1QUM


Conserved Protein Domain Family
nfo
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TIGR00587: nfo 
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apurinic endonuclease (APN1)
All proteins in this family for which functions are known are 5' AP endonculeases that are used in base excision repair and the repair of abasic sites in DNA.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]
Links
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Statistics
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PSSM-Id: 273156
Aligned: 10 rows
Threshold Bit Score: 340.104
Created: 7-Oct-2014
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
1QUM_A     2 KyIGAHVSAAGG--LANAAIRAAEIDATAFALFTKNQRQWRAAPLTTQTIDEFkAACEKYHYT-SaqILPHDSYLINLG- 77  Escherichia coli BW...
P12638     2 KyIGAHVSAAGG--LANAAIRAAEIDATAFALFTKNQRQWRAAPLTTQTIDEFkAACEKYHYT-SaqILPHDSYLINLG- 77  Escherichia coli
CAA81954  15 YkFGAHMSGAGG--ISNSVTNAFNTGCNSFAMFLKSPRKWVSPQYTQEEIDKFkKNCATYNYNpLtdVLPHGQYFINLA- 91  baker's yeast
P75457     3 KlLGSFISFKSPhyLVGSVRDAVSIKAQAFMIFLGAPHTALRVDPNRMQIDEG-HTLMEQHNLsKsgMVVHAPYIINCA- 80  Mycoplasma pneumoni...
P47477     3 KlLGSFISFKAPnyFVQSAQDAIAIDATALMVFLGPPHSAYRVPFNKMQFSLG-YELLKTKNInSngLVVHAPYIINCA- 80  Mycoplasma genitali...
AAC28163   1 ------MCAINK----AYLLTKFYISANSCAFFVKSQRKWTSPDLSEDVAQKFlETASEMKFDaSkqVLVHGSYLINMA- 69  fission yeast
AAB39924   1 MlGFHVSAAGGL--EQAIYNARAEGCRSFAMFVRNQRTWNHKPMSEEVVENWWkAVRETNFPL-DqiVPHGSYLMNAGS- 76  Caenorhabditis elegans
AAC68229  10 AlLGAHTSAAGG--LHNALYEGRDIGATTVQLFTANQRQWKRRTLTQEMVDQFrIALNETSLSy---IMSHAGYLNNPG- 83  Chlamydia trachomat...
O67551     2 AlFGAHVSSAGS--ILKTFKRAKDIGAEVFQFFLRSPRAWYWKGVDKETKQAFiEKLKDFKNP----VMVHAPYLLNLA- 74  Aquifex aeolicus VF5
P54476     3 R-IGSHVSMSGKhmLLAASQEAVSYGANTFMIYTGAPQNTRRKKIEDLNIEAG-RAHMQENGIdE--IIVHAPYIINIGn 78  Bacillus subtilis s...

1QUM_A    78 HPVTEALEKSRDAFIDEMQRCEQLGLSLLNFH------------------------PGSHLMQiSEEDCLARIAESINIA 133 Escherichia coli BW...
P12638    78 HPVTEALEKSRDAFIDEMQRCEQLGLSLLNFH------------------------PGSHLMQiSEEDCLARIAESINIA 133 Escherichia coli
CAA81954  92 NPDREKAEKSYESFMDDLNRCEQLGIGLYNLH------------------------PGSTLKG-DHQLQLKQLASYLNKA 146 baker's yeast
P75457    81 SKDPVKQTFAIDVLTREVKLCHAVGAKLIVLH------------------------PGSAVEQ-TQTQALDHLIKVLNTV 135 Mycoplasma pneumoni...
P47477    81 SKDPLKQQNAISVLTNEIQLCNLAGAHYLVLH------------------------PGSAVAQ-TTNEALDNLVKVLNQV 135 Mycoplasma genitali...
AAC28163  70 NADEQKREQAFNCFVDDLKRCERLGVGLYNFQyvihsvlyllifypkrtnsfdlcsPGSTASC-TKEEGINNLAECINRA 148 fission yeast
AAB39924  77 PEAEKLEKSRLAMLDECQRAEKLGITMYNFHP------------------------GSTVGKCeKEECMTTIAETIDFVV 132 Caenorhabditis elegans
AAC68229  84 APNPEILEKTRVCMHQEIADCISLGISFVNFH------------------------PGAALSD-SKESCLDRTIASFSQM 138 Chlamydia trachomat...
O67551    75 SPNEELREKSVKVFLEELKFCDEVGIHFYNFH------------------------PGTAKGI-SDEEGLRNVIKSLEEV 129 Aquifex aeolicus VF5
P54476    79 TTNPSTFELGVDFLRSEIERTAAIGAKQIVLH------------------------PGAHVGA-GAEAGIKKIIEGLNEV 133 Bacillus subtilis s...

