1BGX


Conserved Protein Domain Family
pola
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TIGR00593: pola 
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DNA polymerase I
All proteins in this family for which functions are known are DNA polymerases Many also have an exonuclease motif. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]
Links
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Statistics
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PSSM-Id: 273160
Aligned: 13 rows
Threshold Bit Score: 1106.64
Created: 7-Oct-2014
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
1BGX_T        14 VLLVDGHHLAYRTFHAL-Kg-----LTTSRGEPVQAVYGFAKSLLKALKEDG--DAVIVVFDAKAPSFRHEAYGGYKAGR 85   Thermus aquaticus
P52028        14 VLLVDGHHLAYRTFFAL-Kg-----LTTSRGEPVQAVYGFAKSLLKALKEDGy-KAVFVVFDAKAPSFRHEAYEAYKAGR 86   Thermus thermo...
AAC36974      14 LVLIDGHALAFRSYFAL-Pp-----LNNSKGEMTDAIVGFMKLLLRLARQKS--NQVIVVFDPPVKTLRHEQYEGYKSGR 85   Deinococcus ra...
O32801         7 LLLIDGSSVAFRAFFAL-Ynql-drFKAPNGLHTNAIFAFHTMLSSLMERIQp-THVLIAFDAGKTTFRTEMFADYKGGR 83   Lactococcus la...
P46835        18 LMLLDGNSLAFRAFYAL-Pte---nFKTRGGLTTNAVYGFTAMLINLLREEAp-THIAAAFDVSRKTFRSECYAGYKANR 92   Mycobacterium ...
Q59156         3 LVIFDGNSILYRAFFAL-Pe-----LTTSNNIPTNAIYGFVNVILKYLEQEKp-DYVAVAFDKRGREARKSEYEEYKANR 75   Caldicellulosi...
O08307         6 LVLVDGHALAYRAFFAL-Res---gLRSSRGEPTYAVFGFAQILLTALAEYRp-DYAAVAFDVGR-TFRDDLYAEYKAGR 79   Chloroflexus a...
O51498         4 LYLIDALNIIFRNYHVM-Kny---pLLNTQGENVNAFIGFFKTLFFIIKEKNp-EHLIITFDSEVPTFRKQKYPSYKATR 78   Borrelia burgd...
Q55971        10 LLLVDGHSLAFRAYYAF-GlskkgpLRTTAGIPTSVCFGFLNSLMQVMESQKp-AAIAIAFDRREPTFRHEADGAYKSNR 87   Synechocystis ...
O05949         7 LLLIDGYGFVFRAYYAQ-Ks-----LSSAKGEPVGALYGFTSMLLKLLSDFKp-QYVAIVFDSGGKNFRHKIYQNYKANR 79   Rickettsia pro...
Q04957         5 LVLIDGSSVAYRAFFAL-Pl-----LHNDKGIHTNAVYGFTMMLNKILAEEEp-THMLVAFDAGKTTFRHEAFQEYKGGR 77   Bacillus caldo...
P74933         7 LYLLDAYGLIYRSYHAF-Ara---pLINDSGANVSAVYGFFRSLHTLLCHYRp-RYFVAVFDSLTPTFRHVQYPAYKAKR 81   Treponema pall...
WP_010875630  12 LALIDTFAYLFRSYYMSaKnk---pLTNDKGFPTGLLTGLVGMVKKFYKDRKnmPFIVFALESQTKTKRAEKLGEYKQNR 88   Helicobacter p...

1BGX_T        86 APTPEDFPRQLALIKELVDLLGLARLEVPGYEADDVLASLAKKAEKE--GYEVRILTADKDLYQLLSD--RIHVLHPeg- 160  Thermus aquaticus
P52028        87 APTPEDFPRQLALIKELVDLLGFTRLEVPGYEADDVLATLAKKAEKE--GYEVRILTADRDLYQLVSD--RVAVLHPeg- 161  Thermus thermo...
AAC36974      86 AQTPEDLRGQINRIRALVDALGFPRLEEPGYEADDVIASLTRMAEGK--GYEVRIVTSDRDAYQLLDE--HVKVIANdf- 160  Deinococcus ra...
O32801        84 SKTPDEFREQLPFIKEMIEKLGIRHYELANYEADDIIGTLDKMAEAPdvNFDVTIVTGDKDMIQLVDG--NTRVEISkkg 161  Lactococcus la...
P46835        93 SSIPAEFHGQIDITKEVLGALGITVFAEAGFEADDLIATLATQAENE--GYRVLVVTGDRDALQLVSN--DVTVLYPrkg 168  Mycobacterium ...
Q59156        76 KPMPDNLQVQIPYVREILYAFNIPIIEFEGYEADDVIGSLVNQFKNT--GLDIVIITGDRDTLQLLDK--NVVVKIVstk 151  Caldicellulosi...
