1DO2


Conserved Protein Domain Family
hslU
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TIGR00390: hslU 
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ATP-dependent protease HslVU, ATPase subunit
This model represents the ATPase subunit of HslVU, while the proteasome-related peptidase subunit is HslV. Residues 54-61 of the model contain a P-loop ATP-binding motif. Cys-287 of E. coli (position 308 in the seed alignment) is Ser in other members of the seed alignment. [Protein fate, Protein folding and stabilization]
Links
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Statistics
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PSSM-Id: 273052
Aligned: 6 rows
Threshold Bit Score: 656.887
Created: 7-Oct-2014
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
1DO2_A         3 MTPREIVSELDKHIIGQDNAKRSVAIALRNRWRRMQLNEELRHEVTPKNILMIGPTGVGKTEIARRLAKLANAPFIKVEA 82  Escherichia coli
P32168         4 MTPREIVSELDKHIIGQDNAKRSVAIALRNRWRRMQLNEELRHEVTPKNILMIGPTGVGKTEIARRLAKLANAPFIKVEA 83  Escherichia coli
P43773         4 MTPREIVSELDQHIIGQADAKRAVAIALRNRWRRMQLQEPLRHEVTPKNILMIGPTGVGKTEIARRLAKLANAPFIKVEA 83  Haemophilus inf...
O25254         6 MTPREIVAYLDEYIIGQKEAKKSIAIAFRNRYRRLQLEKSLQEEITPKNILMIGSTGVGKTEIARRIAKIMELPFVKVEA 85  Helicobacter py...
WP_002656077   9 IVPKDVVAELDKYIIGQDEAKKLVSIALVNRYIRSRLPKEIKDEVMPKNIIMIGSTGIGKTEIARRLSKLIKAPFIKVEA 88  Lyme disease sp...
P39778         6 LTPRQIVDRLDQYIVGQQNAKKAVAVALRNRYRRSLLDEKLKDEVVPKNILMMGPTGVGKTEIARRIAKLSGAPFIKIEA 85  Bacillus subtil...

1DO2_A        83 TKFTEVGYVGKEVDSIIRDLTDAAVKMVRVQAIEKNRYRAEELAEERILDVLIPPAKNN----------WGQTE--QQQE 150 Escherichia coli
P32168        84 TKFTEVGYVGKEVDSIIRDLTDAAVKMVRVQAIEKNRYRAEELAEERILDVLIPPAKNN----------WGQTE--QQQE 151 Escherichia coli
P43773        84 TKFTEVGYVGKEVDSIIRDLTDSAMKLVRQQEIAKNRARAEDVAEERILDALLPPAKNQ----------WGEVE--NHDS 151 Haemophilus inf...
O25254        86 SKYTEVGFVGRDVESMVRDLVNNSVLLVENEHKEKLKDKIEEAVIEKIAKKLLPPLPNG-----------VSEE--KKQE 152 Helicobacter py...
WP_002656077  89 TKYTEVGYVGRDVESMVRDLMSIAVNMVKEEMYSTVRDDALVRTEERIVDSLFKGSSNS-----------ENMDpnEIKA 157 Lyme disease sp...
P39778        86 TKFTEVGYVGRDVESMVRDLVETSVRLIKEEKMNEVKEQAEENANKRIVRLLVPGKKKQsgvknpfemfFGGSQpnGEDE 165 Bacillus subtil...

1DO2_A       151 PSAARQAFRKKLRE--------GQLDDKEIEIDLAAAp--MGVEIMAPPGMEEMTSQLQSMFQNLGGQKQKARKLKIKDA 220 Escherichia coli
P32168       152 PSAARQAFRKKLRE--------GQLDDKEIEIDLAAAp--MGVEIMAPPGMEEMTSQLQSMFQNLGGQKQKARKLKIKDA 221 Escherichia coli
P43773       152 HSSTRQAFRKKLRE--------GQLDDKEIEIDVSAGv-sMGVEIMAPPGMEEMTNQLQSLFQNLGSDKTKKRKMKIKDA 222 Haemophilus inf...
O25254       153 YANSLLKMQQRIAQ--------GELDSREIEIEVRKKs--IEIDSNVPPEILRVQENLIKVFHKE--QDKVKKTLSVKEA 220 Helicobacter py...
WP_002656077 158 EEKVKEKLRKKLRA--------GELDDTTIEIQISSKmpfSTIEIFTGGNFEEIDMGIGGLLGNIF-DRKKKRELKIKKA 228 Lyme disease sp...
P39778       166 AESQEEANIEEKRKrmahqlalGELEDYYVTVEVEEQq-pSMFDMLQGSGMEQMGMNMQDALSGLMPKKKKRRKMTVREA 244 Bacillus subtil...

