2GT3,3PIL


Conserved Protein Domain Family
msrA

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TIGR00401: msrA 
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methionine-S-sulfoxide reductase
This model describes peptide methionine sulfoxide reductase (MsrA), a repair enzyme for proteins that have been inactivated by oxidation. The enzyme from E. coli is coextensive with this model and has enzymatic activity. However, in all completed genomes in which this module is present, a second protein module, described in TIGR00357, is also found, and in several cases as part of the same polypeptide chain: N-terminal to this module in Helicobacter pylori and Haemophilus influenzae (as in PilB of Neisseria gonorrhoeae) but C-terminal to it in Treponema pallidum. PilB, containing both domains, has been shown to be important for the expression of adhesins in certain pathogens. [Protein fate, Protein modification and repair, Cellular processes, Adaptations to atypical conditions]
Statistics
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PSSM-Id: 129496
View PSSM: TIGR00401
Aligned: 9 rows
Threshold Bit Score: 243.504
Threshold Setting Gi: 323714532
Created: 7-Oct-2014
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2GT3_A        44 EIAIFAMGCFWGVERLFW--QLPGVYSTAAGYTG---G---YTPNPT---YREVCSGDTGHAEAVRIVYDPSVISYEQLL 112 Escherichia col...
P75188         2 KQIYFGGGCFWGTQKYFD--LIKGVQKTSVGYLN---S---NMKNPT---YEQVCSGQTNAVEAVFVEYDENKVSLNELI 70  Mycoplasma pneu...
P40029        17 KLITLACGCFWGTEHMYRkyLNDRIVDCKVGYANgeeS---KKDSPSsvsYKRVCGGDTDFAEVLQVSYNPKVITLRELT 93  Saccharomyces c...
P72622        49 ETALFGLGCFWGAERKFW--QIPGVYSTAVGYAA---G---YTPNPT---YQEVCTGMTGHNEVVLVAFDPQQVSYDQLL 117 Synechocystis s...
O26635         8 EKATFGAGCFWGVEDAFR--KVDGVVSTRVGYMG---G---HLENPT---YEDVCTGLTGHAEVVEVTFDPDVVGYSDLL 76  Methanothermoba...
P54154         6 EIATFAGGCFWCMVKPFD--EQPGIEKVVSGYTG---G---HTENPT---YEEVCSETTGHREAVQITFHPDVFPYEKLL 74  Bacillus subtil...
WP_001447411  44 EIAIFAMGCFWGVERLFW--QLPGVYSTAAGYTG---G---YTPNPT---YREVCSGDTGHAEAVRIVYDPSVISYEQLL 112 Escherichia coli
P47648         2 KEIYFGGGCFWGIEKYFQ--LIKGVKKTSVGYLN---S---RIRNPS---YEQVCSGYTNAVEAVKVEYEEKEISLSELI 70  Mycoplasma geni...
3PIL_A        17 KLITLACGCFWGTEHMYRkyLNDRIVDCKVGYAN---GeesKKDSPSsvsYKRVCGGDTDFAEVLQVSYNPKVITLRELT 93  baker's yeast
2GT3_A       113 QVFWENHDPAQGMRQGNDHGTQYRSAIYPLTPEQDAAARASLERFQAamlaaDDDRHITTEIANATPFYYAEDDHQQYLH 192 Escherichia col...
P75188        71 DAFFKVIDPTIRNRQGNDIGTQYRTGVYWVDPQDEQLITQKFRELQA-----NYPKPIVTENRAMENYFLAEEYHQDYLK 145 Mycoplasma pneu...
P40029        94 DFFFRIHDPTTSNSQGPDKGTQYRSGLFAHSDADLKELAKIKEEWQP-----KWGNKIATVIEPIKNFYDAEEYHQLYLD 168 Saccharomyces c...
P72622       118 KVFWESHNPTQGMRQGNDVGTQYRSGIYTYSEAQQQAALASKQAYQQalqqaGYG-EITTEILPAPDFYYAEDYHQQYLA 196 Synechocystis s...
O26635        77 DVFWSIHDPTTLNRQGPDVGEQYRSVIFYHSDEQRRAAIESRRRLEEs---gRFRDRIVTAIEPAGTFYEAEEYHQQYLE 153 Methanothermoba...
P54154        75 ELFWQQIDPTDAGGQFADRGSSYRAAIFYHNDKQKELAEASKQRLAEs---gIFKDPIVTDILKAEPFYEAEGYHQHFYK 151 Bacillus subtil...
WP_001447411 113 QVFWENHDPAQGMRQGNDHGTQYRSAIYPLTPEQDAAARASLERFQAamlaaDDDRHITTEIANATPFYYAEDDHQQYLH 192 Escherichia coli
P47648        71 EALFEVIDPTIRNRQGNDIGTQYRTGIYWTDSSDEKIINDKFLKLQK-----NYSKPIVTENKKVENYYLAEEYHQDYLK 145 Mycoplasma geni...
3PIL_A        94 DFFFRIHDPTTSNSQGPDKGTQYRSGLFAHSDADLKELAKIKEEWQP-----KWGNKIATVIEPIKNFYDAEEYHQLYLD 168 baker's yeast
2GT3_A       193 KNP 195 Escherichia coli BW2952
P75188       146 KNP 148 Mycoplasma pneumoniae M129
P40029       169 KNP 171 Saccharomyces cerevisiae S288c
P72622       197 KNP 199 Synechocystis sp. PCC 6803 substr. Kazusa
O26635       154 KNP 156 Methanothermobacter thermautotrophicus str. Delta H
P54154       152 KNP 154 Bacillus subtilis subsp. subtilis str. 168
WP_001447411 193 KNP 195 Escherichia coli
P47648       146 KNP 148 Mycoplasma genitalium G37
3PIL_A       169 KNP 171 baker's yeast
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