O08307        80 AETPEEFYPQFERIKQLVQALNIPIYTAEGYEADDVIGTLARQATER--GVDTIILTGDSDVLQLVND--HVRVALAnpy 155  Chloroflexus a...
O51498        79 DLPPDDLIPQIGWIKEGLLKAKIPIFEMEGYEADDLLASFAKKAAKN--NYLTYIISPDKDLLQTMSE--YVKILKIenn 154  Borrelia burgd...
Q55971        88 QETPEDFAEDLSYLQQLLEALNLQTITYAGYEADDILGTLACQGSDA--GYQVKILSGDRDLFQLVSPekNISVLYLtrn 165  Synechocystis ...
O05949        80 PLPPKDLIAQLPLVRDVASNFKFAILEKNGYEADDIIATFATKTVSL--GEEVIIISSDKDLLQLMSK--NIKIYDPik- 154  Rickettsia pro...
Q04957        78 QQTPPELSEQFPLLRELLRAYRIPAYELENYEADDIIGTLAARAEQE--GFEVKVISGDRDLTQLASP--HVTVDITkkg 153  Bacillus caldo...
P74933        82 DKTSAELYAQIPLIEEILCALGITVLRHDGFEADDLIATLAKRVAAE--HCHVVIISSDKDVLQLVCD--TVQVLRLdid 157  Treponema pall...
WP_010875630  89 KDAPKEMLLQIPIALEWLQKMGFVCVEVNGFEADDVIASLATLSP-----YKTRIYSKDKDFNQLLSD--KIALFDGk-- 159  Helicobacter p...

1BGX_T       161 --------yLITPAWLWEKY-GLRPDQWADYRALTGDESDNLPGVKGIGEKTARKLLEEWGSLEALLK------------ 219  Thermus aquaticus
P52028       162 --------hLITPEWLWEKY-GLRPEQWVDFRALVGDPSDNLPGVKGIGEKTALKLLKEWGSLENLLK------------ 220  Thermus thermo...
AAC36974     161 --------sLIGPAQVEEKY-GVTVRQWVDYRALTGDASDNIPGAKGIGPKTAAKLLQEYGTLEKVYEa----------a 221  Deinococcus ra...
O32801       162 v----aefeEFTPDYLLEKM-GLTPSQFIDLKALMGDSSDNYPGVTKVGEKTGLKLLQEFGSLENLYE------------ 224  Lactococcus la...
P46835       169 v----seltRFTPEAVIEKY-GVTPAQYPDLAALRGDPSDNLPGIPGVGEKTAAKWIVDYGSLQGLVD------------ 231  Mycobacterium ...
Q59156       152 fd--ktvedLYTVENVKEKY-GVWANQVPDYKALVGDQSDNIPGVKGIGEKSAQKLLEEYSSLEEIYQ------------ 216  Caldicellulosi...
O08307       156 gg--ktsvtLYDLEQVRKRYdGLEPDQLADLRGLKGDTSDNIPGVRGIGEKGAIALLKQFRSLDALLE------------ 221  Chloroflexus a...
O51498       155 ------sfiEMDNEYVTKKF-GVNSFQIKDYLAIVGDRSDNIPGIKGIGAKGAANLLREFKTLDGIYS------------ 215  Borrelia burgd...
Q55971       166 pfssntgydELDWQGVVDKM-GVTPAQIVDFKALCGDKSDCIPGINGIGEKTAIKLLAEYETLEKVYE------------ 232  Synechocystis ...
O05949       155 -------ckYITEDNVVTKF-GTTPDKLREVMALIGDRSDNIPGVPSIGPKTASSLITKFGSVENIFN------------ 214  Rickettsia pro...
Q04957       154 i----tdiePYTPEAVREKY-GLTPEQIVDLKGLMGDKSDNIPGVPGIGEKTAVKLLRQFGTVENVLA------------ 216  Bacillus caldo...
P74933       158 h-----kwtCCDAAYVQQRW-TVMPTQLLDLFSLMGDSSDNVPGVRGIGPKTAAHLLHCFGTLDGIYRhtyslkealrtk 231  Treponema pall...
WP_010875630 160 --------tEFLAKDCVEKY-GILPSQFTDYQGIVGDSSDNYKGVKGIGSKNAKELLQRLGSLEKIYE------------ 218  Helicobacter p...

1BGX_T       220 NLD---RLKPA-IREKILAHMDDLKL---SWDLAKVRTDLPLEVDFa---KRREPDRERLRA-FLERLEFGSLLHEFGLL 288  Thermus aquaticus
P52028       221 NLD---RVKPEnVREKIKAHLEDLRL---SLELSRVRTDLPLEVDLa---QGREPDREGLRA-FLERLEFGSLLHEFGLL 290  Thermus thermo...