1DO2_A       221 MKLLIEEEAAKLVNPEELKQDAIDAVEQHGIVFIDEIDKICKRG-ESSGPDVSREGVQRDLLPLVEGCTVSTKHGMVKTD 299 Escherichia coli
P32168       222 MKLLIEEEAAKLVNPEELKQDAIDAVEQHGIVFIDEIDKICKRG-ESSGPDVSREGVQRDLLPLVEGCTVSTKHGMVKTD 300 Escherichia coli
P43773       223 LKALIDDEAAKLINPEELKQKAIDAVEQNGIVFIDEIDKICKKG-EYSGADVSREGVQRDLLPLVEGSTVSTKHGMVKTD 301 Haemophilus inf...
O25254       221 KEALKAEISDTLLDSEAIKMEGLKRAESSGVIFIDEIDKIAVSSkEGSRQDPSKEGVQRDLLPIVEGSVVNTKYGSIKTE 300 Helicobacter py...
WP_002656077 229 KEIILAEELEKLVDHENISDIAKSKVENMGIIFIDEIDKIAAKN--RSGNDVSREGVQRDILPIIEGSKVNTKYGIVDTS 306 Lyme disease sp...
P39778       245 RKVLTNEEASKLIDMDEVGQEAVQRAEESGIIFIDEIDKIAKNGgASSSADVSREGVQRDILPIVEGSTVVTKYGSVKTD 324 Bacillus subtil...

1DO2_A       300 HILFIASGAFQIAKPSDLIPELQGRLPIRVELQALTTSDFERILTEPNASITVQYKALMATEGVNIEFTDSGIKRIAEAA 379 Escherichia coli
P32168       301 HILFIASGAFQIAKPSDLIPELQGRLPIRVELQALTTSDFERILTEPNASITVQYKALMATEGVNIEFTDSGIKRIAEAA 380 Escherichia coli
P43773       302 HILFIASGAFQVARPSDLIPELQGRLPIRVELTALSAADFERILTEPHASLTEQYKALMATEGVNIAFTTDAVKKIAEAA 381 Haemophilus inf...
O25254       301 HILFIAAGAFHLSKPSDLIPELQGRFPLRVELENLTEEIMYMILTQTKTSIIKQYQALLKVEGVEIAFEDDAIKELAKLS 380 Helicobacter py...
WP_002656077 307 HILFIAAGAFNLAKPSDLIPELQGRFPIKVELKSLSIDDLKKILKQTKNSLIKQYVAMFKVYDLDLKFSEEAIDRIAELT 386 Lyme disease sp...
P39778       325 HVLFIAAGAFHMAKPSDLIPELQGRFPIRVELNKLTVDDFVRILVEPDNALLKQYQALLQTEGISLEFSDEAIHKIAEVA 404 Bacillus subtil...

1DO2_A       380 WQVNESTENIGARRLHTVLERLMEEISYDASDLSGQNITIDADYVSKHLDALVADEDLSRFIL 442 Escherichia coli
P32168       381 WQVNESTENIGARRLHTVLERLMEEISYDASDLSGQNITIDADYVSKHLDALVADEDLSRFIL 443 Escherichia coli
P43773       382 FRVNEKTENIGARRLHTVMERLMDKISFSASDMNGQTVNIDAAYVADALGEVVENEDLSRFIL 444 Haemophilus influenzae Rd KW20
O25254       381 YNANQKSEDIGARRLHTTIEKVLEDISFEAEDYSGQNVTITKELVQSKLEDLVADENLVKYIL 443 Helicobacter pylori 26695
WP_002656077 387 FNMNLESENLGARRLHGVMEIVLADLFFEVPGSKLKKFEINLDYVNKKIQINEQ-KDLNYYII 448 Lyme disease spirochete
P39778       405 YHVNQDTDNIGARRLHTILERLLEDLSFEAPDVTMEKITITPQYVEEKLGTIAKNKDLSQFIL 467 Bacillus subtilis subsp. subtili...
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