3NOY


Conserved Protein Domain Family
ispG_gcpE
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TIGR00612: ispG_gcpE 
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1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase
This protein of previously unknown biochemical function has now been identified as an enzyme of the non-mevalonate pathway of IPP biosynthesis. Chlamydial members of the family have a long insert. The family is largely restricted to Bacteria, where it is widely but not universally distributed. No homology can be detected between the GcpE family and other proteins. [Biosynthesis of cofactors, prosthetic groups, and carriers, Other]
Links
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Statistics
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PSSM-Id: 273174
Aligned: 7 rows
Threshold Bit Score: 401.802
Created: 7-Oct-2014
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
3NOY_A  13 KRKTRQIRVG------NVKIGGDAPIVVQSMTSTKTH--DVEATLNQIKRLYEAGCEIVRVAVPHKEDVEALEEIVK--- 81  Aquifex aeolicus
P73672  20 RRKTRPVPVG------AVTVGGGHPVVVQSMINEDTL--DVDGSVAGIRRLHEIGCEIVRVTVPSMAHAKALADIKQklq 91  Synechocystis sp. PCC...
Q9A9W0  16 RRQSRKIRVG------SVEVGGDAPISVQSMTNTLTS--DAAATLEQIRQLEEAGADIVRVSCPDVESTAAFKTIAR--- 84  Caulobacter crescentu...
O67496   4 KRKTRQIRVG------NVKIGGDAPIVVQSMTSTKTH--DVEATLNQIKRLYEAGCEIVRVAVPHKEDVEALEEIVK--- 72  Aquifex aeolicus VF5
Q98FG0  11 RRTSVGVDVGg------VAVGGGAPVVVQSMTNTDTA--DIDQTVAQVAALHRAGSEIVRITVDRDESAAAVPRIHErlq 82  Mesorhizobium loti MA...
O83460  31 HYRARSLVIGgkehvrALPLGGDAPIPIQTMWKEPLIgaDLQSIVDRLLELEQLGCDVVRFAVPDRESAELFVALCA--- 107 Treponema pallidum su...
Q9Z8H0  12 RRKTHTVRIG------NLYIGSDHSIKTQSMTTTLTT--DIDSTVEQIYALAEHNCDIVRVTVQGIKEAQACEKIKErli 83  Chlamydia pneumoniae

3NOY_A  82 --KSPMPVIADIHFa---PSYAFLSMEKGVHGIRINPGNIGK-----------------------EEIVREIVEEAKRRG 133 Aquifex aeolicus
P73672  92 atYQAVPLVADVHHn---GMKIALEVAKHVDKVRINPGLYVFekpdaqregys-dqefaeigekiRETLEPLVISLRDQG 167 Synechocystis sp. PCC...
Q9A9W0  85 --EAKVPLVADIHFh---YKRGIEAAQAGAACLRINPGNIGS-----------------------PDRVRDVIQAARDHG 136 Caulobacter crescentu...
O67496  73 --KSPMPVIADIHFa---PSYAFLSMEKGVHGIRINPGNIGK-----------------------EEIVREIVEEAKRRG 124 Aquifex aeolicus VF5
Q98FG0  83 rlGINVPLVGDFHYighkLLADHPACAEALAKYRINPGNVGFkd-------------------kkDRQFTDIVEMAIKHD 143 Mesorhizobium loti MA...
O83460 108 --RTRMPLVADIHFd---YRLALRCMDGPVAKVRINPGNIGv-----------------------RERVRAVVEKARATG 159 Treponema pallidum su...
Q9Z8H0  84 alGLNIPLVADIHF----FPQAAMLVADFADKVRINPGNYIDkrnmfkgtkiyteasyaqsllrlEEKFAPLVEKCKRLG 159 Chlamydia pneumoniae

3NOY_A 134 VAVRIGVNSGSLE----KDLLEKYGy------P---SAEALAESALRWSEKFEKWGFT--NYKVSIKGSDVLQNVRANLI 198 Aquifex aeolicus
P73672 168 KSMRIGVNHGSLS----ERMLFTYG-------D---TPEGMVQSALEFIKICESLDFR--NLVVSMKASRVPVMLAAYRL 231 Synechocystis sp. PCC...
Q9A9W0 137 CSMRIGVNAGSLE----RELLEKYGe------P---CPDAMVESALNHARILQDHDFH--EFKISVKASDPFMTVAAYYQ 201 Caulobacter crescentu...
O67496 125 VAVRIGVNSGSLE----KDLLEKYGy------P---SAEALAESALRWSEKFEKWGFT--NYKVSIKGSDVLQNVRANLI 189 Aquifex aeolicus VF5
Q98FG0 144 KPVRIGVNWGSLDqellTRLMDDNQdkgfpltAqevTREAIVQSAILSAEMAEEIGLGrdKIILSAKVSGVQDLIAVYTE 223 Mesorhizobium loti MA...
O83460 160 TALRIGVNTGSLPgvvkRAVAARYAdgmqsvnA---RAEALVQTAFAEAAYLDQLHFD--RVVLSLKASTVAETVRANEL 234 Treponema pallidum su...
Q9Z8H0 160 KAMRIGVNHGSLS----ERIMQKYG-------D---TIEGMVASAIEYIAVCEKLNYR--DVVFSMKSSNPKIMVTAYRQ 223 Chlamydia pneumoniae

