2X7J,3LQ1,3FLM


Conserved Protein Domain Family
menD
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TIGR00173: menD 
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2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic-acid synthase
MenD was thought until recently to act as SHCHC synthase, but has recently been shown to act instead as SEPHCHC synthase. Conversion of SEPHCHC into SHCHC and pyruvate may occur spontaneously but is catalyzed efficiently, at least in some organisms, by MenH (see TIGR03695). 2-oxoglutarate decarboxylase/SHCHC synthase (menD) is a thiamine pyrophosphate enzyme involved in menaquinone biosynthesis. [Biosynthesis of cofactors, prosthetic groups, and carriers, Menaquinone and ubiquinone]
Links
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Statistics
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PSSM-Id: 272941
Aligned: 58 rows
Threshold Bit Score: 375.788
Created: 7-Oct-2014
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
2X7J_A        33 YIGSFIDEFALSGITDAVVCPGSRSTPLAVLC---AAHPD---I---SVHVQIDERSAGFFALGLAKAKQRPVLLICTSG 103 Bacillus subtilis
WP_005874646  10 gVSVLMDLFEMKGIRKLVMSPGSRNAPLLFSF---SRNPA---F---EKYVIADERSAGFFALGLALASGEAVGLVCTSG 80  Porphyromonas g...
WP_005786027   7 NILQLVALLRAHGVTKVVLCPGSRNAPIVHTL---AGHPD---F---TCYSVTDERSAGFFAIGLALQGGTPAAVCCTSG 77  Bacteroides
WP_011293577  12 ISLELLKTLVAKGVKYFVLCPGSRSGPLALAA---ASLSKrkeL---TLITSIDERSAAFLALGISAASGQVSCVITTSG 85  Prochlorococcus...
WP_014709651   7 NVNILTALLVQHGITQVVVCPGSRNSPLVHNL---CECKE---I---KCYPVTDERSAAFFALGVAMSTHSPVVVCVTSG 77  Prevotella inte...
WP_011187498   6 HISDLAHHCIAHGMRHLVISPGSRNAPLIRAF---AASSQ---I---ECLSIVDERSAAFVALGLATELQAPVGVLCTSG 76  Desulfotalea ps...
WP_011364100   3 AALTLLEALCLQGLKQLVLCPGSRSGPLATAAgvlASQAK---L---QLVTAIDERSAAFLALGMATAHGRVVAVVTTSG 76  Synechococcus s...
WP_011175618   5 LALHVIEQALQYGIKEFCVAPGARNAAFVYLL---AQIPT---I---KVYYWSEERSAAFFAVGRIKATHQPIAVVTTSG 75  Candidatus Prot...
WP_011132241  12 rSLQLLDLFTKIGVKNLILCPGSRSGPLAIAA---GELNKrrvL---NVFNSIDERSAGFHSLGISTASGDVSLVVTTSG 85  Prochlorococcus...
WP_011096044   7 iAFCLLNLLAERGVRDIVVAPGARSQALALAA---VALER---AglvRLTVRIDERVAAFTAFGMAKALDSPAVVITTSG 80  Tropheryma whip...

