2VWB,3WUH


Conserved Protein Domain Family
gcp_kae1

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TIGR00329: gcp_kae1 
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metallohydrolase, glycoprotease/Kae1 family
This subfamily includes the well-studied secreted O-sialoglycoprotein endopeptidase (glycoprotease, EC 3.4.24.57) of Pasteurella haemolytica, a pathogen. A member from Riemerella anatipestifer, associated with cohemolysin activity, likewise is exported without benefit of a classical signal peptide and shows glycoprotease activity on the test substrate glycophorin. However, archaeal members of this subfamily show unrelated activities as demonstrated in Pyrococcus abyssi: DNA binding, iron binding, apurinic endonuclease activity, genomic association with a kinase domain, and no glycoprotease activity. This family thus pulls together a set of proteins as a homology group that appears to be near-universal in life, yet heterogeneous in assayed function between bacteria and archaea. [Protein fate, Degradation of proteins, peptides, and glycopeptides]
Statistics
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PSSM-Id: 129429
View PSSM: TIGR00329
Aligned: 13 rows
Threshold Bit Score: 424.459
Threshold Setting Gi: 685425529
Created: 7-Oct-2014
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2VWB_A         4 LGLEGTAEKTGVGIVTSd-----GEVLFNKTIMYKPP---KQGINPREAADHHAETFPKLIKEAF--EVVDKNeIDLIAF 73  Methanocaldococ...
P74034         5 LAIETSCDETAVAIVNN------RNVCSNVVSSQIQThqiFGGVVPEVASRQHLLLINTCLDQALqaSGLGWPeIEAIAV 78  Synechocystis s...
P43764         4 LGIETSCDETGVAIYDEe-----KGLIANQLYTQIALhadYGGVVPELASRDHIRKTAPLIKAALeeANLTASdIDGIAY 78  Haemophilus inf...
O51710         4 LGIETSCDDCCVAVVENg-----IHILSNIKLNQTEhk-kYYGIVPEIASRLHTEAIMSVCIKALkkANTKISeIDLIAV 77  Borrelia burgdo...
P55996         3 LSIESSCDDSSLALTRIe----dAQLIAHFKISQEKHhssYGGVVPELASRLHAENLPLLLERIKisLNKDFSkIKAIAI 78  Helicobacter py...
P47292         8 LGIETTCDDTGLSIVID------QKIKSNIVISSANLhvkTGGVVPEIAARCHEQN----LFKAIrdLNFEIRdLSHIAY 77  Mycoplasma geni...
P75055         8 LGIETTCDDTSIGVITE------SKVQAHIVLSSAKLhaqTGGVVPEVAARSHEQN----LLKALqqSGVVLEqITHIAY 77  Mycoplasma pneu...
Q58530         4 LGLEGTAEKTGVGIVTSd-----GEVLFNKTIMYKPp---KQGINPREAADHHAETFPKLIKEAF--EVVDKNeIDLIAF 73  Methanocaldococ...
O27476         4 LGIEGTAEKTGVGIVDEa-----GNVLSLRGKPLIPe---KGGIHPREAAEHHAKWIPRLIAEACrdAGVELGeIGLISF 75  Methanothermoba...
WP_001264353   4 LGIETSCDETGIAIYDDe-----KGLLANQLYSQVKLhadYGGVVPELASRDHVRKTVPLIQAALkeSGLTAKdIDAVAY 78  Escherichia coli
WP_010878608   4 LGIEGTAWSLSIGVVDEe-----G-VIALENDPYIPk---EGGIHPREASQHHSERLPSLLSRVF--EKVDKNsIDVVAF 72  Archaeoglobus f...
P43122        36 LAIETSCDDTCVSVLDRfsksaaPNVLANLKDTLDSId--EGGIIPTKAHIHHQARIGPLTERALieSNAREG-IDLICV 112 Saccharomyces c...
3WUH_A        12 LAIETSCDDTCVSVLDRfsksaaPNVLANLKDTLDSId--EGGIIPTKAHIHHQARIGPLTERALieSNAREG-IDLICV 88  Saccharomyces c...
2VWB_A        74 SQGPGLGPSLRVTATVARTLSLTLKKPIIGVNHCIAHIEIGKLTTE----AEDPLTLYVSGGNTQVIAYVSK-KYRVFGE 148 Methanocaldococ...
P74034        79 TVAPGLAGALMVGVTAAKTLAMVHQKPFLGVHHLEGHIYASYLSQPd--lQPPFLCLLVSGGHTSLIHVKGCgDYRQLGT 156 Synechocystis s...
P43764        79 TSGPGLVGALLVGATIARSLAYAWNVPAIGVHHMEGHLLAPMLDDNs--pHFPFVALLVSGGHTQLVRVDGVgKYEVIGE 156 Haemophilus inf...
