Conserved Protein Domain Family
lysS_bact
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TIGR00499: lysS_bact 
lysyl-tRNA synthetase, eukaryotic and non-spirochete bacterial
This model represents the lysyl-tRNA synthetases that are class II amino-acyl tRNA synthetases. It includes all eukaryotic and most bacterial examples of the enzyme, but not archaeal or spirochete forms. [Protein synthesis, tRNA aminoacylation]
Links
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Statistics
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PSSM-Id: 273107
Aligned: 8 rows
Threshold Bit Score: 622.079
Created: 7-Oct-2014
Updated: 25-Oct-2021
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
AAA66916  69 DPSQYFETRSRQIQELRKTHepNPYPH-KFHVSISNPEFLAKYAHLKKG----ETLP-EEKVSIAGRIHAKReSGSKLKF 142 baker's yeast
P43825    10 DLNGEMLVRREKLAALRAKG--NAFPN-KFRRDALAQDLHNQYDAEDGEi---LKEK-GIEVQVAGRIMTRR-AMGKATF 81  Haemophilus influen...
P37477    10 ELNDQLQVRRDKMNQLRDNGi-DPFGA-RFERTHQSQEVISAYQDLTKEe---LEEK-AIEVTIAGRMMTKR-GKGKAGF 82  Bacillus subtilis s...
P73443     9 SLEEIRATRLEKAEQLRQLGl-NPYAY-TWEITHQAQDLQETYRDLSn-----GEEV-DLKVAIAGRILARR-VMGKLAF 79  Synechocystis sp. P...
P56126     2 FSNQYIQQRIHKANSLREEGk-NPYQN-GLKRSLTNAAFLEKYAYVKGLe--ePKDK-EKCESIVGRVKLLR-LMGKACF 75  Helicobacter pylori...
P75500     4 RLNDQAQNRLQKLLNLKQTGn-DPYLItKIENTHSAASFQKAFANQSDAe---LK---QYQVILTGRIIALR-----QTF 71  Mycoplasma pneumoni...
P47382     4 RLNDQAQHRLQKLLRLKQTNn-DPYLVtKTSLTHSSKSFQVEFEKCSEEe---LKK--KATVSLAGRIIAIR-----QTF 72  Mycoplasma genitali...
P32048    41 EATRRNGQIVKDLGRYYPSMs-ESALHdLCQEYKEVTIADFNERFLGNPatlhHEDNpNLLLSINGRIKSIRfSGQKIVF 119 Saccharomyces cerev...

AAA66916 143 YVLHGDG------VEVQLMSQLQDY---CDpDSYEKDHDL------LKRGDIVGVEGYVgrtqpKKGGEGEVSVFVSRVQ 207 baker's yeast
P43825    82 ITIQDMS------GKIQLYVARDNL---PE-GVYKDDVGT------WDLGDIVGIKGTL-----FKTKTDELTVKTTEVQ 140 Haemophilus influen...
P37477    83 AHLQDLE------GQIQIYVRKDSV---GD-DQYEIFKSS-------DLGDLIGVTGKV-----FKTNVGELSVKATSFE 140 Bacillus subtilis s...
P73443    80 FTLQDES------GTIQLYLEKQRL---TE-HMPELENAFnllkkiTDVGDILGVTGTL-----KRTEKGELSVYVQTYA 144 Synechocystis sp. P...
P56126    76 IKVEDES------TILQVYVSQNEL---ND-EFKSLKKHL-------EVGDIVLVKGFP-----FATKTGELSIHALEFH 133 Helicobacter pylori...
P75500    72 IIIQDFS------GKMQLYINKKTA---PE-LFEYFNNYI-------DLGDQIVATGHP-----MMTKTGVLTLNVERLQ 129 Mycoplasma pneumoni...
P47382    73 LIIQDFD------GQVQLYINKKIH---PK-LFDYFNEFV-------DIGDQIVVSGKP-----MLTKTKVLTLAVEEMK 130 Mycoplasma genitali...
P32048   120 IDLYNGSsglkndTQLQLIVNYNKIggsSE-DKANFSEYMn----fLKKGDYIKALGYPg---fSQSRVKMLSLICNKLP 191 Saccharomyces cerev...

