2H6R,1TRE


Conserved Protein Domain Family
tim

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TIGR00419: tim 
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triosephosphate isomerase
Triosephosphate isomerase (tim/TPIA) is the glycolytic enzyme that catalyzes the reversible interconversion of glyceraldehyde 3-phosphate and dihydroxyacetone phosphate. The active site of the enzyme is located between residues 240-258 of the model ([AV]-Y-E-P-[LIVM]-W-[SA]-I-G-T-[GK]) with E being the active site residue. There is a slight deviation from this sequence within the archeal members of this family. [Energy metabolism, Glycolysis/gluconeogenesis]
Statistics
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PSSM-Id: 129513
View PSSM: TIGR00419
Aligned: 7 rows
Threshold Bit Score: 265.899
Threshold Setting Gi: 407525
Created: 7-Oct-2014
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2H6R_A     2 VIVINYKtYNESIGNRGLEIAKIAE-KVSEESGITIGVAPQFVDLRMIVENVN---IPVYAQHIDNINPGSHTGHILAEA 77  Methanocaldococcus ...
Q58923     2 LIVINYKtYNESIGNRGLEIAKIAE-KVSEESGITIGVAPQFVDLRMIVENVN---IPVYAQHIDNINPGSHTGHILAEA 77  Methanocaldococcus ...
O27120    12 IVILNFKtYLESTGERALELASICG-DVADETGVNMAVAPQHMDLHRVSDAVE---IPVLAQHIDAVDAGGHTGSILAEC 87  Methanothermobacter...
O28965     6 VVIINFKaYKEGFGKRALELAKIAE-NVASRCDEYVGIAVSFLDLPVIAREVS---IDVYAQHVDAVGFGSHTGRINADM 81  Archaeoglobus fulgi...
CAA81487   6 FVGGNWK-CNGTVSQVETIVNTLNAgQIASPDVVEVVVSPPYVFLPTVKDKLRp-eIQVAAQNCWVKKGGAFTGEVSAEM 83  rye
CAA25253   5 LVMGNWK-LNGSRHMVHELVSNLRK-ELAGVAGCAVAIAPPEMYIDMAKREAEgshIMLGAQNVNLNLSGAFTGETSAAM 82  Escherichia coli
1TRE_A     5 LVMGNWK-LNGSRHMVHELVSNLRK-ELAGVAGCAVAIAPPEMYIDMAKREAEgshIMLGAQNVNLNLSGAFTGETSAAM 82  Escherichia coli
2H6R_A    78 IKDCGCKGTLINHSEKR--MLLAD--IEAVINKCKNLGLETIVCT--------------------NNINTSKAVAA---- 129 Methanocaldococcus ...
Q58923    78 IKDCGCKGTLINHSEKR--MLLAD--IEAVINKCKNLGLETIVCT--------------------NNINTSKAVAA---- 129 Methanocaldococcus ...
O27120    88 ARDAGAAGTLINHSEKR--MQLAD--IEWVISRMKELEMMSVVCT--------------------NNVMTTAAAAA---- 139 Methanothermobacter...
O28965    82 IAEYGAKGSLVNHSERR--LKLAD--IEFNVSRLRELGLTSVVCT--------------------NNVPTTAAAAA---- 133 Archaeoglobus fulgi...
CAA81487  84 LVNLGIPWVILGHSERRslLAESSefVGEKVAYALAQGLKVIACVgetleqr-------eagstmEVVAEQTKAIAdkik 156 rye
CAA25253  83 LKDIGAQYIIIGHSERRtyHKESDelIAKKFAVLKEQGLTPVLCIgeteaeneagkteevcarqiDAVLKTQGAAA---- 158 Escherichia coli
1TRE_A    83 LKDIGAQYIIIGHSERRtyHKESDelIAKKFAVLKEQGLTPVLCIgeteaeneagkteevcarqiDAVLKTQGAAA---- 158 Escherichia coli
2H6R_A   130 -LSPDCIAVEPPELIGTGIPVSKANPEVVEGTVR------AVKEINKDVKVLCGAGISKGEDVKAALDLGAEGVLLASGV 202 Methanocaldococcus ...
Q58923   130 -LSPDYIAVEPPELIGTGIPVSKANPEVVEGTVR------AVKEINKDVKVLCGAGISKGEDVKAALDLGAEGVLLASGV 202 Methanocaldococcus ...
O27120   140 -LGPDFVAVEPPELIGSGIPVSRAEPEVITGSVD------AVKKVNPEVSVLCGAGISTGDDMKAAVDLGAEGVLLASGI 212 Methanothermobacter...
O28965   134 -LNPDFVAVEPPELIGSGIPVSKAEPEVVENSVK------AAKEVNKSVRVLCGAGITTHEDYVKALELGAEGVLLASGV 206 Archaeoglobus fulgi...
CAA81487 157 dWTNVVVAYEPVWAIGTGKVASPAQAQEVHANLRdwlktnVSPEVAESTRIIYGGSVTGASCKELAAQPDVDGFLVGGAS 236 rye
CAA25253 159 -FEGAVIAYEPVWAIGTGKSATPAQAQAVHKFIRdhi-akVDANIAEQVIIQYGGSVNASNAAELFAQPDIDGALVGGAS 236 Escherichia coli
1TRE_A   159 -FEGAVIAYEPVWAIGTGKSATPAQAQAVHKFIRdhi-akVDANIAEQVIIQYGGSVNASNAAELFAQPDIDGALVGGAS 236 Escherichia coli
2H6R_A   203 VKAK 206 Methanocaldococcus jannaschii DSM 2661
Q58923   203 VKAK 206 Methanocaldococcus jannaschii DSM 2661
O27120   213 ILAD 216 Methanothermobacter thermautotrophicus str. Delta H
O28965   207 VKAE 210 Archaeoglobus fulgidus DSM 4304
CAA81487 237 LKPE 240 rye
CAA25253 237 LKAD 240 Escherichia coli
1TRE_A   237 LKAD 240 Escherichia coli
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