Conserved Protein Domain Family
TIGR00298
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TIGR00298: TIGR00298 
2-phosphosulfolactate phosphatase
2-phosphosulfolactate phosphatase catalyzes the sulfonation of phosphoenolpyruvate to form 2-phospho-3-sulfolactate, the second step in coenzyme M biosynthesis. Coenzyme M is the terminal methyl carrier in methanogenesis. [Biosynthesis of cofactors, prosthetic groups, and carriers, Other, Energy metabolism, Methanogenesis]
Links
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Statistics
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PSSM-Id: 273003
Aligned: 8 rows
Threshold Bit Score: 261.586
Created: 7-Oct-2014
Updated: 25-Oct-2021
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q58540        16 VAIVVDVLRASTTITTLLSFIDEVYITTSTSKK------E-NAIYIGERKGRKIEGFdFGNSPTEILANKdiikeryenG 88  Methanocaldococ...
O27250        17 LCIMVDLLRASATITAALDRFREVIPVADIEEAmey-srK-GYLVAGERGGETLPGF-IANSPLEVKNYR---------G 84  Methanothermoba...
EDP41145      88 CAIVIDVLRASTTISTLLELYDKVYITNSIEKTmn---fP-NSIKMGERNGIKIDEFdYGNSPIEILKDKnkiidftknG 163 Methanococcus v...
WP_011954240  15 TSIMVDALRASTTITLALNNFNEIIPCFTPEEAfel-kkEiNGIIAGERSGKRVEGFdVGNSPKDVENYDt-------dI 86  Methanobrevibac...
WP_011869260  25 CVIIIDVLRASTTICTLLELCDKIYITDSLEKAek---iE-NSIKIGERNAQKIEGFdFGNSPVELIVNKnlikehannG 100 Methanococcus m...
WP_011406560  15 VAIVIDLLRASTTITIALNTFNKVIPVNTSNEAfelknkY-NALLAGEDNLKTIEGFdITNSPKEVQKHE---------G 84  Methanosphaera ...
WP_011973712  25 CVIVIDVLRASTTINVLLELHEKIHITEVENIDnem-ykD-KFIKFGEKNGKKIESCdYGNSPLEVRLNKd-------nI 95  Methanococcus a...
WP_011405896  15 LAIVIDLLRASTTISVALNTFKRIVPINDIDEAiklkekH-NAILAGEIKS---SDFdVSNSPVQISNYA---------G 81  Methanosphaera ...

Q58540        89 EK------------VILTTTNGTRVLKSLDAEh----I----FIGAIVNAKYVAKAVEDFED-----VSLVPCHRENNFA 143 Methanocaldococ...
O27250        85 DV------------LVLTTSNGTRILESVKSD-----A----LVGCLNNLDAVAEAARELSDe----VEVVMAGVNGRFA 139 Methanothermoba...
EDP41145     164 GN------------LVLTTTNGTRVLNSIISDd----I----YVGSINTAEAVAKEVYNTAVekdkdIVLIPSHRCGDFA 223 Methanococcus v...
WP_011954240  87 ET------------LILTTSNGTRILKDMDST-----V----LVGSMVNAKAVGYKSVEIAEn---eIDVVMAGYKGNFA 142 Methanobrevibac...
WP_011869260 101 GN------------IVLTTTNGTRVLENISSEh----I----LIGSITNAEEVAKKAYSIAKknkkgIMLVPCHRKGNFA 160 Methanococcus m...
WP_011406560  85 DV------------LVLKTTNGTRVLENTKNNn----KnvtvLIGTGINANAVAKKALEIATe---eIEIVMAGRHEKFN 145 Methanosphaera ...
WP_011973712  96 LNqlnnndntnnkeILLATTNGTRVLKSIISDn----I----FIGSITNAKYVADYVFNVANeqnknIIIIPSHRKGMFA 167 Methanococcus a...
WP_011405896  82 DT------------LILKTTNGTKVLENIKQRnsevnI----LVGASINAKTVAQKALDIADn---eIELVMAGRHQRFT 142 Methanosphaera ...

Q58540       144 IDDFIGCGVIAKYLNG---------E-FDEFIkAALELTKHDWM--SLILNSSSAENLKNLGYEKDVTFAILENSIDAVG 211 Methanocaldococ...
O27250       140 IEDFLCAGEIIAAIDG---------E-MDEYAeASVLAVQDRSLvdDAIRRSRSAERLGGLGFMDDVEYCIKRNITGNVP 209 Methanothermoba...
EDP41145     224 IEDYIGAAIIVENILKipgh-nitnQ-LEQLI-PLRSTIKFDWK--NTILNSKSGQGLRDRGYSYDVLYSVQENICNNVG 298 Methanococcus v...
WP_011954240 143 LEDFLAAGEILYWICDrln---necE-ISDYAkAAIMASRDYDAlkEGFYNCNSGRKLSRLKSKKDIDCCVLKNISENVA 218 Methanobrevibac...
WP_011869260 161 IEDFIGAGIIANYLFKeyde-kipdEkFEELI-SARVLTKSDWV--RKIFESNSGANLKKLGYFEDLIFCTSKNSQKSVG 236 Methanococcus m...
WP_011406560 146 IEDATGAGVIVKEIIKsakdqniplE-LDETAlASTILAKDEKQvkELIGNSWGATKLTKLGLEDDVKLCQLINEINEVP 224 Methanosphaera ...
WP_011973712 168 IEDYIGAGLIAKYILKnankyditiD-IENLI-PAINLVKSDWk--TKIINSASAKNLKNLGYEGDIIFCSSENTQKIVG 243 Methanococcus a...
WP_011405896 143 IEDCIGAGIIINEIVNiakekniylE-LSESAkASKIISNNSNIikQLINTSHSADKLRYLGFGEDIEICSLINKIDTVP 221 Methanosphaera ...

Q58540       212 IYKKd----kSKVVRF 223 Methanocaldococcus jannaschii DSM 2661
O27250       210 VYRDgrielmEEIRRL 225 Methanothermobacter thermautotrophicus str. Delta H
EDP41145     299 KYNKk----eSYIYKV 310 Methanococcus voltae A3
WP_011954240 219 IYEN------N-ILKL 227 Methanobrevibacter smithii
WP_011869260 237 IFDKk----sGIISQL 248 Methanococcus maripaludis
WP_011406560 225 IYKN------NEITKL 234 Methanosphaera stadtmanae
WP_011973712 244 MYKD------GKIVNI 253 Methanococcus aeolicus
WP_011405896 222 IYKN------NYIVSL 231 Methanosphaera stadtmanae
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