AAC36974     222 HAG---TLKPDgTRKKLLDSEENVKF---SHDLSCMVTDLPLDIEFg---VRRLPDNPLVTEdLLTELELHSLRPMILGL 292  Deinococcus ra...
O32801       225 NVE---TLKASkMKDNLIADKEMAFL---SQQLATINTKAPLEIGLed-tLLKEKNVAELGQ-FYDEMGFSQFKSKLLAD 296  Lactococcus la...
P46835       232 NVE---SVRGk-VGEALRTHLASVVR---NRELTELVKDVPLVQTSdt-lRLQPWDRDRIHR-LFDNLEFRVLRDRLFEA 302  Mycobacterium ...
Q59156       217 NLD---KIKSs-IREKLEAGKDMAFL---SKRLATIVCDLPLNVKLed-lRTKEWNKERLYE-ILVQLEFKSIIKRLGLS 287  Caldicellulosi...
O08307       222 QID---AAPKr-YQTLLREQAEAARF---SRQLATIVTDVPVQLDLea-aRIGVYDRSAVMA-LFQELEFGVSSNLIKKL 292  Chloroflexus a...
O51498       216 NLE---IINKk-HRELLIKEKENAFL---SYELVSLEENLKIPEIEnfalKNFSEEIISLFEkHSAIALIKTYKKDILKQ 288  Borrelia burgd...
Q55971       233 NLA---QIKGa-LKTRLDNGKDDAMH---SQMLARIVVDVPLPVTWed-lQLTGFSTDRLVP-LLEKLELRTFIDKIQAF 303  Synechocystis ...
O05949       215 SLD---QISSIkQRKTLQNAREAALI---SWKLIGLDSNVDLDFDLnn-lKWSPPNSKKLTG-FLQEYGFKSLYKRVENL 286  Rickettsia pro...
Q04957       217 SID---EIKGEkLKETLRQHREMALL---SKKLAAIRRDAPVELSLdd-iAYQGEDREKVVA-LFKELGFQSFLEKME-- 286  Bacillus caldo...
P74933       232 IVC---GKKDAfFSRSLIELRDDVPCvfsLEDSCCIPLDVTSAARIf--vREGLHALAQQYRaCVQEIDTEATNDTLQMT 306  Treponema pall...
WP_010875630 219 NLDlakNLLSPkMYRALIHDKASAFL---SKELATLERGCIKEFDFlscaFPSENPLLKIKD-ELKEYGFISTLRDLENS 294  Helicobacter p...

1BGX_T       289 ESPk------------------------------ALEEAPWP-PPEGAFVG-----------FVLSRKEPMWADLLALAA 326  Thermus aquaticus
P52028       291 EAPa------------------------------PLEEAPWP-PPEGAFVG-----------FVLSRPEPMWAELKALAA 328  Thermus thermo...
AAC36974     293 NGPeqdghapddllerehaqtpeedeaaalpafsAPELAEWQtPAEGAVWG-----------YVLSREDDLTAALLAAAT 361  Deinococcus ra...
O32801       297 GGGevtdetvse----------------eikfeivtDKSSVAsVNADDf-------------FYLETLGENYHREQIVAF 347  Lactococcus la...
P46835       303 LAAagervpevd-------------egfdvrgglLESGTVGRwLAKHADDGrrs------glAIVGTHLPHGGDATALAV 363  Mycobacterium ...
Q59156       288 evvqf---------------------------efvqQRTDIPdVEQKE----------------LESISQIRSKEIPLMF 324  Caldicellulosi...
O08307       293 PSVvqaptlaelpadlpaaplttaptqlslfageSEPAQPTAePPPVTIVRd---------aTALADLVSRLRNAPAFAF 363  Chloroflexus a...
O51498       289 EKEnadqkslfk-------------qepttnsldDINTIDTEnVKYRSITTk----------IELDDLIESLKKAKYISI 345  Borrelia burgd...
Q55971       304 HRNfsdnqspvpmgnea----dngepkktvkakkSKEKVNPDdSQQLSLFDgvpvv-nqedgLITIQLPKQIQPQIITTI 378  Synechocystis ...
O05949       287 FDIkindheeiv-------------dnkvteakeISNASELAnFAKEAERIg----------IFGIYLLQQKGENRALIL 343  Rickettsia pro...
Q04957       287 -SPsseeekpl-----------------akmaftlaDRVTEEmLADKAa-------------LVVEVVEENYHDAPIVGI 335  Bacillus caldo...
