Haemophilus inf...
AAB49625       1 MKFISFNINGLRARPHQL----------EAIINKHQPDVIGLQEIKVAD-EDFPHQLV----EHLGYHVFYHGQK----- 60  Haemophilus duc...
CAA20072       1 MRIATWNVNSITARLPRL----------LAWLESSGTDVLCLQEAKVAE-AQFPFDAL----REAGYEAAVHATG----- 60  Streptomyces co...
P21998         1 MKLISWNIDSLNAALTSDsaraklsqevLQTLVAENADIIAIQETKLSAkGPTKKHVEileeLFPGYENTWRSSQepark 80  Streptococcus p...
WP_014407127   1 MDIASWNVNSVRSRQQHI----------LDWLGTNPVDVLCLQETKVVD-EDFPRQPF----EEAGYHCHISGQK----- 60  Synechocystis s...
WP_003900926   6 LRLATWNVNSIRTRLDRV----------LDWLGRADVDVLAMQETKCPD-GQFPALPL----FELGYDVAHVGFD----- 65  Mycobacterium t...
P09030         1 MKFVSFNINGLRARPHQL----------EAIVEKHQPDVIGLQETKVHD-DMFPLEEV----AKLGYNVFYHGQK----- 60  Escherichia col...
1AKO_A         1 MKFVSFNINGLRARPHQL----------EAIVEKHQPDVIGLQETKVHD-DMFPLEEV----AKLGYNVFYHGQK----- 60  Escherichia col...

3W2X_A        70 GYSGVAMYTK--VPPSSLREGFGV-------ERFDTEGR---------IQIADF----DDFLLYNIYFPNGK-MSEE-RL 125 Methanothermoba...
BAA19649      61 GHYGVALLSK--QVPLSVRKGFPT-------DDEEAQKRii-----miDLETKF----GQLTVINGYFPQGEsREHPtKF 122 Aggregatibacter...
P44318        61 GHYGVALLTK--QEPKVIRRGFPT-------DNEDAQKRii-----maDLETEF----GLLTVINGYFPQGEsRAHEtKF 122 Haemophilus inf...
AAB49625      61 GHYGVALLTK--KQPLTIRKGFPN-------DTADAQKRmi-----maEINTDF----GILTVLNGYFPQGEnRQHEtKF 122 Haemophilus duc...
CAA20072      61 RWNGVAVLSR--VGLEDVVKGLPG-------DPGYEGvqe------prAISATC----GPVRVWSVYVPNGReVDHP-HY 120 Streptomyces co...
P21998        81 GYAGTMFLYKkeLTPTISFPEIGAp------STMDLEGR---------IITLEF----DAFFVTQVYTPNAG-DGLK-RL 139 Streptococcus p...
WP_014407127  61 SYNGVAIFSR--EPLQDVKIGFAAlvepaltGDLDEQKR---------VISGVY----DGVRIVNLYVPNGSaLDSE-KY 124 Synechocystis s...
WP_003900926  66 QWNGVAIASR--VGLDDVRVGFDG-------QPSWSGKPevaattearALGATC----GGIRVWSLYVPNGRaLDDP-HY 131 Mycobacterium t...
P09030        61 GHYGVALLTK--ETPIAVRRGFPG-------DDEEAQRRii-----maEIPSLL----GNVTVINGYFPQGEsRDHPiKF 122 Escherichia col...
1AKO_A        61 GHYGVALLTK--ETPIAVRRGFPG-------DDEEAQRR---------IIMAEIpsllGNVTVINGYFPQGEsRDHPiKF 122 Escherichia col...

