2OWO,1DGS


Conserved Protein Domain Family
dnlj
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TIGR00575: dnlj 
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DNA ligase, NAD-dependent
All proteins in this family with known functions are NAD-dependent DNA ligases. Functions of these proteins include DNA repair, DNA replication, and DNA recombination. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). The member of this family from Treponema pallidum differs in having three rather than just one copy of the BRCT (BRCA1 C Terminus) domain (pfam00533) at the C-terminus. It is included in the seed. [DNA metabolism, DNA replication, recombination, and repair]
Links
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Statistics
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PSSM-Id: 273148
Aligned: 17 rows
Threshold Bit Score: 772.993
Created: 7-Oct-2014
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
2OWO_A    11 LRTTLRHHEYLYHVMDAPEIPDAEYDRLMRELRELETKHPELITPDSPTQRVGAAPLAA-FSQIRHEVPMLSLDNVFDEE 89  Escherichia coli AT...
O53261    20 LAEEVREHQFRYYVRDAPIISDAEFDELLRRLEALEEQHPELRTPDSPTQLVGGAGFATdFEPVDHLERMLSLDNAFTAD 99  Mycobacterium tuber...
P15042    11 LRTTLRHHEYLYHVMDAPEIPDAEYDRLMRELRELETKHPELITPDSPTQRVGAAPLAA-FSQIRHEVPMLSLDNVFDEE 89  Escherichia coli K-12
P43813    11 LRKTLRQYEYEYHVLDNPSVPDSEYDRLFHQLKALELEHPEFLTSDSPTQRVGAKPLSG-FSQIRHEIPMLSLDNAFSDA 89  Haemophilus influen...
P47496    11 LVNLIKNYDYHYYVLSEPLIDDFEYDMLYKSLQQLEKDHPDLIQIDSPTQRVGGEAVKG-FKKLNHNSPMLSLENAFSTK 89  Mycoplasma genitali...
P78021    10 IVEQLKRYDYHYYVLDDPLVSDFEYDQLYKQLQALEQAHPELIQPDSPTQRVGGIVVEA-FNKFPHQNPMLSLDNAFDTA 88  Mycoplasma pneumoni...
AAC67737  12 LCTELVEHDRRYYVLNQPTISDYSYDVKMRELQEIEVQHPEWKVSWSPTMYLGDRPSGQ-FPVVPHSSPMLSIANVYSLQ 90  Chlamydia trachomat...
O25336    11 RIAYLNTLSHHYYNLDEPIVSDAIYDELYQELKAYEEKNPNGIQANSPTQKVGATTTNS-FNKNPHLMRMWSLDDVFNQS 89  Helicobacter pylori...
O51502    12 LKKLIRKWDKEYYVDSLPSVEDFVYDKHILRLQELESKYPEYKTLDSPTLKFGSDLLND-FKEVEHSAPILSLDKVYDLD 90  Borrelia burgdorfer...
P28719    38 LAKLISHYDHLYHDKDNPAVPDSEYDALVLRNRRIEQFFPDLIRPDSPSKKVGSRPNSR-LPKIAHRAAMLSLDNGFLDQ 116 Zymomonas mobilis s...

2OWO_A    90 SFLAFNKRVQDRLknNE----KVTWCCELKLDGLAVSILYENGVLVSAATRGDGTTGEDITSNVRTIRAIPLKLHGE--- 162 Escherichia coli AT...
O53261   100 ELAAWAGRIHAEV--GD----AAHYLCELKIDGVALSLVYREGRLTRASTRGDGRTGEDVTLNARTIADVPERLTPGddy 173 Mycobacterium tuber...
P15042    90 SFLAFNKRVQDRL--KNne--kVTWCCELKLDGLAVSILYENGVLVSAATRGDGTTGEDITSNVRTIRAIPLKLHGe--- 162 Escherichia coli K-12
P43813    90 EFNAFVKRIEDRL--ILlp-kpLTFCCEPKLDGLAVSILYVNGELTQAATRGDGTTGEDITANIRTIRNVPLQLLTd--- 163 Haemophilus influen...
P47496    90 EIANFIDNINFQT--NS----KNEFVVEPKIDGVSISLTYKNGVLVHALTRGDGSVGEDVLNNVKTIKSIPLTI------ 157 Mycoplasma genitali...
P78021    89 TIASFIANINNLT--GV----QNRFVVEPKIDGVSISLTYENGLLTRALTRGDGLVGEDVLSNVKTIKSIPLTI------ 156 Mycoplasma pneumoni...
AAC67737  91 ELEEFFSRTEKLL--GY----SPGYSLELKIDGIAVAIRYEKRLFAQALSRGNGVKGEDITANVSTIRSLPMRLPq---- 160 Chlamydia trachomat...
O25336    90 ELQAWLQRILKAY--PS-----ASFVCSPKLDGVSLNLLYQHGKLVKATTRGNGLEGELVSANAKHIANIPHAIA----- 157 Helicobacter pylori...
O51502    91 LLKSWIDKIDFNN--S------FNISVEPKIDGCSIVLYYKDGVLEKALTRGNGKFGNDVTINVRTIRYIPLFLD----- 157 Borrelia burgdorfer...
P28719   117 DVEDFLGRVRRFF--NLkenqAVICTVEPKIDGLSCSLRYEKGILTQAVTRGDGVIGEDVTPNVRVIDDIPKTLKGD--- 191 Zymomonas mobilis s...