P74933       307 ESSvltsgrcanecflsqvegrastpevnsvlksELKTSAVSgAIPIENRDlrqdvmlarsaGHYRGVTDPVELKRIIDC 386  Treponema pall...
WP_010875630 295 PTPlildnaplldntp-----aldntpkkscmivLESAAPLSaFLEKLEKTna--------rVFARLVLDKEKKVLALAF 361  Helicobacter p...

1BGX_T       327 ARGg----RVHRAPEP----------------------------------YKALRDLKEARGLL---------------- 352  Thermus aquaticus
P52028       329 CRDg----RVHRAADP----------------------------------LAGLKDLKEVRGLL---------------- 354  Thermus thermo...
AAC36974     362 FEDgv--aRPARVSEPdewaqaeapenlfgel---lpsdkpltkkeqkalEKAQKDAEKARAKLreqfpatvdeaefvgq 436  Deinococcus ra...
O32801       348 AWGn---sEKIYVSKN----------------------------------LDLLTEMKFP---Ent-------------- 373  Lactococcus la...
P46835       364 AAAd---gNGGYIDTAm---------------------------------LTPDDDDALAAWLAdpdnp----------- 396  Mycobacterium ...
Q59156       325 VQGe---kCFYLYDQEsn-------------------------------tVFITSNKLLIEEILksdtv----------- 359  Caldicellulosi...
O08307       364 DTEct--sLQPVASDLvgisiaiap----------------dtvcyipvgHQSETQVPCGEVVTalapffanp------q 419  Chloroflexus a...
O51498       346 DTEts--sLDTYTAKLigisis----------------------fkefegYYIPIEAKGKIYIEknyiiqkfnnl-fesn 400  Borrelia burgd...
Q55971       379 AQLealveELKKHTDAdfpvawdtetdsldplvanlvgigcawgqepnqvAYIPLKHHQGEQLSlgiikdllgeilgnai 458  Synechocystis ...
O05949       344 SLQnq--sYIIKITNNn--------------------------------yNIKNNNDWFSHIILnlltnk---------- 379  Rickettsia pro...
Q04957       336 AVVn---eHGRFFLRP----------------------------------ETALADPQFVAWLGdetkk----------- 367  Bacillus caldo...
P74933       387 ACAn---gVVAFDCETdglhphdtrlvgfsicfqeaeafyvplivpdvslHTESTQCTCARSTNvetekecteqhgvsas 463  Treponema pall...
WP_010875630 362 LYEdq--gYFLPLEEAlfs-----------------------------pfSLEFLQNAFFKMLQhaqi------------ 398  Helicobacter p...

1BGX_T       353 -------AKDLSVLALREGLGLP---PGDDPMLLAYLLDPSNTt--PEGVARRYGG------------------------ 396  Thermus aquaticus
P52028       355 -------AKDLAVLASREGLDLV---PGDDPMLLAYLLDPSNTt--PEGVARRYGG------------------------ 398  Thermus thermo...
AAC36974     437 rtvtaaaAKALAAHLSVRGTVVE---PGDDPLLYAYLLDPANTn--MPVVAKRYLDr----------------------- 488  Deinococcus ra...
O32801       374 -----ydFKKNRVLLSHLNIELPl--VKFDAMLAKYLISTTEDn-kISTIARLFDVghlatdeeifg----kgtklalpd 441  Lactococcus la...
P46835       397 --kalheAKLAMHDLAGRGWTLGg--ITSDTALAAYLVRPGQRsftLDDLSLRYLRrelraetpeqeq--fslldnvdev 470  Mycobacterium ...
Q59156       360 --kimydLKNIFHQLNLEDTNNIk--NCEDVMIASYVLDSTRSsyeLETLFVSYlntdie-------------------- 415  Caldicellulosi...
O08307       420 qpkfahnAKFDMEVLAGAGIKVSg--LAFDTMIAAAMLGKRQGlkdLAFYELKLPEppttiedligrg--nkqisfaevp 495  Chloroflexus a...
O51498       401 pkiigqnYKFDYKILKNNGFNPIp--PYFDTMIAAYLIDTNSKv-sLDFLAEKYLMhknikyedviq----kndnfanis 473  Borrelia burgd...
Q55971       459 ypkvlqnAKFDRRVLAHHGIELGg--VVLDTMLASYVLQPEETh-nLTDLCRRYNLglvalsykdlgl--kkdqtiadlp 533  Synechocystis ...
O05949       380 --sikkiTYSLKHLLKFYANQSHqitAIEDLELMQYALSAGLVqknLFTKTLTKDN------------------------ 433  Rickettsia pro...
Q04957       368 --ksmfdSKRAAVALKWKGIELCg--VSFDLLLAAYLLDPAQGvddVAAAAKMKQYeavrpdeavyg----kgakravpd 439  Bacillus caldo...
