1LI5,3SP1


Conserved Protein Domain Family
cysS

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TIGR00435: cysS 
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cysteinyl-tRNA synthetase
This model finds the cysteinyl-tRNA synthetase from most but not from all species. The enzyme from one archaeal species, Archaeoglobus fulgidus, is found but the equivalent enzymes from some other Archaea, including Methanococcus jannaschii, are not found, although biochemical evidence suggests that tRNA(Cys) in these species are charged directly with Cys rather than through a misacylation and correction pathway as for tRNA(Gln). [Protein synthesis, tRNA aminoacylation]
Statistics
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PSSM-Id: 273076
Aligned: 12 rows
Threshold Bit Score: 575.486
Created: 7-Oct-2014
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1LI5_A   2 LKIFNTLTRQKEEFKPIHAG-EVGMYVCGITVYDLCHIGHGRTFVAFDVVARYLR-FLGYKLKYVRNITDI--------- 70  Escherichia coli BW2952
O29836   1 MEVYNTLSRKIEKLEDIVDGkRVKMYVCGITAYDYSHIGHARSAVFFDVFRRYLE-YLGYEVVYVQNFTDV--------- 70  Archaeoglobus fulgidu...
P43816   2 LKIFNTLTREKEIFKPIHEN-KVGMYVCGVTVYDLCHIGHGRTFVCFDVIARYLR-SLGYDLTYVRNITDV--------- 70  Haemophilus influenza...
P21888   2 LKIFNTLTRQKEEFKPIHAG-EVGMYVCGITVYDLCHIGHGRTFVAFDVVARYLR-FLGYKLKYVRNITDI--------- 70  Escherichia coli K-12
Q06752   3 ITLYNTLTRQKETFVPLEEG-KVKMYVCGPTVYNYIHIGNARPAIVYDTVRNYLE-YKGYDVQYVSNFTDV--------- 71  Bacillus subtilis sub...
P41259   1 MFIYDTKLKQKVPFEPLVQN-KANIYVCGPTVYDDAHLGHARSAIAFDLLRRTLE-LSGYEVMLVRNFTDI--------- 69  Helicobacter pylori 2...
P53852  36 LKLYNSLTRSKVEFIPQSGNrGVTWYSCGPTVYDASHMGHARNYVSIDINRRIIQdYFGYDVQFVQNVTDI--------- 106 Saccharomyces cerevis...
P75423   8 FTLIDTVS-NQS--VVLEQK-QINIYLCGPTVYNDLHLGNTRPLIVFDVLQRVLQ-AAQYKVQFVQNITDI--------- 73  Mycoplasma pneumoniae...
P47495   1 -MIVDSVS-QKP--TTLVQK-TINIYLCGPTVYNDLHLGNTRPLIVFDVLNRVLK-KAKYTVNFVQNITDI--------- 65  Mycoplasma genitalium...
O51545   3 LKLYNTRT--KD-FSELTNFeNVKVYACGPTVYNYAHIGNFRTYIFGDLLIKTLR-FLGYKVNYAMNITDIghltgdldd 78  Borrelia burgdorferi B31
P74330   3 LRLYDSLTRAKQPLQPLHPG-LVTMYCCGITVYDYCHLGHARTCITWDLVRRYLQ-WSGYEVRYVQNFTDI--------- 71  Synechocystis sp. PCC...
3SP1_A  24 LKLYNTRTK---DFSELTNFeNVKVYACGPTVYNYAHIGNFRTYIFGDLLIKTLR-FLGYKVNYAMNITDIghltgdldd 99  Lyme disease spirochete
1LI5_A  71 -DDKIIKRANENGESFVAM------------------------------------------------------------- 88  Escherichia coli BW2952
O29836  71 -DDKIINRAVKEGKTQKEV------------------------------------------------------------- 88  Archaeoglobus fulgidu...
P43816  71 -DDKIIKRALENKETCDQL------------------------------------------------------------- 88  Haemophilus influenza...
P21888  71 -DDKIIKRANENGESFVAM------------------------------------------------------------- 88  Escherichia coli K-12
Q06752  72 -DDKLIKAANELGEDVPTI------------------------------------------------------------- 89  Bacillus subtilis sub...
P41259  70 -DDKIINKALKENKSIQEL------------------------------------------------------------- 87  Helicobacter pylori 2...
P53852 107 -DDKIILRARQNYLFDNFVkendtkfnatvvdkvktalfqyinknftiqgseiktieefetwlsnadtetlklenpkfpm 185 Saccharomyces cerevis...
P75423  74 -DDKIIKIAQQQEISEAQL------------------------------------------------------------- 91  Mycoplasma pneumoniae...
P47495  66 -DDKIIKIAQQQEVSESVV------------------------------------------------------------- 83  Mycoplasma genitalium...
O51545  79 gEDKVAKTAREKGLTVYEI------------------------------------------------------------- 97  Borrelia burgdorferi B31
P74330  72 -DDKILKRAVDESSTMEAV------------------------------------------------------------- 89  Synechocystis sp. PCC...
3SP1_A 100 gEDKVAKTAREKGLTVYEI------------------------------------------------------------- 118 Lyme disease spirochete
1LI5_A  89 -----------------------------------------------VDRMIAEMHK-----DFDALNILRPDMEPRATH 116 Escherichia coli BW2952
O29836  89 -----------------------------------------------AEKFIEEYLK-----DMEALNVKKPTYQPKVTE 116 Archaeoglobus fulgidu...
P43816  89 -----------------------------------------------VDRMVQEMYK-----DFDALNVLRPDFEPRATH 116 Haemophilus influenza...
P21888  89 -----------------------------------------------VDRMIAEMHK-----DFDALNILRPDMEPRATH 116 Escherichia coli K-12
Q06752  90 -----------------------------------------------SERFIKAYFE-----DVGALGCRKADLHPRVME 117 Bacillus subtilis sub...
P41259  88 -----------------------------------------------SSIYIESYTR-----DLNALNVKKPSLEPKASE 115 Helicobacter pylori 2...
P53852 186 hvtavqnaiesitkgdsmdaevafekvkdvtvplldkelgstisnpeIFRQLPAYWEqkfndDMLSLNVLPPTVTTRVSE 265 Saccharomyces cerevis...
P75423  92 -----------------------------------------------CKQQITAYKS-----LLKKLNILPIK-HLQVTD 118 Mycoplasma pneumoniae...
P47495  84 -----------------------------------------------TKQQITAYKS-----LLKKLNILPIK-HIQITE 110 Mycoplasma genitalium...
O51545  98 -----------------------------------------------SEFFTEAFFN-----DCRKLNIVYPDKVLVASK 125 Borrelia burgdorferi B31
P74330  90 -----------------------------------------------SEKFIAAYFE-----DMEALGVQPADLYPRATH 117 Synechocystis sp. PCC...
3SP1_A 119 -----------------------------------------------SEFFTEAFFN-----DCRKLNIVYPDKVLVASK 146 Lyme disease spirochete
1LI5_A 117 HIAEIIELTEQLIAKGHAYVADnGDVMFDVPTDP-----TYGVLS---RQDLDQLQAgARVDVVDDK------RNPMDFV 182 Escherichia coli BW2952
O29836 117 HIPDIIEFIQNLIEKGYAYVID-GDVYFHVPAFE-----HYGELS---KQSLEELNR-HRIEPDERK------RDVKDFA 180 Archaeoglobus fulgidu...
P43816 117 HIPEIIEIVEKLIKRGHAYVADnGDVMFDVESFK-----EYGKLS---RQDLEQLQAgARIEINEIK------KNPMDFV 182 Haemophilus influenza...
P21888 117 HIAEIIELTEQLIAKGHAYVADnGDVMFDVPTDP-----TYGVLS---RQDLDQLQAgARVDVVDDK------RNPMDFV 182 Escherichia coli K-12
Q06752 118 NMDAIIEFVDQLVKKGYAYESE-GDVYFKTRAFE-----GYGKLS---QQSIDELRSgA--RIRVGEk----kEDALDFA 182 Bacillus subtilis sub...
P41259 116 YLDAMVGMIETLLEKNIAYQVSnGDIYLDTSKDK-----DYGSLS---VHNSS-IEFgRIGLVQEK-------RLEQDFV 179 Helicobacter pylori 2...
P53852 266 YVPEIIDFVQKIIDNGYAYATSdGSVYFDTLKFDkspnhDYAKCQpwnKGQLDLINDgEGSLSNFADng---kKSNNDFA 342 Saccharomyces cerevis...