2OWO_A   163 NIPARLEVRGEVFLPQAGFEKINEDARRTGGKVFANPRNAAAGSLRQLDPRITAKRPLTFFCYGVGvlEGGELPd-THLG 241 Escherichia coli AT...
O53261   174 PVPEVLEVRGEVFFRLDDFQALNASLVEEGKAPFANPRNSAAGSLRQKDPAVTARRRLRMICHGLGhvEGFRPA--TLHQ 251 Mycobacterium tuber...
P15042   163 NIPARLEVRGEVFLPQAGFEKINEDARRTGGKVFANPRNAAAGSLRQLDPRITAKRPLTFFCYGVGvlEGGELPd-THLG 241 Escherichia coli K-12
P43813   164 NPPARLEVRGEVFMPHAGFERLNKYALEHNEKTFANPRNAAAGSLRQLDPNITSKRPLVLNAYGIGiaEGVDLPt-THYA 242 Haemophilus influen...
P47496   158 PFTKTIEIRGEIFVDKKTFLAIN----NQLEKPFANARNLAAGTIRNLNSEITAQRKLRALFYYIp--NGLEESitTQTM 231 Mycoplasma genitali...
P78021   157 PFHKQVEIRGEIFVDKKTFAQIN----ENLAKPFANARNLAAGTLRNLNSEVSAKRKLKAFFYFVp--NALTLGcrSQSA 230 Mycoplasma pneumoni...
AAC67737 161 EAPEDLEVRGEVFLSYEAFEELNACQREQGKLEFANPRNAAGGTLKLLSSKEAAKRKLDLSVYGL---ITDQKKr-SHFE 236 Chlamydia trachomat...
O25336   158 -YNGEIEIRGEVIISKKDFDALNQERLNANEPLFANPRNAASGSLRQLDSEITKKRKLQFIPWGVG---KHSLNflSFKE 233 Helicobacter pylori...
O51502   158 -EKVDLVLRGEVYITKENFLKIN----KFLEKPYTNSRNLASGILRRVDSREVANFPLNIFIYDFLn-AGLEFK--TNDL 229 Borrelia burgdorfer...
P28719   192 NWPEIIEIRGEVYMAKSDFAALNARQTEENKKLFANPRNAAAGSLRQLDPNITARRSLRFLAHGWG--EATSLPadTQYG 269 Zymomonas mobilis s...

