Conserved Protein Domain Family
mnmE_trmE_thdF
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TIGR00450: mnmE_trmE_thdF 
tRNA modification GTPase TrmE
TrmE, also called MnmE and previously designated ThdF (thiophene and furan oxidation protein), is a GTPase involved in tRNA modification to create 5-methylaminomethyl-2-thiouridine in the wobble position of some tRNAs. This protein and GidA form an alpha2/beta2 heterotetramer. [Protein synthesis, tRNA and rRNA base modification]
Links
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Statistics
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PSSM-Id: 273083
Aligned: 5 rows
Threshold Bit Score: 563.262
Created: 7-Oct-2014
Updated: 25-Oct-2021
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
P53364  15 AT----PFLSSALCVIRSSGASSISKFSKIFsnhsALNSASGNTIHYGYILDSENGCKVDEVVVCLYRaPKSFTGQDAIE 90  Borrelia burgdorferi B31
P73839   9 AIataiVPQQGSIGVVRLSGPQSLTIAKTLFda-pGNQTWESHRILYGHVRHPQTKAAIDEALLLLMLaPRSYTKEDVVE 87  Synechocystis sp. PCC...
O25991  20 AT----PLGKGAISIIKISGHNALNILKQLT-----QKQDFTPRYAYVHDIFSNGVLLDKALVIYFKA-PYSFTGEDVCE 89  Helicobacter pylori 2...
P47254  11 AT----APFNSALHIIRFSGPDVYEILNKITn---KKITRKGMQIQRTWIVDENNKRIDDVLLFKFVS-PNSYTGEDLIE 82  Mycoplasma genitalium...
P75104  11 AT----APFNSAIHIIRLSGPDVYRIINQITn---KEVKPLGMRIQRVWLIDHNQKKVDDVLLFKFVA-PNSYTGEDLIE 82  Mycoplasma pneumoniae...

P53364  91 VMAHGSVIGIKKIIDLFLKSGFRMAEPGEFTLRAFLAKKIDLTKAEAIHEIIFAKTNKTYSLAVNKLSGALFVKIDAIKK 170 Borrelia burgdorferi B31
P73839  88 FQCHGGIMPVQQVLQLCLQQGARLAQPGEFSFRAFLNGRLDLTQAESISELVGAQSPQAAAIALAGLQGKLAQPIRDLRN 167 Synechocystis sp. PCC...
O25991  90 IQCHGSPLLAQNILQACLNLGARLAKAGEFSKKAFLNHKMDLSEIEASVQLILCEDESVLNALARQLKGELKIFIEEARG 169 Helicobacter pylori 2...
P47254  83 ISCHGNMLIVNEICALLLKKgGVYAKPGEFTQRSFLNGKMSLQQASAVNKLILSPNLLVKDIVLNNLAGEMDQQLEQIAQ 162 Mycoplasma genitalium...
P75104  83 ISCHGSMVIVNEIIGLLLKHgAVQAQPGEFTQRGYLNGKMSLNQAASVNNLVLSPNTTLKDVALNALAGQVDARLEPLVE 162 Mycoplasma pneumoniae...

P53364 171 SILNFLSAVSVYLDYEVDDHEIS-----IPFDLILSSKAELKKLINSy---KvyEKIDNGVALVLAGSVNAGKSSLFNLF 242 Borrelia burgdorferi B31
P73839 168 TCLDILAEVEARIDFEDDLPPLDe---dSIRQQLQNLYQQLEDILNTaq-rG--ELLRTGLKVAIVGQPNVGKSSLLNAW 241 Synechocystis sp. PCC...
O25991 170 NLLKLLASSEVLIDYSEEDIPSDfldgvSLN--LEKQIASFKDLLDFsnaqK---QRNKGHALSIVGKPNAGKSSLLNAM 244 Helicobacter pylori 2...
P47254 163 QVNQLVMQMEVNIDYPEYLDEqve--lsTLNNKVKLIIEKLKRIIEns--kQl-KKLHDPFKIAIIGETNVGKSSLLNAL 237 Mycoplasma genitalium...
P75104 163 KLGQLVMQMEVNLDYPEYTDEqre--lvTMNQAVVQITQILNQIVVgq--dQl-QRLKDPFKIAIIGNTNVGKSSLLNAL 237 Mycoplasma pneumoniae...

