1VHV


Conserved Protein Domain Family
dph5
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TIGR00522: dph5 
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diphthine synthase
Alternate name: diphthamide biosynthesis S-adenosylmethionine-dependent methyltransferase. This protein participates in the modification of a specific His of elongation factor 2 of eukarotes and Archaea to diphthamide. The protein was characterized in Saccharomyces cerevisiae and designated DPH5. [Protein fate, Protein modification and repair]
Links
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Statistics
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PSSM-Id: 273117
Aligned: 5 rows
Threshold Bit Score: 370.684
Created: 7-Oct-2014
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
1VHV_A        14 LLTFVGLGLWDVKDISVKGLEAVREADEVYVEYYTSKLL-SSIEEXEEFFGKRVVELERSDLEENSFRLIERAKSKSVVL 92  Archaeoglobus f...
WP_010870787   1 MLILAGLGLYDENDMTLKTLKFAKKAEKIYAEFYTAVLTgTTTEKIEEVLGKKIHVLSRKDVEYNGYKLIEEAKDKDIMF 80  Methanocaldococ...
WP_010877476   1 MLYIIGLGLYDENDISIKGLRAIEDCDEVYAEFYTAMLQgSSLSAIERRIGRSVKVLGRGEI-EEERIPIERALELDVAL 79  Methanothermoba...
WP_010877888   1 MLTFVGLGLWDVKDISVKGLEAVREADEVYVEYYTSKLL-SSIEEMEEFFGKRVVELERSDLEENSFRLIERAKSKSVVL 79  Archaeoglobus f...
P32469         1 MLYLIGLGLSYKSDITVRGLEAIKKCSRVYLEHYTSILMaASQEELESYYGKEIILADRELVETGSKQILNNADKEDVAF 80  Saccharomyces c...

1VHV_A        93 LVPGDPXVATTHSAIKLEAERKGVKTRIIHGASISTAVcGLTGLHNYRFGKSATVSW----HRSQTPVNVIKANRSIDAH 168 Archaeoglobus f...
WP_010870787  81 LTAGDPMVATTHVDLAIEAKKKGIEVLIINAPSIYSAV-GITGLQLYKFGKTTSIVFpeenYFPETPYNVIKENLERGLH 159 Methanocaldococ...
WP_010877476  80 LVAGDPLVATTHTELLIDAHRRGIETRVIHSSSIISAApGLAGLQAYKFGRIITIPFtsdnYFPTSPYTNIGENLKAGSH 159 Methanothermoba...
WP_010877888  80 LVPGDPMVATTHSAIKLEAERKGVKTRIIHGASISTAVcGLTGLHNYRFGKSATVSW----HRSQTPVNVIKANRSIDAH 155 Archaeoglobus f...
P32469        81 LVVGDPFGATTHTDLVLRAKREAIPVEIIHNASVMNAV-GACGLQLYNFGQTVSMVFftdnWRPDSWYDKIWENRKIGLH 159 Saccharomyces c...

1VHV_A       169 TLLFLDLHP-----EP--X-------------TIGHAVENLIAEDAQXK------DLYAVGIARAGSGEEVVKCDRLENL 222 Archaeoglobus f...
WP_010870787 160 TLCLLDIRId----ENekRf-----------mTANEGLKVLLELENRKKegiineDTKAVVVARAGSLKPKLVYGKIKDL 224 Methanocaldococ...
WP_010877476 160 SLVLLDIEAh----RN--Ry-----------mTATEGLRYLLKASEKLDdgtisgETLAVVIARAGSEKPLVRADKIATL 222 Methanothermoba...
WP_010877888 156 TLLFLDLHP-----EPm---------------TIGHAVENLIAEDAQMK------DLYAVGIARAGSGEEVVKCDRLENL 209 Archaeoglobus f...
P32469       160 TLVLLDIKVkeqsiEN--MargrliyepprymSIAQCCEQLLEIEEKRGtkaytpDTPAVAISRLGSSSQSFKSGTISEL 237 Saccharomyces c...

1VHV_A       223 KKIDFGKPLHVXVVLAKtLHFXEFECLREFADAP 256 Archaeoglobus fulgidus
WP_010870787 225 INYDFGEPLHCIIIPGK-LHFMEEDALKYLCENI 257 Methanocaldococcus jannaschii
WP_010877476 223 VEEDFGDPLHCLVVPAg-LHFIEADYLVEIAGAP 255 Methanothermobacter thermautotrophicus
WP_010877888 210 KKIDFGKPLHVMVVLAKtLHFMEFECLREFADAP 243 Archaeoglobus fulgidus
P32469       238 ANYDSGEPLHSLVILGRqCHELELEYLLEFADDK 271 Saccharomyces cerevisiae S288c
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