2OWO_A   242 RLLQFKKWGLPVSDRVTLCE---SAEEVLAFYHKVEEDRPTLGFDIDGVVIKVNSLAQQEQLGFVARAPRWAVAFKFPAQ 318 Escherichia coli AT...
O53261   252 AYLALRAWGLPVSEHTTLAT---DLAGVRERIDYWGEHRHEVDHEIDGVVVKVDEVALQRRLGSTSRAPRWAIAYKYPPE 328 Mycobacterium tuber...
P15042   242 RLLQFKKWGLPVSDRVTLCE---SAEEVLAFYHKVEEDRPTLGFDIDGVVIKVNSLAQQEQLGFVARAPRWAVAFKFPAQ 318 Escherichia coli K-12
P43813   243 RLQWLKSIGIPVNPEIRLCN---GADEVLGFYRDIQNKRSSLGYDIDGTVLKINDIALQNELGFISKAPRWAIAYKFPAQ 319 Haemophilus influen...
P47496   232 VLEQLKQWKFPVSDTIRVFQ---NKFQLINYLEAFDKKREQLTFNLDGLVIKLNSLLFYQQLGATSKSPRWAIAFKFSPK 308 Mycoplasma genitali...
P78021   231 VLAQLKQWNFPVSKAVASFD---RPEALIEYLEQFDQTRDQLNFQVDGLVVKLDNFHFYDQLGFTSKFPRWALAYKFKPK 307 Mycoplasma pneumoni...
AAC67737 237 NLQLCSQWGFFVAGMPKQCR---SRQDVVERIREIEEMRAALPMAIDGVVIKVDNIAYQDRLGLTSKHYRWAIAYKYAPE 313 Chlamydia trachomat...
O25336   234 CLDFIVSLGFSAIQYLSLNK---NHQEIEDNYHTLIREREGFFALLDGMVIVVNELNIQKELGYTQKSPKFACAYKFPAL 310 Helicobacter pylori...
O51502   230 ATARLKKLGFKVNPLIRFFDlknSIGEVLNYIADITKKRDSFEYEIDGVVLKVSDFALRERLGYTAHHPKWAMAYKFEAL 309 Borrelia burgdorfer...
P28719   270 MMKVIESYGLSVSNLLARAD---DIGQMLDFYQKIEAERADLDFDIDGVVYKLDQLDWQQRFGFSARAPRFALAHKFPAE 346 Zymomonas mobilis s...

2OWO_A   319 EQMTFVRDVEFQVGRTGAITPVARLEPVHVAGVLVSNATLHNADEIERLGLRIGDKVVIRRAGDVIPQVVNVVLSerPED 398 Escherichia coli AT...
O53261   329 EAQTKLLDIRVNVGRTGRITPFAFMTPVKVAGSTVGQATLHNASEIKRKGVLIGDTVVIRKAGDVIPEVLGPVVElrDGS 408 Mycobacterium tuber...
P15042   319 EQMTFVRDVEFQVGRTGAITPVARLEPVHVAGVLVSNATLHNADEIERLGLRIGDKVVIRRAGDVIPQVVNVVLSerPED 398 Escherichia coli K-12
P43813   320 EELTLLNDVEFQVGRTGAITPVAKLEPVFVAGVTVSNATLHNGDEIERLNIAIGDTVVIRRAGDVIPQIIGVLHErrPDN 399 Haemophilus influen...
P47496   309 FVQTKLTAVLITIGRTGRVNYTAKLESVNLDGTKVTAATLHNFDYIKTKDIRINDTVVIYKAGEIIPKVLKVNLEkrKND 388 Mycoplasma genitali...
P78021   308 FVQTKLRGVLVTVGRTGKINYTAQLDPVNLEGTVVSAATLHNFDYIKEKDIRLNDTVIIYKAGEIIPKVLEVCLPlrTAA 387 Mycoplasma pneumoni...
AAC67737 314 RAETILEDIVVQVGKTGILTPVAELAPVFLSGSRVSRASLYNQDEIEKKDIRIGDSVYVEKGGEVIPKIVGINLAkrSLE 393 Chlamydia trachomat...
O25336   311 EKHTKIVGVINQVGRSGAITPVALLEPVEIAGAMINRATLHNYSEIEKKNIMLSDRVVVIRSGDVIPKIIKPLESyrDGS 390 Helicobacter pylori...
O51502   310 SGFSRVNSIVVQVGRSGKITPVANIDKVFVSGAFITSATLHNQDYIRSIGLNVGDVVKVSRRGDVIPAVEMVINK---FS 386 Borrelia burgdorfer...
P28719   347 KAQTTLLDIEIQVGRTGVLTPVAKLEPVTVGGVVVSSATLHNSDEIERLGVRPGDRVLVQRAGDVIPQIVENLTP--DVD 424 Zymomonas mobilis s...

