1DAM


Conserved Protein Domain Family
bioD
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TIGR00347: bioD 
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dethiobiotin synthase
Dethiobiotin synthase is involved in biotin biosynthesis and catalyses the reaction (CO2 + 7,8-diaminononanoate + ATP = dethiobiotin + phosphate + ADP). The enzyme binds ATP (see motif in first 12 residues of the SEED alignment) and requires magnesium as a co-factor. [Biosynthesis of cofactors, prosthetic groups, and carriers, Biotin]
Links
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Statistics
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PSSM-Id: 129447
Aligned: 9 rows
Threshold Bit Score: -1
Created: 7-Oct-2014
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
1DAM_A         5 FVTGTDTEVGKTVASCALLQAAKAAG--YRTAGYKPVASGSEktpeglrnSDALALQRNSSLQLDYA---TVNPYTFAEP 79  Escherichia coli
P53558         5 FVTGTDTEVGKTVISSGLAALLKDNN--RHVGVYKPFLSGISrhh---pdSDTSLLKDMSQTSLSHE---DITPFAFKAP 76  Bacillus subtil...
O66832         4 LITGTDTGVGKTFITYNLAKELKERG--YKVGCLKPVETYVRev-----pED-GSLLS-KATGQSVN---EIVPVRFSLP 71  Aquifex aeolicu...
P53630        15 FVTGTDTDVGKTFVSTLLVHKWK-------AAYWKPVQTGIEsd-----qGDSETLKNFKIAASTWQppiFTPTYALQKP 82  Saccharomyces c...
P45248         6 FISGIDTDVGKTIATGIYAKKLMEQG--CSVITQKMIQTGCKniaddllvH--RKIQGIDLTEEDLQg--KTCPYVFEYP 79  Haemophilus inf...
Q55849        14 LVAGCDTGVGKTVTTSALAAYWWKCGkdQSFGLMKLMQTGLG--------DD-ELYQQLFGHLTRWD---VVTPLKFATP 81  Synechocystis s...
P36572         6 FVTGTDTEVGKSVASSALLQAANRAG--YPSAGYKPVASGSEmtaeglrnGDALALQANSGVALDYD---EVNPYVFAEP 80  Serratia marces...
WP_000044842   6 FVTGTDTEVGKTVASCALLQAAKAAG--YRTAGYKPVASGSEktpeglrnSDALALQRNSSLQLDYA---TVNPYTFAEP 80  Escherichia coli
AAB99306      37 FITGTDTGIGKTYVSSILAENLKKMG--INVGYLKPVETGGR--------EDTLTLKNILNTDDDLD---LMNPINLKLP 103 Methanocaldococ...
P53558         5 FVTGTDTEVGKTVISSGLAALLKDNN--RHVGVYKPFLSGISrhh---pdSDTSLLKDMSQTSLSHE---DITPFAFKAP 76  Bacillus subtil...
O66832         4 LITGTDTGVGKTFITYNLAKELKERG--YKVGCLKPVETYVRev-----pED-GSLLS-KATGQSVN---EIVPVRFSLP 71  Aquifex aeolicu...
P53630        15 FVTGTDTDVGKTFVSTLLVHKWK-------AAYWKPVQTGIEsd-----qGDSETLKNFKIAASTWQppiFTPTYALQKP 82  Saccharomyces c...
P45248         6 FISGIDTDVGKTIATGIYAKKLMEQG--CSVITQKMIQTGCKniaddllvH--RKIQGIDLTEEDLQg--KTCPYVFEYP 79  Haemophilus inf...
Q55849        14 LVAGCDTGVGKTVTTSALAAYWWKCGkdQSFGLMKLMQTGLG--------DD-ELYQQLFGHLTRWD---VVTPLKFATP 81  Synechocystis s...
P36572         6 FVTGTDTEVGKSVASSALLQAANRAG--YPSAGYKPVASGSEmtaeglrnGDALALQANSGVALDYD---EVNPYVFAEP 80  Serratia marces...
WP_000044842   6 FVTGTDTEVGKTVASCALLQAAKAAG--YRTAGYKPVASGSEktpeglrnSDALALQRNSSLQLDYA---TVNPYTFAEP 80  Escherichia coli
AAB99306      37 FITGTDTGIGKTYVSSILAENLKKMG--INVGYLKPVETGGR--------EDTLTLKNILNTDDDLD---LMNPINLKLP 103 Methanocaldococ...

