Conserved Protein Domain Family
selB

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TIGR00475: selB 
selenocysteine-specific elongation factor SelB
In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements: SelC is the tRNA itself, SelD acts as a donor of reduced selenium, SelA modifies a serine residue on SelC into selenocysteine, and SelB is a selenocysteine-specific translation elongation factor. 3-prime or 5-prime non-coding elements of mRNA have been found as probable structures for directing selenocysteine incorporation. This model describes the elongation factor SelB, a close homolog rf EF-Tu. It may function by replacing EF-Tu. A C-terminal domain not found in EF-Tu is in all SelB sequences in the seed alignment except that from Methanococcus jannaschii. This model does not find an equivalent protein for eukaryotes. [Protein synthesis, Translation factors]
Statistics
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PSSM-Id: 129567
View PSSM: TIGR00475
Aligned: 4 rows
Threshold Bit Score: 582.988
Threshold Setting Gi: 2833515
Created: 7-Oct-2014
Updated: 2-Oct-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
P14081         1 MIIATAGHVDHGKTTLLQAITGVN---ADRLPEEK-KRGMTIDLGYAYWPQPDg-RVPGFIDVPGHEKFLSNMLAGVGGI 75  Escherichia col...
P43927         1 MIIVTSGHVDHGKTALLKALTGTS---TAHLPEEK-KRGMTIDLGYAYLPLEN--KVLGFIDVPGHEKFLSNMLAGLGGV 74  Haemophilus inf...
Q57918        10 VNVGLFGHIDHGKTQLAKQLTEIAstsALDKPKESqKRGITIDLGFSSFTLDR--YRITLVDAPGHSELIRTAIGAGNII 87  Methanocaldococ...
WP_010880642   4 ILFATAGHVDHGKTTLIKTLTGID---TDRLPEEK-KRGLSIDIGFAYIDFPDinTRLEIIDVPGHERFIKNAIAGICSA 79  Aquifex aeolicus
P14081        76 DHALLVVACDDGVMAQTREHLAILQLTGNPMLTVALTKADRVDEArvdEVERQVKEVLREYGFA-EAKLFITAATEGRGM 154 Escherichia col...
P43927        75 HYAMLIVAADEGVAVQTKEHLAILRQLQFHEIIVVITKADRTNSA---QIESLIQTIKQDYSFLrNANYFVTSAETGQGI 151 Haemophilus inf...
Q57918        88 DAALLVVDAKEGPKTQTGEHLLVLDLLNIP-TIVVINKIDIANDEeikRTEMFMKQILNSTINLkNSKIIKISAKTGEGI 166 Methanocaldococ...
WP_010880642  80 SGLILVVDPNEGIMPQTIEHLRVAKSFGIKHGIAVLTKMDKVDEElahIAEEELIAFLEKEEMN--MEIVKVSAVTGQGI 157 Aquifex aeolicus
P14081       155 DALREHLLQLPEREHAs---QHSFRLAIDRAFTVKGAGLVVTGTALSGEVKVGDSLWLTgVNKPMRVRALHAQNQPTETA 231 Escherichia col...
P43927       152 SELRHYLANLAELADT----QKPFRYAIDRVFSVKGAGTVVTGTAFSGTVKVNDEIYLS-TGQKIRIKAIHAQNTSSEQG 226 Haemophilus inf...
Q57918       167 GELKKELKNLLDSLDIkrdiNSYLKMPIDHAFKIKGVGTVVTGTIHKGKVEVGDNLRILpINHEVKVKSIQCFKQDVSIA 246 Methanocaldococ...
WP_010880642 158 EDLKNSIKKLLESINNln-kHKPLRIFVDSAFVVKGYGTVLRGSCFEGEVKEGDKVVVEpIGVISRVRKMQNHGVFVKKA 236 Aquifex aeolicus
P14081       232 NAGQRIALNIAgDAEKEQINRGdwLLADVPPEPFTRVIVELQTHTPLTQWQPLHIHHAASHVTGRVSLLEDN-------- 303 Escherichia col...