2OWO_A   399 TREVVFPTHCPVCGSDVERV-EGEAVARCTgG-LICGAQRKESLKHFVSRRAMDVDGMGDKIIDQLVEKEYVHTPADLFK 476 Escherichia coli AT...
O53261   409 EREFIMPTTCPECGSPLAPEkEGDADIRCP-NaRGCPGQLRERVFHVASRNGLDIEVLGYEAGVALLQAKVIADEGELFA 487 Mycobacterium tuber...
P15042   399 TREVVFPTHCPVCGSDVERV-EGEAVARCT-GgLICGAQRKESLKHFVSRRAMDVDGMGDKIIDQLVEKEYVHTPADLFK 476 Escherichia coli K-12
P43813   400 AKPIIFPTNCPVCDSQIIRI-EGEAVARCT-GgLFCAAQRKEALKHFVSRKAMDIDGVGGKLIEQLVDRELIHTPADLFK 477 Haemophilus influen...
P47496   389 TIIIQEQKYCPSCNSKLVKI-VDEVDQYCT-N-ETCKERNIQLINYFVSKTAMDINGLNINTITKLYEHNLVRSIVDLYD 465 Mycoplasma genitali...
P78021   388 NQPIPEQTHCPACQAPLVQY-KDEVDQYCT-N-ERCDQRNLEAINYFVSKTAMDIQGLSIQTISKLYENNLVRSVVDLYH 464 Mycoplasma pneumoni...
AAC67737 394 SEPWKMPSLCPVCHEPVVK---EKVSVRCV-N-PLCSGGMLEKICFFASKSALNIDHLGEKVVTKLFEVGLISSCSDIFA 468 Chlamydia trachomat...
O25336   391 QHKIERPKVCPICSHELLC---EEIFTYCQ-N-LNCPARLKESLIHFASKDALNIQGLGDKVIEQLFEEKLIFNALDLYA 465 Helicobacter pylori...
O51502   387 TGFFKVPDNCPACKTAVVK---EGAHFFCP-N-NNCPSVAVERIKYFCSKNCMDIEGFSDKIISFLFEKKFIFSEIDLYT 461 Borrelia burgdorfer...
P28719   425 RPIWRFPHRCPVCDSVARRE-EGEVAWRCT-GgLICPAQRVERLCHFVSRTAFEIEGLGKSHIESFFADKLIETPADIFR 502 Zymomonas mobilis s...

2OWO_A   477 LT--AGKLTGLER----MGPKSAQN--VVNALEKAKETTFARFLYALGIREVGEATAAGLAAYFG-TLEALEAASIE--- 544 Escherichia coli AT...
O53261   488 LT--ERDLLRTDLfrtkAGELSANGkrLLVNLDKAKAAPLWRVLVALSIRHVGPTAARALATEFG-SLDAIAAASTD--- 561 Mycobacterium tuber...
P15042   477 LT--AGKLTGLER----MGPKSAQN--VVNALEKAKETTFARFLYALGIREVGEATAAGLAAYFG-TLEALEAASIE--- 544 Escherichia coli K-12
P43813   478 LD--LTTLTRLER----MGAKSAEN--ALNSLENAKSTTLARFIFALGIREVGEATALNLANHFK-TLDALKDANLE--- 545 Haemophilus influen...
P47496   466 LKdkKNQVLKLDLk---IGDKLFNK--LVDNIENSKQKGMARLLTGLGIKHVGNVLAKNLANHFK-NIKALQHASLE--- 536 Mycoplasma genitali...
P78021   465 LKehKAAVLALELk---IGEVLFNK--LISSIEQSKTKGMARLLTGLGIKHVGQVLAKSLTKHFE-NIDALQSASME--- 535 Mycoplasma pneumoni...
AAC67737 469 LA--EEDLKQVPG----FKDRSIQN--LLASIAGAKKVALDRLLTALSIPFVGSSGAIALADHFG-TLDKVIEASLD--- 536 Chlamydia trachomat...
O25336   466 LK--LEDLMRLDK----FKIKKAQN--LLDAILKSKNPPLWRLINALGIEHIGKGASKTLAKYG---LNVLEKSEAE--- 531 Helicobacter pylori...
O51502   462 FD--FYKLLEFKG----FKDRKINN--LINSIEASKKKPFSKLLLSMGIKDLGENTIRLLFLNNLnSFSKLFKLCQDryf 533 Borrelia burgdorfer...
P28719   503 LFqkRQLLIEREG----WGELSVDN--LISAIDKRRKVPFDRFLFALGIRHVGAVTARDLAKSYQ-TWDNFKAAIDEaah 575 Zymomonas mobilis s...