O51710        78 TSRPGLIGSLIVGLNFAKGLAISLKKPIICIDHILGHLYAPLMHSKi---EYPFISLLLSGGHTLIAKQKNFdDVEILGR 154 Borrelia burgdo...
P55996        79 TNQPGLSVTLIEGLMMAKALSLSLNLPLILEDHLRGHVYSLFINEKq--tCMPLSVLLVSGGHSLILEARDYeNIKIVAT 156 Helicobacter py...
P47292        78 ACNPGLAGCLHVGATFARSLSFLLDKPLLPINHLYAHIFSCLIDQDlnklQLPALGLVISGGHTAIYLVKSFyELELIAE 157 Mycoplasma geni...
P75055        78 AANPGLPGCLHVGATFARSLSFLLDKPLLPINHLYAHIFSALIDQDinqlKLPALGLVVSGGHTAIYLIKSLfDLELIAE 157 Mycoplasma pneu...
Q58530        74 SQGPGLGPSLRVTATVARTLSLTLKKPIIGVNHCIAHIEIGKLTTE----AEDPLTLYVSGGNTQVIAYVSK-KYRVFGE 148 Methanocaldococ...
O27476        76 SRGPGLGPALRTVATAARTLALSLDVPIVGVNHCIGHIEIGRLTTG----ASDPVSLYVSGGNTQVIAFNEG-RYRVFGE 150 Methanothermoba...
WP_001264353  79 TAGPGLVGALLVGATVGRSLAFAWDVPAIPVHHMEGHLLAPMLEDNp--pEFPFVALLVSGGHTQLISVTGIgQYELLGE 156 Escherichia coli
WP_010878608  73 SQGPGMGPCLRVVATAARLLAIKLEKPLVGVNHCLAHVEVGRWQTG----ARKPVSLYVSGGNSQVIARRGN-RYRVFGE 147 Archaeoglobus f...
P43122       113 TRGPGMPGSLSGGLDFAKGLAVAWNKPLIGVHHMLGHLLIPRMGTNgkvpQFPFVSLLVSGGHTTFVLSRAIdDHEILCD 192 Saccharomyces c...
3WUH_A        89 TRGPGMPGSLSGGLDFAKGLAVAWNKPLIGVHHMLGHLLIPRMGTNgkvpQFPFVSLLVSGGHTTFVLSRAIdDHEILCD 168 Saccharomyces c...
2VWB_A       149 TLDIAVGNCLDQFARYVNLP-----HPGGPYI--EELARKGKKL---VDLPYTVKG----M------DIAFSGLLTAAMR 208 Methanocaldococ...
P74034       157 TRDDAAGEAFDKVARLLDLG-----YPGGPAI--DRAAKQGDPGtfkLPEGKISLP----QggyhpyDSSFSGLKTAMLR 225 Synechocystis s...
P43764       157 SIDDAAGEAFDKTAKLLGLD-----YPGGAAL--SRLAEKGTPNrftFPRPMTDRA----Gl-----DFSFSGLKTFAAN 220 Haemophilus inf...
O51710       155 TLDDACGEAFDKVAKHYDMG-----FPGGPNI--EQISKNGDENtfqFPVTTFKKK----Enw---yDFSYSGLKTACIH 220 Borrelia burgdo...
P55996       157 SLDDSFGESFDKVSKMLDLG-----YPGGPIVekLALDYRHPNEplmFPIPLKNSP----Nl-----AFSFSGLKNAVRL 222 Helicobacter py...
P47292       158 TSDDAIGEVYDKIGRAMGFD-----YPAGSKI--DSLFNKELVKphyFFKPSTKWT----K-------FSYSGLKSQCLN 219 Mycoplasma geni...
P75055       158 TSDDAIGEVYDKVGRAMGFP-----YPAGPQL--DSLFQPELVKshyFFRPSTKWT----K-------FSYSGLKSQCFT 219 Mycoplasma pneu...
Q58530       149 TLDIAVGNCLDQFARYVNLP-----HPGGPYI--EELARKGKKl---VDLPYTVKG----M------DIAFSGLLTAAMR 208 Methanocaldococ...
O27476       151 TLDIAVGNMLDQFARESGLG-----HPGGPVI--EQLALKASEy---IELPYSVKG----M------DISFSGLLTAALR 210 Methanothermoba...
WP_001264353 157 SIDDAAGEAFDKTAKLLGLD-----YPGGPLL--SKMAAQGTAGrfvFPRPMTDRP----Gl-----DFSFSGLKTFAAN 220 Escherichia coli
WP_010878608 148 TLDIGIGNALDKLARHMGLK-----HPGGPKI--EELAKKGQKy---HFLPYVVKG----M------DFSFSGMVTAAQR 207 Archaeoglobus f...