P75423 119 KIDKMPGYIARLVKKGFAYVSPlGNTYFSVSQLP-----QYGILA---NRVVETIEDeATDK-----------RNKLDFV 179 Mycoplasma pneumoniae...
P47495 111 KIDKIPDYIDQLVNQNHAYVSTqNNVYFAVNSLK-----QYGYLA---NRMVH-LEEtDTDK-----------KNKLDFV 170 Mycoplasma genitalium...
O51545 126 HIPIMIEVVKILEEKKITYFSN-GNVYFDTSCFK-----SYGEMAg--IDLIDKDMTlPRVDVDKFK------RNKTDFV 191 Borrelia burgdorferi B31
P74330 118 TLDGIKRLIAELEAKGYAYPSG-GDVYYSVRNFD-----GYGKLS---GRRLEDLQAgASGRVTVADpdgaqkQDPFDFA 188 Synechocystis sp. PCC...
3SP1_A 147 HIPIMIEVVKILEEKKITYFSn-GNVYFDTSCFK-----SYGEMAg--IDLIDKDMTlPRVDVDKFK------RNKTDFV 212 Lyme disease spirochete
1LI5_A 183 LWKMSKEG----EPSWPSPWGAGRPGWHIECSAMNCKQLG-----NHFDIHGGGSDLMFPHHENEIAQSTCAHD-GQYVN 252 Escherichia coli BW2952
O29836 181 LWKSAKEAdlkaQAVFDSPWGRGRPGWHIECSVMSAKYLG-----VPFDIHGGGKDLIFPHHENERAQSFARFG-VEPVK 254 Archaeoglobus fulgidu...
P43816 183 LWKMSKEN----EPSWASPWGAGRPGWHIECSAMNCKQLG-----EYFDIHGGGSDLMFPHHENEIAQSCCAHG-GQYVN 252 Haemophilus influenza...
P21888 183 LWKMSKEG----EPSWPSPWGAGRPGWHIECSAMNCKQLG-----NHFDIHGGGSDLMFPHHENEIAQSTCAHD-GQYVN 252 Escherichia coli K-12
Q06752 183 LWKAAKEG----EISWDSPWGKGRPGWHIECSAMVKKYLG-----DQIDIHAGGQDLTFPHHENEIAQSEALTG-KTFAK 252 Bacillus subtilis sub...
P41259 180 LWKSYKGDn---DVGFDSPLGKGRPGWHIECSSMVFETLAltntpYQIDIHAGGADLLFPHHENEACQTRCAFG-VELAK 255 Helicobacter pylori 2...
P53852 343 LWKASKAG----EPEWESPWGKGRPGWHIECSVMASDILG-----SNIDIHSGGIDLAFPHHDNELAQSEARFDnQQWIN 413 Saccharomyces cerevis...
P75423 180 LWKQTTAG-----VKWNSPWGWGRPGWHVECAFLIDYSFK-----DQLTIHGGGVDLKFPHHENENAMHMALYD-KPLTQ 248 Mycoplasma pneumoniae...
P47495 171 LWKITTAG-----IKWNSKWGLGRPGWHVECAFLIDYCFK-----NELTIHGGGVDLKFPHHENENALHMALYN-QPITK 239 Mycoplasma genitalium...
O51545 192 LWFTNSKFkd-qEMKWDSPWGFGYPSWHLECAAMNLEYFK-----DALDIHLGGVDHIGVHHINEIAIAECFLN-KKWCD 264 Borrelia burgdorferi B31
P74330 189 LWKSAKPG----EPAWESPWGKGRPGWHIECSAMVREFLG-----ETIDLHVGGNDLIFPHHENEIAQSEAVTG-QPLAQ 258 Synechocystis sp. PCC...
3SP1_A 213 LWFTNSKFkd-qEMKWDSPWGFGYPSWHLECAAMNLEYFK-----DALDIHLGGVDHIGVHHINEIAIAECFLN-KKWCD 285 Lyme disease spirochete
1LI5_A 253 YWMHSGMVMVDREKMSKSLGNFFTVRDVLK-YYDAETVRYFLMSGHYRSQLNYSEENLKQAR---AALERLYTALRgTDK 328 Escherichia coli BW2952
O29836 255 IWVHNDFIRIKGEKMSKSLGNIVRIRDVLQ-RYEGEVLRYFLLTAHYRSPLDYTEEALERAK---RAYEYLRSALInLDM 330 Archaeoglobus fulgidu...