2X7J_A       104 TAAANFYPAVVEAHYSRVPIIVLTADRPHELREVGAPQAINQHFLFGNFVKFFTDS-A-LPEES-PQmL-RYIRTLASRA 179 Bacillus subtilis
WP_005874646  81 TAMLNYAPAVAEAFYRGIPLVAVTADRPAEWIDQDEGQTIRQEGAMAGFVKSYCSLrA-EFDTS-AS-A-WYANRRLNEV 156 Porphyromonas g...
WP_005786027  78 TALLNLHPAIAEAYYQKVSLVVISADRPAAWINQMDGQTLPQPGVFRSLVKKSVDL-P-EIHTD-ED-E-WYCNRLLNEA 152 Bacteroides
WP_011293577  86 SAVANLLPAAVEADRSCHPLLFLTADRPLRLKECGANQAVNQQDFLKSVCRHFDES-P-KEGIHlIS-K-ERLTSLVGKS 161 Prochlorococcus...
WP_014709651  78 SALLNVAPAVAEAYYQNLPLIVVSADRPQQWIGQSDGQTMPQANALAPFVRKSVHL-I-EPKTK-EE-H-WYCNRLVNEV 152 Prevotella inte...
WP_011187498  77 TALLNYGPAIAEAYYLRAPLIVLSADRPARLVGQQDSQTICQDNLFANIVKGSYSL-PeEPETV-AE-L-ELSARVIAQA 152 Desulfotalea ps...
WP_011364100  77 TAVSNLLPAAVEADRSCQPLLLLTADRPVRLKNCGANQTVNQESFLLAACRWFGSG-A-ADGIH-TQ-AnDALNALAVKA 152 Synechococcus s...
WP_011175618  76 TAVAELLPATIEAYYTSLPLLLITADRPRRFRLSGAPQSIEQVGIFSCYTILEKDL-A-E-----------------NEF 136 Candidatus Prot...
WP_011132241  86 TAVGNLLPAAIEADKSCKSIVFITADRPLRLKNCGSNQTVNQEEFLNSVCRSNLST-N-LNGIH-EN-N-DDDILKIVET 160 Prochlorococcus...
WP_011096044  81 SAVANLYPAVVEASHSFVPLIVITADRPRELHGKRSNQTMNQEKFFSHWVRFFCHI-E-QDVPG-E----RVIDSALQAA 153 Tropheryma whip...

2X7J_A       180 AGEAQ--KR---PMGPVHVNVPLREPLMPDLSDE--PFGRM-------RTGRH----VSVKTGTQSVDRESLSDVAEMLA 241 Bacillus subtilis
WP_005874646 157 LNHAL--MP---RRGPVHINMSFCEPLYGTS------SGYS-------GKERA----ITFVRERQELPEEVWDMLVKRFL 214 Porphyromonas g...
WP_005786027 153 LLELN--HH---GKGPVHINVPVSEPLF--QFTA--ESLPE-------VR--V----ITRYQGLNVYDRD-YDGLIDRLN 209 Bacteroides
WP_011293577 162 FEMAS--NI----PGPVHINLAYEEPLHPCELDQkkVLDGW-------VIEGFlkgkITPTKDEVVKSFQSLKLL--KLD 226 Prochlorococcus...
WP_014709651 153 LIECK--RF---SYAPVHINIPISEPLF--DYDV--ATLPT-------ER--------HISATSVCNDNAAVADVVTMAR 208 Prevotella inte...
WP_011187498 153 FSTAL--SP---CFGPVHINIPLDEPLYGGELMA--ESLIA-------L---S----PLQLAEPKGMSPALWQEVESAWR 211 Desulfotalea ps...
WP_011364100 153 WQQAQ--GAgtgPPGAVHLNLPFEEPLH-TTLEQ--QQQLA-------SAA---------LPPTACPEPSPGIGPALRLD 211 Synechococcus s...
WP_011175618 137 FQLDQ--WS---GRGPCHLNVCFEEPSKNDN-------QEC-------ARSFS----MGIFTPKPILCDSHLLDEFIQKC 193 Candidatus Prot...
WP_011132241 161 VKKQI--LQ---SPGPIHLNIAFEKPL-DISLKN--KKKNFevferfyLNKTY----KFLKNDNQNKNIQFSEKFFKRIN 228 Prochlorococcus...
WP_011096044 154 LGVSSlrGA---GPGPVHINVAFDNPL---SCAH--AVQPG-------DNKGS----ALKHKKVLRSKRETLVLRKDD-- 212 Tropheryma whip...