P74933       464 avqdpayVQAVMHQLRRLWNDETltlVMHNGKFDYHVMHRAGVfehCACNIFDTMVaawlldpdrgtygmdvlaasffqi 543  Treponema pall...
WP_010875630 399 ---ighdLKPLLSFLKAKYQVPLeniRIQDTQILAFLKNPEKVg--FDEVLKEYLKeeliphek----------ikdfkt 463  Helicobacter p...

1BGX_T       397 --EWTEEAGERAALSERLFANLWGRLEg------------------EERLLWLYREVERPLSAVLAHMEATGVRLDVAYL 456  Thermus aquaticus
P52028       399 --EWTEDAAHRALLSERLHRNLLKRLEg------------------EEKLLWLYHEVEKPLSRVLAHMEATGVRLDVAYL 458  Thermus thermo...
AAC36974     489 --EWPADAPTRAAITGHLVRELPPLLD--------------------DARRKMYDEMEKPLSGVLGRMEVRGVQVDSDFL 546  Deinococcus ra...
O32801       442 deILFDHLARKIRVLARAKEKMMAELI-------------------ENEQEHLLSDMELPLAEVLAKMEITGISVSQNTL 502  Lactococcus la...
P46835       471 dkQAIQTLILRARAVVDLAAALDAELD-------------------LIDSTSLLGEMELPVQQVLADMEKAGIAADLRLL 531  Mycobacterium ...
Q59156       416 -avkkdKKIVSVVLLKRLWDELLRLID-------------------LNSCQFLYENIERPLIPVLYEMEKTGFKVDRDAL 475  Caldicellulosi...
O08307       496 veQAAPYAAADALYTLRLTERLQRQLEa------------------EPALHDLYYRVELPLIEVLTDMELTGIRLDQEYL 557  Chloroflexus a...
O51498       474 leMATSYSSEDADITFRLFNIFTKKLK-------------------EDKLDKLMHEIEMPFNKVIIEMEENGIYLDKEYL 534  Borrelia burgd...
Q55971       534 leTAGQYCGLDCYATYLLASKLQKELDq------------------YPELKEILKEIEQPLEKILAAMEDRGIRIDCDYL 595  Synechocystis ...
O05949       434 ---IINESARIVINFISLYKQTLLELQ-------------------KNKAFRLYREIDLPTCFILDKMEKVGIKVDANYL 491  Rickettsia pro...
Q04957       440 epVLAEHLVRKAAAIWALERPFLDELR-------------------RNEQDRLLVELEQPLSSILAEMEFAGVKVDTKRL 500  Bacillus caldo...
P74933       544 rtITFEEVVAKGQTFAHVPYECAVRYAaedaditfrlyhylklrleTAGLLSVFETIEMPLLPILARMEEVGIFLRKDVV 623  Treponema pall...
WP_010875630 464 kaEKLELLSVELNALKRLCEYFEKGGL-------------------EENLLSLAREIETPFMKVLMGMEFQGFKIDAPYF 524  Helicobacter p...

1BGX_T       457 RALSLEVAEEIARLEAEVFRLAGHPFNLNSRDQLERVLFDELGLPAiG----KTEKTGkRSTSAAVLEALREa--HPI-V 529  Thermus aquaticus
P52028       459 QALSLELAEEIRRLEEEVFRLAGHPFNLNSRDQLERVLFDELRLPA-Lg---KTQKTGkRSTSAAVLEALREa--HPI-V 531  Thermus thermo...
AAC36974     547 QTLSIQAGVRLADLESQIHEYAGEEFHIRSPKQLETVLYDKLELAS-Sk---KTKLTGqRSTAVSALEPLRDa--HPI-I 619  Deinococcus ra...
O32801       503 EEIGAENEEKLASLTREIYDLAGEEFNINSPKQLGVILFEKLQLPV-G----KKTKTG-YSTAVDVLEDLAAl--SPV-V 573  Lactococcus la...
P46835       532 TELQSQFGDQIRDAAEAAYAVIGKQINLSSPKQLQVVLFEELGMPK-T----KRTKTG-YTTDADALQSLFCkteHPF-L 604  Mycobacterium ...
Q59156       476 IQYTKEIENKILKLETQIYQIAGEWFNINSPKQLSYILFEKLKLPV-I----KKTKTG-YSTDAEVLEELFDk--HEI-V 546  Caldicellulosi...
O08307       558 RELGRHFAQRIADLVERIYQQAGGPFNINSGQQLNDVLFGRLGIDP-RahglSKLKSGgYSITAEVLEELS----QLYpI 632  Chloroflexus a...
O51498       535 KEYGKELGKELEAIENEIIKSIGIDFNLNSPKQMHEILFEKLNLKL-P----EKMKKD--STDIKVLESLREq--HES-- 603  Borrelia burgd...