1QUM_A   134 LDKTQG---VTAVIENTAGQGSNLGFKFEHLAAIIDGVEDKSRVGVCIDTCHAFAAGYDLrtPAECEKTFADFARTVGFK 210 Escherichia coli BW...
P12638   134 LDKTQG---VTAVIENTAGQGSNLGFKFEHLAAIIDGVEDKSRVGVCIDTCHAFAAGYDLrtPAECEKTFADFARTVGFK 210 Escherichia coli
CAA81954 147 IKETKF---VKIVLENMAGTGNLVGSSLVDLKEVIGMIEDKSRIGVCIDTCHTFAAGYDIstTETFNNFWKEFNDVIGFK 223 baker's yeast
P75457   136 IANTKE---VIICLETMAGKGNEIGRDLDQLKYVINHIEQQERIGVCLDTCHFHDSGND---FNNTAEIMETIDTKLGFE 209 Mycoplasma pneumoni...
P47477   136 INKTKT---TVICLETMAGKGNEIGRDLTELKYVIDRIVDKDRIGVCLDTCHFHDSGID---FSDLTGVFNTITTKLGFE 209 Mycoplasma genitali...
AAC28163 149 HEETKS---VIIVTENMAGQGNCLGGTFDDFAALKSKIKNLDRWRVCLDTCHTFAAGYDIrtEESYKKVIDEFDEKVGAK 225 fission yeast
AAB39924 133 EKTENI---ILVLETMAGQGNSIGGTFEELKFIIDKVKVKSRVGVCIDTCHIFAGGYDIRtqKAYEEVMKNFGEVVGWNY 209 Caenorhabditis elegans
AAC68229 139 APLFENnppLVVLLETTAGQGSLIGSSFEELAYLIQGIKAHIPIGVCLDTCHIFAAGYDIssVAGWEQVLKHFDAVIGLS 218 Chlamydia trachomat...
O67551   130 FSEYTPk-fTTVLLENTAGERGDLGKNFKELKEIMNVFRG-IKLGVCLDTCHAFAYGYEIntKEGFENFKREIEKMVGLE 207 Aquifex aeolicus VF5
P54476   134 IDPNQN---VQIALETMAGKGSECGRSFEELAQIIEGVTHNEQLSVCFDTCHTHDAGYNI--VEDFDGVLNEFDKIIGID 208 Bacillus subtilis s...

1QUM_A   211 YLRGMHLNDAKSTFGSRVDRHHSLGEGNIGHDAFRWIMQDDRFDGIPLILET--------INPDIWAEEIA 273 Escherichia coli BW2952
P12638   211 YLRGMHLNDAKSTFGSRVDRHHSLGEGNIGHDAFRWIMQDDRFDGIPLILET--------INPDIWAEEIA 273 Escherichia coli
CAA81954 224 YLSAVHLNDSKAPLGANRDLHERLGQGYLGIDVFRMIAHSEYLQGIPIVLETp------yENDEGYGNEIK 288 baker's yeast
P75457   210 FLKVIHLNESKNVCGSKKDRHANLGEGMIGFDNLMRFIAQPQIKQIPIVLETpsd---khNYPAVYGAEIE 277 Mycoplasma pneumoniae M129
P47477   210 FLKVIHLNESKNNCGSKKDRHANINAGMIGFENLMKFISHPQIKDLPIILETpst---slNYPTIYREEIS 277 Mycoplasma genitalium G37
AAC28163 226 YVSGWHLNDSKAPLGSNRDLHENIGLGFLGLEPFRLIMNDSRWDGIPLVLETp------aKSPEQWKKEVE 290 fission yeast
AAB39924 210 LKAIHINDSKGDVGSKLDRHEHIGQGKIGKAAFELLMNDNRLDGIPMILETPe---------GKYPEEMMI 271 Caenorhabditis elegans
AAC68229 219 FLRAIHLNDSVFALGKNKDRHAPIGEGCIGSDSFCFLMQDERTRMLPKYLETp-------GGPDLWTKEIR 282 Chlamydia trachomatis D/UW-3/CX
O67551   208 SVKAVHANDSKVPLGGRKDRHEHIGKGYIGLEGFKNLLKDEYFSTLPYYIETp-------KENNMDPVNLS 271 Aquifex aeolicus VF5
P54476   209 RIKVLHINDSKNVKGARKDRHENIGFGEIGFDALQYVVHHEQLKDIPKILETpyvgedkkNKKPPYRFEIE 279 Bacillus subtilis subsp. sub...
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