Conserved Protein Domain Family
zpr1_rel

?
TIGR00340: zpr1_rel 
ZPR1-related zinc finger protein
This model describes a strictly archaeal family homologous to the domain duplicated in the eukaryotic zinc-binding protein ZPR1. ZPR1 was shown experimentally to bind approximately two moles of zinc; each copy of the domain contains a putative zinc finger of the form CXXCX(25)CXXC. ZPR1 binds the tyrosine kinase domain of epidermal growth factor receptor, but is displaced by receptor activation and autophosphorylation after which it redistributes in part to the nucleus. The proteins described by this model by analogy may be suggested to play a role in signal transduction. A model ZPR1_znf (TIGR00310) has been created to describe the domain shared by this protein and ZPR1. [Unknown function, General]
Statistics
?
PSSM-Id: 129440
View PSSM: TIGR00340
Aligned: 5 rows
Threshold Bit Score: 211.199
Threshold Setting Gi: 499218894
Created: 7-Oct-2014
Updated: 2-Oct-2020
Structure
?
Aligned Rows:
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
WP_010868148  21 CPVCGG-KgTLKAIQFIHRIPYFGEVMESTVICEKCGYRSADVMILEEREPRVYEVRVENeKDLFTRVVRSKSGTIELEE 99  Pyrococcus abyssi
WP_010877436  10 CPVCGGeR-CMTAVTRVEKIPYFGEIMESVLICERCNYRSTDIICLEQKEPSRYIIEAGA-DTLNARVVKSQSATIRIPE 87  Methanothermoba...
WP_010878286   4 CPSCG--R-ELRAVVSTYDVPFFGKVLLTSISCE-CGFRHADSVVLGEKDPVRYIIKINRe-NLFTKVIRSTSGTIRIPE 78  Archaeoglobus f...
WP_010923852  17 CPVCKS-K-TLKAVDYLYNTPHTGKLVLSNWYCENCGYKFRDVKPYETREPKLVEMKIENeDDLSALVYRSAFAKIVIPE 94  Sulfolobus solf...
WP_010916434  13 CPVCGS---LLYLLTYDTDIPYEGRISIYTYQCKKCMYRKTEVYQEEEKNPVRITLKIESpEDLKTLVYRSRKADIYIPE 89  Thermoplasma vo...
WP_010868148 100 LGIKIEPGPAAEGFVSNIEGVLERAKEVLLMARDFKEqenDE-EAVKKIDELLKYIEEVKEGKKP-LTVRIMDPFGNSAL 177 Pyrococcus abyssi
WP_010877436  88 LGLKVEPGPRSAGYISNIEGVVERFEAALKTALNLFE---DD-ESKKKASKILEMLHEVREGVRK-VTVIIEDPFGQSFV 162 Methanothermoba...
WP_010878286  79 IGVAIEPGPASQAFITNLEGVLDRVEGVVRTAMRWNS---DDeEKVRRCEWILERIRNTIDGDEE-LTLILEDPFGNSLI 154 Archaeoglobus f...
WP_010923852  95 LGIEIEPAGMSQGYISTIEGILEILLDQVGNFCDKEC---ED------------RIRSAMEGKIK-FTLIIEDESGLSFI 158 Sulfolobus solf...
WP_010916434  90 IEASIDSAEYANGEITTVEGIIYRIGEKLDLLSYDDE---EK-EAVK---EVRKKIDDIINGYFGsFTLIITDESGKSVI 162 Thermoplasma vo...
WP_010868148 178 IGEKVKSRKL 187 Pyrococcus abyssi
WP_010877436 163 GHPRALKEKL 172 Methanothermobacter thermautotrophicus
WP_010878286 155 VSDEAFKEIM 164 Archaeoglobus fulgidus
WP_010923852 159 KSEKASTRPL 168 Sulfolobus solfataricus
WP_010916434 163 ESEKAITEKI 172 Thermoplasma volcanium
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap