Conserved Protein Domain Family
polC

?
TIGR00354: polC 
DNA polymerase, archaeal type II, large subunit
This model represents the large subunit, DP2, of a two subunit novel Archaeal replicative DNA polymerase first characterized for Pyrococcus furiosus. Structure of DP2 appears to be organized as a ~950 residue component separated from a ~300 residue component by a ~150 residue intein. The other subunit, DP1, has sequence similarity to the eukaryotic DNA polymerase delta small subunit. [DNA metabolism, DNA replication, recombination, and repair]
Statistics
?
PSSM-Id: 273031
Aligned: 3 rows
Threshold Bit Score: 1947.77
Created: 7-Oct-2014
Updated: 25-Oct-2021
Structure
?
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
Q59024   11 ENMKKYFENIVDEVKKIYRIAEECRKKGFDPTDEVEIPLAADMADRVEGLVGPKGVAERIRELV-KELGKEPAALEIAKE 89   Methanocaldococcus ...
O28552   24 EEIRRYHESLMVELDRIYRIAEAARKKGLDPELSVEIPIAKNMAERVEKLMNLQGLAKRIMELEeGGLSRELICFKVADE 103  Archaeoglobus fulgi...
O27579    1 --MMDYFNELERETERLYEIARKARARGLDVSTTPEIPLAKDLAERVEGLVGPEGIARRIKELE-GDRGREEVAFQIAAE 77   Methanothermobacter...
Q59024   90 IVEGKFGNFD---KEKKAEQAVRTALAVLTEGIVAAPLEGIADVKIKKNpdgtEYLAIYYAGPIRSAGGTAQALSVLVGD 166  Methanocaldococcus ...
O28552  104 IVEGKFGEMP---KEEAIDKAVRTAVAIMTEGVVAAPIEGIARVRIDRE----NFLRVYYAGPIRSAGGTAQVISVLVAD 176  Archaeoglobus fulgi...
O27579   78 IASQAVPDDDpeeREKLADQALRTALAILTEGVVAAPLEGIARVRIKENfdksRYLAVYFAGPIRSAGGTAAALSVLIAD 157  Methanothermobacter...
Q59024  167 FVRKAMGLDRYKPTEDEIERYVEEVELYQsEVGSFQYNPTADEIRTAIRNIPIEITGEATDDVEVSGHRDLPRVETNQLR 246  Methanocaldococcus ...
O28552  177 YVRRKAEIGRYVPTEEEILRYCEEIPLYK-KVANLQYLPSDEEIRLIVSNCPICIDGEPTESAEVSGYRNLPRVETNRVR 255  Archaeoglobus fulgi...
O27579  158 YIRLAVGLDRYKPVEREIERYVEEVELYEsEVTNLQYSPKPDEVRLAASKIPVEVTGEPTDKVEVS-HRDLERVETNNIR 236  Methanothermobacter...
Q59024  247 GGALLVLVEGVLLKAPKILRHVDKLGIEGWDWLKDLMSKKEEKEEEkdekvddeeidEEEeeisgywrdVKIEANKKFIS 326  Methanocaldococcus ...
O28552  256 GGMALVIAEGIALKAPKLKKMVDEVGIEGWEWLDALIKGGGDSGSE-----------EEK---------AVIKPKDKYLS 315  Archaeoglobus fulgi...
O27579  237 GGALLAMVEGVIQKAPKVLKYAKQLKLEGWDWLEKFS--KAPKKGEg----------EEK---------VVVKADSKYVE 295  Methanothermobacter...
Q59024  327 EVIAGRPVFAHPSKVGGFRLRYGRSRNTGFATQGFHPALMYLVdEFMAVGTQLKTERPGKATCVVPVDSIEPPIVKLKNG 406  Methanocaldococcus ...
O28552  316 DIVAGRPVLSHPSRKGGFRLRYGRARNSGFATVGVNPATMYLL-EFVAVGTQLKVERPGKAGGVVPVSTIEGPTVRLKNG 394  Archaeoglobus fulgi...
O27579  296 DIIGGRPVLAYPSEKGAFRLRYGRARNTGLAAMGVHPATMELL-QFLAVGTQMKIERPGKGNCVVPVDTIDGPVVKLRNG 374  Methanothermobacter...
Q59024  407 DVIRVDTIEKAMDVRNRVEEILFLGDVLVNYGDFLENNHPLLPSCWCEEWYEKILIANni---------eyDKDFIKNPK 477  Methanocaldococcus ...
O28552  395 DVVKINTLSEAKALKGEVAAILDLGEILINYGDFLENNHPLIPASYTYEWWIQEAEKAg------------LRGDYRKIS 462  Archaeoglobus fulgi...
O27579  375 DVIRIEDAETASRVRSEVEEILFLGDMLVAFGEFLRNNHVLMPAGWCEEWWIQTILSSpkypgddplnlsyYRTRWNELE 454  Methanothermobacter...
Q59024  478 PEE--AVKFALETKTPLHPRFTYHWHDVSKEDIILLRNWLLKgkEDSLEGKKVwIVDLEIEEDKKAKRILELIGCCHLVR 555  Methanocaldococcus ...
O28552  463 EEE--ALKLCDEFHVPLHPDYTYLWHDISVEDYRYLRNFVSD--NGKIEGKHG-KSVLLLPYDSRVKEILEALLLEHKVR 537  Archaeoglobus fulgi...
O27579  455 VSAgdAFRISEEYDVPLHPRYTYFYHDVTVRELNMLREWLN---TSQLE-------DELVLELRPEKRILEILGVPHRVK 524  Methanothermobacter...