Q55971       596 QTLSQQLAENLLTIETAAYEAAGESFNLSSPKQLGTILFDKLGLDR-Kk--sRKTKTG-YSTDHATLEKLQGd--HP--I 667  Synechocystis ...
O05949       492 NRLSDEFGTEILKIEEEIFALSGTKFNIGSQKQLGEILFKKMQLPS-Gn---TLAKTSsYSTRAGILKKLSE---DGYhI 564  Rickettsia pro...
Q04957       501 EQMGEELAEQLRTVEQRIYELAGQEFNINSPKQLGVILFEKLQLPV-L----KKSKTG-YSTSADVLEKLAPy--HEI-V 571  Bacillus caldo...
P74933       624 QQLTRSFSDLIQQYEHDIFSLAGHEFNIGSPKQLQTVLFQELHLPP-G----KKNTQG-YSTDHSVLKKLAR---KHP-I 693  Treponema pall...
WP_010875630 525 KRLEQEFKNELHVLERQILELIGVDFNLNSPKQLSEVLYDKLGLP--------KNKS--HSTDEKSLLKILDk--HPS-I 591  Helicobacter p...

1BGX_T       530 EKIL-QYRELTKLKSTyIDPLPDLIHPRTGRLHTRFNQTATATGRLSSSDPNLQNIPVRTPLGQRIRRAFIA-E----EG 603  Thermus aquaticus
P52028       532 EKIL-QHRELTKLKNTyVDPLPSLVHPRTGRLHTRFNQTATATGRLSSSDPNLQNIPVRTPLGQRIRRAFVA-E----AG 605  Thermus thermo...
AAC36974     620 PLVL-EFRELDKLRGTyLDPIPNLVNPHTGRLHTTFAQTAVATGRLSSLNPNLQNIPIRSELGREIRKGFIA-E----DG 693  Deinococcus ra...
O32801       574 AKIL-EYRQINKVQSTyVKGLIPQIADD-GKIHTRYVQDLTQTGRLSSVDPNLQNIPVRLEEGRKIRKAFVP-S----QD 646  Lactococcus la...
P46835       605 QHLL-THRDVTRLKVT-VDGLLNAVAAD-GRIHTTFNQTIATTGRLSSTEPNLQNIPIRTNAGRQIRDAFVV-GsennGY 680  Mycobacterium ...
Q59156       547 PLIL-DYRMYTKILTTyCQGLLQAINPSSGRVHTTFIQTGTATGRLASSDPNLQNIPVKYDEGKLIRKVFVP-E----GG 620  Caldicellulosi...
O08307       633 AADIlTYRQLTKLKSTyIDALPDLVNPRTGRIHTSYNQLGAATGRLSSNNPNLQNIPVRTEEGREIRRAFVA-Ep----G 707  Chloroflexus a...
O51498       604 IENLiKYRQIAKLKSTyTDNLIELINYKTNRLHTSFIQTKTATGRITSINPNLQNIPIKDEKGRKIRKAFKP-E----NG 678  Borrelia burgd...
Q55971       668 IDAIlEHRTLAKLKSTyVDALPELVNGQTQRIHTDFNQAVTSTGRLSSSNPNLQNIPIRSDFSRQIRRAFLP-Q----KD 742  Synechocystis ...
O05949       565 ATLLlRWRQLTKLKNTyTDSLPKQINNITKRIHTTFLQTSTTTGRLSSQEPNLQNVPIRSSDGNKIREAFIA-E----EG 639  Rickettsia pro...
Q04957       572 ENILqHYRQLGKLQSTyIEGLLKVVRPDTKKVHTIFNQALTQTGRLSSTEPNLQNIPIRLEEGRKIRQAFVPsE----SD 647  Bacillus caldo...
P74933       694 AEKIlLFRDLSKLRST-YTESLAKLADQTGRVHTSFVQIGTATGRLSSRNPNLQNIPIKSTEGRKIRQAFQA-T----VG 767  Treponema pall...
WP_010875630 592 ALIL-EYRELNKLFNTyTTPLLRLKDKD-DKIHTTFIQTGTATGRLSSHSPNLQNIPVRSPKGLLIRKGFIAsS----KE 665  Helicobacter p...

1BGX_T       604 WLLVALDYSQIELRVLAHLSGDENLIRVFQEGRDIHTETASWMFGVPR-EAVDPLMRRAAKTINFGVLYGMSAHRLSQEL 682  Thermus aquaticus
P52028       606 WALVALDYSQIELRVLAHLSGDENLIRVFQEGKDIHTQTASWMFGVPP-EAVDPLMRRAAKTVNFGVLYGMSAHRLSQEL 684  Thermus thermo...