2X7J_A       242 EAEKGMIVCGELHS-----D-----AD-KEN-IIALSKALQYPILADPLSNLRNGVHDksTVIDAY-DS-FL--KDDEL- 304 Bacillus subtilis
WP_005874646 215 EAPRVMIVAGFYPP-----D-----EDvSAA-LQDICKFPHTVLFAESLSNIRTDTG-----ICTA-DR-VL--AAAGE- 273 Porphyromonas g...
WP_005786027 210 KYNRRMMIVGQMNLi----Y-----LF-EKK-YSKMLYK-QFAWFTEHLGNQTVPGIP----IRNF-DA-ALyaMSPEM- 270 Bacteroides
WP_011293577 227 PFSLGIIIVGPWRG-----KvkqlnSF-RGA-LKKWQKLTGWPILADPLSGVENDQEG---LINHW-DL-FF--SIGLF- 291 Prochlorococcus...
WP_014709651 209 QAQRPLLIIGQEAW-----Anm--vEA-KTV-LASLRQR--IVVIQDKLSDVTDTAPQ--LV-----DA-AI--AIAED- 266 Prevotella inte...
WP_011187498 212 GAKRRMIVCGQGVA-----D-----AE-LQAlLARFAPDKTVTIIAENTANIVG---P--WLVDRP-DAvLL--ACDEAs 272 Desulfotalea ps...
WP_011364100 212 PERPGVVVAGPWRGltlslE-----AH-QQA-LHRWLNLSGWPLLADPLAALPPDC-P--NRIEHW-EL-QL------D- 272 Synechococcus s...
WP_011175618 194 QF--PLVIVGALNQ-----N-----E--TTP-ILSFLRHLKAPVYLEAQSGLRENSLLenLRIESVeDV-WN--CSSQH- 254 Candidatus Prot...
WP_011132241 229 LSNPGIIIVGPYQGstkdlF-----SF-NSA-LKKLQEITGWPVFVDPVSGVSAELKG--LV-ENW-EL-IL--KKNKN- 293 Prochlorococcus...
WP_011096044 213 --PPTVIIAGTGSG---------------RR-PADIACATGWPLVAEISSGSRFGP----FLIKNY-RN-WL--TEN--- 263 Tropheryma whip...

2X7J_A       305 KRKLRPD-VVIRFGPMPVSKPVFLWLKdD-P-TIQQIVIDE-DG-G-WRDPTQAS-A--HMIHCNASVFAEEIMAGLtaA 375 Bacillus subtilis
WP_005874646 274 DESLYPE-LLISFGGSLISRMLKTFLR-R-AkPAEHWGIDE-RF-P-APDTFCAL-T--HHICTGASGFWKEFAGRL--K 342 Porphyromonas g...
WP_005786027 271 QEKMIPE-LVITYGGHIVSKRMKKYLR-QhP-PKEHWHVSP-DG-E-VIDLFQGAlT--TIIEMDPFEFMEKIAFLL--D 340 Bacteroides
WP_011293577 292 -EKIKEI-QVLRLGPIPPSRELQTWLK-K-P-GKFQLLITE-GDsR-NLDPIGG--S--TQFSEGFSCWVDKMLEVI--P 358 Prochlorococcus...
WP_014709651 267 TEALRPD-LIIYIGGTLVSKLCKQFLR-ScT-PTDSILIDP-RG-D-IRDTFTNL-T--AVVQCQSDAFIKALASGL--E 335 Prevotella inte...
WP_011187498 273 RSLLAPD-CLISFGGHLVAKHIKLLLR-EfK-PAFHFRLDP-AQ-M-GIDTYQCL-S--AELDLAPTTFFRRLAQQV--- 340 Desulfotalea ps...
WP_011364100 273 RLSLPDDaQVLRLGPMPASRRLEAWLQ-R-H-QGPQLLITEgDP-R-PLDPLHTA----NQWSGGMAAWIAQQPGLK--Q 341 Synechococcus s...
WP_011175618 255 GY--PID-GILRIGGIPTARLWRDLEE-T-N-NVKVCSISE--------NPFAGL-TngNIIHTSLREFFKNYRLSF--K 317 Candidatus Prot...
WP_011132241 294 II--QCD-QILRFGPLSSSNYLEDFLL-N-F-EGLQILVKE-NNiR-KLDPIKK--S--LEYDFGISNFVNQLLGAF--L 359 Prochlorococcus...
WP_011096044 264 --SLDIR-RAIVFGHPTLSSEIPTFLT-K-R-NIDTIVVAP-FG-ReFYNPSGTA-R--PVANVLVDEDSFSGIPLG--A 330 Tropheryma whip...

