Conserved Protein Domain Family
cobD
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TIGR00380: cobD 
cobalamin biosynthesis protein CobD
This protein is involved in cobalamin (vitamin B12) biosynthesis and porphyrin biosynthesis. It converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. It is part of the cob operon. [Biosynthesis of cofactors, prosthetic groups, and carriers, Heme, porphyrin, and cobalamin]
Links
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Statistics
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PSSM-Id: 273045
Aligned: 4 rows
Threshold Bit Score: 390.739
Created: 7-Oct-2014
Updated: 25-Oct-2021
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q58710   1 MLNPIILFLAIIFDRIIGELPESIHPTVWIGKLIAFLENIFKSTncknkyRdfLFGSLTTFITLLVVGVIAFFVDkcimL 80  Methanocaldococcus ja...
O27460   1 MSEVSVLLLAVILDLLIGEPPHRLHPVVWMGSAVEWMRNILGNS------R--ISGIILTIAVAAPFTLPLFLIN----H 68  Methanothermobacter t...
O28933   2 GIEVVVLLTTLMLDAAVGEPPALLHPVVWYGKLISLLERAKFRKm----lVeiFYGAFCCLIVIT-FALILSLLP----- 71  Archaeoglobus fulgidu...
P74475  11 LIAVIILGGSALLDFLLGDPKSWRHPVEFIGSVINFASQLIIRKvndknsRr-LWGIFLGLKIIISSGFLAWLIVylaeK 89  Synechocystis sp. PCC...

Q58710  81 LPFPLNYIIYGFLLSTTIGYKSLFEFCKKPIEYIKNgDLEGARKAVQHIVSRDASKLDKEHVLSAAVESLSENITDSIIG 160 Methanocaldococcus ja...
O27460  69 LQDPLNLIISSILLSAVISIRMLVTSALEVGGSLKE-DIEDARRKLSMLVSRDTTSLSDEQITSAAIETLTENITDSVTA 147 Methanothermobacter t...
O28933  72 FPYPLNFLWAVYLLFSSISVKSMVNHARVCVESGVD------RKAVQMIVSRNTEELSEEQLCSAVIESVAENYVDGVVA 145 Archaeoglobus fulgidu...
P74475  90 VSPVLAVIIQIIGVASCFAGHSLAQAAQSVIEPLKAgDLPTARQKLALFVGRDTNNLSEREILRATVESVAENTVDGVTS 169 Synechocystis sp. PCC...

Q58710 161 ALFYA---IFFGLPG----AFVYRAINTLDAMIGYKNEKYLWYGKLAARLDDIANFIPSRIAgillIITAPFYKGDVKKA 233 Methanocaldococcus ja...
O27460 148 PIFYF---ILLGLPG----AFLYRVVNTLDAMVGYLDSENRDIGWFPARLDDILNYIPSRITgvlmVPAALLLGMNWRGS 220 Methanothermobacter t...
O28933 146 PLFYF---SIFGVAG----AVVYRAVNTCDAMVGYRKGRYEAFGKFAARLDDILNYIPARLS-------LLFFELLKRGA 211 Archaeoglobus fulgidu...
P74475 170 PLFYAllgILFPFVGpwplAIAYKAASTLDSMVGYKREPYTDLGWFSARLEDYLTWLPCRLT----VFMLAILSGKPKQT 245 Synechocystis sp. PCC...

Q58710 234 IYGFLKEANKVPSPNSGYTMATLANALNITLE----KIGYYKLGS---GKIDVEKSLNAFKAVDYTVVVFL-IIYTLIWW 305 Methanocaldococcus ja...
O27460 221 FRILLRDARRTPSPNSGFTMAAAAGALSVQLE----KPGVYVLGDp-cDGLDNEKLLDAVKLSSLTLILFT-LAAAGVML 294 Methanothermobacter t...
O28933 212 FSYGLKRNVKL---N-GCAIAAMSYLLGVKLE----KPGYYSLPGiepSAADIERAIKAFVRLTVIAVIFT-TIAVSIRI 282 Archaeoglobus fulgidu...
P74475 246 WAIVRRDGPLDPSPNSGWSEAIYAAILGIQLGgdnyYQGVLKSKPllgDGIQPLTIAKIAQSLWYSRTVFLwQLLLGLTV 325 Synechocystis sp. PCC...

Q58710 306 IT 307 Methanocaldococcus jannaschii DSM 2661
O27460 295 VI 296 Methanothermobacter thermautotrophicus str. Delta H
O28933 283 VL 284 Archaeoglobus fulgidus DSM 4304
P74475 326 IL 327 Synechocystis sp. PCC 6803 substr. Kazusa
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