AAC36974     694 FTLIAADYSQIELRLLAHIADDPLMQQAFVEGADIHRRTAAQVLGLDE-ATVDANQRRAAKTVNFGVLYGMSAHRLSNDL 772  Deinococcus ra...
O32801       647 SLLLSSDYSQIELRVLAHISADEHLIDAFKHGADIHTSTAMRVFGIEKaEDVTANDRRNAKAVNFGVVYGISDFGLARNL 726  Lactococcus la...
P46835       681 TELMTADYSQIEMRIMAHLSRDEGLIEAFHTGEDLHSFVASRAFGIPI-EDITPELRRRVKAMSYGLAYGLSAYGLATQL 759  Mycobacterium ...
Q59156       621 HVLIDADYSQIELRILAHISEDERLISAFKNNVDIHSQTAAEVFGVDI-ADVTPEMRSQAKAVNFGIVYGISDYGLARDI 699  Caldicellulosi...
O08307       708 WRFVAADYSQIELRVLAHMSGDENLIAAFQQGLDIHAATASRLFGVEP-TAVDKNQRRVAKTVVFGVIYGISAFGLAQRL 786  Chloroflexus a...
O51498       679 NIFISADYSQIELAILAHLSQDEVLIKAFENNKDIHTETASKLFKIEE-KEITPNLRRIAKSINFGIIYRMSDFRLAKEL 757  Borrelia burgd...
Q55971       743 WLLVSADYSQIELRILAHLSQEPVLLQAYGDRQDVHGVTAKLLFGK---EDITPAERNLGKTINFGVIYGMGAQRFARET 819  Synechocystis ...
O05949       640 YKLISADYSQIELRILSHIANIDVLKQAFINKEDIHTQTACQIFNLKK-HELTSEHRRKAKAINFGIIYGISAFGLAKQL 718  Rickettsia pro...
Q04957       648 WLIFAADYSQIELRVLAHIAEDDNLMEAFRRDLDIHTKTAMDIFQVSE-DEVTPNMRRQAKAVNFGIVYGISDYGLAQNL 726  Bacillus caldo...
P74933       768 HELISADYTQIELVVLAHLSQDRNLLNAFRQHIDIHALTAAYIFNVSI-DDVQPAMRRIAKTINFGIVYGMSAFRLSDEL 846  Treponema pall...
WP_010875630 666 YCLLGVDYSQIELRLLAHFSQDKDLMEAFLKGRDIHLETSKALFG----EYLAKEKRSIAKSINFGLVYGMGSKKLSETL 741  Helicobacter p...

1BGX_T       683 AIPYEEAQAFIERYFQSFPKVRAWIEKTLEEGRRRGYVETLFGRRRYVPDLEARVKSVREA------------------A 744  Thermus aquaticus
P52028       685 AIPYEEAVAFIERYFQSFPKVRAWIEKTLEEGRKRGYVETLFGRRRYVPDLNARVKSVREA------------------A 746  Thermus thermo...
AAC36974     773 GIPYAEAATFIEIYFATYPGIRRYINHTLDFGRTHGYVETLYGRRRYVPGLSSRNRVQREA------------------E 834  Deinococcus ra...
O32801       727 GITRKDAKNYIETYFERYPGIKTYMENIVREARDKGFVETMSHRRRKIPDINARNFNVRGF------------------A 788  Lactococcus la...
P46835       760 KISTEEAKLQMEQYFARFGGVRDYLMDVVEQARKDGYTSTVLGRRRYLPELDSSNRQIREA------------------A 821  Mycobacterium ...
Q59156       700 KISRKEAAEFINKYFERYPKVKEYLDNTVKFARDNGFVLTLFNRKRYIKDIKSTNRNLRGY------------------A 761  Caldicellulosi...
O08307       787 GIERDLARQLIDNLFAQFPGIRRYIDQTLEFGRQHGYVQTLFGRRRVMEDLR-ASGARRAA------------------A 847  Chloroflexus a...
O51498       758 GITKEEAKGFINSYFDSYPKIKEFIINQINFVRNAGYSETILKRRRYIKEINSNNYLERSA------------------A 819  Borrelia burgd...
Q55971       820 GISAVEGREFIDRYHRTYAQVFDYLETMKLEAIAKGYVTTIVGRRRYFNFVTEALRQLRGKtvteldlvdvkmnyndaqL 899  Synechocystis ...
O05949       719 NVSNSTASEYIKQYFAEYKGVQEYMTQTKACASRNGYVTNFFGRKCFIPLIH--DKKLKQF------------------A 778  Rickettsia pro...
Q04957       727 NISRKEAAEFIERYFESFPGVKRYMENIVQEAKQKGYVTTLLHRRRYLPDITSRNFNVRSF------------------A 788  Bacillus caldo...