2OWO_A   545 --------ELQKVPDVGIVVASHVHNFFAEESNR--NVISELLAEGVHWP------------APIVINAEEIdSpf-agK 601 Escherichia coli AT...
O53261   562 --------QLAAVEGVGPTIAAAVTEWFAVDWHR--EIVDKWRAAGVRMVd----------eRDESVPRTLA-G-----L 615 Mycobacterium tuber...
P15042   545 --------ELQKVPDVGIVVASHVHNFFAEESNR--NVISELLAEGVHWP------------APIVINAEEI-DspfagK 601 Escherichia coli K-12
P43813   546 --------ELQQVPDVGEVVANRIFIFWREAHNV--AVVEDLIAQGVHWE------------TVEVKEASENlf---kdK 600 Haemophilus influen...
P47496   537 --------NLISLNDVGITVAESLYNWFHDPNHL--QLIEQLELRQVKTDq-----------LPLKINFETN-Siy-fqK 593 Mycoplasma genitali...
P78021   536 --------TLLELPDVGPTVAESLFNWFHNDNNL--QLLAALKAVGVQMDa-----------LKSNTNFDTA-Siy-fqK 592 Mycoplasma pneumoni...
AAC67737 537 --------ELMSIEGIGPKVAASIVAFFSKHENR--EEIRRMQELGVQVLs-----------KQSDKEAPLQ-G-----K 589 Chlamydia trachomat...
O25336   532 ---------FLEMEGFGVEMARSLVNFYASNQEFirSLFELLNPKNSDMAe-----------EKQKSSSVFN-N-----K 585 Helicobacter pylori...
O51502   534 -----afsTLLKIKGIGEKIALNIIEAFNDSVML--NKFKFFENLEFKME-------------EV-VAIDGE-NkllagK 591 Borrelia burgdorfer...
P28719   576 lrtilqpsSEESEEKYQKRVDKELISFFHIPNMGg-KIIRSLLDFFAETHnsdvvsdllqevQIEPLYFELA-SsplsgK 653 Zymomonas mobilis s...

2OWO_A   602 TVVLTGSLSQMSRDDAKARLV-ELGAKVAGSVSKKTDLVIAGEAAGS-KLAKAQELGIEVIDEAEM 665 Escherichia coli ATCC 8739
O53261   616 TIVVTGSLTGFSRDDAKEAIV-ARGGKAAGSVSKKTNYVVAGDSPGS-KYDKAVELGVPILDEDGF 679 Mycobacterium tuberculosis
P15042   602 TVVLTGSLSQMSRDDAKARLV-ELGAKVAGSVSKKTDLVIAGEAAGS-KLAKAQELGIEVIDEAEM 665 Escherichia coli K-12
P43813   601 TVVLTGTLTQMGRNEAKALLQ-QLGAKVSGSVSSKTDFVIAGDAAGS-KLAKAQELNITVLTEEEF 664 Haemophilus influenzae Rd KW20
P47496   594 RFLITGSFN-ISRDQIKDLLSaKFDCQFASEVKPTVDFVIAGNKPTLrKINHAKELNIPIINEAIW 658 Mycoplasma genitalium G37
P78021   593 SFVITGSFP-ISRDTIKNLLVnKYDCRFTNNVTSKVDFVLAGIKATPrKLEQAKALNIPIINEPIW 657 Mycoplasma pneumoniae M129
AAC67737 590 VFVLTGTLQQMTRTQAEERIR-CLGGKVSSSVSKSTYAVIAGSEAGG-KLKKAQDLGLSIWNESEL 653 Chlamydia trachomatis D/UW-3/CX
O25336   586 TIVLTGTLSKP-RQEYAQMLE-NLGAKISSSVSAKTDFLIAGENPGS-KLALAQKHGVSVLNEEEL 648 Helicobacter pylori 26695
O51502   592 KFCITGTFNGYSRSIIIDKLK-NKGAIFNTCVTGSLDFLIVGEKAGS-KLKKALSLNIKIMSFEDI 655 Borrelia burgdorferi B31
P28719   654 IIVFTGSLQKITRDEAKRQAE-NLGAKVASSVSKKTNLVVAGEAAGS-KLSKAKELDISIIDEDRW 717 Zymomonas mobilis subsp. mobilis ...
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