1DAM_A        80 TSPHIISAQEGRPIESLVMSAGLR----ALEQQADWVLVEGAGGWFTPLS-DTFTFADWVTQE------QLPVILVVGVK 148 Escherichia coli
P53558        77 LAPYVAGKLEGKTVTMEEVLSHWG----RIREKHECFIVEGAGGISVPLG-EDYLVSHVIKAL------QLPMIIVARPR 145 Bacillus subtil...
O66832        72 LAPYAATLEEGRDFALEELGKHYE----ELSKKYKFLLVEGAGGIAVPIK-KNYTYANLARDW------KLKVLIVGRAG 140 Aquifex aeolicu...
P53630        83 LSPLQAMEYEPN-VDIRLLDFVVP----EEWSAENPLVVEGAGGVCVPITrKLEITTDLIKHLietsghPVYVVVVARSG 157 Saccharomyces c...
P45248        80 CSPHLAAKRESRKIEAKIIEKSTA----LLAEKYDYVLLEGAGGLMVPYC-EEATTLDYIQLN------NYPLILVTSGK 148 Haemophilus inf...
Q55849        82 LAPPLAADQEGKTIDLGVVWQTLQ----TMQQNHDHVLVEALGSLGSPVT-HELTVADIAALW------RLETILVVPVQ 150 Synechocystis s...
P36572        81 TSPHIVSADEGRPIDAARLSDGLR----RLEQRADWVLVEGAGGWFTPLS-AEYTFADWVRQE------QLPVILVVGIK 149 Serratia marces...
WP_000044842  81 TSPHIISAQEGRPIESLVMSAGLR----ALEQQADWVLVEGAGGWFTPLS-DTFTFADWVTQE------QLPVILVVGVK 149 Escherichia coli
AAB99306     104 LSPNIAFDVENSPLTLDEIKEKIKnayeTLKEKYDFLIVEGAGGVCVPIK-EDFLMSDLIKFL------GLDAVVVSRPN 176 Methanocaldococ...
P53558        77 LAPYVAGKLEGKTVTMEEVLSHWG----RIREKHECFIVEGAGGISVPLG-EDYLVSHVIKAL------QLPMIIVARPR 145 Bacillus subtil...
O66832        72 LAPYAATLEEGRDFALEELGKHYE----ELSKKYKFLLVEGAGGIAVPIK-KNYTYANLARDW------KLKVLIVGRAG 140 Aquifex aeolicu...
P53630        83 LSPLQAMEYEPN-VDIRLLDFVVP----EEWSAENPLVVEGAGGVCVPITrKLEITTDLIKHLietsghPVYVVVVARSG 157 Saccharomyces c...
P45248        80 CSPHLAAKRESRKIEAKIIEKSTA----LLAEKYDYVLLEGAGGLMVPYC-EEATTLDYIQLN------NYPLILVTSGK 148 Haemophilus inf...
Q55849        82 LAPPLAADQEGKTIDLGVVWQTLQ----TMQQNHDHVLVEALGSLGSPVT-HELTVADIAALW------RLETILVVPVQ 150 Synechocystis s...
P36572        81 TSPHIVSADEGRPIDAARLSDGLR----RLEQRADWVLVEGAGGWFTPLS-AEYTFADWVRQE------QLPVILVVGIK 149 Serratia marces...
WP_000044842  81 TSPHIISAQEGRPIESLVMSAGLR----ALEQQADWVLVEGAGGWFTPLS-DTFTFADWVTQE------QLPVILVVGVK 149 Escherichia coli
AAB99306     104 LSPNIAFDVENSPLTLDEIKEKIKnayeTLKEKYDFLIVEGAGGVCVPIK-EDFLMSDLIKFL------GLDAVVVSRPN 176 Methanocaldococ...

1DAM_A       149 LGCINHAMLTAQVIQHAGLT--LAGWVAN 175 Escherichia coli
P53558       146 LGTINHTFLTVKYAESMGLP--IAGIIIN 172 Bacillus subtilis subsp. subtilis str. 168
O66832       141 LGTINHTFLTWYYAKATGLE--VIGIILN 167 Aquifex aeolicus VF5
P53630       158 LGTLNHTLLTWNHLCDNGLRshLFGVILN 186 Saccharomyces cerevisiae S288c
P45248       149 LGSINHTLLSLEACRTRGIS--VLSVMYN 175 Haemophilus influenzae Rd KW20
Q55849       151 LGAMGQAIAQVALARQTKVK--LKGLVLS 177 Synechocystis sp. PCC 6803 substr. Kazusa
P36572       150 LGCINHAVLTAQAVQQAGLT--LAGWIAN 176 Serratia marcescens
WP_000044842 150 LGCINHAMLTAQVIQHAGLT--LAGWVAN 176 Escherichia coli
AAB99306     177 LGTINHTLLTVEHLRNKGIN--VRGVIIN 203 Methanocaldococcus jannaschii DSM 2661
P53558       146 LGTINHTFLTVKYAESMGLP--IAGIIIN 172 Bacillus subtilis subsp. subtilis str. 168
O66832       141 LGTINHTFLTWYYAKATGLE--VIGIILN 167 Aquifex aeolicus VF5
P53630       158 LGTLNHTLLTWNHLCDNGLRshLFGVILN 186 Saccharomyces cerevisiae S288c
P45248       149 LGSINHTLLSLEACRTRGIS--VLSVMYN 175 Haemophilus influenzae Rd KW20
Q55849       151 LGAMGQAIAQVALARQTKVK--LKGLVLS 177 Synechocystis sp. PCC 6803 substr. Kazusa
P36572       150 LGCINHAVLTAQAVQQAGLT--LAGWIAN 176 Serratia marcescens
WP_000044842 150 LGCINHAMLTAQVIQHAGLT--LAGWVAN 176 Escherichia coli
AAB99306     177 LGTINHTLLTVEHLRNKGIN--VRGVIIN 203 Methanocaldococcus jannaschii DSM 2661
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