P43122       193 TIDIAVGDSLDKCGRELGFKgtmiaREMEKFIn-QDINDQDFALkleMPSPLKNSA----Skrn-mlSFSFSAFITALRT 266 Saccharomyces c...
3WUH_A       169 TIDIAVGDSLDKCGRELGFKgtmiaREMEKFIn-QDINDQDFALkleMPSPLKNSAskrnMl-----SFSFSAFITALRT 242 Saccharomyces c...
2VWB_A       209 AYDAG----------ERLEDICYSLQEYAFSMLTEITERALAH-----TNKGEVMLVGGVAANNRLREMLKAMCEGQN-- 271 Methanocaldococ...
P74034       226 LTQELkqs----sapLPVDDLAASFQDTVARSLTKKTIQCVLD-----HGLTTITVGGGVAANSRLRYHLQTAAQEHQ-- 294 Synechocystis s...
P43764       221 TVNQAikneg-elieQTKADIAYAFQDAVVDTLAIKCKRALKE-----TGYKRLVIAGGVSANKKLRETLAHLMQNLG-- 292 Haemophilus inf...
O51710       221 QLEKFksk----dnpTTKNNIAASFQKAAFENLITPLKRAIKD-----TQINKLVIAGGVASNLYLREKIDKLK------ 285 Borrelia burgdo...
P55996       223 EVEKNapn----lneAIKQKIGYHFQSAAIEHLIQQTKRYFKI-----KRPKIFGIVGGASQNLALRKAFENLCDAFD-- 291 Helicobacter py...
P47292       220 KIKQIsan----ktrIDWSELASNFQATIIDHYIDHVKNAIKK-----FAPKMLLVGGGVSANSYLSNRISTLN---L-- 285 Mycoplasma geni...
P75055       220 KIKQLrerkgfnpqtHDWNEFASNFQATIIDHYINHVKDAIQQ-----HQPQMLLLGGGVSANKYLREQVTQLQ---L-- 289 Mycoplasma pneu...
Q58530       209 AYDAG----------ERLEDICYSLQEYAFSMLTEITERALAH-----TNKGEVMLVGGVAANNRLREMLKAMCEGQN-- 271 Methanocaldococ...
O27476       211 KMEAG----------ASLEDLAYSIQETAFSMLVEVTERALAY-----TEKNQVLLCGGVAVNRRLRDMLREMCQEHH-- 273 Methanothermoba...
WP_001264353 221 TIRDNgt------ddQTRADIARAFEDAVVDTLMIKCKRALDQ-----TGFKRLVMAGGVSANRTLRAKLAEMMKKRR-- 287 Escherichia coli
WP_010878608 208 LFDSG----------VRMEDVAFSFQETAFAMLTEVTERALAY-----LDLNEVLLVGGVAANKRLQEMLRIMCEDRG-- 270 Archaeoglobus f...
P43122       267 NLTKLgkteiqelpeREIRSIAYQVQESVFDHIINKLKHVLKSqpekfKNVREFVCSGGVSSNQRLRTKLETELGTLNst 346 Saccharomyces c...
3WUH_A       243 NLTKLgkteiqelpeREIRSIAYQVQESVFDHIINKLKHVLKSqpekfKNVREFVCSGGVSSNQRLRTKLETELGTLNst 322 Saccharomyces c...
2VWB_A       272 --VDFYVPPKEFCGDNGAMIA 290 Methanocaldococcus jannaschii DSM 2661
P74034       295 --LQVFFPPLKFCTDNAAMIA 313 Synechocystis sp. PCC 6803 substr. Kazusa
P43764       293 --GEVFYPQPQFCTDNGAMIA 311 Haemophilus influenzae Rd KW20
O51710       286 --IQTYYPPLDLCTDNGAMIA 304 Borrelia burgdorferi B31
P55996       292 --CKLVLAPLEFCSDNAAMIG 310 Helicobacter pylori 26695
P47292       286 ---PFLIADSKYTSDNGAMIG 303 Mycoplasma genitalium G37
P75055       290 ---PYLIAPLKYTSDNGAMIG 307 Mycoplasma pneumoniae M129
Q58530       272 --VDFYVPPKEFCGDNGAMIA 290 Methanocaldococcus jannaschii DSM 2661
O27476       274 --VEFHMPPPEYCGDNGAMIA 292 Methanothermobacter thermautotrophicus str. Delta H
WP_001264353 288 --GEVFYARPEFCTDNGAMIA 306 Escherichia coli
WP_010878608 271 --AKFYVPPKELAGDNGAMIA 289 Archaeoglobus fulgidus
P43122       347 sfFNFYYPPMDLCSDNSIMIG 367 Saccharomyces cerevisiae S288c
3WUH_A       323 sfFNFYYPPMDLCSDNSIMIG 343 Saccharomyces cerevisiae S288c
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