Q59024  556 NKKVIIEEYYpllysLGFDVENkkdLVENIEKILESA-KNSMHLINLLAPFEVRRNTYVYVGARMGRPEKAAPRKMKPPV 634  Methanocaldococcus ...
O28552  538 ESFIVIETWR-----AFIRCLG---LDEKLSKVSEVSgKDVLEIVNGISGIKVRPKALSRIGARMGRPEKAKERKMSPPP 609  Archaeoglobus fulgi...
O27579  525 DSRVVIGH-------DDAHA-----LIKTLRKPLEDS-SDTVEALNRVSPVRIMKKAPTYIGTRVGRPEKTKERKMRPAP 591  Methanothermobacter...
Q59024  635 NGLFPIGNAGGQVRLINKAVEENN-------TDDVDVSYTRCPNCGKISLYRVCPFCGTKVELDNFG------------- 694  Methanocaldococcus ...
O28552  610 HILFPVGMAGGNTRDIKNAINYTKsynakkgEIEVEIAIRKCPQCGKETFWLKCDVCGELTEQLYYCpscrmkntssvce 689  Archaeoglobus fulgi...
O27579  592 HVLFPIGKYGGSRRNIPDAAKKG--------SITVEIGRATCPSCRVSSMQSICPSCGSRTVIGEPG------------- 650  Methanothermobacter...
Q59024  695 ----------RIKAPLKDYWYAALKRLGINK-PGDVKCIKGMTSKQKIVEPLEKAILRAINEVYVFKDGTTRFDCTDVPV 763  Methanocaldococcus ...
O28552  690 scgrecegymKRKVDLRELYEEAIANLGEYDsFDTIKGVKGMTSKTKIPERLEKGILRVKHGVFVFKDGTARFDATDLPI 769  Archaeoglobus fulgi...
O27579  651 ----------KRNINLAALLKRAAENVSVRK-LDEIKGVEGMISAEKFPEPLEKGILRAKNDVYTFKDATIRHDSTDLPL 719  Methanothermobacter...
Q59024  764 THFKPNEINVTVEKLRELGYDKDIYGNELVDGEQVVELKPQDVIIPESCAEYFVKVANFIDDLLEKFYKVERFYNVKKKE 843  Methanocaldococcus ...
O28552  770 THFKPAEIGVSVEKLRELGYERDYKGAELKNENQIVELKPQDVILPKSGAEYLLRVANFIDDLLVKFYKMEPFYNAKSVE 849  Archaeoglobus fulgi...
O27579  720 THFTPREVGVSVERLRELGYTRDCYGDELEDEDQILELRVQDVVISEDCADYLVRVANFVDDLLERFYDLERFYNVKTRE 799  Methanothermobacter...
Q59024  844 DLIGHLVIGMAPHTSAGMVGRIIGYTKANVGYAHPYFHAAKRRNCDGDEDSFFLLLDAFLNFSKKFLPDKRGGQMDAPLV 923  Methanocaldococcus ...
O28552  850 DLIGHLVIGLAPHTSAGVLGRIIGFSDVLAGYAHPYFHAAKRRNCDGDEDCFMLLLDGLLNFSRKFLPDKRGGQMDAPLV 929  Archaeoglobus fulgi...
O27579  800 DLVGHLIAGLAPHTSAAVLGRIIGFTGASACYAHPYFHSAKRRNCDSDEDSVMLLLDALLNFSKSYLPSSRGGSMDAPLV 879  Methanothermobacter...
Q59024  924 LTTILDPKEVDGEVHNMDTMWSYPLEFYEKTLEMPSPKEVKEFMETVEDRLGKPEQYEGIGYTHETSRIDLGPKVCAYKT 1003 Methanocaldococcus ...
O28552  930 LTAIVDPREVDKEVHNMDIVERYPLEFYEATMRFASPKEMEDYVEKVKDRLKDESRFCGLFFTHDTENIAAGVKESAYKS 1009 Archaeoglobus fulgi...
O27579  880 LSTRIDPEEIDDESHNIDTMDMIPLEVYERSFDHPRPSEVLDVIDNVEKRLGKPEQYTGLMFSHNTSRIDEGPKVCLYKL 959  Methanothermobacter...
Q59024 1004 LGSMLEKTTSQLSVAKKIRATDERDVAEKVIQSHFIPDLIGNLRAFSRQAVRC-KCGAKYRRIPLKGKCPKCGSNLILTV 1082 Methanocaldococcus ...
O28552 1010 LKTMQDKVYRQMELARMIVAVDEHDVAERVINVHFLPDIIGNLRAFSRQEFRCtRCNTKYRRIPLVGKCLKCGNKLTLTV 1089 Archaeoglobus fulgi...
O27579  960 LPTMKEKVESQITLAEKIRAVDQRSVVEGVLMSHFLPDMMGNIRAFSRQKVRCtKCNRKYRRIPLSGEC-RCGGNLVLTV 1038 Methanothermobacter...
Q59024 1083 SKGAVEKYMDVAEKMAEEYNVNDYIKQRLKIIKEGINSIFENEKSRQVKLSDF 1135 Methanocaldococcus jannaschii DSM 2661
O28552 1090 HSSSIMKYLELSKFLCENFNVSSYTKQRLMLLEQEIKSMFENGTEKQVSISDF 1142 Archaeoglobus fulgidus DSM 4304
O27579 1039 SKGSVIKYLEISKELASRYPIDPYLMQRIEILEYGVNSLFESDRSKQSSLDVF 1091 Methanothermobacter thermautotrophicus str. De...
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap