Conserved Protein Domain Family
nadA

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TIGR00550: nadA 
quinolinate synthetase complex, A subunit
This protein, termed NadA, plays a role in the synthesis of pyridine, a precursor to NAD. The quinolinate synthetase complex consists of A protein (this protein) and B protein. B protein converts L-aspartate to iminoaspartate, an unstable reaction product which in the absence of A protein is spontaneously hydrolyzed to form oxaloacetate. The A protein, NadA, converts iminoaspartate to quinolate. [Biosynthesis of cofactors, prosthetic groups, and carriers, Pyridine nucleotides]
Statistics
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PSSM-Id: 129641
View PSSM: TIGR00550
Aligned: 6 rows
Threshold Bit Score: 421.103
Threshold Setting Gi: 24418568
Created: 7-Oct-2014
Updated: 2-Oct-2020
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q9KWZ1  21 LSRKD---METRVAAIKKKFGsrLFIPGHHYQKDEVIQFADQTG----DSLQLAQVAEKNKeADYIVFCGVHFMAETADM 93  Bacillus subtilis sub...
P11458  21 LSIDEkayYREKIKRLLKERN--AVMVAHYYTDPEIQQLAEETGgcisDSLEMARFGAKHP-ASTLLVAGVRFMGETAKI 97  Escherichia coli K-12
P74578  12 LPRD----LVGAIQSLKKELN--AVILAHYYQEAAIQDIADYLG----DSLGLSQQAASTD-ADVIVFAGVHFMAETAKI 80  Synechocystis sp. PCC...
Q57850   1 MSMD----IVERINKLKEEKN--AVILAHNYQPKEIQKIADFLG----DSLELCIKAKETD-ADIIVFCGVDFMGESAKI 69  Methanocaldococcus ja...
O27855   1 MLNQ----LQRDILRLKKEKN--AIILAHNYQSREIQEIADFKG----DSLELCIEASRIEgKDIVVFCGVDFMAETAYI 70  Methanothermobacter t...
O25910   1 MPTDNd--LKAAILELLRDLD--VLLVAHFYQKDEIVELAHYTG----DSLELAKIASQSD-KNLIVFCGVHFMGESVKA 71  Helicobacter pylori 2...
Q9KWZ1  94 LTSEqQTVVLPD-MRAGCSMADMADMQQtnraWKKLQHIFGDTIIpLTYVNSTAEIKAFVgkhgGATVTSSNAKKVLEWA 172 Bacillus subtilis sub...
P11458  98 LSPE-KTILMPT-LQAECSLDLGCPVEE----FNAFCDAHPDRTV-VVYANTSAAVKARA----DWVVTSSIAVELIDHL 166 Escherichia coli K-12
P74578  81 LNPH-KLVLLPD-LEAGCSLADSCPPRE----FAEFKQRHPDHLV-ISYINCTAEIKALS----DIICTSSNAVKIVQQL 149 Synechocystis sp. PCC...
Q57850  70 LNPE-KKVLMPEiEGTQCPMAHQLPPEI----IKKYRELYPEAPL-VVYVNTTAETKALA----DITCTSANADRVVNSL 139 Methanocaldococcus ja...
O27855  71 LNPD-KKILIPD-RGAECPMAHMLSAED----VRMARKRYPDAAV-VLYVNTLAEAKAEA----DILCTSANAVRVVESL 139 Methanothermobacter t...
O25910  72 LAFD-KQVIMPK--LSCCSMARMIDSHYydrsVHLLKECGVKEFYpITYINSNAEVKAKVakddGVVCTSRNASKIFNHA 148 Helicobacter pylori 2...
Q9KWZ1 173 FTQKKRILFLPDQHLGRntaYDLGIALEDMAVWdpmkdelvaesghtnvkvilwKGHCSVHEKFTTKNIHDMRERDPDIQ 252 Bacillus subtilis sub...
P11458 167 DSLGEKIIWAPDKHLGR---YVQKQTGGDILCW---------------------QGACIVHDEFKTQALTRLQEEYPDAA 222 Escherichia coli K-12
P74578 150 PPDQ-KIIFAPDRNLGR---YVMEQTGREMVLW---------------------QGSCIVHETFSERRLLELKTQYPQAE 204 Synechocystis sp. PCC...
Q57850 140 DAD--TVLFGPDNNLAY---YVQKRTDKKVIAIp-------------------eGGGCYVHKKFTIDDLKRVKSKYPNAK 195 Methanocaldococcus ja...
O27855 140 DED--LVLFGPDRNLAW---YVQEHTDKTIIPIp-------------------eEGHCYVHKMFTAGDVMAAKEKYPEAE 195 Methanothermobacter t...
O25910 149 LKQNKKIFFLPDKCLGEn--LALENGLKSAILGansqeeik------nadvvcyNGFCSVHQLFKLEDIEFYRQKYPDIL 220 Helicobacter pylori 2...
Q9KWZ1 253 IIVHPECSHEVVTLSDDNGSTKYIIDTINQAPAgSKWAIGTEMNLVQRIIHEHPDK-----QIESLNP-DMCPCLT---- 322 Bacillus subtilis sub...
P11458 223 ILVHPESPQAIVDMADAVGSTSQLIAAAKTLPH-QRLIVATDRGIFYKMQQAVPDKel--lEAPTAGEgATCRSCAhcpw 299 Escherichia coli K-12
P74578 205 IIAHPECEKAILRHADFIGSTTALLNYSGKSQG-KEFIVGTEPGIIHQMEKLSPSKq----FIPLPNN-SNCDCNEcp-y 277 Synechocystis sp. PCC...
Q57850 196 VLIHPECSPELQDNADYIASTSGILRIVLESDD-EEFIIGTEVGMINRLEIELEKLgkkktLIPLRKD-AICHE------ 267 Methanocaldococcus ja...
O27855 196 LLIHPECDPEVQELADHILSTGGMLRRVLESDA-ESFIIGTEVDMTTRISLESDKK-----TIPLLEE-AICEN------ 262 Methanothermobacter t...
O25910 221 IAVHPECEPSVVSNADFSGSTSQIIEFVEKLSPnQKVAIGTESHLVNRLKAKRHHQn----TFILSSTlALCPT------ 290 Helicobacter pylori 2...
Q9KWZ1 323 MNRIDLPHLLWSLEQIEKgepSGVIKVPKAIQEDALLALNRMLSIT 368 Bacillus subtilis subsp. subtilis str. 168
P11458 300 MAMNGLQAIAEALEQEGS---NHEVHVDERLRERALVPLNRMLDFA 342 Escherichia coli K-12
P74578 278 MRLNTLEKLYWAMQRR-----SPEITLPEATMAAALKPIQRMLAMS 318 Synechocystis sp. PCC 6803 substr. Kazusa
Q57850 268 MKRITLEKIEKCLLEE-----RYEIKLEKEIIEKAQKAIERMLRI- 307 Methanocaldococcus jannaschii DSM 2661
O27855 263 MKLHTLEKVKNSLINE-----EFVVTVPDEIARRARRAVERMIRVS 303 Methanothermobacter thermautotrophicus str. Delta H
O25910 291 MNETTLKDLFEVLKAYKNhraYNTIELKDEVARLAKLALTKMMELS 336 Helicobacter pylori 26695
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