3W2X_A       126 KYKLeFYDAFLEDVNRERDS--GRNVIICGDFNTAHREIDLARPKEN------S------NVSGFLPVERAWIDK-FIEN 190 Methanothermoba...
BAA19649     123 PAKQkFYADLQRYLEQDHNA--QNPVIIMGDMNISPSDLDIGIGEENrkrwlrT------GKCSFLPEEREWYQRlYAYG 194 Aggregatibacter...
P44318       123 PAKEkFYADLQQYLEKEHDK--SNPILIMGDMNISPSDLDIGIGDENrkrwlrT------GKCSFLPEERAWYQRlYDYG 194 Haemophilus inf...
AAB49625     123 PAKAkFYADLQHYLETALTA--YNPIIIMGDMNICSTDLDIGIGEANrkrwlrE------GKCSFLPEEREWLDRlYHYG 194 Haemophilus duc...
CAA20072     121 AYKLqWFEALRAAVEGDAAG--GRPFAVLGDYNVAPTDDDVYDra------afE------GATHVTPAERAALASlRGAG 186 Streptomyces co...
P21998       140 EERQ-VWDAKYAEYLAELDK--EKPVLATGDYNVAHNEIDLANPASN------R------RSPGFTDEERAGFTNlLATG 204 Streptococcus p...
WP_014407127 125 LYKL-RWLNLLQTYLEQLRRsdTPEFLVCGDFNIAPEDRDIHDPVGR------E------NHIMATAMEREALTEvLAIA 191 Synechocystis s...
WP_003900926 132 TYKLdWLAALRDTAEGWLRDdpAAPIALMGDWNIAPTDDDVWSte------ffA------GCTHVSEPERKAFNAiVDAQ 199 Mycobacterium t...
P09030       123 PAKAqFYQNLQNYLETELKR--DNPVLIMGDMNISPTDLDIGIGEENrkrwlrT------GKCSFLPEEREWMDRlMSWG 194 Escherichia col...
1AKO_A       123 PAKAqFYQNLQNYLETELKR--DNPVLIMGDMNISPTDLDIGIGEEN------RkrwlrtGKCSFLPEEREWMDRlMSWG 194 Escherichia col...

3W2X_A       191 gYVDTFRMFNSDPG-QYTWWSYRT-RARERNVGWRLDYFFVNEEFKGKV-KRSWILSDVMG----SDHCPIGLEIE 259 Methanothermobacter...
BAA19649     195 -LEDTFRHMNPTVNdKFSWFDYRS-KGFDDNRGLRIDHILANKALVAHC-VDTGIALDIRAmnkpSDHAPIWAEFK 267 Aggregatibacter act...
P44318       195 -LEDSFRKLNPTANdKFSWFDYRS-KGFDDNRGLRIDHILVSQKLAERC-VDVGIALDIRAmekpSDHAPIWAEFK 267 Haemophilus influen...
AAB49625     195 -LVDTFRAMHPTTTdQFSWFDYRS-KGFNDNRGLRIDLILASTTLANHC-VETGIDLEIRAmekpSDHAPIWAVFK 267 Haemophilus ducreyi
CAA20072     187 -LSDVVPRPLKYDh-PFTYWDYRQ-LCFPKNRGMRIDLVYGNEPFAKAV-TDSYVDREERKgkgaSDHAPVVVDLD 258 Streptomyces coelic...
P21998       205 -FTDTFRHVHGDVPeRYTWWAQRSkTSKINNTGWRIDYWLTSNRIADKVtKSDMIDSGARQ-----DHTPIVLEID 274 Streptococcus pneum...
WP_014407127 192 nLQDAFRKFTEETG-HYSWWDYRT-RGFSRNRGWRIDHHYLTPQLYDQA-QKCWIDREPRGwekpSDHAPVVVTIN 264 Synechocystis sp. P...
WP_003900926 200 -FTDVVRPFTPGPg-VYTYWDYTQ-LRFPKKQGMRIDFILGSPALAARV-MDAQIVREERKgkapSDHAPVLVDLH 271 Mycobacterium tuber...
P09030       195 -LVDTFRHANPQTAdRFSWFDYRS-KGFDDNRGLRIDLLLASQPLAECC-VETGIDYEIRSmekpSDHAPVWATFR 267 Escherichia coli K-12
1AKO_A       195 -LVDTFRHANPQTAdRFSWFDYRS-KGFDDNRGLRIDLLLASQPLAECC-VETGIDYEIRSmekpSDHAPVWATFR 267 Escherichia coli K-12
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