AAA66916 208 LLTPCLHMLPADHFGFKDQETRYR-KRYLDLIMNKDARNRFITRSEIIRYIRRFLDQRKFIEVETPMMNVIAGGATAKPF 286 baker's yeast
P43825   141 LLTKALRPLPDKFHGLTDQEVRYR-QRYLDLISNEESRRTFIIRSKVVAGIREYFISKGFMEVETPMLQVIPGGASARPF 219 Haemophilus influen...
P37477   141 LLTKALRPLPDKYHGLKDVEQRYR-QRYLDLIVNPDSKHTFITRSKIIQAMRRYLDDHGYLEVETPTMHSIPGGASARPF 219 Bacillus subtilis s...
P73443   145 VLTKSLLPLPDKWHGLTDTEKRYR-QRYVDLIVNPTVRQTFRRRAQITAAIRRYLDKQGFIEIETPVLQGESGGAEARPF 223 Synechocystis sp. P...
P56126   134 ILSKTIVPLPEKFHGLSDIELRYR-QRYLDLIVNPSVKDVFKKRSLIVSSVRKFFEMEGFLEVETPMMHPIPGGANARPF 212 Helicobacter pylori...
P75500   130 IVAKCLQTPPEKWHGLTDPEARAR-KRYLDLTYNRAQVEVFLKRTQIITAIRTFLNEAGFLEVETPILQAVLGGANAKPF 208 Mycoplasma pneumoni...
P47382   131 IIAKCLLVPPEKWHGLTDIETRAR-KRFLDLTYNLAMRDVFLKRTKIIKSIRSFLDQNGFIEVETPTLQAVLGGANAKPF 209 Mycoplasma genitali...
P32048   192 IVLSVSQ-LPLPSR-L-NDETKIKsNRVVDYQLN--GTQTLLVRARIIKLLRKFLDDRNFVEVETPILSSKSNGAMAKPF 266 Saccharomyces cerev...

AAA66916 287 ITHHNDLDMDMYMRIAPELFLKQLVVGGLDRVYEIGRQFRNEGIDMTHNPEFTTCEFYQAYADVYDLMDMTELMFSEMVK 366 baker's yeast
P43825   220 VTHHNALDVDMYLRIAPELYLKRLVVGGFERVFELNRNFRNEGVSVRHNPEFTMLEYYQAYADYHDLMDNTEELLRKLAI 299 Haemophilus influen...
P37477   220 ITHHNALDIPLYMRIAIELHLKRLIVGGLEKVYEIGRVFRNEGVSTRHNPEFTMIELYEAYADYKDIMSLTENLVAHIAQ 299 Bacillus subtilis s...
P73443   224 ITHHNTLGMPLYLRIATELHLKRLVVGGFEKVFELGRIFRNEGVSTRHNPEFTSIEVYQAYVDYNEMMALTEALVTTAAQ 303 Synechocystis sp. P...
P56126   213 ITYHNALEVERYLRIAPELYLKRLIVGGFEAVFEINRNFRNEGMDHSHNPEFTMIEFYWAYHTYEDLIELSKRLFDYLLK 292 Helicobacter pylori...
P75500   209 KTHYNALKGDFYLRIANEIALKKLIVGGLPKVYEMGRMFRNEGVDTTHNPEFTSIEMYQANADYAVMMDLTENLIKFVCK 288 Mycoplasma pneumoni...
P47382   210 KTHYNALKADFYLRIANEIALKKLIIGGFNKVYEMGKMFRNEGVDTTHNPEFTSIEIYQAYADFEVMLVLVEKLIQSLCE 289 Mycoplasma genitali...
P32048   267 ITSS-KDFDHLELRIAPELWLKRLIISGLQKVYEIGKVFRNEGIDSTHNAEFSTLEFYETYMSMDDIVTRTEDLFKFLIT 345 Saccharomyces cerev...

AAA66916 367 EITGSYIIkyhp----dpadPAKELELNFSR-PWKRINMIEELEkvfnVKFP-SGDQLHTAETGEFLKKILVD---NKlE 437 baker's yeast
P43825   300 DILGTTIV------------KYGDLEFDFGK-PFERITLHDATIky-gADKGiVKEDLYDFDRAKATAERLGI---EV-Q 361 Haemophilus influen...
P37477   300 EVLGTTTI------------QYGEEQIDLKP-EWKRIHMVDAVK----EATGvDFWEEVTVEQAREYAKEHEV---EI-K 358 Bacillus subtilis s...
P73443   304 AVLGTLKI------------TYQGEEIDLTP-PWKRITMHEAVQ----LETGiDFSQFTDLETAKQAATKAGI---GVpE 363 Synechocystis sp. P...
P56126   293 TLNLDSKI------------IYNDMEVDFN--QTSVISYLDALE----TIGGiSKDILEKEDRLLAYLLEQGI---KV-E 350 Helicobacter pylori...
P75500   289 TLN-QWSF------------NWNGQTLDLAK-PFKKVKMVDLIC----QVTGvNFDDVKDDQTAIALAKQHKV---ELkK 347 Mycoplasma pneumoni...
P47382   290 SLN-QFSF------------NWNNKTINLKT-PFHKITMVELIK----KVTGiDFNSVKDDQSAILLAEKHHV---KLaK 348 Mycoplasma genitali...
P32048   346 NLQKFFQDtrlpvpktfselHLALSENNWKFrKVEFLPTLNKELgidlMNS--GLDINKPSELLKALPKDIAKkyfPSaD 423 Saccharomyces cerev...

