3LFX,3NKD


Conserved Protein Domain Family
cas1
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TIGR00287: cas1 
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CRISPR-associated endonuclease Cas1
This model identifies CRISPR-associated protein Cas1, the most universal CRISPR system protein. CRISPR is an acronym for Clustered Regularly Interspaced Short Palindromic Repeats, a system for heritable host defense by prokaryotic cells against phage and other foreign DNA. Cas1 is a metal-dependent DNA-specific endonuclease.
Links
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Statistics
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PSSM-Id: 272998
Aligned: 22 rows
Threshold Bit Score: 219.521
Created: 7-Oct-2014
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
3LFX_A         3 SVYLFSSG-TLKRKANTICLETESg---RKYIPVENVMDIKVFGEVDLNKRFLEFLSQKRIPIHFFNREGYYVGTf---- 74  Thermotoga mari...
Q46896        16 SMIFLQYGqIDVIDGAFVLIDKTGi---RTHIPVGSVACIMLEPGTRVSHAAVRLAAQVGTLLVWVGEAGVRVYA----- 87  Escherichia col...
WP_011016963  12 SFFLYSNG-TLKRKDNTITFINEKd--eKRDIPIEMVDDFYVMSEMNFNTKFINYISQFGIPIHFFNYYTFYTGSf---- 84  Fusobacterium n...
WP_011026650   4 TLYLFANG-KLYRKDNTICVEGEKe--kK-YFPVESVRDIYVFGEVDLNKKFIEFAEEKEIILHFFGYYGNYVGSf---- 75  Caldanaerobacte...
Q57823         5 SLTLLSDG-YLFRKENTIYFENARg---KKPLAIEGIYDIYIYGKVSISSQALHYLAQKGIALHFFNHYGYYDGSf---- 76  Methanocaldococ...
WP_010916362   3 NFYITQDG-TITREGNTLYFIGPDf---KRHLPVMNVQEIIISAKVSLSSWALDYLSKLGIIVHIISTNGKYMSSl---- 74  Thermoplasma vo...
WP_031669398   3 QLYVSDSVsRISFADGRVIVWSEEl--gESQYPIETLDGITLFGRPTMTTPFIVEMLKRERDIQLFTTDGHYQGRi---- 76  Mycobacterium a...
WP_005753659  22 NIYYLEHCrVLLNGGRVEYVTDEGreslYWNIPIANTSCLLLGSGTSITQAAMRELSKAGVMVGFCSGGGTPLFNgteae 101 Pasteurella mul...
3NKD_A        16 SMIFLQYGqIDVIDGAFVLIDKTGi---RTHIPVGSVACIMLEPGTRVSHAAVRLAAQVGTLLVWVGEAGVRVYA----- 87  Escherichia col...
WP_010933633  32 PFLYLEKGrIEIDDSSIKWIDCDCn---VVRLPVAMLNCILLGPGTTVTHEAVKVMAAANCGICWVGDDSLMFYA----- 103 Chlorobaculum t...

3LFX_A        75 ------YPREYLnSGFLILKQAEHYINqEKRMLIAREIVSRSFQNMVDFLKkrkvradsltr-------ykkkaeeasnV 141 Thermotoga mari...
Q46896        88 ------SGQPGGaRSDKLLYQAKLALDeDLRLKVVRKMFELRFGEPAPARRs---------------------------V 134 Escherichia col...
WP_011016963  85 ------YPREMNiSGQLLVKQVEHYTNeQKRVEIAREFIEGASFNIYRNLRyyngrgkdlklymdqieelrkhlkevnnV 158 Fusobacterium n...
WP_011026650  76 ------YPREHYnSGYIILKQAEHYLDsARRLDLARRFVQGAVANMTQVLKyyqnrgrdledylhaisaleasllsvssI 149 Caldanaerobacte...
Q57823        77 ------YPRESLhSGYLVVNQVEHYLDkDKRLELAKLFIIGGIKNMEWNLLkfknktkfss--------yieelnncnkI 142 Methanocaldococ...
WP_010916362  75 ------IPGNRNeRGNTTVQQVKAYLs-DKRFKIAAEMVNGIKNNILANLRyysdnneitkyik--aiesynpdynsndI 145 Thermoplasma vo...
WP_031669398  77 ------STP-DVsYAPRLRQQVHRTDDpAFCLALSKRIVSRKILNQQALIRahtsgqdvaesirt-mkhslawvdrsgsL 148 Mycobacterium a...
WP_005753659 102 igceffSPQSEYrPVMYLQQWCKFWFDdEKRLAVAKALQQQRLALLEPIWSklewvyscekltal-vtqyqhefaqaahS 180 Pasteurella mul...
3NKD_A        88 ------SGQPGGaRSDKLLYQAKLALDeDLRLKVVRKMFELRFGEPAPARRs---------------------------V 134 Escherichia col...
WP_010933633 104 ------SGQTPTsNTRNMTHQMKLAANpAKALEVARRLFAYRFPDANLENKt---------------------------L 150 Chlorobaculum t...