3NOY_A 199 FAERTD-----VPLHIGITEAGMGTKGIIKSSVGIGILLYMGIGDTVRVSLTDDP----VVEVETA-------------- 255 Aquifex aeolicus
P73672 232 MVKRMDelgmdYPLHLGVTEAGDGEYGRIKSTAGIATLLADGIGDTIRVSLTEAP----EKEIPVC-------------- 293 Synechocystis sp. PCC...
Q9A9W0 202 LAEAID-----CPLHLGVTEAGATRTGTVKSAIGIGAMLWAGIGDTIRVSLAADP----VEEIKVG-------------- 258 Caulobacter crescentu...
O67496 190 FAERTD-----VPLHIGITEAGMGTKGIIKSSVGIGILLYMGIGDTVRVSLTDDP----VVEVETA-------------- 246 Aquifex aeolicus VF5
Q98FG0 224 LATRSD-----HALHLGLTEAGMGSKGIVASSAAMGILLQQGIGDTIRISLTPEPngdrTREVQVA-------------- 284 Mesorhizobium loti MA...
O83460 235 FAQQSD-----IPLHLGVTEAGPLVSGIVKSTLAFSQLLSRNIGATVRVSLSDSM----EHEVLAAr------------- 292 Treponema pallidum su...
Q9Z8H0 224 LAKDLDargwlYPLHLGVTEAGMGVDGIIKSAVGIGTLLAEGLGDTIRCSLTGCP----TTEIPVCdsllrhtkiyldlp 299 Chlamydia pneumoniae

3NOY_A     --------------------------------------------------------------------------------     Aquifex aeolicus
P73672     --------------------------------------------------------------------------------     Synechocystis sp. PCC...
Q9A9W0     --------------------------------------------------------------------------------     Caulobacter crescentu...
O67496     --------------------------------------------------------------------------------     Aquifex aeolicus VF5
Q98FG0     --------------------------------------------------------------------------------     Mesorhizobium loti MA...
O83460     --------------------------------------------------------------------------------     Treponema pallidum su...
Q9Z8H0 300 ekknpfslqhsenfvsaaekpakttlwgdvygvflklyphhltdftpeellehlgvnpvtkekafttpegvvvppelkda 379 Chlamydia pneumoniae

3NOY_A     --------------------------------------------------------------------------------     Aquifex aeolicus
P73672     --------------------------------------------------------------------------------     Synechocystis sp. PCC...
Q9A9W0     --------------------------------------------------------------------------------     Caulobacter crescentu...
O67496     --------------------------------------------------------------------------------     Aquifex aeolicus VF5
Q98FG0     --------------------------------------------------------------------------------     Mesorhizobium loti MA...
O83460     --------------------------------------------------------------------------------     Treponema pallidum su...
Q9Z8H0 380 pitdvlrehflvfhhhqvpclyehneeiwdspavhqapfvhfhasdpfihtsrdffekqghqgkptklvfsrdfdnkeea 459 Chlamydia pneumoniae

3NOY_A 256 ------------------------------------YEILKSLGLRRRGVEIVACPTCGRIEVDLPKVVKEVQEKLSGVK 299 Aquifex aeolicus
P73672 294 ------------------------------------YSILQALGLRKTMVEYVACPSCGRTLFNLEDVLHEVREATKHLT 337 Synechocystis sp. PCC...
Q9A9W0 259 ------------------------------------FDILKSLGLRHRGVNIIACPSCARQGFNVIKTVEALEERLAHIS 302 Caulobacter crescentu...
O67496 247 ------------------------------------YEILKSLGLRRRGVEIVACPTCGRIEVDLPKVVKEVQEKLSGVK 290 Aquifex aeolicus VF5
Q98FG0 285 ------------------------------------QELLQTMGFRQFVPIVAACPGCGRTTSTVFQELAQNIQADLRKN 328 Mesorhizobium loti MA...
O83460 293 -------------------------------------EILAECGKRAGGVRLVSCPRCGRIGFDVHAFVRRWQKELFSLK 335 Treponema pallidum su...
Q9Z8H0 460 aisiatefgallldglgeavvldlpnlplqdvlkiaFGTLQNAGVRLVKTEYISCPMCGRTLFDLEEVTTRIRKRTQHLP 539 Chlamydia pneumoniae

3NOY_A 300 Tp-----------LKVAVMGCVVNAIGEAREADIGLAC-GRGF---AWLFKHGKP-IKkVDESEMVDELLKEIQ 357 Aquifex aeolicus
P73672 338 G------------LDIAVMGCIVNGPGEMADADYGYVGkQAGY---IALYRGREEiKR-VPETDGVQELINLIK 395 Synechocystis sp. PCC 6803 ...
Q9A9W0 303 Tp-----------MSLSIIGCVVNGPGEALMTDIGFTGgGAGA---GMVYMAGKP-DHkQSNEGMIDHIVDLVE 361 Caulobacter crescentus CB15
O67496 291 Tp-----------LKVAVMGCVVNAIGEAREADIGLACg-RGF---AWLFKHGKP-IKkVDESEMVDELLKEIQ 348 Aquifex aeolicus VF5
Q98FG0 329 MpvwrekypgvenLKVAVMGCIVNGPGESKHADIGISLpGTGEtptAPVFVDGKK-AAtLRGTSIAADFEKMVT 401 Mesorhizobium loti MAFF303099
O83460 336 Kd-----------ITVAVMGCVVNGPGEGKHADLGISGa-EDS---VIFFKRGKIvRRiQVRDLCADERTRIID 394 Treponema pallidum subsp. p...
Q9Z8H0 540 G------------LKIAIMGCIVNGPGEMADADFGFVGsKTGM---IDLYVKHTCvKAhIPMEDAEEELIRLLQ 598 Chlamydia pneumoniae
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