Conserved Protein Domain Family
pgsA
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TIGR00560: pgsA 
CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase
Alternate names: phosphatidylglycerophosphate synthase; glycerophosphate phosphatidyltransferase; PGP synthase. A number of related enzymes are quite similar in both sequence and catalytic activity, including Saccharamyces cerevisiae YDL142c, now known to be a cardiolipin synthase. There may be problems with incorrect transitive annotation of near homologs as authentic CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase. [Fatty acid and phospholipid metabolism, Biosynthesis]
Links
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Statistics
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PSSM-Id: 273139
Aligned: 8 rows
Threshold Bit Score: 167.143
Created: 7-Oct-2014
Updated: 25-Oct-2021
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
P75520        19 KKLPNWLTIYRIfIAVPTIIFLGLNHllgsvasftvlgnvTIHLQVSLFIGGVLFITAVISDYLDGYWARKWRVVSNFGK 98  Mycoplasma pneu...
P46322         2 FNLPNKITLARI-ALIPIFMIIMLAPfdwgr-----levgDESIPVAHLAGAILFIIASTTDWVDGYYARKLNLVTNFGK 75  Bacillus subtil...
P44528         3 FNIPIFLTIFRV-ILIPFFVIAFY-----------------LPIESSPFITTLIFFIAGVTDWLDGYLARKWKQTTRFGA 64  Haemophilus inf...
P47360        28 KKIANWLTVYRIfIALPTIIFIALDNqlgvlan-fsvgaiSISLQISLLIGGFLFLTAVISDYLDGYLARKWLAVSNFGK 106 Mycoplasma geni...
WP_001160187   3 FNIPTLLTLFRV-ILIPFFVLVFY-----------------LPVTWSPFAAALIFCVAAVTDWFDGFLARRWNQSTRFGA 64  Enterobacteriaceae
WP_010889808   7 VITPNKITLVRIaLSFIILILFFLEN--------------VFFSYLFFGIIWFLIIFNEFTDFIDGYLARKYGLVSNVGK 72  Lyme disease sp...
WP_010873088   1 MNIPNWVTVSRL-LALPL---LFLWL--------------PTPEAETRWWGVGIFLLAASTDWLDGYLARRLNQVTELGK 62  Synechocystis s...
WP_001862813   5 KLLPNFLTILRI--VLSLFLLFLLLNtrt--------yfsFLTPFQTNMISSLVFLFAALTDLLDGYIARSYKAKSRFGE 74  Helicobacter py...

P75520        99 LWDPLADKVIING--VLIALVAYGYFHFSFLIVIVLRDLVLDGLRFYAQE--Kq--LIIPANQWGKWKTTWQMIAILMsC 172 Mycoplasma pneu...
P46322        76 FLDPLADKLLVSA--ALIILVQFDLAPAWMVIVIISREFAVTGLRLVLAG--Tg--EVVAANMLGKIKTWAQIIAVSA-L 148 Bacillus subtil...
P44528        65 FLDPVADKVMVVAalVLIVEHQHTFWITIPAIIMISREIIISALREWMAE--LgerSKIAVSWWGKWKTTAQMLALGG-- 140 Haemophilus inf...
P47360       107 LWDPIADKVIING--VLIALAINGYFHFSLLIVFIVRDLVLDGMRIYAYE--Kk--VVIAANWLGKWKTIMQMVGIVFsC 180 Mycoplasma geni...
WP_001160187  65 FLDPVADKVLVAIamVLVTEHYHSWWVTLPAATMIAREIIISALREWMAElgKr--SSVAVSWIGKVKTTAQMVALAW-- 140 Enterobacteriaceae
WP_010889808  73 ILDPYADVLQHLT--YFVFFFYKGITPYYFFVIFIYREISIGFVRNLIIQ--Fn--VVQQANFLGKLKSLLYAVCTFA-S 145 Lyme disease sp...
WP_010873088  63 FLDPLVDKLLVLA--PLLILLTWQVVPPWAVGLILARELVIAGWRVNPQL--AsqtEIAGANLWGKVKTVTQITAI-A-L 136 Synechocystis s...
WP_001862813  75 IFDPLADKILILS--AFLGLVYLDRVNAWIPFVILGREFFISGLRVLAAN--Ek--KDIPVNALGKYKTVSQVVAIGA-- 146 Helicobacter py...

P75520       173 FV------------------FSFSlketnsanTKIFYWAIVHLPYYLATAFSLVSFGIYAQQIYKTIKVK 224 Mycoplasma pneumoniae M129
P46322       149 LL------------------HNLP--------FELVSFPFADLALWVAVFFTVVSGWEYFSKNWEALKTS 192 Bacillus subtilis subsp. ...
P44528       141 LL------------------WRYN----------NYMEIAAIILLYIAAILTIWSMIQYLQVAKGSLLDN 182 Haemophilus influenzae Rd...
P47360       181 FV------------------WSFKqseiaslnSGLFFWLLTQLPYYLAAVFSIWSFIVYNIQIYQQLKAY 232 Mycoplasma genitalium G37
WP_001160187 141 LL------------------WRPN----------IWVEYAGIALFFVAAVLTLWSMLQYLSAARADLLDQ 182 Enterobacteriaceae
WP_010889808 146 LLfytlnqlnftesvqnfisYILT--------FKFKFLFIVQMTYVCAAFFAILSFLEYVLIFLNVKKYE 207 Lyme disease spirochete
WP_010873088 137 LL------------------APLP----------EIYGQIGTVIFWIAVVLTLISGAIYLFPPGNNKVEA 178 Synechocystis sp. PCC 6803
WP_001862813 147 LL------------------ADVT-------------Y--SYALVAIAVFLTLYSGIDYTIKYYKS---- 179 Helicobacter pylori
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