P53364 243 LKKDRSIVSSYPGTTRDYIEASFELDGILFNLFDTAGLRDADNFVERLGIEKSNSLIKEASLVIYVIDVSSNLTKDDf-L 321 Borrelia burgdorferi B31
P73839 242 SRTDRAIVTDLPGTTRDVVESQLVVEGIPIQVLDTAGIRETADQVEQIGVERSRKAAQQADLVLLTVDAHQGWTEAD--Q 319 Synechocystis sp. PCC...
O25991 245 LLEERALVSDIKGTTRDTIEEVIELKGHKVRLIDTAGIRESADKIERLGIEKSLKSLENCDIILGVFDLSKPLEKEDfnL 324 Helicobacter pylori 2...
P47254 238 LNQDKAIVSNIKGSTRDVVEGDFNLNGYLIKILDTAGIRKHKSGLEKAGIKKSFESIKQANLVIYLLDATHPK-KDLe-L 315 Mycoplasma genitalium...
P75104 238 LDQDKAIVSAIKGSTRDIVEGDFALNGHFVKILDTAGIRQHQSALEKAGIQKTFGAIKTANLVIYLLDARQPE-PDPk-I 315 Mycoplasma pneumoniae...

P53364 322 FIDSNKSNSKILFVLNKIDLKinksTEEFVRSKVLNSSNLIMISTKNLEGIDILYDKIRALISYeRVEigLDDIIISSNR 401 Borrelia burgdorferi B31
P73839 320 LIYEQVKDRPLILVINKIDLGra-dLVSYPPEITNTVLTAAAANLGIEALENAIIEQVNQTNLS-PQN--LDFAINQRQE 395 Synechocystis sp. PCC...
O25991 325 IDTLNRAKKPCIVVLNKNDLApkleLEILKSYLKIPYTLLETNTLNSKACLKDLSQKISAFFPK-LDT---QNKLLLTSL 400 Helicobacter pylori 2...
P47254 316 ISFFKKNKKDFFVFYNKKDLIt---NKFENS--------ISAKQKDIKELVDLLTKYINEFYKKiD----QKIYLIENWQ 380 Mycoplasma genitalium...
P75104 316 IARLKKLKKDFFLVHNKADLVq---QSFQVS--------ISAKQKQIQPLVDLLTQYLHQFYSVeQ----NQLYLISDWQ 380 Mycoplasma pneumoniae...

P53364 402 Q-MQLLEKAYALILD-LLSKIDrqvsYDMLAFDAYEIINCLGEITGEVSSEDVLDNMFKNFCLGK 464 Borrelia burgdorferi B31
P73839 396 AvLTEAQLALKQLQQtMAEQLP----LDFWTIDLRLAINALGQVTGETVTESVLDRIFSRFCIGK 456 Synechocystis sp. PCC 6803 substr. K...
O25991 401 AqKIALENAITELQN-AKNHLEt---LELFSYHILSAIENLNLLTRPYETSQMLDSMFSEFCLGK 461 Helicobacter pylori 26695
P47254 381 Q--ILIEKIKEQLEQ-FLKQQKkylfFDVLVTHLREAQQDILKLLGKDVGFDLVNEIFNNFCLGK 442 Mycoplasma genitalium G37
P75104 381 T--ILLQKAIAELEH-FLIKQQnclfFDILVVHLRAAHEYILQVLGKNTNYDLINEIFKHFCLGK 442 Mycoplasma pneumoniae M129
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