1VB3


Conserved Protein Domain Family
thrC
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TIGR00260: thrC 
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threonine synthase
Involved in threonine biosynthesis it catalyses the reaction O-PHOSPHO-L-HOMOSERINE + H(2)O = L-THREONINE + ORTHOPHOSPHATE using pyridoxal phosphate as a cofactor. the enzyme is distantly related to the serine/threonine dehydratases which are also pyridoxal-phosphate dependent enzymes. the pyridoxal-phosphate binding site is a Lys (K) residues present at residue 70 of the model. [Amino acid biosynthesis, Aspartate family]
Links
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Statistics
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PSSM-Id: 272986
Aligned: 12 rows
Threshold Bit Score: 318.942
Created: 7-Oct-2014
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
1VB3_A        52 VTRSAKILSAFigdEIPQEILEERVRAAFAFPAPV---ANVES---DVGCLELFHG-PTLAFKDFGgrfMAQMLTHIAGD 124 Escherichia coli
P00934        52 VTRSAKILSAFigdEIPQEILEERVRAAFAFPAPV---ANVES---DVGCLELFHG-PTLAFKDFGgrfMAQMLTHIAGD 124 Escherichia col...
P44503        50 VERSQKILGALidgELPQATLDAMVKNAFTFPAPL---EKVEE---NIYALELFHG-PTLAFKDFGgrfMAQALAAVRGD 122 Haemophilus inf...
O24924        55 CVFERLGLEIP----KNLLASALKRYENFDNPKNP---APIFAlneRLFVQELYHG-PSLAFKDMAlqpLASLFSNLAVG 126 Helicobacter py...
P74193        38 IETYRPYLPVSd--QTPVVTLLEGNTPLIPAPAIA---KRIGKd-vRVFVKYDGLN-PTGSFKDRG---MTMAISKAKEA 107 Synechocystis s...
P04990         6 IHQYKEFLPVTd--QTPALTLHEGNTPLIHLPKLS---EQLGi---ELHVKTEGVN-PTGSFKDRG---MVMAVAKAKEE 73  Bacillus subtil...
Q58860        52 VWRYLEYLPVKd--ESKIVSLCEGGTPLYRCNNLE---KELGIk--ELYVKNEGAN-PTGSFKDRG---MTVGVTRANEL 120 Methanocaldococ...
WP_010878813  48 VWKYRSLLPV----KIDPVTLKEGGTPLYRAERLE---KEVGVr--RVYVKHEGLN-PSGSFKDRG---MTVGVTKALEL 114 Archaeoglobus f...
WP_010875892  52 MWRYREFMPVd---PSRIVSLDEGGTPFVRCDTIG---SELGIe---LYVKVEGSN-PTGSFKDRG---MSVGITKALEL 118 Methanothermoba...
WP_010872388  67 IWRYRAFLPVTg---KDVIDVGTGMTPLVKSHRLA---RRLGLk--NLYIKNDAVNmPTLSFKDRV---VSVALTRAREL 135 Synechocystis s...
WP_010878058  55 VWRYREFLPTN----HDPVDLGAGFTRFIHAKNLG---ECLGLk--NLYLLDDSTN-PTYSFKDRV---VSVAVTKALEF 121 Archaeoglobus f...
P16120        65 IMRLYIAQEEIp--DADLKDLIKRSYSTFRSDEVTplvQNVTGdkeNLHILELFHG-PTYAFKDVAlqfVGNLFEYFLQR 141 Saccharomyces c...

1VB3_A       125 KPV----------TILTATSGDTGAAVAhAFYGLPNVKVVILYPRGKISp-lQEKLFCTLGGNIETVAIDGDFDACQALV 193 Escherichia coli
P00934       125 KPV----------TILTATSGDTGAAVAhAFYGLPNVKVVILYPRGKISp-lQEKLFCTLGGNIETVAIDGDFDACQALV 193 Escherichia col...
P44503       123 GKI----------TILTATSGDTGAAVAhAFYGLENINVVILYPKGKISp-lQEKLFCTLGGNIRTVAINADFDACQALV 191 Haemophilus inf...
O24924       127 KNEk--------yLMLVSTSGDTGPATLeSLAGMPNVFVVCLYPKDGTSlvqKLQMVTQSASNLKVFGISGDFDDAQNAL 198 Helicobacter py...
P74193       108 GAK----------AVICASTGNTSAAAA-AYARRAGLRAFVIIPDGYVA---LGKLGQALIYGAEVIAIDGNFDDALTTV 173 Synechocystis s...
P04990        74 GND----------TIMCASTGNTSAAAA-AYAARANMKCIVIIPNGKIA---FGKLAQAVMYGAEIIAIDGNFDDALKIV 139 Bacillus subtil...
Q58860       121 GVE----------VVGCASTGNTSASLA-AYSARSGKKCIVLLPEGKVA---LGKLAQAMFYGAKVIQVKGNFDDALDMV 186 Methanocaldococ...
WP_010878813 115 GRK----------AVACASTGNTSASMA-MYAAKAGLKAYVLLPAGKVA---LGKVAQALMHGAKVIGIDGNFDDALRIV 180 Archaeoglobus f...
WP_010875892 119 GVD----------TVGCASTGNTSASLA-AYAARAGLGCVVLLPSGKVA---LGKLAQAMFHGARVLSVRGNFDEALEAV 184 Methanothermoba...
WP_010872388 136 GFT----------TVSCASTGNLANSTA-AIAAHAGLDCCVFIPAD-LE---AGKVLGTLIYNPTLMAVKGNYDQVNRLC 200 Synechocystis s...
WP_010878058 122 GMD----------VVGCASTGNLAGSLA-AHAAKAGLKAFIFVPAG-IE---KNKIVQALVHGATVVEVNGTYDDANRLA 186 Archaeoglobus f...
P16120       142 TNAnlpegekkqiTVVGATSGDTGSAAIyGLRGKKDVSVFILYPTGRISpiqEEQMTTVPDENVQTLSVTGTFDNCQDIV 221 Saccharomyces c...