AAA66916 438 CPppLTNARMLDKLVGE-LEDTCIN---PTFIFGHPQMMSPLAKYSRDQPGLCERFEVFVATKEICNAYTELNDPFDQRA 513 baker's yeast
P43825   362 KS--WGLGSIVNAIFEEvAEHHLIQ---PTFLNGSPAEISPLARRNDENPEVTDRFELFIGGREIGNGFSELNDAEDQNE 436 Haemophilus influen...
P37477   359 DS--MTVGHIINEFFEQkIEETLIQ---PTFIYGHPVEISPLAKKNPEDPRFTDRFELFIVGREHANAFTELNDPIDQRE 433 Bacillus subtilis s...
P73443   364 DC--PSLGHLLNHAFEQkVEGTLMQ---PTFIIDFPVEISPLAKPHRSKPGLVERFELFVYGRELANSFSELTDPIDQRS 438 Synechocystis sp. P...
P56126   351 PN--LTYGKLLAEAFDHfVEHQLIN---PTFVTQYPIEISPLARRNDSNPNIADRFELFIAGKEIANGFSELNDPLDQLE 425 Helicobacter pylori...
P75500   348 HE--QNKQHIINRFFEQfCEHTLIQ---PTFVTHYPKAVSPLAKQDPHNPEFTERFELFINTKELANAYSELNDPLEQRA 422 Mycoplasma pneumoni...
P47382   349 HQ--QNKQHIINLFFEQfCEQTLIE---PTFVTHYPKAVSPLAKQDPSNPEFTQRFELFINGKEIANAYSELNDPLEQRK 423 Mycoplasma genitali...
P32048   424 NTgqLSSLQILNKLSDVfLEQRHCQstlPTVIYHQPAILSPLAKTDPQNKQVTKRFEVFIKGKEYINAYEEENCPQLQLQ 503 Saccharomyces cerev...

AAA66916 514 RFEEQARQKDQG----DDEAQLVDETFCNALEYGLPPTGGWGCGIDRLAMFLTDSNTIREVLLFPTLKpDV 580 baker's yeast
P43825   437 RFDAQVAAKEAG----DDEAMFKDEDFVVALEHGLPPTAGEGLGIDRLAMLYANAPSIRDVILFPAMR-QK 502 Haemophilus influenzae Rd KW20
P37477   434 RFEAQLKEREAG----NDEAHLMDEDFVEALEYGMPPTGGLGIGIDRLVMLLTNAPSIRDVLLFPQMR-QR 499 Bacillus subtilis subsp. sub...
P73443   439 RLEAQAAKKAAG----DLEAHSVDEDFLTALEYGMPPTGGLGIGIDRLVMLLTDSPSIRDVIAFPLLKnQE 505 Synechocystis sp. PCC 6803 s...
P56126   426 RFKNQVAEKEKG----DEEAQYMDEDYVWALAHGMPPTAGQGIGIDRLVMLLTGAKSIKDVILFPAMRpVK 492 Helicobacter pylori 26695
P75500   423 RFEQQLQEKRMG----NDEASELDESFLDALSFGLPPTGGLGIGVDRLVMLLCECSSIRDVVFFPQLReLK 489 Mycoplasma pneumoniae M129
P47382   424 RFEQQLEEKQLG----NDETSELDESFLEALSFGMVNTAGLGIGIDRLVMLLCECNSIRDVVFFPQLReHK 490 Mycoplasma genitalium G37
P32048   504 KFLQQKQINELTgnktETLSPVIDYQYVETMKYGMPPVGGFGLGIDRLCMLFCDKKRIEEVLPFGCVD-DV 573 Saccharomyces cerevisiae S288c
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