Conserved Protein Domain Family
unchar_dom_2

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TIGR00451: unchar_dom_2 
uncharacterized domain 2
This uncharacterized domain is found a number of enzymes and uncharacterized proteins, often at the C-terminus. It is found in some but not all members of a family of related tRNA-guanine transglycosylases (tgt), which exchange a guanine base for some modified base without breaking the phosphodiester backbone of the tRNA. It is also found in rRNA pseudouridine synthase, another enzyme of RNA base modification not otherwise homologous to tgt. It is found, again at the C-terminus, in two putative glutamate 5-kinases. It is also found in a family of small, uncharacterized archaeal proteins consisting mostly of this domain.
Statistics
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PSSM-Id: 129543
View PSSM: TIGR00451
Aligned: 5 rows
Threshold Bit Score: 134.098
Threshold Setting Gi: 2495775
Created: 7-Oct-2014
Updated: 2-Oct-2020
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
AAB64566      61 YSVDGEVLFFQKFD------ELIPSLKLVHKFPEA---YPTVQVDRGAIKFVLS-GANIMCPGLTSAGADLPpapgyeKG 130 baker's yeast
Q60377        93 IIVDGEVKYLIYFDedkekwKVKLKLNGAKDLMEKgayKKIIKIKNDVVEFLKNrKGSVLRPGIVEFTDDIE------EK 166 Methanocaldococ...
WP_010876288  47 ILVNGEPLLMFIDD------RVVPTLRGALKMEID---RGYVVVDMGAVRFLAN-GADVMSPGIVDADPEIS------EN 110 Methanothermoba...
WP_010878902  41 ILVDNEPLVINYDG------RYYLSVYGAIKLKPE---KYRVTVDEGALKFVMN-GADVMKPGIVYADERIK------EG 104 Archaeoglobus f...
WP_010870950  49 ILVDKEPIAFKKDD------KVIPTLKLLLKSLPD---KNLVVVDIGAIKFLIN-GADVMAPGIVDADENIK------EE 112 Methanocaldococ...
AAB64566     131 TIVVINAENkENALAIGELMMGTEEIKSVNKGHSIELIHHLGD 173 baker's yeast
Q60377       167 DDVIIVDEN-DRVVGVGLAVVSSEDIKNMEKGKVVKVRFFIKD 208 Methanocaldococcus jannaschii DSM 2661
WP_010876288 111 DTVVVVDERnRRPLAVGISLISGPEMVERDSGKAVKTIHHIGD 153 Methanothermobacter thermautotrophicus
WP_010878902 105 DFVFVTVEGkDSPIAVGVALCNGEEMVR-GKGKAVKNIHHIKD 146 Archaeoglobus fulgidus
WP_010870950 113 DVVFVVDENhKKPICVGIALMNGKEMKEADKGKAIKNLHYVGD 155 Methanocaldococcus jannaschii
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