1VB3_A       194 KQAFD---DeelKV-------ALGLNSANSInISRLLAQI-CYYFEAVAQLPQ---ETRNQLVVSVP-SGNFGDLTAGlL 258 Escherichia coli
P00934       194 KQAFDdeeL---KV-------ALGLNSANSInISRLLAQI-CYYFEAVAQLPQ---ETRNQLVVSVP-SGNFGDLTAG-L 257 Escherichia col...
P44503       192 KQAFDdveL---RQ-------AIGLNSANSInISRLLAQV-CYYFEAVAQLPK---EKRDNVVVSVP-SGNFGNLTAG-L 255 Haemophilus inf...
O24924       199 KNLLKd--D---DFnealkacQLKLSVANSVnFGRIAFQIvYHIWGFLELYKKgaiNSKEKITLAIP-SGNFGNALGAfY 272 Helicobacter py...
P74193       174 RQLSE---H---YP-------VTLVNSVN---PYRLEGQK-TAAFEIVDVLG----QAPDWLCIPVGnAGNITAYWMGfC 232 Synechocystis s...
P04990       140 RSICE---K---SP-------IALVNSVN---PYRIEGQK-TAAFEVCEQLG----EAPDVLAIPVGnAGNITAYWKGfK 198 Bacillus subtil...
Q58860       187 KQLAK---E---KL-------IYLLNSIN---PFRLEGQK-TIAFEICDQLNW---QVPDRVIVPVGnAGNISAIWKGfK 246 Methanocaldococ...
WP_010878813 181 REVCS---R---EP-------IYLLNSIN---PFRPEGQK-TIAYEIADEIG-----VPDRVVLPVGnAGNISAIYKGfK 238 Archaeoglobus f...
WP_010875892 185 TELAL---M---GE-------LYLLNSVN---PFRLEGQK-SIGFEIVDDLGW---ESPDRIILPVGnAGNISAIWKGiS 244 Methanothermoba...
WP_010872388 201 CEV-G---N---SY-------GWGFVNINLR-PYYSEGSK-TLGFEVAEQLGW---KLPDHIVAPLAsGSLFTKIHKGfQ 261 Synechocystis s...
WP_010878058 187 AEIAE---K---NR-------NWGFVNINLR-PYYVEGSK-TLAFEAAERLGW---EAPSQVVVPVAsGALLYSIYRGfK 248 Archaeoglobus f...
P16120       222 KAIFG---D---KEfn----sKHNVGAVNSInWARILAQMtYYFYSFFQATNG---KDSKKVKFVVP-SGNFGDILAGyF 287 Saccharomyces c...

1VB3_A       259 A-KSLg----LP-V-KRFIAATNVnDTVPRFLHDGq-WSPKATQ--ATLSNAMDVSQPNNWPRVEE---LFRRKIWQLKE 325 Escherichia coli
P00934       258 LaKSLg----LP-V-KRFIAATNVnDTVPRFLHDGq-WSPKATQ--ATLSNAMDVSQPNNWPRVEE---LFRRKIWQLKE 325 Escherichia col...
P44503       256 IaKTLg----LP-I-KRFVASTNAnDTVPRYLKSGn-WDPKTTV--ATLSNAMDVSRPNNWPRVEE---LFKRNGWDLTD 323 Haemophilus inf...
O24924       273 AkKMG-----LNiD-KIKVVTNSN-DVLREFIETGryDLTHRSLk-QTYSPAMDILKSSNVERALFslfGFERTLELMQA 344 Helicobacter py...
P74193       233 QyKELgkgdrLP-R-MMGFQAAGSaPFIQGQ--------PISHP--ETLATAIRIGNPANWDKAWA---ASRESNGEFHP 297 Synechocystis s...
P04990       199 EyHEKng-tgLP-K-MRGFEAEGAaAIVRNE--------VIENP--ETIATAIRIGNPASWDKAVK---AAEESNGKIDE 262 Bacillus subtil...
Q58860       247 EfEITgiideLP-K-MTGIQADGAkPIVEAFRKRAkdIIPYKNP--ETIATAIRIGNPVNAPKALD---AIYSSGGYAEA 319 Methanocaldococ...
WP_010878813 239 ElREVgltdsMP-K-MTGIQAEGAaPIYRAFKEGKedITPMENP--ETIATAIRIGNPVSAKKALR---AIYSTNGLAEV 311 Archaeoglobus f...
WP_010875892 245 EfYRAgfideRP-M-MTGIQAEGAsPVVEAFRKGRteIEPVRDP--ETVATAIRIGAPVSYLKALR---AIYESDGYAES 317 Methanothermoba...
WP_010872388 262 EfIKVglvddKPvR-FSGAQAEGCsPIATAFQEGRd-FVKPVKP--NTIAKSIAIGNPADGVYALD---IARKTNGNIES 334 Synechocystis s...
WP_010878058 249 ElETVglidsAE-VaFNAAQPEGF-PVARAVKERRq-VEPIERF--STIVHSLAIGNPADGIFAKE---VVERSGGYAED 320 Archaeoglobus f...
P16120       288 AkKMG-----LPiE-KLAIATNEN-DILDRFLKSG--LYERSDKvaATLSPAMDILISSNFERLLWy--LAREYLANGDD 356 Saccharomyces c...

