3PRH_A 34 MKQTIFSGIQPSG-SVTLGNYIGAMKQFVEL-QHDYNSYFCIVDQHAITVPQd-rLE--LRKNIRNLAALYLAVGLDPEK 108 Bacillus subtilis P56396 2 HKKRVFSGIQPTG-QIHLGNYLGAIKHWVEM-QDEYENLFCVVNSHAITLPI---DPafLKSQSYELVKLLLACGIDPKQ 76 Helicobacter pylori 2... Q12109 101 KPFFLYTGRGPSSdSMHLGHMIPFVFTKWLQeVFDVPLVIELTDDEKFLFKHkltINdvKNFAREN-AKDIIAVGFDPKN 179 Saccharomyces cerevis... Q09692 81 KPFYLYTGRGPSSdSMHLGHMIPFMFCKWLQdVFQVPLVIQLTDDEKFLFKQgvsLEdcQRFAREN-AKDIIAVGFDPKK 159 Schizosaccharomyces p... P23381 154 KPFYLYTGRGPSSeAMHVGHLIPFIFTKWLQdVFNVPLVIQMTDDEKYLWKDl-tLDqaYSYAVEN-AKDIIACGFDINK 231 human Q8U453 72 KGFFLYTGRGPSG-PMHIGHIIPFFATKWLQeKFDVNLYIQITDDEKFLFKEnltFEdtKYWAYQN-ILDIIAVGFDPDK 149 Pyrococcus furiosus D... Q58810 65 KEFAVVSGMMPSG-KMHFGHKMVVDLLKFYQ-KYTDNINIPIADLEAYWARNm-sFEttKELALNEYITNYIALGLDPEK 141 Methanocaldococcus ja... O26352 60 EDFAVVTGMMPSG-RMHIGHKMIVDQLRWYD-RMGAEIFIPIADMEAYSARGv-dFEdsRRIAIEEYIAGYIALGLDLEK 136 Methanothermobacter t... 2IP1_A 101 KPFFLYTGRGPSSdSMHLGHMIPFVFTKWLQeVFDVPLVIELTDDEKFLFKHkltINdvKNFAREN-AKDIIAVGFDPKN 179 Saccharomyces cerevis... 3JXE_A 72 rgFFLYTGRGPSG-PMHIGHIIPFFATKWLQeKFGVNLYIQITDDEKFLFKEnltFDdtKRWAYDN-ILDIIAVGFDPDK 149 Pyrococcus horikoshii
3PRH_A 109 --ATLFIQSEVP----AHAQAGWMMQCVAYIGELERMTQFKDKS--KgNEAVVSGLLTYPPLMAADILLY-GTD------ 173 Bacillus subtilis P56396 77 --SGLFIQSEVD----EHPALAWLLNCQVSMGEMQRMTQFKDKSlkN-PKSVNVGLFNYPILMASDILLY-QSD------ 142 Helicobacter pylori 2... Q12109 180 --TFIFSDLQYMg--gAFYETVVRVSRQITGSTAKAVFGFNDSD--------CIGKFHFASIQIATAFPS-SFPnvlglp 246 Saccharomyces cerevis... Q09692 160 --TFIFMNSTYVg--gAFYQNVVRIAKCITANQSKACFGFTDSD--------SIGKIHFASIQAAPSFSS-SFPhifnga 226 Schizosaccharomyces p... P23381 232 --TFIFSDLDYMgmssGFYKNVVKIQKHVTFNQVKGIFGFTDSD--------CIGKISFPAIQAAPSFSN-SFPqifrdr 300 human Q8U453 150 --TFIFQNSEFT----KIYEMAIPIAKKINFSMAKAVFGFTEQS--------KIGMIFFPAIQAAPTF----FEkk---- 207 Pyrococcus furiosus D... Q58810 142 --INVYLQSKYq----KVKDLALILSKRTNWSEMKAIYGFKGET--------NIGHVFAPIVQVADILHP-QLDenlsp- 205 Methanocaldococcus ja... O26352 137 dnIHVYLQSENl----MVEDLAYVLAGKVNFNELRAIYGFTGST--------SMAHMYAPIIQVSDILHP-QLDelgg-- 201 Methanothermobacter t... 2IP1_A 180 --TFIFSDLQYMg--gAFYETVVRVSRQITGSTAKAVFGFNDSD--------CIGKFHFASIQIATAFPS-SFPnvlglp 246 Saccharomyces cerevis... 3JXE_A 150 --TFIFQNSEFT----KIYEMAIPIAKKINFSMAKAVFGFTEQS--------KIGMIFFPAIQIAPTFFErKRC------ 209 Pyrococcus horikoshii
3PRH_A 174 -----LVPPGEDQKQHLELTRNLAERFNKKYNDIFTIPEVKIPKVgARIMSLNDplKKMSKSDPNqkAYITLLDEPKQLE 248 Bacillus subtilis P56396 143 -----LVPVGEDQKQHLELTRNIAEKFNRDFGNCFKVPEPLIAKVgARVMGLDDpkVKMSKSHQGanHAIFLLDEPDIIV 217 Helicobacter pylori 2... Q12109 247 dktpcLIPCAIDQDPYFRVCRDVADKLK------YSKPALLHSRFfPALQGSTT---KMSASDDT--TAIFMTDTPKQIQ 315 Saccharomyces cerevis... Q09692 227 kdipcLIPCAIDQDPYFRLTRDVSGRLK------FKKPALLHSRFfPALQGPQS---KMSASKDS--SAIFMTDTPNKIK 295 