3LFX_A       142 SELMGIEGNAREEYYSMIDSLVSderFRIEKR----TRRP-PKNFANTLISFGNSLLYTTVLSLIYQTHLDPRIGYLHEt 216 Thermotoga mari...
Q46896       135 EQLRGIEGSRVRATYALLAKQYG---VTWNGRrydpKDWE-KGDTINQCISAATSCLYGVTEAAILAAGYAPAIGFVHT- 209 Escherichia col...
WP_011016963 159 EELMGYEGNIRKIYYEAWNIIVNq-eIDFEKR----VKNP-PDNMINSLISFVNTLFYTKVLGEIYKTQLNPTVSYLHQp 232 Fusobacterium n...
WP_011026650 150 EELMALEGNIRRYYYESFNTILDdtpFVLKNR----NKRP-PTDPLNALISFGNSLVYTKILTEIYKTHLDPRIGYLHTt 224 Caldanaerobacte...
Q57823       143 TEVMNVEGRVRTEYYRLWDETLPd-dFKIVKR----TRRP-PKNEMNALISFLNSRLYPAIITELYNTQLTPTVSYLHEp 216 Methanocaldococ...
WP_010916362 146 NKILGVEGNIWSTYYSAFPFIYKk--YPDFKR----EFYP-PKDELNAMISYGNALLYATVLTKIFITGLNPSISFLHEp 218 Thermoplasma vo...
WP_031669398 149 AELNGFEGNAAKAYFTALGHLVPq-eFAFQGR----STRP-PLDAFNSMVSLGYSLLYKNIIGAIERHSLNAYIGFLHQd 222 Mycobacterium a...
WP_005753659 181 QALLAAEGRLTTKLYALANQATMn--ePDFKR----SERGkSIDLVNQFLDHGNYLAYGLGATACWVLGLPHGLAVLHGk 254 Pasteurella mul...
3NKD_A       135 EQLRGIEGSRVRATYALLAKQYG---VTWNGRrydpKDWE-KGDTINQCISAATSCLYGVTEAAILAAGYAPAIGFVHT- 209 Escherichia col...
WP_010933633 151 PQMMGMEGLRVRKLYEEMAVKYK---VGWKGRrfepGKFE-MSDTTNKILTASNAALYSIILSAVHSMGYSPHIGFIHS- 225 Chlorobaculum t...

3LFX_A       217 nFRRFSLNLDIAELFKPAVVDRLFLNLVNTRqinekhfd--eiseglmLNDEGKsLFVKNYEQALRetvfhkKln-ryVS 293 Thermotoga mari...
Q46896       210 -GKPLSFVYDIADIIKFDTVVPKAFEIARRN-----------------PGEPDR-EVRLACRDIFR------S-----SK 259 Escherichia col...
WP_011016963 233 sTRRFSLSLDISEVFKPLIVDRLIFSLLNKNqiteksfv--kdfeylrLKEDVSkLIVQEFEDRLKqiithkDln-rkIS 309 Fusobacterium n...
WP_011026650 225 nFRRFTLNLDVAEIFKPIYADRVLFTLLKKNiikeddfe--tqgeislLKERGRrLYVQEFEGKLQttfyhrRlk-rnVS 301 Caldanaerobacte...
Q57823       217 hERRFSLALDLSEIFKPMIADRLANRLVKQGiiqkkhfr--ddlngvlLNKEGMkVVLEHFNKEMDktvnhkKlk-knVS 293 Methanocaldococ...
WP_010916362 219 sERSFSLALDIADIFKPVIVERTIANLVNKNimahdsfr--fedngcyLSLNGRrKFIEYYNEKLNtviki---gnnyLS 293 Thermoplasma vo...
WP_031669398 223 sRGHATLASDLMEVWRAPIIDDTVLRLIADGvvdtrafsknsdtgavfATREATrSIARAFGNRIArtatyiKgdphrYT 302 Mycobacterium a...
WP_005753659 255 -TRRGGLVFDAADIIKDSMILPQAFISAQNG--------------------DSEkEFRQACIQNLLr-----------FG 302 Pasteurella mul...
3NKD_A       210 -GKPLSFVYDIADIIKFDTVVPKAFEIARRN-----------------PGEPDR-EVRLACRDIFRs-----------sK 259 Escherichia col...
WP_010933633 226 -GSPLPFIYDLADLYKQQVSIDLAFSLTADM-----------------AGYYDRhKIASEFRKRVI------E-----ID 276 Chlorobaculum t...

3LFX_A       294 MRSLIKMELHKLEKHLIGEQVFGS 317 Thermotoga maritima
Q46896       260 TLAKLIPLIEDVLAAGEIQPPAPP 283 Escherichia coli K-12
WP_011016963 310 YQYLVRLECYKLIKHLLGEKKYKS 333 Fusobacterium nucleatum
WP_011026650 302 YQTLMRLELYKLEKHLIGEELYEP 325 Caldanaerobacter subterraneus
Q57823       294 KRRLIRLEAYKLVKHLVGQKRYEP 317 Methanocaldococcus jannaschii DSM 2661
WP_010916362 294 YNNIIEREAYNLLNAIRNDEDYKS 317 Thermoplasma volcanium
WP_031669398 303 FQYALDLQLQSLVRVIEAGHPSRl 326 Mycobacterium africanum
WP_005753659 303 ALDIIIERLQQLALQGASDEYFAG 326 Pasteurella multocida
3NKD_A       260 TLAKLIPLIEDVLAAGEIQPPAPP 283 Escherichia coli DH1
WP_010933633 277 LLGKIGPDIETILGKKQCSS---- 296 Chlorobaculum tepidum
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