1VB3_A       326 Lgy----------------------------------aaVDDETTQQTMRELKE----LGYTSEPHAAVAYRALRDQLNP 367 Escherichia coli
P00934       326 Lgy----------------------------------aaVDDETTQQTMRELKE----LGYTSEPHAAVAYRALRDQLNP 367 Escherichia col...
P44503       324 Lgs----------------------------------gmLSDSETEDTLKAMQS----KGYLCEPHGAIAYQVLKDQLKA 365 Haemophilus inf...
O24924       345 Leeekfyalkpkel-------------allqehfscascSDEACLKTIQEVYAE----HQYLIDPHTATALNASLKTHEK 407 Helicobacter py...
P74193       298 V--------------------------------------TDAEILEAYRILAAE----EGVFCEPASAASVAGLLKQKD- 334 Synechocystis s...
P04990       263 V--------------------------------------TDDEILHAYQLIARV----EGVFAEPGSCASIAGVLKQVKS 300 Bacillus subtil...
Q58860       320 V--------------------------------------TDEEIVEAQKLLARK----EGIFVEPASASSIAGLKKLLEE 357 Methanocaldococ...
WP_010878813 312 V--------------------------------------SDSEIIEAQKFLAAK----EGIGVEPASAASVAGLRKLAAN 349 Archaeoglobus f...
WP_010875892 318 V--------------------------------------TDEEILSAQKLLARR----EGIGVEPASAASIAGLIKLVDE 355 Methanothermoba...
WP_010872388 335 V--------------------------------------NDAEIIEGIKLLAET----EGIFTETAGGTTVAVLKKLVEA 372 Synechocystis s...
WP_010878058 321 P--------------------------------------SDAEVIEAVKLLART----EGIFTELAGGVTVAALIRLVED 358 Archaeoglobus f...
P16120       357 LkageivnnwfqelktngkfqvdksiiegaskdftservSNEETSETIKKIYESsvnpKHYILDPHTAVGVCATERLIAK 436 Saccharomyces c...

1VB3_A       368 geyglflG-----------TAHPAkfKESVE-AILGETLDLPK 398 Escherichia coli
P00934       368 -------Geygl----flgTAHPAkfKESVE-AILGETLDLPK 398 Escherichia coli K-12
P44503       366 -------Setgi----flcTAHPAkfKESVE-RILGIQLPLPE 396 Haemophilus influenzae Rd KW20
O24924       408 -------Tlv-------saTASYEkfPRITLlALNEQKKNDND 436 Helicobacter pylori 26695
P74193       335 -------------------QVPAG--ATVVC-VLTGNGLKDPD 355 Synechocystis sp. PCC 6803 substr. Kazusa
P04990       301 -------G-----------EIPKG--SKVVA-VLTGNGLKDPN 322 Bacillus subtilis subsp. subtilis str. 168
Q58860       358 -------G-----------IIDRD--ERIVC-ITTGHGLKDPD 379 Methanocaldococcus jannaschii DSM 2661
WP_010878813 350 -------G-----------MLDPD--ETIVC-VVTGNLLKDPE 371 Archaeoglobus fulgidus
WP_010875892 356 -------G-----------VVDRG--ERVVC-VVTGHVLKDPD 377 Methanothermobacter thermautotrophicus
WP_010872388 373 -------G-----------KIDPE--ETTVV-YITGNGLKTQE 394 Synechocystis sp. PCC 6803
WP_010878058 359 -------G-----------RIDRD--EKVVA-YLTGNGLKTAE 380 Archaeoglobus fulgidus
P16120       437 -------DndksiqyislsTAHPAkfADAVNnALSGFSNYSFE 472 Saccharomyces cerevisiae S288c
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