Schizosaccharomyces p... P23381 301 tdiqcLIPCAIDQDPYFRMTRDVAPRIG------YPKPALLHSTFfPALQGAQT---KMSASDPN--SSIFLTDTAKQIK 369 human Q8U453 208 ---rcLIPAAIDQDPYWRLQRDFAESLG------YYKTAALHSKFfPPLTGLEG---KMSASKPE--TAIYLTDNPEEAG 273 Pyrococcus furiosus D... Q58810 206 epkpvVVPVGIDQDPHIRLTRDIANRAKE-FK--FIPPSSTYHRFmTGLLG--G---KMSSSKPE--TAIFLTDDEKTVK 275 Methanocaldococcus ja... O26352 202 -prpvIVPVGPDQDPHIRLTRDIAARFRDRYG--FILPSSTYHRFmGGLTG--G---KMSSNRPK--SAIFLSDTPEEAE 271 Methanothermobacter t... 2IP1_A 247 dktpcLIPCAIDQDPYFRVCRDVADKLK------YSKPALLHSRFfPALQG-ST--TKMSASDDT--TAIFMTDTPKQIQ 315 Saccharomyces cerevis... 3JXE_A 210 -----LIPAAIDQDPYWRLQRDFAESLG------YYKTAALHSKFvPSLTSLSG---KMSASKPE--TAIYLTDSPEDVE 273 Pyrococcus horikoshii
3PRH_A 249 KKIKSAVTDSEGIVKFDKENKPGVSNLLTIYSILG-NTTI-------EELEAKYEGKg-YGEFKGDLAEVVVNALKPIQD 319 Bacillus subtilis P56396 218 KKIKKAATDSMGVIAFDE-KREGIFNLLNIYMLLS-NESP-------ENIEERFKNKg-YGDFKKELAEVMIQALKPIQE 287 Helicobacter pylori 2... Q12109 316 KKINKYAFSGGQVSADLHRELGGNPDVDVAYQYLS-FFKDddv-flkECYDKYKSGEllSGEMKKLCIETLQEFVKAFQE 393 Saccharomyces cerevis... Q09692 296 NKINRHAFSGGGATIEIHREKGGNPDVDVAYQYLS-FFLDdde-klkQLYNTYKAGTlsTGEMKGECIKLLQQFVSDFQA 373 Schizosaccharomyces p... P23381 370 TKVNKHAFSGGRDTIEEHRQFGGNCDVDVSFMYLT-FFLEddd-kleQIRKDYTSGAmlTGELKKALIEVLQPLIAEHQA 447 human Q8U453 274 KKIWKFALTGGQPTLKEQREKGGNPEKCVVFKWLE-IFFEpddkklmERYYACKNGEllCGECKRYLIQRVQEFLKEHQE 352 Pyrococcus furiosus D... Q58810 276 KKIFS-AKTGGRETLEEHKKYGGVPEECVVYELFL-YHLIlddkelaEIYQKCRSGEltCGKCKKMAYERVVEFLKDLKE 353 Methanocaldococcus ja... O26352 272 AKIRN-AKTGGRETLKEQRELGGVPEECIIYETLL-YHMSgsdsrleEIYESCRNGTlmCGECKNNTAEFIRKFFEELSV 349 Methanothermobacter t... 2IP1_A 316 KKINKYAFSGGQVSADLHRELGGNPDVDVAYQYLS-FFKDddv-flkECYDKYKSGEllSGEMKKLCIETLQEFVKAFQE 393 Saccharomyces cerevis... 3JXE_A 274 KKVWKFTLTGGRPTLKEQREKGGEPEKCVVFKWLEiFFEEddk-klkERYYACKNGEltCGECKRYLISKIQEFLKEHQR 352 Pyrococcus horikoshii
3PRH_A 320 RYYELIEsEELDRILDEGAERANRTANKMLKKMENAMGL 358 Bacillus subtilis P56396 288 RYKEISD-DEVKAILNGGAEKARPLARATYQKAKELMGL 325 Helicobacter pylori 26695 Q12109 394 RRAQVDE-ETLDKFMVP-HKLVWGEKERLVAPKPKtkqe 430 Saccharomyces cerevisiae S288c Q09692 374 ARSKVDE-ATLDMFMDGSRKLEW---------------- 395 Schizosaccharomyces pombe 972h- P23381 448 RRKEVTD-EIVKEFMTP-RKLSFDFQ------------- 471 human Q8U453 353 KR-KKAE-KLVEKFKYT-GKLAQEQWNKAIPDPLKk--- 385 Pyrococcus furiosus DSM 3638 Q58810 354 KR-EQAK-EIAVKILEGKY-------------------- 370 Methanocaldococcus jannaschii DSM 2661 O26352 350 KR-EKAL-PAARRILEG---------------------- 364 Methanothermobacter thermautotrophicus str. Delta H 2IP1_A 394 RRAQVDE-ETLDKFMVP-HKLVWGEKERLVAPKPKtkqe 430 Saccharomyces cerevisiae S288c 3JXE_A 353 RR-KKAE-KLVEKFKYTG-KLAQEMWNEAIPEPLKrshh 388 Pyrococcus horikoshii
Jiyao W et al.(2023). "The conserved domain database in 2023.",