2X7J_A       376 TRS-S--------E--------WLEKWQFVNGRFREHLQTISseDVSf-----eGNLYRILQHLVPENSSLFVGNSMPIR 433 Bacillus subtilis
WP_005874646 343 DKA-P--------EslspegisYAGSWQKIKRKADLLHRTFMadAGWs-----dLKAFEVILRHIPHDAALHAANSTPVR 408 Porphyromonas g...
WP_005786027 341 NRT-P--------E--------YPRQW---ENFCKELPRp---eLPYs-----eMSAIGSLIQALPASCALHLANSSAVR 392 Bacteroides
WP_011293577 359 VKP-AidkkivskK--------LIKELIKYDLFIHDWLDKRLfrNGLit----ePALARLLPRLLPESIPVMIASSSPIR 425 Prochlorococcus...
WP_014709651 336 DFAlS--------K--------FYHDWQKALNDAAAAAQSYVpaYSQil----aVKRFHTLLQQNNDAKALVYGNSSAVR 395 Prevotella inte...
WP_011187498 341 EPA-A--------G--------FRDLWALPEGVAENQDDEFL--------------VLKRLLGQLPAGSIAHLGNSMSVR 389 Desulfotalea ps...
WP_011364100 342 ATK-P--------Svg----tnDLSPWLETQLPLRGAVt--------------ePALAYWLPQLLPEQLPVMLAASSPVR 394 Synechococcus s...
WP_011175618 318 PIY-S--------F----------QAWKDANRSYQLELLKLFeeEPLa-----eLSLFHLLSKKIPEESKIYVGNSLPIR 373 Candidatus Prot...
WP_011132241 360 NHK-Kksk--pliN--------LGQVLIKEGAKIKEILKEQLfsNTEit----eYKLANFVPKIWPENYPIMLSASSPIR 424 Prochlorococcus...
WP_011096044 331 AK--------------------------FASASAGCISQDVIssDRPrghrvtrQQLVSEIWNITKEDEILFFGSSQLIR 384 Tropheryma whip...

2X7J_A       434 DVDTFFEKQDRPFRIYSNRGANGIDGVVSSAMGVCEG 470 Bacillus subtilis
WP_005874646 409 YLQLFEHAHYAGGE-WSNRGTNGIEGATSTAMGFSEv 444 Porphyromonas gingivalis
WP_005786027 393 YAQLYSLPD--TVEVCCNRGTSGIEGSLSTAIGYAAA 427 Bacteroides
WP_011293577 426 DWLSYSGEGAFLRRCFGFRGASGIDGTLSMGMGLSII 462 Prochlorococcus marinus
WP_014709651 396 LGNFCSS-----DYIFVNRGVNGIEGTLSTAVGMAAA 427 Prevotella intermedia
WP_011187498 390 HAQKLASRADLLY--HSNRGVAGIDGCLSTAVGVALA 424 Desulfotalea psychrophila
WP_011364100 395 DWLTWGGYSCGRHRCFSFRGASGIDGTLSLAMGLAAn 431 Synechococcus sp. CC9605
WP_011175618 374 EWDQAADWTNKHFQVFANRGANGIEGQLSTFLGLAsp 410 Candidatus Protochlamydia amoebophila
WP_011132241 425 DWLTFSENATLTRECFSFRGASGIDGTLSLALGIARI 461 Prochlorococcus marinus
WP_011096044 385 VAD--SILPGKRVTVFANRGLSGIDGNLSTAAGIAIA 419 Tropheryma whipplei
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