Conserved Protein Domain Family
mscL

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TIGR00220: mscL 
large conductance mechanosensitive channel protein
Protein encodes a channel which opens in response to a membrane stretch force. Probably serves as an osmotic gauge. Carboxy terminus tends to be more divergent across species with a high degree of sequence conservation found at the N-terminus. [Cellular processes, Adaptations to atypical conditions]
Statistics
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PSSM-Id: 272967
Aligned: 4 rows
Threshold Bit Score: 119.974
Created: 7-Oct-2014
Updated: 25-Oct-2021
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
P23867   3 IIKEFREFAMRGNVVDLAVGVIIGAAFGKIVSSLVADIIMPPLGLLIGGIDFKQFAVTLRDAQgdipAVVmHYGVFIQNV 82  Escherichia coli
P44789   3 FIKEFREFAMRGNVVDMAVGVIIGSAFGKIVSSLVSDIFTPVLGILTGGIDFKDMKFVLAQAQgdvpAVTlNYGLFIQNV 82  Haemophilus influenza...
P94585   1 MWNEFKAFAMRGNIVDLAIGVVIGGAFGKIVTSLVNDIIMPLVGLLLGGLDFSGLSFTFGDA-----VV--KYGSFIQTI 73  Bacillus subtilis sub...
P73553  12 FWRDFKDFILRGNVVDLAVAVVIGGAFTSIVNAFVAWLMAVLLQPVLDQAGVS----QLQDLP-----LG--LGELVIAI 80  Synechocystis sp. PCC...
P23867  83 FDFLIVAFAIFMAIKLINKLNr--KKEEPAAAPap-----tKEEVLLTEIRDLLK---EQ 132 Escherichia coli
P44789  83 IDFIIIAFAIFMMIKVINKVR---KPEEKKTAP--------KAETLLTEIRDLLK---NK 128 Haemophilus influenzae Rd KW20
P94585  74 VNFLIISFSIFIVIRTLNGLRrkkEAEEEAAEEav-----dAQEELLKEIRDLLK---QQ 125 Bacillus subtilis subsp. subtilis str. 168
P73553  81 INFLIIAFVIFLIIKAIEKMQrkkAVEEEIVAEaqpdpvleAQTNLTDSINRLITtleNQ 140 Synechocystis sp. PCC 6803 substr. Kazusa
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