P43927       227 IAGQRLALNLNaDLDRTPMKRGdwLLQNEPLPPTDRISVQILAEVPLNESQPVHIYHGASRTTGKLTLLQGKnaakndrt 306 Haemophilus inf...
Q57918       247 YAGDRVGMALM-GVEPESLFRG---CILTSEDTKLKVVDKFIAKVKILELFKYNLAPKMKVHIN---------------- 306 Methanocaldococ...
WP_010880642 237 VAGERIALNLP-EVDAKKVKRG--FLILKPESYEKSNVLIVKTEIDLKPGKIYQVFFGMRETVGKISVIDKG-------- 305 Aquifex aeolicus
P14081       304 LAELVFDTPLWLADNDRLVLRDiSARNTLAGARVVMLnpPRRGKRKpeylQWLASLARAQSDADALSVHLERGAVNLAdF 383 Escherichia col...
P43927       307 LAEIILDSPLFLAFGDKLILRSgDTKTLIAGARVLEInsPKRHKRTevrlNFLANLALAENASQRIALTLQHNATTARqL 386 Haemophilus inf...
Q57918       307 IGLLTVPATIIPYKIEKINDKE-------------EP--------------IILEEIKGGDSCYCIFKLEERVVVDEG-- 357 Methanocaldococ...
WP_010880642 306 IYLVRLKENAIVRRGDKLVVLD-SSGNFLGGAEVLHP--KVRVTKK----AFIKKNIKDLLENFECYLLKERGPIGLK-L 377 Aquifex aeolicus
P14081       384 AWARQLNGEGMRELLQQPGYIQAGYSLLNAPVAARWQRKILDTLATyhEQHrDEPGPGRERLRRMALPMedEALVLLLIE 463 Escherichia col...
P43927       387 MWTEQLTSLQLDKALAERDAVRYQDWCFNPNYVQEKTQQILTALNIyhEQHnDQLGVSKARLYRMATLNqpENLIHHFID 466 Haemophilus inf...
Q57918       358 ------DKILIMRLDLPPTTLRICGFGEVIDFGEVEVKKIVVKEGK------VVKKKDKIYIEGLASSK-------TAGE 418 Methanocaldococ...
WP_010880642 378 EFFKRITGVSPKVANLKPESIEIRGVYYLKGFIENLKLKIKKFLDT--ELQ-NAFGVDKEKVKSMFSLN--EELLKYILD 452 Aquifex aeolicus
P14081       464 KMREsgdIHSHHGWLHLPDHKAGFSEEQQaIWQKAEPLFGDE---PWWVRDLAKETGTDEQAMRLTLRQAAQQGIITAIV 540 Escherichia col...
P43927       467 EMLDdgrLQQTRGWIHLPEHKIQFNTEEKsRWTDVLNEFEKAngqAIWVRDMANALAIDESIMRNFMYKAGKLGYLTPIV 546 Haemophilus inf...
Q57918       419 KLIG-------G-KVYIPDKN---------IWGVIKGTFGTK---GALIAEFDEEVNGGEKVVLKRVRKWG--------- 469 Methanocaldococ...
WP_010880642 453 ELK----TYKIVNELIIDERKSDLEKNED--FQKLMSILKGG---IKEEREIILEGIPKEILTLSIKRKYAHRIGEYLII 523 Aquifex aeolicus
P14081       541 KDRYYRndrivefaNMIRDLDQECGSTCAADFRDRLGVGRKLAIQILEYFDRIGFTRRRGNDHLLRD 607 Escherichia coli K-12
P43927       547 KDRFFLtetlyayaRLIKQIAEEKGKVSVNEVRDKLNFGRKLTVQLMEYFDRMGFLRRKGNDHILRD 613 Haemophilus influenzae Rd KW20
Q57918           -------------------------------------------------------------------     Methanocaldococcus jannaschi...
WP_010880642 524 SDELLK--------KYINELKELGKTFNVQQAKNKLGLTRKYLIPLLEYLDYLGLTVREGNERRWKR 582 Aquifex aeolicus
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