P74933       847 KISQKEAQSFIYRYFETYPGVYAFSTQVAEQTRKTGYVTSLAGRRRYIRTIDSRNTLERAR------------------A 908  Treponema pall...
WP_010875630 742 NISLNEAKSYIEAYFKRFPSIKDYLNRMKEEILKTSKAFTLLGRYRVFDFTGANDYVKGNY------------------- 802  Helicobacter p...

1BGX_T       745 ERMAFNMPVQGTAADLMKLAMVKLFPRLEEMG--ARMLLQVHDELVLEAPKERAEAVARLAKEVME-GVYPLA-VPLEVE 820  Thermus aquaticus
P52028       747 ERMAFNMPVQGTAADLMKLAMVKLFPRLREMG--ARMLLQVHDELLLEAPQARAEEVAALAKEAME-KAYPLA-VPLEVE 822  Thermus thermo...
AAC36974     835 ERLAYNMPIQGTAADIMKLAMVQLDPQLDAIG--ARMLLQVHDELLIEAPLDKAEQVAALTKKVME-NVVQLK-VPLAVE 910  Deinococcus ra...
O32801       789 ERTAINSPIQGSAADILKIAMINLDKALTERQskSKLLLQVHDEIILDVPLEELEDIKALVKQTME-EAIELA-VPLKVD 866  Lactococcus la...
P46835       822 ERAALNAPIQGSAADIIKVAMIAVDKSLKQAKlaSRMLLQVHDELLFEVAIGEREQIEAMVREQMG-SAYPLD-VPLEVS 899  Mycobacterium ...
Q59156       762 ERIAMNSPIQGSAADIMKLAMIKVYQKLKENNlkSKIILQVHDELLIEAPYEEKDIVKEIVKREME-NAVALK-VPLVVE 839  Caldicellulosi...
O08307       848 EREAINAPIQGTAADLMKMAMVNVHRALREQGlrTRLLLQVHDELIAEAPEDEVEPAARLLRDVMS-SVYRDLvVPLSVN 926  Chloroflexus a...
O51498       820 ERIAINSIIQGSAADIMKIAMVKVFNEFKSKKmeSKILLQVHDEMLIESPIEEENEVKKILKIMME-TAYTLN-LPLRAN 897  Borrelia burgd...
Q55971       900 LRSAANAPIQGSSADIIKIAMVKLAKLLESYQ--TRMLLQVHDELIFEMPPEEWEELAPLIQNTME-QALTLS-VPLVVE 975  Synechocystis ...
O05949       779 ERAAINAPIQGTNADIIKIAMIKLDKEIEERKlkTRLILQIHDELLFEVPEIEVEIVIPIIKKIME-HSTNMN-VPIITE 856  Rickettsia pro...
Q04957       789 ERMAMNTPIQGSAADIIKKAMIDLNARLKEERlqARLLLQVHDELILEAPKEEMERLCRLVPEVME-QAVTLR-VPLKVD 866  Bacillus caldo...
P74933       909 ERMALNTQIQSSAADIVKIAMIAIQRAFARRPlrAQLLLQVHDELIFEAPAAETAIVKEILFAEME-HAVELS-IPLRIH 986  Treponema pall...
WP_010875630 803 LREGVNAIFQGSASDLLKLGMLKVSERFKNNPs-VRLLLQVHDELIFEIEEKNAPELQQEIQRILNdEVYPLR-VPLETS 880  Helicobacter p...

1BGX_T       821 VGIGEDWLSAK 831  Thermus aquaticus
P52028       823 VGMGEDWLSAK 833  Thermus thermophilus HB8
AAC36974     911 VGTGPNWFDTK 921  Deinococcus radiodurans R1
O32801       867 DNTGKTWYEAK 877  Lactococcus lactis subsp. cremoris MG1363
P46835       900 VGFGRSWGAAA 910  Mycobacterium leprae TN
Q59156       840 VKEGLNWYETK 850  Caldicellulosiruptor bescii DSM 6725
O08307       927 LEVGPNWDEMS 937  Chloroflexus aurantiacus J-10-fl
O51498       898 IETGKSWGEIH 908  Borrelia burgdorferi B31
Q55971       976 MHRGSNWMEAK 986  Synechocystis sp. PCC 6803 substr. Kazusa
O05949       857 IKAGNNWKEIH 867  Rickettsia prowazekii str. Madrid E
Q04957       867 YHYGSTWYDAK 877  Bacillus caldotenax
P74933       987 VESGNSWGDFH 997  Treponema pallidum subsp. pallidum str. Nichols
WP_010875630 881 AFIAKRWNELK 891  Helicobacter pylori
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