4LIM


Conserved Protein Domain Family
primase_sml
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TIGR00335: primase_sml 
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DNA primase, eukaryotic-type, small subunit, putative
Archaeal members differ substantially from eukaryotic members and should be considered putative pending experimental evidence. The protein is universal and single copy among completed archaeal and eukarotic genomes to date. DNA primase creates RNA primers needed for DNA replication.This model is named putative because the assignment is putative for archaeal proteins. Eukaryotic proteins scoring above the trusted cutoff can be considered authentic. [DNA metabolism, DNA replication, recombination, and repair]
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Statistics
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PSSM-Id: 273020
Aligned: 5 rows
Threshold Bit Score: 313.755
Created: 7-Oct-2014
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
4LIM_A   8 SDMEYYYKSLYPFKHIFNWLNHSPKP-SRDMINREFAMAFRSGAYK----RYNSFNSVQDFKAQIEKANPDRFEIGAIYN 82  Saccharomyces cerevis...
O29516   1 MLTKLFLKKKFEEYYSKNEVELPRKFkNREFAFVPLELLPDFVMHRhisfRSETDFRAYILSNVPAHIYFSSAYYERPAE 80  Archaeoglobus fulgidu...
O26685  11 LERKRYYREEWNVRDLPDFIADN-------LHMREFGFDHNGRGPSd---RYRVFRDERSLARFMRVRYPFAAYSSVAFY 80  Methanothermobacter t...
Q58249   5 AEVQKLYREYYNFAIKNNILEIPEG-----IEYREFGYGYLKKVDN----RNLSFKNEREYKDWVLKNAPMHFYKSLAYM 75  Methanocaldococcus ja...
P10363  13 SDMEYYYKSLYPFKHIFNWLNHSPKP-SRDMINREFAMAFRSGAYK----RYNSFNSVQDFKAQIEKANPDRFEIGAIYN 87  Saccharomyces cerevis...

4LIM_A  83 KPPRERD-TLLKSELKAlekELVFDIDMDDYDAFRTCCSGAqvcskCWKFISLAMKITNTALReDFGYK--DFIWVFSGR 159 Saccharomyces cerevis...
O29516  81 DKMENKG-WLGADLIFD---IDADHLPVKAQSFEKALEMAK-----REIKKLTAVLRADFGIR-DMKIY--FSGGRGYHV 148 Archaeoglobus fulgidu...
O26685  81 REPWKR-----KGWQRS---ELIFDVDAKDLPVRSCECDGVcp-tcLDEARELVLMMVDTLKG-DLGLG--DIHVIYSG- 147 Methanothermobacter t...
Q58249  76 LYPNKSGgASKKGIFRR---ELAFDIDVHKTKKCKHEDDWIck-hcLEEAKNQAIYLIEEFLIpDFGLNeeDLKIVFSGN 151 Methanocaldococcus ja...
P10363  88 KPPRERD-TLLKSELKAlekELVFDIDMDDYDAFRTCCSGAqvcskCWKFISLAMKITNTALReDFGYK--DFIWVFSGR 164 Saccharomyces cerevis...

4LIM_A 160 RGAHCWVS--DKRARALTDVQRRNVLDYVNVIrdrnTDK----------------RlalkrpyhphlarsleQLKPFFVS 221 Saccharomyces cerevis...
O29516 149 HVHDEEFL--SLGSAERREIVDYLRLNSPKIV----VED----------------R----------------FANSNAAK 190 Archaeoglobus fulgidu...
O26685 148 RGYHVRVL--DPEVMELGSEVRAEILRYTAGAr---EPRrkftdgvssyemehfsI----------------PLGYHRVF 206 Methanothermobacter t...
Q58249 152 RGYHIYIKprDEKIRDIIESYSKEDRRFLMDYi---LGK---------------------------------NLNLNSVG 195 Methanocaldococcus ja...
P10363 165 RGAHCWVS--DKRARALTDVQRRNVLDYVNVIrdrnTDKrlalkrpyhphlarslE----------------QLKPFFVS 226 Saccharomyces cerevis...

4LIM_A 222 IMLEeqnpweddqhaiQTLLPALY--DkqLIDSLKKYWLDNPRRsskeKWNDIDQIatsLFKGPKqdshiiKLRECKEDL 299 Saccharomyces cerevis...
O29516 191 RVLN------------YLRKKLEE--D--ERLTSKLKIKPADLK----KEKLTKKV---IRAVEK------FDYSALSIY 241 Archaeoglobus fulgidu...
O26685 207 TERA------------RHVLLHLRgdE--DIEDVTARTVKTAVR----NRNLILEDrwgEFRSVIg----pRVYPRLVKG 264 Methanothermobacter t...
Q58249 196 SGWR------------RRLIKAIK--E--RDKRISTKKLENEK-----NWKKVIEN----LKSKN------KIYNIIEET 244 Methanocaldococcus ja...
P10363 227 IMLEeqnpweddqhaiQTLLPALYdkQ--LIDSLKKYWLDNPRRsskeKWNDIDQIatsLFKGPKqdshiiKLRECKEDL 304 Saccharomyces cerevis...

4LIM_A 300 VLMtlyP---KLDVEVTKQTIHLLKAPFCIHPATGNVCVPID-----ESFAPEKAPKLidLQTEME 357 Saccharomyces cerevisiae S288c
O29516 242 IDA---P---VTADVKRLIRLPGSLHGKTGLRVTEVEDIESFn---pLKDALAFGDEA--VVVKVA 296 Archaeoglobus fulgidus DSM 4304
O26685 265 ISK---InmrMLDAKVTIDLKRILRLPTSLHSKVSMICMEVKn---pETFDPLKSAVPr-FVDERE 323 Methanothermobacter thermautotrophi...
Q58249 245 KNK---I---ELDEKVMDDDIRLLRVINSLHGYTGFIVKPLSgldelRRFNPLEDAIFkdFENKVY 304 Methanocaldococcus jannaschii DSM 2661
P10363 305 VLM---TlypKLDVEVTKQTIHLLKAPFCIHPATGNVCVPID-----ESFAPEKAPKLidLQTEME 362 Saccharomyces cerevisiae S288c
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