P43816 253 YWIHSGMIMVDKEKMSKSLGNFFTIRDVLN-HYNAEAVRYFLLTAHYRSQLNYSEENLNLAQ---GALERLYTALRgTDQ 328 Haemophilus influenza...
P21888 253 YWMHSGMVMVDREKMSKSLGNFFTVRDVLK-YYDAETVRYFLMSGHYRSQLNYSEENLKQAR---AALERLYTALRgTDK 328 Escherichia coli K-12
Q06752 253 YWLHNGYINIDNEKMSKSLGNFVLVHDIIK-QHDPQLLRFFMLSVHYRHPINYSEELLENTK---SAFSRLKTAYSnLQH 328 Bacillus subtilis sub...
P41259 256 YWMHNGFVNINNEKMSKSLGNSFFVKDALK-NYDGEILRNYLLGVHYRSVLNFNEEDLLVSK---KRLDKIYRLKQrVLG 331 Helicobacter pylori 2...
P53852 414 YFLHTGHLHIEGQKMSKSLKNFITIQEALK-KFSPRQLRLAFASVQWNNQLDFKESLIHEVKsfeNSMNNFFKTIRaLKN 492 Saccharomyces cerevis...
P75423 249 HWMHIGHLMFENQKMSKSLQNFLLAVDFLT-IHDFRILRWLFYQKHYYHPLDLSQSLIEQAC---SDIKRIQKAVNvCRT 324 Mycoplasma pneumoniae...
P47495 240 HWMHIGHLMIENQKMSKSLQNFLLAVDFLN-FHDFRVLRWIFYQKHYLHPIDLNQSLIEKAN---NDIQRIAKTLNvART 315 Mycoplasma genitalium...
O51545 265 VFVHGEFLIMDYNKMSKSRGNFITVKDLEDqNFSPLDFRYLCLTSHYRNQLKFSLDNLQASK---IARENLINKLSyFYE 341 Borrelia burgdorferi B31
P74330 259 YWLHNGMVKVDGEKMSKSLGNFTTIRALLK-TVDPMAIRLLVLQGHYRKPLDFTETAIAAAT---NGWHTLREGLQ-FGY 333 Synechocystis sp. PCC...
3SP1_A 286 VFVHGEFLIMDYNKMSKSRGNFITVKDLEDqNFSPLDFRYLCLTSHYRNQLKFSLDNLQASK---IARENLINKLSyFYE 362 Lyme disease spirochete
1LI5_A 329 TVAPAGG---------------EAFEARFIE-------AMDDDFNTPEAYSVLFDMAREVNr------LKAEDMAAANAM 380 Escherichia coli BW2952
O29836 331 EIAYLKTfgdrke---gnqvdvEDYIRRFEE-------AMNRDLHTPDAIAVLHEFAGLINk-----sLYELSLNQAEEL 395 Archaeoglobus fulgidu...
P43816 329 SAV---Afg------------gENFVATFRE-------AMDDDFNTPNALSVLFEMAREINk------LKTEDVEKANGL 380 Haemophilus influenza...
P21888 329 TVA---Pag------------gEAFEARFIE-------AMDDDFNTPEAYSVLFDMAREVNr------LKAEDMAAANAM 380 Escherichia coli K-12
Q06752 329 RLNSSTNlteddd---qwlekvEEHRKAFEE-------EMDDDFNTANAISVLFDLAKHAN-------YYLQKDHTADHV 391 Bacillus subtilis sub...
P41259 332 TLGgi----------------npNFKKEILE-------CMQDDLNVSKALSVLESMLSSTNek---ldQNPKNKALKGEI 385 Helicobacter pylori 2...
P53852 493 DAASAGHiskkf------spleKELLADFVEseskvhsAFCDNLSTPVALKTLSELVTKSN--------TYITTAGAALK 558 Saccharomyces cerevis...
P75423 325 WFVYS-Eqsai--------papKQFEPVFK--------ALLNNLNFANAITHIWKLVKQIN--------HDVSKQNLSGL 379 Mycoplasma pneumoniae...
P47495 316 WLVYS-Eqsel--------ispKQYDPVFS--------ALLDNLNFANAVAAIWKLIKKIN--------TSIKTKDFSVL 370 Mycoplasma genitalium...
O51545 342 SLDPVDLntlnkdlknfgfsveKEYYDSFVE-------KISFDLNVAQGLALLWEIIKSDN-------LSFVSKLRLAFI 407 Borrelia burgdorferi B31
P74330 334 DYGGDFGwelaft---plgpdaNQWTVAFQE-------AVDDDFNFAGGLAVMFELAKHLRsegnklkFEGSTPADLDLL 403 Synechocystis sp. PCC...
3SP1_A 363 SLDPVDLntlnkdlknfgfsveKEYYDSFVE-------KISFDLNVAQGLALLWEIIKSDN-------LSFVSKLRLAFI 428 Lyme disease spirochete
1LI5_A 381 ASHLRKLSAvLGLLE---QEPEa------fLQSGAQadDSev--aeIEALIQq------------RLDARKAKD----WA 433 Escherichia coli BW2952
O29836 396 YEAFKRLCGvLGLFE---KMER--------VPALSR--ED------AEKVVE-------------RERARKERN----FE 439 Archaeoglobus fulgidu...
P43816 381 AARLRELGAiLGLLQ---QEPEk------fLQAGSN--DDev--akIEALIKq------------RNEARTAKD----WS 431 Haemophilus influenza...
P21888 381 ASHLRKLSAvLGLLE---QEPEa------fLQSGAQ--ADdsevaeIEALIQq------------RLDARKAKD----WA 433 Escherichia coli K-12
Q06752 392 ITAFIEMFDrIVSVL---GFSLg-------EQElld--------qeIEDLIEk------------RNEARRNRD----FA 437 Bacillus subtilis sub...
P41259 386 LANLKFIEElLGIGF---KDPSa------yFQLGVS--ESek--qeIENKIEe------------RKRAKERKD----FL 436 Helicobacter pylori 2...
P53852 559 IEPLIAICSyITKILriiGFPSrpdnlgwaAQAGSN--DGsl--gsLEDTVMpyvkclstfrddvRSLAIKKAEpkefLQ 634 Saccharomyces cerevis...
P75423 380 KEHLSHLEWaLNIL----GIGFk------sIHTKLN-----------VQLIKk------------WASLRKNGQ----LD 422 Mycoplasma pneumoniae...
P47495 371 REQLSFLEWsIDLL----GISFk------sIHTKLN-----------VRLIKe------------WSILHKQKA----MD 413 Mycoplasma genitalium...
O51545 408 FDEIMSLNLrEEILK---NLQNh------dVVIDEN----------MKALIEe------------RRIAKCEKN----FK 452 Borrelia burgdorferi B31
P74330 404 QTQWITLVS-LAEIL---GLSIn------pESQSSN--DNgltdgdIEQLVAq------------RTQARKDKN----WA 455 Synechocystis sp. PCC...
3SP1_A 429 FDEIMSLNLrEEILK---NLQNh------dVVIDEN----------MKALIEe------------RRIAKCEKN----FK 473 Lyme disease spirochete
1LI5_A 434 AADAAR-DRLNEMGIVLEDGPQG-TTWRR 460 Escherichia coli BW2952
O29836 440 LADAIR-DEFAKRGIRLIDTPKG-TRWRV 466 Archaeoglobus fulgidus DSM 4304
P43816 432 AADSAR-NELTAMGIVLEDGPNG-TTWRK 458 Haemophilus influenzae Rd KW20
P21888 434 AADAAR-DRLNEMGIVLEDGPQG-TTWRR 460 Escherichia coli K-12
Q06752 438 LSDQIR-DQLKSMNIILEDTAQG-TRWKR 464 Bacillus subtilis subsp. subtilis str. 168
P41259 437 KADSIR-EELLKQKIALMDTPQG-TIWEK 463 Helicobacter pylori 26695
P53852 635 LTDKIRnEDLLNLNVALDDR-NGqSALIK 662 Saccharomyces cerevisiae S288c
P75423 423 KADEVR-QKLIKKGLL------------- 437 Mycoplasma pneumoniae M129
P47495 414 KADQIR-KKLIKKMLL------------- 428 Mycoplasma genitalium G37
O51545 453 RADEIR-DFFAKKGFVLVDTKEG-TKVKR 479 Borrelia burgdorferi B31
P74330 456 EGDRLR-DVLQEAGITLVDKPGGlTEWFR 483 Synechocystis sp. PCC 6803 substr. Kazusa
3SP1_A 474 RADEIR-DFFAKKGFVLVDTKEG-TKVKR 500 Lyme disease spirochete
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